Synuclein γ protects Akt and mTOR and renders tumor resistance to Hsp90 disruption.

abstract：:Akt/PKB is a serine/threonine kinase that promotes tumor cell growth by phosphorylating transcription factors and cell cycle proteins. There is particular interest in finding tumor-specific substrates for Akt to understand how this protein functions in cancer and to provide new avenues for therapeutic targeting. Our l...

journal_title：Oncogene

authors： Sutherland BW,Kucab J,Wu J,Lee C,Cheang MC,Yorida E,Turbin D,Dedhar S,Nelson C,Pollak M,Leighton Grimes H,Miller K,Badve S,Huntsman D,Blake-Gilks C,Chen M,Pallen CJ,Dunn SE

更新日期：2005-06-16 00:00:00

abstract：:RAS is a small GTP binding protein mutated in approximately 30% human cancer. Despite its important role in the initiation and progression of human cancer, the underlying mechanism of RAS-induced human epithelial transformation remains elusive. In this study, we probe the cellular and molecular mechanisms of RAS-media...

journal_title：Oncogene

authors： Young T,Mei F,Liu J,Bast RC Jr,Kurosky A,Cheng X

更新日期：2005-09-08 00:00:00

abstract：:The human cellular homolog of v-rel, the transforming gene of reticuloendotheliosis virus, strain T, was previously localized to 2 cent-2p13 by a combination of somatic cell hybrid and in situ hybridization analyses. In this study, we use translocation chromosome analysis to refine c-rel's genetic assignment to 2p12-2...

journal_title：Oncogene

authors： Brownell E,Fell HP,Tucker PW,Geurts van Kessel AH,Hagemeijer A,Rice NR

更新日期：1988-05-01 00:00:00

abstract：:The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protei...

journal_title：Oncogene

authors： Chikamori M,Fujimoto J,Tokai-Nishizumi N,Yamamoto T

更新日期：2007-05-03 00:00:00

abstract：:Many anticancer drugs exert their cytotoxicity through DNA damage and induction of apoptosis. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) have different sensitivity to treatment with radiation and chemotherapeutic agents with SCLC being more sensitive than NSCLC both in vitro and in vivo...

journal_title：Oncogene

authors： Joseph B,Ekedahl J,Lewensohn R,Marchetti P,Formstecher P,Zhivotovsky B

更新日期：2001-05-24 00:00:00

abstract：:The p53 tumor suppressor protein plays a critical role in mediating cellular response to stress. Upon DNA damage, post-translational modifications stabilize and activate this nuclear phosphoprotein. To determine the effect of phosphorylation site mutants in the context of the whole p53 protein, we performed reporter a...

journal_title：Oncogene

authors： Dohoney KM,Guillerm C,Whiteford C,Elbi C,Lambert PF,Hager GL,Brady JN

更新日期：2004-01-08 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) family members play pivotal roles in cell proliferation, differentiation and survival. Overexpression and mutations of EGFRs, or aberrant EGFR signaling are commonly associated with the development of various cancers, where constitutive NF-κB activation is often found to promote...

journal_title：Oncogene

authors： Jiang C,Zhu Y,Zhou Z,Gumin J,Bengtsson L,Wu W,Songyang Z,Lang FF,Lin X

更新日期：2017-05-18 00:00:00

abstract：:The establishment of a system for in vitro clonal development of hematopoietic cells made it possible to discover the cytokines that regulate hematopoiesis. These cytokines include colony stimulating factors and others, which interact in a network, and there is a cytokine cascade which couples growth and differentiati...

journal_title：Oncogene

authors： Lotem J,Sachs L

更新日期：2002-05-13 00:00:00

abstract：:Neuroblastoma is the second most common pediatric malignancy, characterized by a high rate of unexplained spontaneous remissions. Much progress has been made in understanding neuroblastoma differentiation triggered by certain agents such as retinoic acid. However, little is known about the signalling pathways that lea...

journal_title：Oncogene

authors： Evangelopoulos ME,Weis J,Krüttgen A

更新日期：2005-05-05 00:00:00

abstract：:Downregulation of E-cadherin by the transcriptional repressor Snail is associated with acquisition of metastatic potential. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, it is unclear whether Snail is involved in HCV core-induced dysregulation of E-cadherin. Herein, we inve...

journal_title：Oncogene

authors： Nie D,Shan X,Nie L,Duan Y,Chen Z,Yang Y,Li Z,Tian L,Gao Q,Shan Y,Tang N

更新日期：2016-07-14 00:00:00

abstract：:Migration and invasion inhibitory protein (MIIP) is recently identified as an inhibitor in tumor development. However, the regulatory mechanism and biological contributions of MIIP in pancreatic cancer (PC) have been not elucidated. In this study, we demonstrated a negative feedback of MIIP and hypoxia-induced factor-...

journal_title：Oncogene

authors： Niu Y,Jin Y,Deng SC,Deng SJ,Zhu S,Liu Y,Li X,He C,Liu ML,Zeng Z,Chen HY,Zhong JX,Ye Z,Wang CY,Zhao G

更新日期：2018-03-01 00:00:00

abstract：:Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1...

journal_title：Oncogene

authors： Rondinelli RH,Haslam SZ,Fluck MM

更新日期：1995-11-02 00:00:00

abstract：:We previously described the oral-esophageal tissue-specific expression of cyclin D1 with the Epstein-Barr virus ED-L2 promoter in transgenic mice, and resulting dysplasia. Given the evidence for an interplay between environmental and genetic factors in esophageal squamous carcinogenesis, the aim of this study was to d...

journal_title：Oncogene

authors： Jenkins TD,Mueller A,Odze R,Shahsafaei A,Zukerberg LR,Kent R,Stoner GD,Rustgi AK

更新日期：1999-01-07 00:00:00

abstract：:The matricellular protein CCN5/WISP-2 represents a promising target in triple-negative breast cancer (TNBC) because treatment or induced activation of CCN5 in TNBC cells promotes cell growth arrest at the G0/G1 phase, reduces cell proliferation and delays tumor growth in the xenograft model. Our studies found that the...

journal_title：Oncogene

authors： Haque I,Banerjee S,De A,Maity G,Sarkar S,Majumdar M,Jha SS,McGragor D,Banerjee SK

更新日期：2015-06-11 00:00:00

abstract：:Bone morphogenetic protein 3B (BMP3B) is a member of the TGF-beta superfamily. The BMP3B promoter sequence was previously identified as a target for aberrant DNA methylation in non-small-cell lung cancer (NSCLC). Aberrant DNA hypermethylation in the BMP3B promoter is associated with downregulation of BMP3B transcripti...

journal_title：Oncogene

authors： Dai Z,Popkie AP,Zhu WG,Timmers CD,Raval A,Tannehill-Gregg S,Morrison CD,Auer H,Kratzke RA,Niehans G,Amatschek S,Sommergruber W,Leone GW,Rosol T,Otterson GA,Plass C

更新日期：2004-04-29 00:00:00

abstract：:Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecular structure of EWS-ETS lacks prognostic value. Moreover, CDKN2A deletion and TP53 mutation, despite...

journal_title：Oncogene

authors： Mackintosh C,Ordóñez JL,García-Domínguez DJ,Sevillano V,Llombart-Bosch A,Szuhai K,Scotlandi K,Alberghini M,Sciot R,Sinnaeve F,Hogendoorn PC,Picci P,Knuutila S,Dirksen U,Debiec-Rychter M,Schaefer KL,de Álava E

更新日期：2012-03-08 00:00:00

abstract：:Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progression springs from the combined forces of both genetic and epigenetic events, which produce variant clonal populations, together with the selective pressures of the microenvironment, which promote growth and, perhaps, d...

journal_title：Oncogene

authors： Macaluso M,Paggi MG,Giordano A

更新日期：2003-09-29 00:00:00

abstract：:To understand the mechanism of interferon (IFN)-mediated suppression of cell cycle progression, we have earlier shown that IFN-alpha enhances the expression of underphosphorylated retinoblastoma protein by inhibiting the cyclin-dependent kinase-2 (CDK-2) activity (Kumar and Atlas, Proc. Natl. Acad. Sci. 89, 6599-6603,...

journal_title：Oncogene

authors： Mandal M,Bandyopadhyay D,Goepfert TM,Kumar R

更新日期：1998-01-15 00:00:00

abstract：:Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure. Biological effects of the RAS are media...

journal_title：Oncogene

authors： Renziehausen A,Wang H,Rao B,Weir L,Nigro CL,Lattanzio L,Merlano M,Vega-Rioja A,Del Carmen Fernandez-Carranco M,Hajji N,Matin R,Harwood C,Li S,Sim VR,O'Neill K,Evans A,Thompson A,Szlosarek P,Fleming C,Stebbing J,Pr

更新日期：2019-03-01 00:00:00

abstract：:Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression pattern of p120 in breast cancer, we analysed 326 breast tissue biopsies by tissue microarray. Most of the lobular tumors (88%) showed exclusive cyt...

journal_title：Oncogene

authors： Sarrió D,Pérez-Mies B,Hardisson D,Moreno-Bueno G,Suárez A,Cano A,Martín-Pérez J,Gamallo C,Palacios J

更新日期：2004-04-22 00:00:00

abstract：:CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA. We show here that CD97 was expressed in a majority of thyroid cancers but not normal thyroid epithelium and that the level of CD97...

journal_title：Oncogene

authors： Ward Y,Lake R,Martin PL,Killian K,Salerno P,Wang T,Meltzer P,Merino M,Cheng SY,Santoro M,Garcia-Rostan G,Kelly K

更新日期：2013-05-30 00:00:00

abstract：:Many of the signaling responses induced by transforming growth factor-beta (TGF-beta) are mediated by Smad proteins, but there is evidence that it can also signal independently of Smads. Here, we provide evidence that multiple signal pathways induced by TGF-beta1-including Src family tyrosine kinases (SFKs), generatio...

journal_title：Oncogene

authors： Joo CK,Kim HS,Park JY,Seomun Y,Son MJ,Kim JT

更新日期：2008-01-24 00:00:00

abstract：:In Xiphophorus the causative, primary cellular oncogene for melanoma formation has been assigned by classical genetics to a sex-chromosomal locus, designated Tu. Activation of Tu was proposed to be the result of the elimination of Tu-specific regulatory genes which normally suppress the transforming function in the no...

journal_title：Oncogene

authors： Mäueler W,Raulf F,Schartl M

更新日期：1988-05-01 00:00:00

abstract：:The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive 'TGF-β paradox'. Herein, we identify a mechanism by which Six1 ...

journal_title：Oncogene

authors： Smith AL,Iwanaga R,Drasin DJ,Micalizzi DS,Vartuli RL,Tan AC,Ford HL

更新日期：2012-12-13 00:00:00

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:We have analysed the immortalizing function of Human Papillomavirus type 16 (HPV16) in a rat cell line which has been derived by immortalizing rat embryo fibroblasts with a thermolabile SV40 large T antigen and is temperature sensitive for growth. Introduction of wild type SV40 large T antigen or the adenovirus E1a 12...

journal_title：Oncogene

authors： Vousden KH,Jat PS

更新日期：1989-02-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...

journal_title：Oncogene

authors： Hsu PC,Gopinath RK,Hsueh YA,Shieh SY

更新日期：2019-02-01 00:00:00

abstract：:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...

journal_title：Oncogene

authors： Simpson SC,Bolen JB,Veillette A

更新日期：1989-09-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progressi...

journal_title：Oncogene

authors： Stieglitz D,Lamm S,Braig S,Feuerer L,Kuphal S,Dietrich P,Arndt S,Echtenacher B,Hellerbrand C,Karrer S,Bosserhoff AK

更新日期：2019-01-01 00:00:00

abstract：:Large cancer projects measure somatic mutations in thousands of samples, gradually assembling a catalog of recurring mutations in cancer. Many methods analyze these data jointly with auxiliary information with the aim of identifying subtype-specific results. Here, we show that somatic gene mutations alone can reliably...

journal_title：Oncogene

authors： Amar D,Izraeli S,Shamir R

更新日期：2017-06-15 00:00:00