The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells.

Abstract:

:Vascular endothelial growth factor (VEGF) production by stromal fibroblasts plays an important role in tumor angiogenesis. However, VEGF is also expressed by normal tissue fibroblasts, raising the question of how the VEGF activity of fibroblasts is regulated. Here we report that the latent VEGF angiogenic activity of fibroblasts is activated by cancer cells, resulting in tumor-selective utilization of fibroblast-derived VEGF. Through the production of VEGF, human VA-13 fibroblasts promote angiogenesis in and growth of human pancreas cancer Capan-1 xenograft tumors, whereas VA-13 fibroblasts alone do not show significant angiogenesis. Treatment of VA-13 fibroblast supernatant with matrix metalloproteinase-7 (MMP-7), an extracellular proteinase characteristically expressed by cancer cells, elicits endothelial tube formation. This effect is abrogated by anti-VEGF antibody or connective tissue growth factor (CTGF), which was previously reported to sequester VEGF and be degraded by MMP-7. Suppression of MMP-7 in Capan-1 cells abrogates the tumor angiogenic activity of VA-13 fibroblasts, which is restored by suppression of CTGF in VA-13 fibroblasts. We further show that these molecular mechanisms that trigger angiogenesis are effective in human primary fibroblasts and human colorectal tissue. These data suggest that fibroblasts may store VEGF in a latent state in the extracellular environment for urgent use in angiogenesis.

journal_name

Oncogene

journal_title

Oncogene

authors

Ito TK,Ishii G,Chiba H,Ochiai A

doi

10.1038/sj.onc.1210535

subject

Has Abstract

pub_date

2007-11-08 00:00:00

pages

7194-203

issue

51

eissn

0950-9232

issn

1476-5594

pii

1210535

journal_volume

26

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Caspase-independent cell death?

    abstract::Many cells die with apoptotic morphology and with documented activation of an effector caspase, but there are also many exceptions. Cells frequently display activation of other proteases, including granzymes, lysosomal cathepsins, matrix metalloproteinases, and proteasomal proteases, and others display morphologies th...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/sj.onc.1207514

    authors: Lockshin RA,Zakeri Z

    更新日期:2004-04-12 00:00:00

  • Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death.

    abstract::Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2014.338

    authors: Schoeneberger H,Belz K,Schenk B,Fulda S

    更新日期:2015-07-30 00:00:00

  • The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling.

    abstract::Inactivation of the tumor suppressor NF2/merlin underlies neurofibromatosis type 2 (NF2) and some sporadic tumors. Previous studies have established that merlin mediates contact inhibition of proliferation; however, the exact mechanisms remain obscure and multiple pathways have been implicated. We have previously repo...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/s41388-019-0883-6

    authors: Cui Y,Groth S,Troutman S,Carlstedt A,Sperka T,Riecken LB,Kissil JL,Jin H,Morrison H

    更新日期:2019-09-01 00:00:00

  • Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.

    abstract::Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with autosomal dominant inheritance of disease in humans. Similarly, mice that contain a single mutant APC gene encoding a protein truncated at residue 716 (Apc(Δ716...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2010.633

    authors: Mohammad HP,Zhang W,Prevas HS,Leadem BR,Zhang M,Herman JG,Hooker CM,Watkins DN,Karim B,Huso DL,Baylin SB

    更新日期:2011-06-09 00:00:00

  • Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas.

    abstract::Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations of MYC, BCL2 and BCL6 promote specific GC lymphoma subtypes, other genetic and epigenetic modifications that contribute to malignant progression in the GC remain poorly defined. Recently, a...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1210211

    authors: Dawson DW,Hong JS,Shen RR,French SW,Troke JJ,Wu YZ,Chen SS,Gui D,Regelson M,Marahrens Y,Morse HC 3rd,Said J,Plass C,Teitell MA

    更新日期:2007-06-21 00:00:00

  • The bovine papillomavirus type 1 E6 oncoprotein sensitizes cells to tumor necrosis factor alpha-induced apoptosis.

    abstract::Expression of viral proteins may result in susceptibility of cells to the cytotoxic effect of Tumor Necrosis Factor Alpha (TNF). While murine C127 cells containing the bovine papillomavirus type 1 (BPV-1) genome were reported to exhibit increased TNF sensitivity, the gene(s) responsible was not identified. The BPV-1 E...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202373

    authors: Rapp L,Liu Y,Hong Y,Androphy EJ,Chen JJ

    更新日期:1999-01-21 00:00:00

  • Viral rel and cellular rel associate with cellular proteins in transformed and normal cells.

    abstract::The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellul...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJ

    更新日期:1989-06-01 00:00:00

  • The role of v-mos in transformation, oncogenicity, and metastatic potential of mink lung cells.

    abstract::A cloned line of S + L- mink lung cells (A clone), which exhibited a flat morphology, was superinfected with a novel dual-tropic virus (E1BX-MuLV) showing a broad host range and a B-tropism. These cells gave rise to transformed cells with two phenotypes: those which were still anchorage-dependent (AD), and those which...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Gao CL,Wang LC,Vass WC,Seth A,Chang KS

    更新日期:1988-09-01 00:00:00

  • Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.

    abstract::In this study we have investigated DNA-protein interactions at an AP1-like motif of the neuropeptide tyrosine (NPY) promoter during in vitro differentiation of human neuroblastoma cells SH-SY5Y to mature nonproliferative sympathetic neuron-like cells. These neuroblast-like cells originate from the parental cell line S...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Jalava A,Mai S

    更新日期:1994-08-01 00:00:00

  • Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

    abstract::In this study we have surveyed by immunoblotting the protein levels of Cyclin D1, D2, D3 and their catalytic partners, Cdk4 and Cdk6 in normal and transformed human cells. We found that all these proteins were differentially expressed in diploid cells derived from different tissues, in contrast to Cyclin E, Cyclin A a...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Tam SW,Theodoras AM,Shay JW,Draetta GF,Pagano M

    更新日期:1994-09-01 00:00:00

  • The PR status of the originating cell of ER/PR-negative mouse mammary tumors.

    abstract::Progesterone receptor (PR) is usually co-localized with estrogen receptor (ER) in normal mammary cells. It is not known whether ER/PR-negative human breast cancer arises from an ER/PR-negative cell or from an ER/PR-positive cell that later lost ER/PR. Using intraductal injection of a lentivirus to deliver both an onco...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2015.465

    authors: Dong J,Zhao W,Shi A,Toneff M,Lydon J,So D,Li Y

    更新日期:2016-08-04 00:00:00

  • ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth.

    abstract::Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2015.220

    authors: Humtsoe JO,Pham E,Louie RJ,Chan DA,Kramer RH

    更新日期:2016-03-24 00:00:00

  • Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21.

    abstract::The death mediator caspase acts as the dominant regulator during cell death induction. The CPP32 subfamily, including caspase 3 (CPP32/Yama/Apopain), is essential for the cell death signaling. We recently reported that activation of caspase 3 is regulated by complex formation with p21 or ILP. In the present study, we ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202409

    authors: Suzuki A,Tsutomi Y,Miura M,Akahane K

    更新日期:1999-02-04 00:00:00

  • p53 in complex with DNA is resistant to ubiquitin-dependent proteolysis in the presence of HPV-16 E6.

    abstract::The tumour suppressor p53 is a transcription factor with high affinity for specific DNA target sequences. Wild type p53 has a very short half life in normal cells but the protein shows transient accumulation in response to DNA damage, accompanied by up-regulation of target genes such as p21 and induction of growth arr...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Molinari M,Milner J

    更新日期:1995-05-04 00:00:00

  • Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells.

    abstract::Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive brea...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2009.130

    authors: Walter M,Liang S,Ghosh S,Hornsby PJ,Li R

    更新日期:2009-07-30 00:00:00

  • Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells.

    abstract::Human papillomaviruses (HPVs) are involved in the pathogenesis of cancer of the cervix (CaCx). MicroRNA (miRNA) expression analysis using Ambion (Austin, TX, USA) arrays showed that three miRNAs were overexpressed and 24 underexpressed in cervical cell lines containing integrated HPV-16 DNA compared to the normal cerv...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1210919

    authors: Martinez I,Gardiner AS,Board KF,Monzon FA,Edwards RP,Khan SA

    更新日期:2008-04-17 00:00:00

  • Human papillomavirus E7 proteins stimulate proliferation independently of their ability to associate with retinoblastoma protein.

    abstract::Studies on human papillomavirus type 16 have demonstrated that the product of the early gene, E7, plays a key role in the immortalization and malignant transformation of the host cell. Several of the biological activities of HPV16 E7 are mediated by inactivation of the members of the pocket protein family, pRb, p107 a...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1203375

    authors: Caldeira S,de Villiers EM,Tommasino M

    更新日期:2000-02-10 00:00:00

  • The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.

    abstract::Infection by HTLV-1 has been correlated with the appearance of various proliferative or degenerative diseases. Some of these disorders have been observed in transgenic mice expressing the Tax protein, which is known to transactivate various viral and cellular promoters through interactions with several transcription f...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1201567

    authors: Rousset R,Fabre S,Desbois C,Bantignies F,Jalinot P

    更新日期:1998-02-05 00:00:00

  • Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.

    abstract::Degradation of cellular proteins through ubiquitination is a fundamental strategy for regulating biological pathways. De-ubiquitination, i.e. the removal of ubiquitin from proteins and peptides to which ubiquitin is attached, is catalyzed by processing proteases known as de-ubiquitinating enzymes. We are studying the ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1204553

    authors: Soncini C,Berdo I,Draetta G

    更新日期:2001-06-28 00:00:00

  • FZD7 has a critical role in cell proliferation in triple negative breast cancer.

    abstract::Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breas...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2011.145

    authors: Yang L,Wu X,Wang Y,Zhang K,Wu J,Yuan YC,Deng X,Chen L,Kim CC,Lau S,Somlo G,Yen Y

    更新日期:2011-10-27 00:00:00

  • Hereditary suppression of lethal (2) giant larvae malignant tumor development in Drosophila by gene transfer.

    abstract::Homozygous mutations of the recessive oncogene lethal-(2) giant larvae (l(2)gl) of Drosophila melanogaster cause lethal neoplasms of the imaginal discs and the brain hemisphere. A 13-kb DNA segment spanning the l(2)gl+ locus has been inserted into P element vectors and used for P-mediated transformation. The P-l(2)gl+...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Opper M,Schuler G,Mechler BM

    更新日期:1987-05-01 00:00:00

  • Catch of the day: zebrafish as a human cancer model.

    abstract::Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects o...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/onc.2008.95

    authors: Stoletov K,Klemke R

    更新日期:2008-07-31 00:00:00

  • Hepatitis B virus-related insertional mutagenesis in chronic hepatitis B patients as an early drastic genetic change leading to hepatocarcinogenesis.

    abstract::Growing evidence demonstrates that hepatitis B virus (HBV) integration and resulting insertional mutagenesis play an important role in cell growth or maintenance in hepatocellular carcinomas (HCCs). To determine if HBV integration occurs and affects cellular genes at such a stage of infection, we analysed viral-host j...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1208628

    authors: Minami M,Daimon Y,Mori K,Takashima H,Nakajima T,Itoh Y,Okanoue T

    更新日期:2005-06-23 00:00:00

  • TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation.

    abstract::The biological outcome of TMPRSS2:ERG chromosomal translocations in prostate cancer (PC) remains poorly understood. To address this, we compared the transcriptional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a TMPRSS2:ERG-positive PC cell line. This reveals that ERG re...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2014.308

    authors: Mounir Z,Lin F,Lin VG,Korn JM,Yu Y,Valdez R,Aina OH,Buchwalter G,Jaffe AB,Korpal M,Zhu P,Brown M,Cardiff RD,Rocnik JL,Yang Y,Pagliarini R

    更新日期:2015-07-01 00:00:00

  • Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation.

    abstract::TrkA is the receptor tyrosine kinase (RTK) for nerve growth factor (NGF) and stimulates NGF-dependent cell survival and differentiation in primary neurons. TrkA expression in neuronal tumors also supports NGF-dependent differentiation of neuroblastomas and apoptosis of medulloblastomas. Phosphorylation of the activati...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1203330

    authors: Gryz EA,Meakin SO

    更新日期:2000-01-20 00:00:00

  • Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells.

    abstract::Gastrin and its precursors promote proliferation in different gastrointestinal cells. Since mature, amidated gastrin (G-17) can induce cyclin D1, we determined whether G-17-mediated induction of cyclin D1 transcription involved Wnt signaling and CRE-binding protein (CREB) pathways. Our studies indicate that G-17 induc...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1207454

    authors: Pradeep A,Sharma C,Sathyanarayana P,Albanese C,Fleming JV,Wang TC,Wolfe MM,Baker KM,Pestell RG,Rana B

    更新日期:2004-04-29 00:00:00

  • Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter.

    abstract::REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanisms of c-fos downregulation in E1A+cHa-ras transformants, we studied th...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1205118

    authors: Kukushkin AN,Abramova MV,Svetlikova SB,Darieva ZA,Pospelova TV,Pospelov VA

    更新日期:2002-01-24 00:00:00

  • Diet and cancer prevention.

    abstract::Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains ill-defined. The evidence for a role of energy balance, physical inactivity, and obesity has st...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/sj.onc.1207716

    authors: McCullough ML,Giovannucci EL

    更新日期:2004-08-23 00:00:00

  • HGF-independent potentiation of EGFR action by c-Met.

    abstract::The c-Met receptor is a potential therapeutic target for non-small cell lung cancer (NSCLC). Signaling interactions between c-Met and the mutant epidermal growth factor receptor (EGFR) have been studied extensively, but signaling intermediates and biological consequences of lateral signaling to c-Met in EGFR wild-type...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2011.84

    authors: Dulak AM,Gubish CT,Stabile LP,Henry C,Siegfried JM

    更新日期:2011-08-18 00:00:00

  • The adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300.

    abstract::A protein of 300 kDa (p300) associates with the adenovirus E1A proteins and has been implicated in the control of cell cycle progression. In mammalian cells, p300 is actively phosphorylated in both quiescent and proliferating cells and its level of phosphorylation increases as it travels from late G1 into M phase. E1A...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Banerjee AC,Recupero AJ,Mal A,Piotrkowski AM,Wang DM,Harter ML

    更新日期:1994-06-01 00:00:00