Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

abstract：:In classical Hodgkin lymphoma the malignant Hodgkin/Reed-Sternberg (HRS) cells characteristically constitute only a small minority of the tumour load. Their origin has been debated for decades, but on the basis of rearrangement and somatic hypermutations of their immunoglubulin (Ig) genes, HRS cells are now ascribed t...

journal_title：Oncogene

authors： Hertel CB,Zhou XG,Hamilton-Dutoit SJ,Junker S

更新日期：2002-07-25 00:00:00

abstract：:We previously reported the sequence of a cDNA, TIS11, cloned from TPA-treated Swiss 3T3 cells. Two laboratories have reported sequences for cDNAs that have a region of identity with the TIS11 cDNA, but differ in their 5' and 3' flanking regions. We now report that the original TIS11 cDNA is likely to be a chimeric mol...

journal_title：Oncogene

authors： Ma Q,Herschman HR

更新日期：1991-07-01 00:00:00

abstract：:The post-translational modifications ubiquitination and sumoylation have been implicated in regulating many critical cellular pathways. Like ubiquitination, sumoylation is a multistep process involving maturation, activation, conjugation and deconjugation. Ubc9 is a sole E2-conjugating enzyme essential for sumoylation...

journal_title：Oncogene

authors： Mo YY,Yu Y,Theodosiou E,Ee PL,Beck WT

更新日期：2005-04-14 00:00:00

abstract：:The E1a gene of group C adenoviruses is one of the most studied transforming genes of DNA tumor viruses. These transforming genes have been conventionally considered as dominant oncogenes since they transform cells in vitro and many of the resulting transformed cell lines induce tumors in experimental animals. It now ...

journal_title：Oncogene

authors： Chinnadurai G

更新日期：1992-07-01 00:00:00

abstract：:The development of hepatocellular carcinomas (HCC) depends on their local microenvironment and the induction of neovascularization is a decisive step in tumor progression, since the growth of solid tumors is limited by nutrient and oxygen supply. Hypoxia is the critical factor that induces transcription of the hypoxia...

journal_title：Oncogene

authors： Wen Y,Zhou X,Lu M,He M,Tian Y,Liu L,Wang M,Tan W,Deng Y,Yang X,Mayer MP,Zou F,Chen X

更新日期：2019-03-01 00:00:00

abstract：:The Crk II adaptor protein encodes an SH2/SH3-domain containing adaptor protein with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The two SH3 domains are separated by a 54 amino acid linker region, whose length is highly conserved in xenopus, chicken, and mamalian Crk II proteins. To g...

journal_title：Oncogene

authors： Zvara A,Fajardo JE,Escalante M,Cotton G,Muir T,Kirsch KH,Birge RB

更新日期：2001-02-22 00:00:00

abstract：:A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the...

journal_title：Oncogene

authors： Obaya AJ,Mateyak MK,Sedivy JM

更新日期：1999-05-13 00:00:00

abstract：:Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice, show an increased susceptibility to spontaneous tumor development. Human and mouse Ptc1 heterozygotes (Ptc1(+/-)) are also hypersensitive to ionizing radiation...

journal_title：Oncogene

authors： Pazzaglia S,Mancuso M,Atkinson MJ,Tanori M,Rebessi S,Majo VD,Covelli V,Hahn H,Saran A

更新日期：2002-10-24 00:00:00

abstract：:The ARF tumour suppressor protein plays a critical role in the activation of p53 in response to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2. However, several lines of evidence indicate that this is not the only way of action of ARF, and alternative mechanisms must exist. p33ING1 is a...

journal_title：Oncogene

authors： González L,Freije JM,Cal S,López-Otín C,Serrano M,Palmero I

更新日期：2006-08-24 00:00:00

abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

journal_title：Oncogene

authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

更新日期：1996-02-01 00:00:00

abstract：:Mammalian Vav signal transducer proteins couple receptor tyrosine kinase signals to the activation of the Rho/Rac GTPases, leading to cell differentiation and/or proliferation. The unique and complex structure of mammalian Vav proteins is preserved in the Drosophila melanogaster homologue, DroVav. We demonstrate that ...

journal_title：Oncogene

authors： Hornstein I,Mortin MA,Katzav S

更新日期：2003-10-02 00:00:00

abstract：:The p53 tumor suppressor protein and the Akt/PKB kinase play important roles in the transduction of pro-apoptotic and anti-apoptotic signals, respectively. We provide evidence that conflicting signals transduced by Akt and p53 are integrated via negative feedback between the two pathways. On the one hand, the combinat...

journal_title：Oncogene

authors： Gottlieb TM,Leal JF,Seger R,Taya Y,Oren M

更新日期：2002-02-14 00:00:00

abstract：:Diffuse intrinsic pontine glioma (or DIPG) are pediatric high-grade gliomas associated with a dismal prognosis. They harbor specific substitution in histone H3 at position K27 that induces major epigenetic dysregulations. Most clinical trials failed so far to increase survival, and radiotherapy remains the most effici...

journal_title：Oncogene

authors： Silva-Evangelista C,Barret E,Ménez V,Merlevede J,Kergrohen T,Saccasyn A,Oberlin E,Puget S,Beccaria K,Grill J,Castel D,Debily MA

更新日期：2019-09-01 00:00:00

abstract：:The c-myc proto-oncogene has been shown to cause blockages to differentiation in many cell lineages. Although the mechanism by which c-Myc affects this process remains unknown, it is considered that it might result indirectly as an outcome of the continued cell-cycle progression invoked by c-Myc in cells which must gr...

journal_title：Oncogene

authors： Ryan KM,Birnie GD

更新日期：1997-06-12 00:00:00

abstract：:The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tube...

journal_title：Oncogene

authors： Rosner M,Freilinger A,Hengstschläger M

更新日期：2007-01-25 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:To investigate the effect of p33(ING1) on wild-type p53 gene therapy, T.Tn human esophageal carcinoma cells were stably transfected with p33(ING1) cDNA. Infection with Ad-p53 (recombinant adenovirus containing wild-type p53) into p33-transfected cells reduced cell viability, while infection with empty vector had littl...

journal_title：Oncogene

authors： Shimada H,Liu TL,Ochiai T,Shimizu T,Haupt Y,Hamada H,Abe T,Oka M,Takiguchi M,Hiwasa T

更新日期：2002-02-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Oncogene

authors： Wang K,Ji W,Yu Y,Li Z,Niu X,Xia W,Lu S

更新日期：2020-10-01 00:00:00

abstract：:Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...

journal_title：Oncogene

authors： Varga AE,Stourman NV,Zheng Q,Safina AF,Quan L,Li X,Sossey-Alaoui K,Bakin AV

更新日期：2005-07-28 00:00:00

abstract：:Oncogenic RAS promotes production of reactive oxygen species (ROS), which mediate pro-malignant signaling but can also trigger DNA damage-induced tumor suppression. Thus RAS-driven tumor cells require redox-protective mechanisms to mitigate the damaging aspects of ROS. Here, we show that MutT Homolog 1 (MTH1), the mam...

journal_title：Oncogene

authors： Patel A,Burton DG,Halvorsen K,Balkan W,Reiner T,Perez-Stable C,Cohen A,Munoz A,Giribaldi MG,Singh S,Robbins DJ,Nguyen DM,Rai P

更新日期：2015-05-14 00:00:00

abstract：:The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different c...

journal_title：Oncogene

authors： Ling LS,Voskas D,Woodgett JR

更新日期：2013-11-21 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non-PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that ...

journal_title：Oncogene

authors： Totani H,Shinjo K,Suzuki M,Katsushima K,Mase S,Masaki A,Ito A,Ri M,Kusumoto S,Komatsu H,Ishida T,Inagaki H,Iida S,Kondo Y

更新日期：2020-08-01 00:00:00

abstract：:Targeting altered cancer cell metabolism with the glycolysis inhibitor, 2-deoxyglucose (2DG), is a viable therapeutic strategy, but the effects of 2DG on lymphoma cells and the mechanism of action are unknown. Five T-cell lymphoma lines and two B-cell lymphoma lines were shown to be highly sensitive to 2DG. Examinatio...

journal_title：Oncogene

authors： Zagorodna O,Martin SM,Rutkowski DT,Kuwana T,Spitz DR,Knudson CM

更新日期：2012-05-31 00:00:00

abstract：:Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...

journal_title：Oncogene

authors： Liu W,Li H,Hong SH,Piszczek GP,Chen W,Rodgers GP

更新日期：2016-10-06 00:00:00

abstract：:Cellular senescence functions as a tumor suppressor that protects against cancer progression. α-Catulin, an α-catenin-related protein, is reported to have tumorigenic potential because it regulates the nuclear factor-κB (NF-κB) pathway, but little is known about its clinical relevance and the mechanism through which i...

journal_title：Oncogene

authors： Fan LC,Chiang WF,Liang CH,Tsai YT,Wong TY,Chen KC,Hong TM,Chen YL

更新日期：2011-06-09 00:00:00

abstract：:Phosphorylation of linker histone H1(S)-3 (previously named H1b) and core histone H3 is elevated in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase (MAPK) kinase (MEK). H1(S)-3 phosphorylation is the only histone modification known to be dependent upon transcripti...

journal_title：Oncogene

authors： Chadee DN,Peltier CP,Davie JR

更新日期：2002-12-05 00:00:00

abstract：:The promoter of the human ETS1 gene contains binding site motifs for transcription factors Sp1, Ap1, Ap2, ETS, PEA3 and Oct. It has been shown previously that Ap1, Ap2, and ETS are positive regulators for the transcription of the ETS1 gene and that the ETS1 gene is autoregulated. In addition, two regions on the ETS1 p...

journal_title：Oncogene

authors： Chen JH,Wright CD

更新日期：1993-12-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated th...

journal_title：Oncogene

authors： Busch S,Acar A,Magnusson Y,Gregersson P,Rydén L,Landberg G

更新日期：2015-01-02 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production by stromal fibroblasts plays an important role in tumor angiogenesis. However, VEGF is also expressed by normal tissue fibroblasts, raising the question of how the VEGF activity of fibroblasts is regulated. Here we report that the latent VEGF angiogenic activity of ...

journal_title：Oncogene

authors： Ito TK,Ishii G,Chiba H,Ochiai A

更新日期：2007-11-08 00:00:00

abstract：:Fallopian tube carcinoma (FTC) is a rare, poorly studied and aggressive cancer, associated with poor survival. Since tumorigenesis is related to the acquisition of genetic changes, we used genome-wide array comparative genomic hybridization to analyse copy number aberrations occurring in FTC in order to obtain a bette...

journal_title：Oncogene

authors： Snijders AM,Nowee ME,Fridlyand J,Piek JM,Dorsman JC,Jain AN,Pinkel D,van Diest PJ,Verheijen RH,Albertson DG

更新日期：2003-07-03 00:00:00