AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation.

abstract：:Somatic mitochondrial DNA (mtDNA) mutations have been increasingly observed in primary human cancers. As each cell contains many mitochondria with multiple copies of mtDNA, it is possible that wild-type and mutant mtDNA can co-exist in a state called heteroplasmy. During cell division, mitochondria are randomly distri...

journal_title：Oncogene

authors： Chatterjee A,Mambo E,Sidransky D

更新日期：2006-08-07 00:00:00

abstract：:Prostate cancer is the second highest cause of cancer-related deaths of men in the US. Signal transducers and activators of transcription (STATs) proteins are a small family of latent cytoplasmic transcription factors that act downstream of Janus kinase (JAK) activation and mediate intracellular signaling from a wide ...

journal_title：Oncogene

authors： Flowers LO,Subramaniam PS,Johnson HM

更新日期：2005-03-17 00:00:00

abstract：:Thymosin beta-4 (Tbeta-4), a small peptide originally isolated from calf thymus, modulates the formation of F-actin microfilaments by sequestering the monomeric G-actin. Recent studies have shown that overexpression of the Tbeta-4 gene occurs not only in many human carcinomas but also in the highly metastatic melanoma...

journal_title：Oncogene

authors： Wang WS,Chen PM,Hsiao HL,Ju SY,Su Y

更新日期：2003-05-22 00:00:00

abstract：:Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) is known to regulate cell growth and survival in multiple cancers; how...

journal_title：Oncogene

authors： Nitta RT,Bolin S,Luo E,Solow-Codero DE,Samghabadi P,Purzner T,Aujla PS,Nwagbo G,Cho YJ,Li G

更新日期：2019-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for lung cancer and an aberrant microbiota of the lung. Microbial colonization contributes to chronic neutrophilic inflammation in COPD. Nontypeable Haemophilus influenzae (NTHi) is frequently found in lungs of stable COPD patients and i...

journal_title：Oncogene

authors： Jungnickel C,Schmidt LH,Bittigkoffer L,Wolf L,Wolf A,Ritzmann F,Kamyschnikow A,Herr C,Menger MD,Spieker T,Wiewrodt R,Bals R,Beisswenger C

更新日期：2017-07-20 00:00:00

abstract：:Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...

journal_title：Oncogene

authors： Jin JK,Tien PC,Cheng CJ,Song JH,Huang C,Lin SH,Gallick GE

更新日期：2015-04-02 00:00:00

abstract：:Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. Here we report the identification by yeast interaction trap of a CK2 interacting protein, UBC3B, which is highly homologous to the E2 ubiquitin conjugating enzyme UBC3/CDC34. UBC3B complements the yeas...

journal_title：Oncogene

authors： Semplici F,Meggio F,Pinna LA,Oliviero S

更新日期：2002-06-06 00:00:00

abstract：:We describe the cytogenetic and molecular characterization of a t(1;13)(q22;q12) constitutional rearrangement occurring in a patient with a relatively benign form of neuroblastoma, called ganglioneuroblastoma. Somatic cell hybrids were generated between mouse 3T3 cells and a lymphoblastoid cell line from this patient,...

journal_title：Oncogene

authors： Michalski AJ,Cotter FE,Cowell JK

更新日期：1992-08-01 00:00:00

abstract：:Mxi1 is a basic region helix-loop-helix leucine zipper (bHLH/LZ) protein that, in association with Max, antagonizes Myc oncogenic activities. A possible mechanistic basis for Mxi1-mediated repression was provided by the recent demonstration that the repressive potential of Mxi1 correlates with its ability to physicall...

journal_title：Oncogene

authors： Rao G,Alland L,Guida P,Schreiber-Agus N,Chen K,Chin L,Rochelle JM,Seldin MF,Skoultchi AI,DePinho RA

更新日期：1996-03-07 00:00:00

abstract：:BRCA1 mutation carriers have an 85% lifetime risk of breast cancer and 60% for ovarian cancer. BRCA1 facilitates DNA double-strand break repair, and dysfunction of BRCA1 leads to hypersensitivity to DNA damaging agents and consequently genomic instability of cells. In this communication, we have examined the tumor inc...

journal_title：Oncogene

authors： Jeng YM,Cai-Ng S,Li A,Furuta S,Chew H,Chen PL,Lee EY,Lee WH

更新日期：2007-09-13 00:00:00

abstract：:Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to protect chromosome ends from cellular DNA-damage responses such as cell cycle arrest or apoptosis. This property of telomer...

journal_title：Oncogene

authors： Chan SW,Blackburn EH

更新日期：2002-01-21 00:00:00

abstract：:Gut-enriched Krüppel-like factor (GKLF or KLF4) is a zinc finger-containing, epithelial-specific transcription factor, that functions as a suppressor of cell proliferation. We previously showed that GKLF expression is decreased in intestinal and colonic adenomas, respectively, from multiple intestinal neoplasia (Min) ...

journal_title：Oncogene

authors： Dang DT,Mahatan CS,Dang LH,Agboola IA,Yang VW

更新日期：2001-08-09 00:00:00

abstract：:To identify genes that are differentially over-expressed in Small Cell Lung Carcinoma (SCLC) we have used a combination of suppression subtractive hybridization and cDNA microarray to analyse the expression profiles of 2400 cDNAs clones. Genes that are over-expressed in SCLC were identified using 32 pairs of fluoresce...

journal_title：Oncogene

authors： Bangur CS,Switzer A,Fan L,Marton MJ,Meyer MR,Wang T

更新日期：2002-05-23 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells, overactivation of mTOR has been reported. In addition, mTOR inhibitors, such as rapamycin and its derivatives, are being evaluated ...

journal_title：Oncogene

authors： Sato T,Nakashima A,Guo L,Coffman K,Tamanoi F

更新日期：2010-05-06 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, possesses significant anti-inflammatory and cancer chemopreventive properties. Studies have shown the photochemopreventive effects of green tea and EGCG in cell culture, animal models, and human skin. The molecular mechanism(s) of photochemoprevent...

journal_title：Oncogene

authors： Afaq F,Adhami VM,Ahmad N,Mukhtar H

更新日期：2003-02-20 00:00:00

abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...

journal_title：Oncogene

authors： Olmeda D,Jordá M,Peinado H,Fabra A,Cano A

更新日期：2007-03-22 00:00:00

abstract：:Somatic alterations of fibroblast growth factor receptors (FGFRs) have been described in a wide range of malignancies. A number of anti-FGFR therapies are currently under investigation in clinical trials for subjects with FGFR gene amplifications, mutations and translocations. Here, we develop cell line models of acqu...

journal_title：Oncogene

authors： Wang J,Mikse O,Liao RG,Li Y,Tan L,Janne PA,Gray NS,Wong KK,Hammerman PS

更新日期：2015-04-23 00:00:00

abstract：:Retinoids (natural and synthetic derivatives of vitamin A) signal potent differentiation and growth-suppressive effects in diverse normal, premalignant, and malignant cells. A strong rationale exists for the use of retinoids in cancer treatment and chemoprevention based on preclinical, epidemiological, and early clini...

journal_title：Oncogene

authors： Freemantle SJ,Spinella MJ,Dmitrovsky E

更新日期：2003-10-20 00:00:00

abstract：:MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression is not well defined. We aimed to determine whether specific miRNAs and their target mRNAs contribute to head and neck cancer pathogenesis and progression. To ide...

journal_title：Oncogene

authors： Nakanishi H,Taccioli C,Palatini J,Fernandez-Cymering C,Cui R,Kim T,Volinia S,Croce CM

更新日期：2014-02-06 00:00:00

abstract：:We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs. Furthermore, we show functional interchangeability with hTERT in in vitro telomeras...

journal_title：Oncogene

authors： Greenberg RA,Allsopp RC,Chin L,Morin GB,DePinho RA

更新日期：1998-04-02 00:00:00

abstract：:Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired drug resistance are unknown. We show for the first time that, to induce apoptosi...

journal_title：Oncogene

authors： Busacca S,Law EW,Powley IR,Proia DA,Sequeira M,Le Quesne J,Klabatsa A,Edwards JM,Matchett KB,Luo JL,Pringle JH,El-Tanani M,MacFarlane M,Fennell DA

更新日期：2016-03-24 00:00:00

abstract：:Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. Although gain-of-functions by mutant p53 have been demonstrated experimentally, the precise mechanism for malignant progression in in vivo tumors remains unsolved. We generated ApcΔ716 Trp53LSL•R270H villin-Cr...

journal_title：Oncogene

authors： Nakayama M,Sakai E,Echizen K,Yamada Y,Oshima H,Han TS,Ohki R,Fujii S,Ochiai A,Robine S,Voon DC,Tanaka T,Taketo MM,Oshima M

更新日期：2017-10-19 00:00:00

abstract：:Melanoma-associated antigen A1 (MAGEA1) is member of the MAGE gene family that is expressed in male germ line cells and placenta under normal physiological conditions. Although MAGEA1's expression levels have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and several other cance...

journal_title：Oncogene

authors： Zhao J,Wang Y,Mu C,Xu Y,Sang J

更新日期：2017-08-31 00:00:00

abstract：:Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer, as well as in the host response to cytotoxic anti-tumor therapy. As such, DAMPs may...

journal_title：Oncogene

authors： Hernandez C,Huebener P,Schwabe RF

更新日期：2016-11-17 00:00:00

abstract：:The cell polarity regulator, human Scribble (hScrib), is a potential tumour suppressor whose loss is a frequent event in late-stage cancer development. Little is yet known about the mode of action of hScrib, although recent reports suggest its role in the regulation of cell signalling. In this study we show that hScri...

journal_title：Oncogene

authors： Nagasaka K,Pim D,Massimi P,Thomas M,Tomaić V,Subbaiah VK,Kranjec C,Nakagawa S,Yano T,Taketani Y,Myers M,Banks L

更新日期：2010-09-23 00:00:00

abstract：:Interest in research on neuroendocrine tumors (NETs) has grown in the past 10 years, coinciding with improvements in our understanding of the molecular pathogenesis of NETs. In addition, NETs have become one of the most exciting settings for drug development. Two targeted agents for the management of advanced pancreat...

journal_title：Oncogene

authors： Capdevila J,Casanovas O,Salazar R,Castellano D,Segura A,Fuster P,Aller J,García-Carbonero R,Jimenez-Fonseca P,Grande E,Castaño JP

更新日期：2017-04-06 00:00:00

abstract：:ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...

journal_title：Oncogene

authors： Li Y,Zhou Z,Alimandi M,Chen C

更新日期：2009-08-20 00:00:00

abstract：:We examined the biological role of p12(CDK2-AP1) in cisplatin-mediated responses by using murine ES p12(CDK2-AP1) knockout clones generated by a targeted disruption of murine p12(CDK2-AP1). Homozygous knockout clones showed an increased cellular proliferation along with an increase in S and a decrease in G2/M phase po...

journal_title：Oncogene

authors： Kim Y,McBride J,Zhang R,Zhou X,Wong DT

更新日期：2005-01-13 00:00:00

abstract：:To investigate the relationship between the local configuration of a gene and its level of expression, we constructed a rat cell line, Hy5, carrying a mutant polyomavirus middle T oncogene (pmt) whose overexpression converted the cells to the transformed state. The structure of the transgene was such that pmt was able...

journal_title：Oncogene

authors： St-Onge L,Bastin M

更新日期：1994-03-01 00:00:00

abstract：:To achieve a better understanding of mechanisms that underlie hepatocarcinogenesis and to identify novel target molecules for diagnosis and therapy of hepatocellular carcinoma (HCC), we previously analysed gene-expression profiles of 20 HCC tissues on a cDNA microarray. Among the genes upregulated in the tumor tissues...

journal_title：Oncogene

authors： Silva FP,Hamamoto R,Furukawa Y,Nakamura Y

更新日期：2006-08-17 00:00:00