Abstract：
:Germline mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers. Current evidence demonstrates that mutations in BRCA1 do not directly result in tumor formation, but instead cause genetic instability, subjecting cells to high risks of malignant transformation. In an animal model in which Brca1 is mutated specifically in mammary epithelium, tumorigenesis occurs in mutant glands at low frequency after a long latency. Notably, introduction of a p53-null allele significantly enhanced mammary gland tumor formation in Brca1 conditional mutant mice. These results are consistent with a model that Brca1 is a caretaker gene, whose absence causes genetic instability and triggers further alterations, including inactivation of tumor suppressor genes and/or activation of oncogenes, leading to tumor formation.
journal_name
Oncogenejournal_title
Oncogeneauthors
Deng CX,Scott Fdoi
10.1038/sj.onc.1203269subject
Has Abstractpub_date
2000-02-21 00:00:00pages
1059-64issue
8eissn
0950-9232issn
1476-5594journal_volume
19pub_type
杂志文章,评审相关文献
ONCOGENE文献大全abstract：:LASP-1 is a multidomain protein predominantly localized at focal contacts, where it regulates cytoskeleton dynamics and cell migration. However, in different tumor entities, a nuclear LASP-1 accumulation is observed, thought to have an important role in cancer progression. Until now, the molecular mechanisms that cont...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.216
更新日期：2013-04-18 00:00:00
abstract：:Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid modulator of allergic and inflammatory reactions, is diverse and functions as a modulator of a variety of physiological and pathological events in many cell types and tissues. Its role (if any) in modulating the prolifera...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206348
更新日期：2003-04-10 00:00:00
abstract：:To understand the mechanism of interferon (IFN)-mediated suppression of cell cycle progression, we have earlier shown that IFN-alpha enhances the expression of underphosphorylated retinoblastoma protein by inhibiting the cyclin-dependent kinase-2 (CDK-2) activity (Kumar and Atlas, Proc. Natl. Acad. Sci. 89, 6599-6603,...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201529
更新日期：1998-01-15 00:00:00
abstract：:Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic proteins might result in the sensitization of cancer cells to chemothe...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209832
更新日期：2007-02-01 00:00:00
abstract：:We compared the mitogenic and signaling pathways of three Fibroblast Growth Factor Receptors (FGFRs), FGFR1, KGFR and FGFR4 in the same cell line. Each receptor was expressed in L6E9 rat myoblasts that do not normally express detectable levels of FGFRs and clones that express comparable levels of each receptor were se...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-04-20 00:00:00
abstract：:The human MSH2/6 complex is essential for mismatch recognition during the repair of replication errors. Although mismatch repair components have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in this pathway is unclear. Here, we show that the recombinant hMSH2/6 protein complex s...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207462
更新日期：2004-05-06 00:00:00
abstract：:Radioresistance becomes the major obstacle to reduce tumor recurrence and improve prognosis in the treatment of esophageal squamous cell carcinoma (ESCC). Thus new strategies for radioresistant ESCC are urgently needed. Herein, we reported that tribbles pseudokinase 3 (TRIB3) serves as a key regulator of radioresistan...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-020-1245-0
更新日期：2020-04-01 00:00:00
abstract：:Activation of Stat5 by many cytokines implies that it cannot alone insure the specificity of the regulation of its target genes. We have evidenced a physical and functional interaction between members of two unrelated transcription factor families, Ets-1, Ets-2 and Stat5, which could contribute to the proliferative re...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203542
更新日期：2000-04-20 00:00:00
abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.375
更新日期：2010-02-04 00:00:00
abstract：:The regulatory step in ubiquitin (Ub)-mediated protein degradation involves recognition and selection of the target substrate by an E3 Ub-ligase. E3 Ub-ligases evoke sophisticated mechanisms to regulate their activity temporally and spatially, including multiple post-translational modifications, combinatorial E3 Ub-li...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1208614
更新日期：2005-04-18 00:00:00
abstract：:Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.453
更新日期：2014-10-23 00:00:00
abstract：:It has been suggested that the embryonic microenvironment can control the survival and the transformed phenotype of tumour cells. Here, we addressed the hypothesis that the murine embryonic microenvironment can induce the differentiation of human tumour cells. To examine such interactions, we injected human leukaemic ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207134
更新日期：2003-12-11 00:00:00
abstract：:Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined. Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells were...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204203
更新日期：2001-03-08 00:00:00
abstract：:Casitas B-lineage lymphoma (CBL) protein family functions as multifunctional adaptor proteins and E3 ubiquitin ligases that are implicated as regulators of signaling in various cell types. Recent discovery revealed mutations of proto-oncogenic CBL in the linker region and RING finger domain in human acute myeloid neop...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.18
更新日期：2012-12-13 00:00:00
abstract：:Chronic inflammation has been associated with a variety of human cancers including prostate cancer. Interleukin-17 (IL-17) is a critical pro-inflammatory cytokine, which has been demonstrated to promote development of prostate cancer, colon cancer, skin cancer, breast cancer, lung cancer and pancreas cancer. IL-17 pro...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.240
更新日期：2017-02-02 00:00:00
abstract：:Wnt genes encode a set of structurally related cell surface glycoproteins that appear to have roles in cell-cell signalling. The ectopic expression of several murine Wnt genes has been implicated in the transformation of mammary epithelial and the onset of mammary tumours. Wnt11 is expressed in the developing embryo i...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-06-20 00:00:00
abstract：:Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.41
更新日期：2015-02-26 00:00:00
abstract：:We report here the nucleic acid sequence and deduced amino acid sequence of a cDNA for TIS7, a gene induced by mitogens in 3T3 cells and by nerve growth factor in PC12 pheochromocytoma cells. A fragment of the TIS7 gene has previously been cloned from murine fibroblast cells infected with Newcastle Disease Virus. The ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Inhibitor of apoptosis (IAP) proteins are a family comprised of a total of eight mammalian members that were initially described to act as endogenous inhibitors of caspases. In addition, extensive evidence has been accumulated over the last years showing that IAP proteins can regulate various signal transduction pathw...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2013.63
更新日期：2014-02-06 00:00:00
abstract：:The products of two cellular proto-oncogenes c-fos and c-jun form a heterodimeric complex that contribute to the DNA-binding activity referred to as AP-1 (activator protein-1). Two domains have been proposed to be required for heterodimer formation and protein-DNA complex formation. The leucine zipper domain mediated ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:We have cloned a novel quail cDNA with strong homology to the pim family of proto-oncogenes. The deduced amino acid (aa) sequence of the cDNA, named qpim, is more closely related to Xenopus Pim and to the recently identified rat Pim-3 than to human or rodent Pim-1 or Pim-2. The protein encoded by the qpim cDNA can aut...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203355
更新日期：2000-02-24 00:00:00
abstract：:Mammalian systems respond to environmental stress by either adapting or undergoing programmed cell death. While there is general agreement that the caspase family of proteases serve as the effectors of the apoptotic death response, the signaling apparatus involved in the decision to activate the caspase system is less...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1202570
更新日期：1998-12-24 00:00:00
abstract：:Transforming growth factor beta1 (TGF-beta1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of mammalian cells. Although solid data established the role of TGF-beta's as suppressor factors in tumorigenic processes, in the context of an advanced stage of di...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208664
更新日期：2005-06-30 00:00:00
abstract：:Rho GTPases are critical signal transducers of multiple pathways. They have been proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven cancers. Until recently, however, few in vivo studies had been carried out to test this premise. Several recent mouse model studies have verified...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2016.473
更新日期：2017-06-08 00:00:00
abstract：:The majority (75%) of human breast cancers express estrogen receptor (ER). Although ER-positive tumors usually respond to antiestrogen therapies, 30% of them do not. It is not known what controls the ER status of breast cancers or their responsiveness to antihormone interventions. In this report, we document that tran...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208597
更新日期：2005-06-16 00:00:00
abstract：:The RAF-mitogen-activated protein kinase kinase 1/2-extracellular signal-regulated kinase 1/2 (RAF-MEK1/2-ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; however, most such studies have relied upon overexpression of RAF or MEK constructs that are not found in...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2008.335
更新日期：2008-12-04 00:00:00
abstract：:Oncolytic adenoviruses, such as Delta-24-RGD (Δ24RGD), are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Δ24RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular mechanisms unde...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.452
更新日期：2015-10-08 00:00:00
abstract：:The balance between acetylation and deacetylation of histone and nonhistone proteins controls gene expression in a variety of cellular processes, with transcription being activated by acetyltransferases and silenced by deacetylases. We report here the formation and enzymatic characterization of a complex between the a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207327
更新日期：2004-03-18 00:00:00
abstract：:The status of the p53 gene in lymphoblastoid cell lines (LCLs) and Burkitt lymphoma cell lines (BLs) was investigated. Southern blot analysis demonstrated that no major deletions or rearrangements had occurred in the p53 gene in any of the cell lines. The p53 protein was examined by immunoprecipitation using two monoc...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：:Antimicrobial peptides, such as the cathelicidin LL-37/hCAP-18 and its mouse homolog cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune system with direct anti-bacterial activity. Cathelicidin is possibly involved in the regulation of tumor cell growth. The aim of this stu...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.248
更新日期：2014-05-22 00:00:00
