Abstract:
:A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the Cdk inhibitor p27KIP1. Cyclin D/Cdk4/6 complexes have also been implicated as targets of c-Myc activity. However, in spite of considerable effort, the mechanisms by which c-Myc interacts with the intrinsic cyclin/Cdk cell cycle machinery remain undefined.
journal_name
Oncogenejournal_title
Oncogeneauthors
Obaya AJ,Mateyak MK,Sedivy JMdoi
10.1038/sj.onc.1202749subject
Has Abstractpub_date
1999-05-13 00:00:00pages
2934-41issue
19eissn
0950-9232issn
1476-5594journal_volume
18pub_type
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