Abstract:
:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific components are not required for the CD4-lck interaction. These results also suggest that co-expression of CD4 and p56lck in non-lymphoid cells may prove to be a useful model system for the analysis of structural and possibly functional CD4-lck interactions.
journal_name
Oncogenejournal_title
Oncogeneauthors
Simpson SC,Bolen JB,Veillette Asubject
Has Abstractpub_date
1989-09-01 00:00:00pages
1141-3issue
9eissn
0950-9232issn
1476-5594journal_volume
4pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Using a temperature-sensitive mutant of the p210 BCR-ABL gene, transfected into a growth factor-dependent cell line (BaF3), we show that transient BCR-ABL kinase expression increases single cell and clonogenic resistance to apoptosis arising from genotoxic damage induced by ionizing radiation and VP-16/etoposide. This...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-11-21 00:00:00
abstract::We recently reported the cloning and sequencing of the mouse A-myb proto-oncogene cDNA and the abundant expression of this mRNA primarily in the testis of adult mice. The A-myb mRNA is detectable by in situ hybridization specifically in the spermatogenic cells, and is downregulated during terminal differentiation. A l...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-09-19 00:00:00
abstract::The MLL (HRX/ALL-1 gene is frequently disrupted in infantile leukemias and therapy-related leukemias and fused to various translocation partner genes. We previously showed that chimeric MLL proteins localize in the nuclei in a fashion similar to that of MLL protein even if the partner gene encodes a cytoplasmic protei...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202400
更新日期:1999-01-28 00:00:00
abstract::Gastric carcinogenesis is a multistep process involving genetic and epigenetic alteration of protein-coding proto-oncogenes and tumor-suppressor genes. Recent discoveries have shed new light on the involvement of a class of noncoding RNA known as microRNA (miRNA) in gastric cancer. A substantial number of miRNAs show ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2010.352
更新日期:2010-10-28 00:00:00
abstract::Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death. MDM2 can inhibit p53 activity, in part, by promoting its rapid degradation through the ubiquitin proteolysis pathway. ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203980
更新日期:2000-11-30 00:00:00
abstract::The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial tran...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.259
更新日期:2017-11-23 00:00:00
abstract::Studies have reported that interactions between keratins (KRTs) and other proteins initiate signaling cascades that regulate cell migration, invasion, and metastasis. In the current study, we found that expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Mo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.221
更新日期:2017-01-19 00:00:00
abstract::To investigate Mad1 function in vivo, transgenic mice were generated that express a Mad1 transgene in T lineage cells under the control of the proximal lck promoter. Thymus size in lck-Mad1 transgenic mice is drastically reduced although representation of the various thymocyte sub populations appears normal. To invest...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204196
更新日期:2001-03-08 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01428-3
更新日期:2020-09-01 00:00:00
abstract::Microsatellite-stable, near-diploid (MSI-CIN-) colorectal carcinomas have been reported, but it is not clear as to whether these tumours form a discrete group or represent one end of the distribution of MSI-CIN+ cancers. In order to address this question, we screened 23 MSI-CIN- colorectal cancers for gains and losses...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208194
更新日期:2005-01-06 00:00:00
abstract::Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the β-catenin protein. In previous work, we used microarray-based methods to compare gene expression in OEAs with and without dysr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.123
更新日期:2011-10-06 00:00:00
abstract::A proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203156
更新日期:1999-12-09 00:00:00
abstract::The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replication in mammalian cells. We show that RAD1 is an essential gene f...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207753
更新日期:2004-07-22 00:00:00
abstract::Apoptin has been described to induce apoptosis in various human cancer cell lines, but not in normal cells, thus making it an interesting candidate for the development of novel therapeutic strategies. Apoptin was generated and cloned into several mammalian expression vectors. Transfection or microinjection of apoptin ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207224
更新日期:2004-02-05 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is as...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.481
更新日期:2016-08-04 00:00:00
abstract::The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3beta. Overexpression of ILK in cultured intestinal an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204910
更新日期:2001-10-25 00:00:00
abstract::Retinoic acid receptor-beta (RAR beta) and signal transducer and activator of transcription 1 (STAT1) are important mediators of the antiproliferative and apoptotic actions of retinoids and cytokines/growth factors, respectively. Expression of both RAR beta and STAT1 is lost in most breast cancer cell lines but it can...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203084
更新日期:1999-11-18 00:00:00
abstract::Autophagy, hallmarked by the formation of double-membrane bound organelles known as autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of autophagy in carcinogenesis is context dependent. As a tumor-suppressing mechanism in early-stage carcinogenesis, autophagy inhibits inflammation and ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2011.295
更新日期:2012-02-23 00:00:00
abstract::TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204842
更新日期:2001-10-18 00:00:00
abstract::The putative tumor suppressor CDKN1C is an imprinted gene at 11p15.5, a well-known imprinted region often deleted in tumors. The absence of somatic mutations and the frequent diminished expression in tumors would suggest that CDKN1C expression is regulated epigenetically. It has been, however, controversial whether th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207576
更新日期:2004-05-27 00:00:00
abstract::Chromosome 17 is one of the most frequently altered chromosomes in malignant breast cancer. At least four genes implicated in breast cancer reside on chromosome 17 (p53, 17p13; Her-2/neu/ERBB2, 17q12; BRCA1, 17q21; and nm23, 17q22). In addition, allelic imbalance has been described for at least five regions of chromos...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201073
更新日期:1997-05-15 00:00:00
abstract::The DNA-binding, transcriptional activation and transforming activities of the Myc protein require dimerization with Max. Max can form also homodimers which are able to bind the same DNA sequence as Myc/Max heterodimers and suppress Myc-induced transcription and transformation. We have recently identified a naturally ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-08-03 00:00:00
abstract::PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204765
更新日期:2001-10-29 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression pro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.579
更新日期:2014-01-09 00:00:00
abstract::BRCA1, a familial breast and ovarian cancer susceptibility gene encodes nuclear phosphoproteins that function as tumor suppressors in human breast cancer cells. Previously, we have shown that overexpression of a BRCA1 splice variant BRCA1a accelerates apoptosis in human breast cancer cells. In an attempt to determine ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201252
更新日期:1997-07-10 00:00:00
abstract::Loss of p53 function is associated with the acquisition of cisplatin resistance in the human ovarian adenocarcinoma A2780 cell line. Selection for cisplatin resistance of A2780 cells was used to isolate genetic suppressor elements (GSEs) from a retroviral library expressing random fragments of human or murine TP53 cDN...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200813
更新日期:1997-01-16 00:00:00
abstract::In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202165
更新日期:1998-11-19 00:00:00
abstract::Mutations in VHL underlie von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome with several subtypes depending on the risk of developing certain combination of classic features, such as clear cell renal cell carcinoma (ccRCC), hemangioblastoma and pheochromocytoma. Although numerous potential substrates and f...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2017.338
更新日期:2018-01-11 00:00:00
abstract::The human ETS2 gene is a member of the ets gene family (ETS1, ETS2, ERG, ELK1 and ELK2) with amino acid similarity to the v-ets oncogene of the avian leukemia virus, E26. The ETS2 gene is composed of 10 exons, nine of which contribute to the open reading frame encoding 469 amino acids. The ETS2 gene directs the synthe...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic malignancies including chronic myeloid leukemia (CML), where BCL6 expression was shown to be essential for CML stem cell survival and self-renewal during imatinib mesylate (IM) treatment. As several lines of evidence suggest that inte...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.85
更新日期:2017-08-10 00:00:00