Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide.

abstract：:Survivin is a member of the inhibitor of apoptosis protein family and has an essential role in mitosis. Survivin is overexpressed in a large variety of human cancers and represents an attractive target for cancer therapy. Epidermal growth factor receptor and Her/neu-transformed human tumors in particular exhibit high ...

journal_title：Oncogene

authors： Berezov A,Cai Z,Freudenberg JA,Zhang H,Cheng X,Thompson T,Murali R,Greene MI,Wang Q

更新日期：2012-04-12 00:00:00

abstract：:SAP-1 (stomach cancer-associated protein tyrosine phosphatase-1) is a transmembrane-type protein tyrosine phosphatase that has been implicated as a negative regulator of integrin-mediated signaling. The potential role of this enzyme in hepatocarcinogenesis has now been investigated by examining its expression in 32 su...

journal_title：Oncogene

authors： Nagano H,Noguchi T,Inagaki K,Yoon S,Matozaki T,Itoh H,Kasuga M,Hayashi Y

更新日期：2003-07-24 00:00:00

abstract：:Basic helix-loop-helix (bHLH) transcription factors play a pivotal role in the regulation of tumorigenesis, and also in a wide range of other developmental processes in diverse species from yeast to humans. Here we demonstrate for the first time that Ret finger protein (RFP), a member of the TRIM family of proteins in...

journal_title：Oncogene

authors： Bloor AJ,Kotsopoulou E,Hayward P,Champion BR,Green AR

更新日期：2005-10-13 00:00:00

abstract：:The understanding of the organisation of cell cycle events is of utmost importance to devise effective therapeutic strategies for cancer. In this article we gather evidences from the literature in support of a system model of the cell cycle, in which a growth-sensitive threshold controls entry into S phase and the seq...

journal_title：Oncogene

authors： Alberghina L,Porro D,Cazzador L

更新日期：2001-03-01 00:00:00

abstract：:Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression pro...

journal_title：Oncogene

authors： Wu J,Patmore DM,Jousma E,Eaves DW,Breving K,Patel AV,Schwartz EB,Fuchs JR,Cripe TP,Stemmer-Rachamimov AO,Ratner N

更新日期：2014-01-09 00:00:00

abstract：:Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' eleme...

journal_title：Oncogene

authors： Philips A,Chambeyron S,Lamb N,Vié A,Blanchard JM

更新日期：1999-11-04 00:00:00

abstract：:Polyomavirus large T-antigen (PyLT-Ag), a nucleophosphoprotein essential for regulating viral gene expression, modulates the cell cycle by binding to the Rb tumor suppressor gene product. PyLT-Ag/Rb binding is essential for in vitro immortalization. However, the effect of PyLT-Ag on apoptosis has not been extensively ...

journal_title：Oncogene

authors： Rodier F,Bertrand R,Bossolasco M,Mes-Masson AM

更新日期：2000-12-14 00:00:00

abstract：:The candidate proto-oncogene BCL3 was isolated through its involvement in the t(14;19) found in chronic lymphocytic leukemia and other B-cell neoplasms. As a member of the I kappaB family, BCL3 plays a role in the immune response by interactions with the NF-kappaB family of transcription factors. In order to study the...

journal_title：Oncogene

authors： Ong ST,Hackbarth ML,Degenstein LC,Baunoch DA,Anastasi J,McKeithan TW

更新日期：1998-05-07 00:00:00

abstract：:tal-1 deletions are caused by a site specific recombination, which exclusively occurs in 12-26% of T-cell acute lymphoblastic leukemias (T-ALL). In a previous study on a large series of T-ALL we demonstrated an apparent preferential occurrence of tal-1 deletions in CD3- and CD3+ alpha beta lineage T-ALL with TcR-delta...

journal_title：Oncogene

authors： Breit TM,Wolvers-Tettero IL,van Dongen JJ

更新日期：1994-07-01 00:00:00

abstract：:P21waf1/cip1 is a potent inhibitor of cell cycle progression and can inhibit the growth of both normal cells and cells transformed by a number of oncogenes. However, the ability of p21waf1/cip1 to inhibit the growth of cells that overexpress the transcriptional transactivator E2F1 is controversial: it has been reporte...

journal_title：Oncogene

authors： Givol I,Givol D,Hughes SH

更新日期：1998-06-18 00:00:00

abstract：:Cell migration is an integral component of metastatic disease. The ability of cells to transit between mesenchymal and amoeboid modes of migration has complicated the development of successful therapies designed to target cell migration as a means of inhibiting metastasis. Therefore, investigations of the mechanisms t...

journal_title：Oncogene

authors： Lees JG,Bach CT,Bradbury P,Paul A,Gunning PW,O'Neill GM

更新日期：2011-03-10 00:00:00

abstract：:Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells (MSCs). The resulting lesions greatly contribute to patient morbidity and mortality, underscoring the need for defining how prostate metastases subvert the MSC-osteob...

journal_title：Oncogene

authors： Cook LM,Frieling JS,Nerlakanti N,McGuire JJ,Stewart PA,Burger KL,Cleveland JL,Lynch CC

更新日期：2019-10-01 00:00:00

abstract：:Apoptin has been described to induce apoptosis in various human cancer cell lines, but not in normal cells, thus making it an interesting candidate for the development of novel therapeutic strategies. Apoptin was generated and cloned into several mammalian expression vectors. Transfection or microinjection of apoptin ...

journal_title：Oncogene

authors： Guelen L,Paterson H,Gäken J,Meyers M,Farzaneh F,Tavassoli M

更新日期：2004-02-05 00:00:00

abstract：:This study examines whether the serine/threonine protein kinase, Akt, is involved in the crosstalk between the ErbB2 and estrogen receptor-alpha (ER-alpha) pathways. Treatment of MCF-7 cells with 10(-9) M heregulin-beta1 (HRG-beta1) resulted in a rapid phosphorylation of Akt and a 15-fold increase in Akt activity. Akt...

journal_title：Oncogene

authors： Stoica GE,Franke TF,Wellstein A,Morgan E,Czubayko F,List HJ,Reiter R,Martin MB,Stoica A

更新日期：2003-04-10 00:00:00

abstract：:Tumor suppressor gene CDKN2 (also called MTS1, CDK4I and p16INK4) is located in 9p21 and deleted homozygously in a high percentage of tumor cell lines. We have examined the sequence of CDKN2 in 154 tumor cell lines that are not homozygously deleted for CDKN2. Overall, 18% (27/154) of the cell lines carried mutations i...

journal_title：Oncogene

authors： Liu Q,Neuhausen S,McClure M,Frye C,Weaver-Feldhaus J,Gruis NA,Eddington K,Allalunis-Turner MJ,Skolnick MH,Fujimura FK

更新日期：1995-03-16 00:00:00

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:We have analysed the immortalizing function of Human Papillomavirus type 16 (HPV16) in a rat cell line which has been derived by immortalizing rat embryo fibroblasts with a thermolabile SV40 large T antigen and is temperature sensitive for growth. Introduction of wild type SV40 large T antigen or the adenovirus E1a 12...

journal_title：Oncogene

authors： Vousden KH,Jat PS

更新日期：1989-02-01 00:00:00

abstract：:The c-fos proto-oncogene is found to be overexpressed at least 30-fold in SMS-SB, a pre-B leukemic cell line compared to other cell types. No gross alteration of the c-fos gene structure in SMS-SB cells can be detected by karyotypic or Southern analyses. C-fos in SMS-SB cells can still be induced by serum, TPA and the...

journal_title：Oncogene

authors： Tsai LH,Nanu L,Smith RG,Ozanne B

更新日期：1991-01-01 00:00:00

abstract：:The v-Myb oncogene causes monoblastic leukemia and transforms only myelomonocytic cells in culture. The v-Myb protein is nuclear and binds to specific DNA sequences. To identify genes regulated by v-Myb, we utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The E...

journal_title：Oncogene

authors： Wang DM,Sevcikova S,Wen H,Roberts S,Lipsick JS

更新日期：2007-02-22 00:00:00

abstract：:The steady-state levels of p53 mRNA were dramatically lower in immortal chicken embryo fibroblast (CEF) cell lines compared to primary CEF cells. In the presence of cycloheximide (CHX), the steady-state levels of p53 mRNA markedly increased in immortal CEF cell lines, similar to levels found in primary cells. The de n...

journal_title：Oncogene

authors： Kim H,You S,Foster LK,Farris J,Foster DN

更新日期：2001-08-23 00:00:00

abstract：:Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o...

journal_title：Oncogene

authors： Mysliwiec T,Perego R,Kruh GD

更新日期：1996-02-01 00:00:00

abstract：:Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular endothelial cell growth factor (VEGF) is known to be one of the most important inducers of angiogenesis and is upregulated in carcinoma of ...

journal_title：Oncogene

authors： López-Ocejo O,Viloria-Petit A,Bequet-Romero M,Mukhopadhyay D,Rak J,Kerbel RS

更新日期：2000-09-21 00:00:00

abstract：:A wealth of cytogenetic data has demonstrated that numerous somatic genetic changes are involved in the pathogenesis of human lung cancer. Despite the complexity of the genomic changes observed in these neoplasms, recurrent chromosomal patterns have emerged. In this review, we summarize chromosomal alterations identif...

journal_title：Oncogene

authors： Balsara BR,Testa JR

更新日期：2002-10-07 00:00:00

abstract：:The Ets transcription factor PU.1 is a hematopoietic master regulator essential for the development of myeloid and B-cell lineages. As we previously reported, PU.1 sometimes represses transcription on forming a complex with mSin3A-histone deacetyl transferase-MeCP2. Here, we show an interaction between PU.1 and DNA me...

journal_title：Oncogene

authors： Suzuki M,Yamada T,Kihara-Negishi F,Sakurai T,Hara E,Tenen DG,Hozumi N,Oikawa T

更新日期：2006-04-20 00:00:00

abstract：:Cell lines derived from cervical neoplasias, as well as cells from normal cervix and neonatal foreskin were examined in an in vitro culture system (raft system) that allows for stratification and differentiation of epithelial cells at an air-liquid interface. Epithelial cells from human foreskin and ectocervix were ob...

journal_title：Oncogene

authors： Rader JS,Golub TR,Hudson JB,Patel D,Bedell MA,Laimins LA

更新日期：1990-04-01 00:00:00

abstract：:Infection by HTLV-1 has been correlated with the appearance of various proliferative or degenerative diseases. Some of these disorders have been observed in transgenic mice expressing the Tax protein, which is known to transactivate various viral and cellular promoters through interactions with several transcription f...

journal_title：Oncogene

authors： Rousset R,Fabre S,Desbois C,Bantignies F,Jalinot P

更新日期：1998-02-05 00:00:00

abstract：:The ARF tumour suppressor protein plays a critical role in the activation of p53 in response to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2. However, several lines of evidence indicate that this is not the only way of action of ARF, and alternative mechanisms must exist. p33ING1 is a...

journal_title：Oncogene

authors： González L,Freije JM,Cal S,López-Otín C,Serrano M,Palmero I

更新日期：2006-08-24 00:00:00

abstract：:Treatment of many cancers relies on the combined action of several genotoxins, but the detrimental effect of these drugs on normal cells can cause severe side effects. One major challenge in anticancer therapy is therefore to increase the selectivity of current treatments toward cancer cells in order to spare normal c...

journal_title：Oncogene

authors： Michod D,Yang JY,Chen J,Bonny C,Widmann C

更新日期：2004-11-25 00:00:00

abstract：:While screening a chicken kidney cDNA library for the normal homolog of the yes oncogene, we isolated a clone that encodes a novel non-receptor type protein tyrosine kinase of the Src family. We named this gene product Yrk (York), as an acronym for Yes-related kinase. As predicted from the cDNA sequence, the Yrk prote...

journal_title：Oncogene

authors： Sudol M,Greulich H,Newman L,Sarkar A,Sukegawa J,Yamamoto T

更新日期：1993-04-01 00:00:00

abstract：:Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G(1) and mitotic checkpoints. Here, we show that RACK1 also induces apoptosis of the cells, partly by inhibiting Src. In the intrinsic pathway, RACK1 inhibits expression of anti-apoptotic Bcl-2 and Bcl-X(L), induces expre...

journal_title：Oncogene

authors： Mamidipudi V,Cartwright CA

更新日期：2009-12-17 00:00:00