Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240.

abstract：:Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure. Biological effects of the RAS are media...

journal_title：Oncogene

authors： Renziehausen A,Wang H,Rao B,Weir L,Nigro CL,Lattanzio L,Merlano M,Vega-Rioja A,Del Carmen Fernandez-Carranco M,Hajji N,Matin R,Harwood C,Li S,Sim VR,O'Neill K,Evans A,Thompson A,Szlosarek P,Fleming C,Stebbing J,Pr

更新日期：2019-03-01 00:00:00

abstract：:Although established cell lines can be transformed with oncogenic ras, primary epithelial cells cannot, but require the coexpression of an immortalizing oncogene, such as the E1A region of adenovirus. We have previously shown that immortalization of primary epithelial cells by E1A 12S requires the expression of five r...

journal_title：Oncogene

authors： Gopalakrishnan S,Fischer RS,Quinlan MP

更新日期：1996-12-19 00:00:00

abstract：:Tumor suppressor gene CDKN2 (also called MTS1, CDK4I and p16INK4) is located in 9p21 and deleted homozygously in a high percentage of tumor cell lines. We have examined the sequence of CDKN2 in 154 tumor cell lines that are not homozygously deleted for CDKN2. Overall, 18% (27/154) of the cell lines carried mutations i...

journal_title：Oncogene

authors： Liu Q,Neuhausen S,McClure M,Frye C,Weaver-Feldhaus J,Gruis NA,Eddington K,Allalunis-Turner MJ,Skolnick MH,Fujimura FK

更新日期：1995-03-16 00:00:00

abstract：:The Ov/Br septin gene, which is also a fusion partner of MLL in acute myeloid leukaemia, is a member of a family of novel GTP binding proteins that have been implicated in cytokinesis and exocytosis. In this study, we describe the genomic and transcriptional organization of this gene, detailing seventeen exons distrib...

journal_title：Oncogene

authors： McIlhatton MA,Burrows JF,Donaghy PG,Chanduloy S,Johnston PG,Russell SE

更新日期：2001-09-13 00:00:00

abstract：:The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for ho...

journal_title：Oncogene

authors： Scandura JM,Boccuni P,Cammenga J,Nimer SD

更新日期：2002-05-13 00:00:00

abstract：:Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate that stromal-derived MMP1 may exert direct oncogenic activity by signaling through protease-activated receptor-1 (PAR1) in car...

journal_title：Oncogene

authors： Foley CJ,Fanjul-Fernández M,Bohm A,Nguyen N,Agarwal A,Austin K,Koukos G,Covic L,López-Otín C,Kuliopulos A

更新日期：2014-04-24 00:00:00

abstract：:Human xeroderma pigmentosum (XP) fibroblasts were transformed with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The transformed cells, called ASKMN, were immortalized, grew in agar and were tumorigenic in nude mice. A trp-met oncogene was identified in ASKMN cells, after transfection of high molecular weight DNA on 3T...

journal_title：Oncogene

authors： Michelin S,Daya-Grosjean L,Sureau F,Saïd S,Sarasin A,Suárez HG

更新日期：1993-07-01 00:00:00

abstract：:p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) ...

journal_title：Oncogene

authors： Zhao D,Besser AH,Wander SA,Sun J,Zhou W,Wang B,Ince T,Durante MA,Guo W,Mills G,Theodorescu D,Slingerland J

更新日期：2015-10-01 00:00:00

abstract：:E mu-bcl-2 transgenic mice bearing the bcl-2 proto-oncogene linked to the immunoglobulin enhancer (E mu) sporadically develop B or T cell lymphomas after a long latent period. To identify genes that play important roles in development of lymphoid malignancies, proviral insertional mutagenesis with Moloney murine leuke...

journal_title：Oncogene

authors： Shinto Y,Morimoto M,Katsumata M,Uchida A,Aozasa K,Okamoto M,Kurosawa T,Ochi T,Greene MI,Tsujimoto Y

更新日期：1995-11-02 00:00:00

abstract：:One of the key events in tumor initiation in mouse skin is mutational activation of the H-ras gene. Papillomas induced by the most carcinogenic environmental polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DB[a,l]P), in SENCAR mouse skin contain a specific H-ras codon 61 (CAA-->CTA) mutation. We describe he...

journal_title：Oncogene

authors： Chakravarti D,Mailander P,Franzen J,Higginbotham S,Cavalieri EL,Rogan EG

更新日期：1998-06-18 00:00:00

abstract：:The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro. To delineate the contribution of the 10 EGF-family ligands to the pathogenesis of MM, we have assessed th...

journal_title：Oncogene

authors： Mahtouk K,Cremer FW,Rème T,Jourdan M,Baudard M,Moreaux J,Requirand G,Fiol G,De Vos J,Moos M,Quittet P,Goldschmidt H,Rossi JF,Hose D,Klein B

更新日期：2006-11-16 00:00:00

abstract：:Genetic amplification at chromosome 8p23.1 has been reported in some solid tumors. Translocation of 8p23.1 has also been reported in hematological malignancies and head and neck squamous cell cancer. In an attempt to clarify whether this translocation is implicated in lymphomagenesis, we performed FISH analysis of the...

journal_title：Oncogene

authors： Tagawa H,Karnan S,Kasugai Y,Tuzuki S,Suzuki R,Hosokawa Y,Seto M

更新日期：2004-04-01 00:00:00

abstract：:The fate of cells exposed to ionizing radiation (IR) may depend greatly on changes in gene expression, so that an improved view of gene induction profiles is important for understanding mechanisms of checkpoint control, repair and cell death following such exposures. We have used a quantitative fluorescent cDNA microa...

journal_title：Oncogene

authors： Amundson SA,Bittner M,Chen Y,Trent J,Meltzer P,Fornace AJ Jr

更新日期：1999-06-17 00:00:00

abstract：:The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has been reported that SIRT1 is upregulated in various kinds of tumors and is associated with cell growth and metastasis. However, the factors a...

journal_title：Oncogene

authors： Yu L,Dong L,Li H,Liu Z,Luo Z,Duan G,Dai X,Lin Z

更新日期：2020-05-01 00:00:00

abstract：:Graft versus host disease (GvHD), which is the primary complication of allogeneic bone marrow transplantation, can alter the intestinal barrier targeted by activated donor T-cells. Chemical inhibition of the stress protein HSP90 was demonstrated in vitro to inhibit T-cell activation and to modulate endoplasmic reticul...

journal_title：Oncogene

authors： Joly AL,Deepti A,Seignez A,Goloudina A,Hebrard S,Schmitt E,Richaud S,Fourmaux E,Hammann A,Collura A,Svrcek M,Jego G,Robinet E,Solary E,Demidov O,Kohli E,Garrido C

更新日期：2016-06-02 00:00:00

abstract：:Low oxygen tension (hypoxia) is a common feature of solid tumors and stimulates the expressions of a variety of genes including those related to angiogenesis, apoptosis and endoplasmic reticulum (ER) stress response. Here we show a close correlation between metastatic potential and the resistance to hypoxia- and ER st...

journal_title：Oncogene

authors： Koshikawa N,Maejima C,Miyazaki K,Nakagawara A,Takenaga K

更新日期：2006-02-09 00:00:00

abstract：:The human MSH2/6 complex is essential for mismatch recognition during the repair of replication errors. Although mismatch repair components have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in this pathway is unclear. Here, we show that the recombinant hMSH2/6 protein complex s...

journal_title：Oncogene

authors： Yang Q,Zhang R,Wang XW,Linke SP,Sengupta S,Hickson ID,Pedrazzi G,Perrera C,Stagljar I,Littman SJ,Modrich P,Harris CC

更新日期：2004-05-06 00:00:00

abstract：:We examined the biological role of p12(CDK2-AP1) in cisplatin-mediated responses by using murine ES p12(CDK2-AP1) knockout clones generated by a targeted disruption of murine p12(CDK2-AP1). Homozygous knockout clones showed an increased cellular proliferation along with an increase in S and a decrease in G2/M phase po...

journal_title：Oncogene

authors： Kim Y,McBride J,Zhang R,Zhou X,Wong DT

更新日期：2005-01-13 00:00:00

abstract：:The diverse checkpoint responses to DNA damage may reflect differential sensitivities by molecular components of the damage-signalling network to the type and amount of lesions. Here, we determined the kinetics of activation of the checkpoint kinases ATM and Chk2 (the latter substrate of ATM) in relation to the initia...

journal_title：Oncogene

authors： Buscemi G,Perego P,Carenini N,Nakanishi M,Chessa L,Chen J,Khanna K,Delia D

更新日期：2004-10-07 00:00:00

abstract：:To gain a more complete understanding of c-myc regulation in chickens, we have completed the structural characterization of the chicken c-myc gene and have begun to investigate c-myc transcription and protein expression. A comparison of c-myc structure and expression between mammals and birds presents an enigma: there...

journal_title：Oncogene

authors： Petropoulos CJ,Givol I,Hughes SH

更新日期：1996-06-20 00:00:00

abstract：:Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein highly expressed in breast cancer that contributes to tumor progression through largely undefined mechanisms. By analyzing publicly available gene expression profiles of breast carcinomas, we found that MFG-E8 is highly expressed in primary and metastatic breast...

journal_title：Oncogene

authors： Carrascosa C,Obula RG,Missiaglia E,Lehr HA,Delorenzi M,Frattini M,Rüegg C,Mariotti A

更新日期：2012-03-22 00:00:00

abstract：:Pilocytic astrocytomas (PAs, WHO grade I) are the most common brain tumors in the pediatric and adolescent population, accounting for approximately one-fifth of central nervous system tumors. Because few consistent molecular alterations have been identified in PAs compared to higher grade gliomas, we performed array c...

journal_title：Oncogene

authors： Deshmukh H,Yeh TH,Yu J,Sharma MK,Perry A,Leonard JR,Watson MA,Gutmann DH,Nagarajan R

更新日期：2008-08-07 00:00:00

abstract：:Alu sequences are the most abundant short interspersed repeated elements in the human genome. Here we show that in a cell culture model of colorectal cancer (CRC) progression, we observe accumulation of Alu RNA that is associated with reduced DICER1 levels. Alu RNA induces epithelial-to-mesenchymal transition (EMT) by...

journal_title：Oncogene

authors： Di Ruocco F,Basso V,Rivoire M,Mehlen P,Ambati J,De Falco S,Tarallo V

更新日期：2018-02-01 00:00:00

abstract：:Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...

journal_title：Oncogene

authors： Lopez-Delisle L,Pierre-Eugène C,Louis-Brennetot C,Surdez D,Raynal V,Baulande S,Boeva V,Grossetête-Lalami S,Combaret V,Peuchmaur M,Delattre O,Janoueix-Lerosey I

更新日期：2018-03-01 00:00:00

abstract：:Activator protein one (AP1) (jun/fos) factors comprise a family of transcriptional regulators (c-jun, junB, junD, c-fos, FosB, Fra-1 and Fra-2) that are key controllers of epidermal keratinocyte survival and differentiation, and are important drivers of cancer development. Understanding the role of these factors in ep...

journal_title：Oncogene

authors： Rorke EA,Adhikary G,Jans R,Crish JF,Eckert RL

更新日期：2010-11-04 00:00:00

abstract：:Transforming Growth Factor-beta1 (TGF-beta1) inhibits the proliferation of most cells, but stimulates some mesenchymal cell types, including murine NIH3T3 fibroblasts. We show here that TGF-beta1 growth stimulation of NIH3T3 fibroblasts is reversed when these cells are transformed by SV40 or are transfected with a pla...

journal_title：Oncogene

authors： Dkhissi F,Raynal S,Jullien P,Lawrence DA

更新日期：1999-01-21 00:00:00

abstract：:The mechanism by which Bcl-2 inhibits apoptosis is unknown. The Bcl-2 protein is localized to intracellular membranes, including the endoplasmic reticulum (ER). The ER is the major intracellular reservoir of Ca2+ in non-muscle cells, sequestering Ca2+ for use in intracellular signaling, and is a prime target of oxidat...

journal_title：Oncogene

authors： Distelhorst CW,Lam M,McCormick TS

更新日期：1996-05-16 00:00:00

abstract：:We previously reported that YY-1, a versatile transcription factor, regulates expression of glycophorin gene by binding to its locus control region-like region (Gp-LCR) in combination with E-box binding protein during murine erythroleukemia (MEL) cell differentiation. In the present work, we demonstrated that YY-1 and...

journal_title：Oncogene

authors： Zhao JH,Inoue T,Shoji W,Nemoto Y,Obinata M

更新日期：1998-08-27 00:00:00

abstract：:Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...

journal_title：Oncogene

authors： Jin JK,Tien PC,Cheng CJ,Song JH,Huang C,Lin SH,Gallick GE

更新日期：2015-04-02 00:00:00

abstract：:Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel disease and arise as a consequence of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironment. An intrinsic defect in the...

journal_title：Oncogene

authors： Kosa P,Szabo R,Molinolo AA,Bugge TH

更新日期：2012-08-09 00:00:00