Abstract:
:P21waf1/cip1 is a potent inhibitor of cell cycle progression and can inhibit the growth of both normal cells and cells transformed by a number of oncogenes. However, the ability of p21waf1/cip1 to inhibit the growth of cells that overexpress the transcriptional transactivator E2F1 is controversial: it has been reported both that E2F1 can and cannot overcome the block in the cell cycle induced by p21waf1/cip1. To avoid the complications that arise when such experiments are done with permanent cell lines, we tested the effects of overexpressing p21waf/cip1 and E2F1 in primary chicken embryo fibroblasts. In this system very high levels of E2F1 overexpression cause considerable apoptosis; however, the surviving cells still overexpress E2F1. These cells are transformed and their growth is blocked by overexpression of p21waf1/cip1.
journal_name
Oncogenejournal_title
Oncogeneauthors
Givol I,Givol D,Hughes SHdoi
10.1038/sj.onc.1201849subject
Has Abstractpub_date
1998-06-18 00:00:00pages
3115-22issue
24eissn
0950-9232issn
1476-5594journal_volume
16pub_type
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