当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Temporal patterns of A-myb and B-myb gene expression during testis development.

Temporal patterns of A-myb and B-myb gene expression during testis development.

Abstract：

:We recently reported the cloning and sequencing of the mouse A-myb proto-oncogene cDNA and the abundant expression of this mRNA primarily in the testis of adult mice. The A-myb mRNA is detectable by in situ hybridization specifically in the spermatogenic cells, and is downregulated during terminal differentiation. A low level of expression is observed in a few other tissues, including ovary, spleen and brain. We have extended those studies by examining A-myb and B-myb expression during testis development in the mouse. The A-myb and B-myb genes are both expressed in a cell- and stage-specific manner during testis development. The B-myb mRNA is expressed most highly in gonocytes of the fetal testis and in spermatogonia and early spermatocytes in the adult. B-myb expression decreases at day 18 post partum, coincident with the initial appearance of late pachytene spermatocytes. B-myb expression was also detectable in some interstitial cells of the fetal and adult testis. The A-myb mRNA was not detectable by in situ hybridization in fetal day 15.5 gonocytes but was detectable at a low abundance by RT-PCR in fetal and newborn mice. A-myb mRNA expression increased at post-natal day 10, when primary spermatocytes first appear. In the adult, the A-myb mRNA was expressed highly in a sub-population of spermatogonia and in primary spermatocytes, but was not detectable in spermatids. This expression of A-myb is consistent with the meiotic arrest that is observed in A-myb-deficient male mice. We conclude that B-myb may play a critical role in controlling the proliferation or differentiation of gonocytes and spermatogonia and possibly the somatic lineages as well, whereas A-myb is required for progression through the first meiotic prophase. These distinct roles for B-myb and A-myb during spermatogenesis may reflect distinct transactivation potentials of the two proteins. Further studies to determine the functions of A-myb and B-myb in the developing testis should improve our understanding of the molecular events associated with spermatogenesis and differentiation of the Sertoli and other somatic cell types of the testis.

journal_name

Oncogene

journal_title

Oncogene

authors

Latham KE,Litvin J,Orth JM,Patel B,Mettus R,Reddy EP

subject

Has Abstract

pub_date

1996-09-19 00:00:00

pages

1161-8

issue

6

eissn

0950-9232

issn

1476-5594

journal_volume

13

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP.

    abstract：:YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes. The Amot-mediated retention of YAP in the cytoplasm results in the inhibition of its ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.216

    authors： Oka T,Schmitt AP,Sudol M

    更新日期：2012-01-05 00:00:00

  • Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration.

    abstract：:While studying Bim, a BH3-only proapoptotic protein, we identified an approximately 36 kDa protein, which was abundantly expressed in all five strains of primary normal human prostate (NHP) epithelial cells but significantly reduced or lost in seven prostate cancer cell lines. The approximately 36 kDa protein was subs...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206196

    authors： Liu JW,Shen JJ,Tanzillo-Swarts A,Bhatia B,Maldonado CM,Person MD,Lau SS,Tang DG

    更新日期：2003-03-13 00:00:00

  • Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA.

    abstract：:The transcription factor activator protein-1 (AP-1) has been implicated in a large variety of biological processes including cell differentiation, proliferation, apoptosis and oncogenic transformation. It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206102

    authors： Li J,Ma C,Huang Y,Luo J,Huang C

    更新日期：2003-01-16 00:00:00

  • Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails.

    abstract：:Prostate cancer is one of the major causes of cancer-related death in the western world. Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the androgen receptor (AR) has been the norm of prostate cancer treatment. Despite early success to suppress prostate tumor growth, ADT eventually fail...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2010.121

    authors： Niu Y,Chang TM,Yeh S,Ma WL,Wang YZ,Chang C

    更新日期：2010-06-24 00:00:00

  • Mutation of GATA3 in human breast tumors.

    abstract：:GATA3 is an essential transcription factor that was first identified as a regulator of immune cell function. In recent microarray analyses of human breast tumors, both normal breast luminal epithelium and estrogen receptor (ESR1)-positive tumors showed high expression of GATA3. We sequenced genomic DNA from 111 breast...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207966

    authors： Usary J,Llaca V,Karaca G,Presswala S,Karaca M,He X,Langerød A,Kåresen R,Oh DS,Dressler LG,Lønning PE,Strausberg RL,Chanock S,Børresen-Dale AL,Perou CM

    更新日期：2004-10-07 00:00:00

  • Fibroblast growth factor receptors display both common and distinct signaling pathways.

    abstract：:We compared the mitogenic and signaling pathways of three Fibroblast Growth Factor Receptors (FGFRs), FGFR1, KGFR and FGFR4 in the same cell line. Each receptor was expressed in L6E9 rat myoblasts that do not normally express detectable levels of FGFRs and clones that express comparable levels of each receptor were se...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Shaoul E,Reich-Slotky R,Berman B,Ron D

    更新日期：1995-04-20 00:00:00

  • The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells.

    abstract：:Somatostatin receptors (sst1-5) are present in different types of tumors, where they inhibit key cellular processes such as proliferation and invasion. Although ssts are densely expressed in breast cancer, especially sst2, their role and therapeutic potential remain uncertain. Recently, we identified a new truncated s...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.389

    authors： Durán-Prado M,Gahete MD,Hergueta-Redondo M,Martínez-Fuentes AJ,Córdoba-Chacón J,Palacios J,Gracia-Navarro F,Moreno-Bueno G,Malagón MM,Luque RM,Castaño JP

    更新日期：2012-04-19 00:00:00

  • Metabolic reprogramming of the tumor.

    abstract：:Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...

    journal_title：Oncogene

    pub_type： 历史文章,杂志文章,评审

    doi：10.1038/onc.2011.576

    authors： Ferreira LM,Hebrant A,Dumont JE

    更新日期：2012-09-06 00:00:00

  • Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O2.- upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells.

    abstract：:Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.346

    authors： Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

    更新日期：2017-03-30 00:00:00

  • Synuclein γ protects Akt and mTOR and renders tumor resistance to Hsp90 disruption.

    abstract：:Heat shock protein (Hsp)90 regulates many key pathways in oncogenesis, including Akt and mammalian target of rapamycin (mTOR). The strengths of disruption of Hsp90 in cancer therapy include their versatility in inhibiting a wide range of oncogenic pathways. The present study demonstrated that synuclein γ (SNCG) protec...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.126

    authors： Liang W,Miao S,Zhang B,He S,Shou C,Manivel P,Krishna R,Chen Y,Shi YE

    更新日期：2015-04-30 00:00:00

  • The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction.

    abstract：:The cell polarity regulator, human Scribble (hScrib), is a potential tumour suppressor whose loss is a frequent event in late-stage cancer development. Little is yet known about the mode of action of hScrib, although recent reports suggest its role in the regulation of cell signalling. In this study we show that hScri...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.265

    authors： Nagasaka K,Pim D,Massimi P,Thomas M,Tomaić V,Subbaiah VK,Kranjec C,Nakagawa S,Yano T,Taketani Y,Myers M,Banks L

    更新日期：2010-09-23 00:00:00

  • Prognostic significance of allelic losses in primary melanoma.

    abstract：:Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1200203

    authors： Healy E,Belgaid C,Takata M,Harrison D,Zhu NW,Burd DA,Rigby HS,Matthews JN,Rees JL

    更新日期：1998-04-30 00:00:00

  • The adenovirus E1A domains required for induction of DNA rereplication in G2/M arrested cells coincide with those required for apoptosis.

    abstract：:Induction of apoptosis by adenovirus E1A in rodent cells is stimulated by wild type (wt) p53 but completely suppressed by mutated p53. The suppression is overcome by coexpression with Id proteins (Ids). The cells expressing E1A and Ids undergo apoptosis after accumulation in S phase, suggesting that S phase events are...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203063

    authors： Yageta M,Tsunoda H,Yamanaka T,Nakajima T,Tomooka Y,Tsuchida N,Oda K

    更新日期：1999-08-26 00:00:00

  • Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3.

    abstract：:The Ov/Br septin gene, which is also a fusion partner of MLL in acute myeloid leukaemia, is a member of a family of novel GTP binding proteins that have been implicated in cytokinesis and exocytosis. In this study, we describe the genomic and transcriptional organization of this gene, detailing seventeen exons distrib...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204752

    authors： McIlhatton MA,Burrows JF,Donaghy PG,Chanduloy S,Johnston PG,Russell SE

    更新日期：2001-09-13 00:00:00

  • CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.

    abstract：:Breast cancer is a heterogeneous genetic disease driven by the accumulation of individual mutations per tumor. Whole-genome sequencing approaches have identified numerous genes with recurrent mutations in primary tumors. Although mutations in well characterized tumor suppressors and oncogenes are overrepresented in th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0739-0

    authors： Block I,Müller C,Sdogati D,Pedersen H,List M,Jaskot AM,Syse SD,Lund Hansen P,Schmidt S,Christiansen H,Casella C,Bering Olsen S,Blomstrøm MM,Riedel A,Thomassen M,Kruse TA,Karlskov Hansen SW,Kioschis P,Mollenhauer J

    更新日期：2019-06-01 00:00:00

  • Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia.

    abstract：:Murine radiation-induced acute myeloid leukaemia (AML) is characterized by loss of one copy of chromosome 2. Previously, we positioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted region. We now report a high frequency (>65%) of missense mutation at codon 235 in the DNA-bin...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208422

    authors： Suraweera N,Meijne E,Moody J,Carvajal-Carmona LG,Yoshida K,Pollard P,Fitzgibbon J,Riches A,van Laar T,Huiskamp R,Rowan A,Tomlinson IP,Silver A

    更新日期：2005-05-19 00:00:00

  • Correlation between the conformational phenotype of p53 and its subcellular location.

    abstract：:In order to obtain insight into the parameters determining the subcellular localization of mutant and wild-type forms of p53, we analysed the subcellular distribution of p53 in four Balb/c mouse-derived cell lines ranging in their cellular phenotypes from normal (3T3), via minimal transformant (T3T3), to maximally tra...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Zerrahn J,Deppert W,Weidemann D,Patschinsky T,Richards F,Milner J

    更新日期：1992-07-01 00:00:00

  • Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.

    abstract：:Loss-of-function mutations in the LKB1 (STK11) serine-threonine kinase gene cause Peutz-Jeghers syndrome, which is associated with inherited susceptibility to colorectal and other cancers. No downstream targets of LKB1 kinase activity have been identified. Here we show that LKB1 can direct the phosphorylation of the s...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206669

    authors： Spicer J,Rayter S,Young N,Elliott R,Ashworth A,Smith D

    更新日期：2003-07-24 00:00:00

  • Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts.

    abstract：:Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.73

    authors： Lee YC,Huang CF,Murshed M,Chu K,Araujo JC,Ye X,deCrombrugghe B,Yu-Lee LY,Gallick GE,Lin SH

    更新日期：2010-06-03 00:00:00

  • Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma.

    abstract：:Tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (TRAIL-R1) and tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) are cell-surface receptors involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling. TRAIL-R1 and TRAIL-R2 gene...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204103

    authors： Lee SH,Shin MS,Kim HS,Lee HK,Park WS,Kim SY,Lee JH,Han SY,Park JY,Oh RR,Kang CS,Kim KM,Jang JJ,Nam SW,Lee JY,Yoo NJ

    更新日期：2001-01-18 00:00:00

  • The GATA-1 and Spi-1 transcriptional factors bind to a GATA/EBS dual element in the Fli-1 exon 1.

    abstract：:Fli-1 is a proto-oncogene which is rearranged in tumors induced by three different retroviruses, Cas-Br-E, F-MuLV, and 10A1. This gene is a member of the Ets gene family, a class of transcription factors that recognize and bind to a DNA motif known as the Ets binding site (EBS). Our laboratory has previously cloned an...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202913

    authors： Barbeau B,Barat C,Bergeron D,Rassart E

    更新日期：1999-09-30 00:00:00

  • Studying the pathogenesis of BCR-ABL+ leukemia in mice.

    abstract：:Animal models of BCR-ABL+ leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1206091

    authors： Van Etten RA

    更新日期：2002-12-09 00:00:00

  • G-proteins in growth and apoptosis: lessons from the heart.

    abstract：:The acute contractile function of the heart is controlled by the effects of released nonepinephrine (NE) on cardiac adrenergic receptors. NE can also act in a more chronic fashion to induce cardiomyocyte growth, characterized by cell enlargement (hypertrophy), increased protein synthesis, alterations in gene expressio...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1204275

    authors： Adams JW,Brown JH

    更新日期：2001-03-26 00:00:00

  • Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells.

    abstract：:Low dose treatment with the DNA methylation inhibitor decitabine has been shown to be applicable for the management of certain types of cancer. However, its antitumor effect and mechanisms are context dependent and its activity has never been systematically studied in bladder cancer treatment. We used mouse models, cu...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0799-1

    authors： Wu M,Sheng L,Cheng M,Zhang H,Jiang Y,Lin S,Liang Y,Zhu F,Liu Z,Zhang Y,Zhang X,Gao Q,Chen D,Li J,Li Y

    更新日期：2019-07-01 00:00:00

  • Inhibition of anchorage-independent growth and lung metastasis of A549 lung carcinoma cells by IkappaBbeta.

    abstract：:To evaluate the role of the NF-kappaB signaling pathway in oncogenic transformation, we expressed IkappaBbeta, a specific inhibitor of NF-kappaB, in two human lung adenocarcinoma cell lines, A549 and H441. Expression of IkappaBbeta significantly reduced NF-kappaB activation induced by cotransfection with p65/RelA or T...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204293

    authors： Jiang Y,Cui L,Yie TA,Rom WN,Cheng H,Tchou-Wong KM

    更新日期：2001-04-26 00:00:00

  • MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells.

    abstract：:Over 70% of human breast cancers are estrogen receptor-positive (ER+), most of which express MYB. In these and other cell types, the MYB transcription factor regulates the expression of many genes involved in cell proliferation, differentiation, tumorigenesis, and apoptosis. So far, no clear link has been established ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0789-3

    authors： Yang RM,Nanayakkara D,Kalimutho M,Mitra P,Khanna KK,Dray E,Gonda TJ

    更新日期：2019-06-01 00:00:00

  • Identification of a nuclear targeting sequence in the Fos protein.

    abstract：:The product of the proto-oncogene fos is a nuclear phosphoprotein. We have investigated if nuclear location of Fos protein is mediated by a nuclear targeting sequence. We show that the cytoplasmic chicken pyruvate kinase protein translocates to the nucleus if fused to the 22 amino acid Fos basic region (amino acids 13...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Tratner I,Verma IM

    更新日期：1991-11-01 00:00:00

  • Formation of PML/RAR alpha high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML/RAR alpha-mediated retinoic acid response.

    abstract：:Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patients by triggering terminal differentiation of neoplastic cells. RA-sensitivity in APL is mediated by its oncogenic protein, which results from the recombination of the PML and the RA receptor alpha (RAR alpha) genes (PML...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203029

    authors： Grignani F,Gelmetti V,Fanelli M,Rogaia D,De Matteis S,Ferrara FF,Bonci D,Grignani F,Nervi C,Pelicci PG

    更新日期：1999-11-04 00:00:00

  • Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

    abstract：:We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces an increase of intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide, leading us to propose that defec...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.468

    authors： White-Gilbertson S,Mullen T,Senkal C,Lu P,Ogretmen B,Obeid L,Voelkel-Johnson C

    更新日期：2009-02-26 00:00:00

  • Correlation of Snail expression with histological grade and lymph node status in breast carcinomas.

    abstract：:Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205416

    authors： Blanco MJ,Moreno-Bueno G,Sarrio D,Locascio A,Cano A,Palacios J,Nieto MA

    更新日期：2002-05-09 00:00:00