Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA.

abstract：:We recently reported the cloning and overexpression of full-length forms of human fibroblast growth factor (FGF) receptors, bek and flg. These receptors contain three immunoglobulin (Ig)-like domains and an unusual acidic motif in the extracellular region, a single transmembrane segment and a protein tyrosine kinase c...

journal_title：Oncogene

authors： Crumley G,Bellot F,Kaplow JM,Schlessinger J,Jaye M,Dionne CA

更新日期：1991-12-01 00:00:00

abstract：:The v-myb oncogene of the avian myeloblastosis virus (AMV) is unique among known oncogenes in that it causes only acute leukemia in animals and transforms only hematopoietic cells in culture. AMV was discovered in the 1930s as a virus that caused a disease in chickens that is similar to acute myelogenous leukemia in h...

journal_title：Oncogene

authors： Lipsick JS,Wang DM

更新日期：1999-05-13 00:00:00

abstract：:The RAD17 gene product of S. Pombe is an essential component of the checkpoint control pathway which responds to both DNA damage and disruption of replication. We have identified a human cDNA that encodes a polypeptide which is structurally conserved with the S. Pombe Rad17 protein. The human gene, designated hRAD17, ...

journal_title：Oncogene

authors： Li L,Peterson CA,Kanter-Smoler G,Wei YF,Ramagli LS,Sunnerhagen P,Siciliano MJ,Legerski RJ

更新日期：1999-03-04 00:00:00

abstract：:Early growth response-1 (Egr-1) is overexpressed in human prostate tumors and contributes to cancer progression. On the other hand, mutation of p53 is associated with advanced prostate cancer, as well as with metastasis and hormone independence. This study shows that in prostate cell lines in culture, Egr-1 overexpres...

journal_title：Oncogene

authors： Sauer L,Gitenay D,Vo C,Baron VT

更新日期：2010-05-06 00:00:00

abstract：:In both humans with long-standing ulcerative colitis and mouse models of colitis-associated carcinogenesis (CAC), tumors develop predominantly in the distal part of the large intestine but the biological basis of this intriguing pathology remains unknown. Herein we report intrinsic differences in gene expression betwe...

journal_title：Oncogene

authors： Gkouskou KK,Ioannou M,Pavlopoulos GA,Georgila K,Siganou A,Nikolaidis G,Kanellis DC,Moore S,Papadakis KA,Kardassis D,Iliopoulos I,McDyer FA,Drakos E,Eliopoulos AG

更新日期：2016-05-12 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare human tumor affecting the calcitonin-secreting c-cells of the thyroid. Here we report that two independent strains of transgenic mice expressing a Polyomavirus (Py) truncated middle-T antigen (deltaMT), consisting of the amino-terminal 304 amino acids, and the full length Py...

journal_title：Oncogene

authors： Felici A,Giorgio M,Krauzewicz N,Della Rocca C,Santoro M,Rovere P,Manni I,Amati P,Pozzi L

更新日期：1999-04-08 00:00:00

abstract：:Syndecan-1 is a heparan sulfate proteoglycan (HSPG) commonly upregulated in AIDS-related B lymphoid malignancies. Tat is the main HIV-1 transactivating factor that has a major role in the pathogenesis of AIDS-related lymphomas (ARL) by engaging heparan sulfate proteoglycans (HSPGs), chemokine receptors and integrins a...

journal_title：Oncogene

authors： Urbinati C,Grillo E,Chiodelli P,Tobia C,Caccuri F,Fiorentini S,David G,Rusnati M

更新日期：2017-05-04 00:00:00

abstract：:Rho GTPases are critical signal transducers of multiple pathways. They have been proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven cancers. Until recently, however, few in vivo studies had been carried out to test this premise. Several recent mouse model studies have verified...

journal_title：Oncogene

authors： Zandvakili I,Lin Y,Morris JC,Zheng Y

更新日期：2017-06-08 00:00:00

abstract：:We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces an increase of intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide, leading us to propose that defec...

journal_title：Oncogene

authors： White-Gilbertson S,Mullen T,Senkal C,Lu P,Ogretmen B,Obeid L,Voelkel-Johnson C

更新日期：2009-02-26 00:00:00

abstract：:BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have generated cell lines with inducible expression of BRCA1 to evaluate its role in mediating the cellular response to various chemotherapeutic drugs commonly used in the treatment of breast and ovarian can...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Gilmore PM,McWilliams S,Andrews H,Gervin C,McCabe N,McKenna S,White P,Song YH,Maheswaran S,Liu E,Haber DA,Johnston PG,Harkin DP

更新日期：2001-09-27 00:00:00

abstract：:Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal breast cancer; however, currently used biomarkers, such as, estrogen receptor-alpha/progesterone receptor (ERα/PR), predict only slightly more than half of the potential responders to AI treatment. To identify novel markers of AI responsi...

journal_title：Oncogene

authors： Moy I,Todorović V,Dubash AD,Coon JS,Parker JB,Buranapramest M,Huang CC,Zhao H,Green KJ,Bulun SE

更新日期：2015-01-15 00:00:00

abstract：:Pdcd4 is a novel transformation suppressor that is highly expressed in promotion-resistant (P-) mouse epidermal JB6 cells but not in susceptible (P+) cells. Overexpression of pdcd4 cDNA in stably transfected P+ cells rendered cells resistant to tumor promoter-induced transformation, indicating that elevated expression...

journal_title：Oncogene

authors： Yang HS,Jansen AP,Nair R,Shibahara K,Verma AK,Cmarik JL,Colburn NH

更新日期：2001-02-08 00:00:00

abstract：:To evaluate the role of the NF-kappaB signaling pathway in oncogenic transformation, we expressed IkappaBbeta, a specific inhibitor of NF-kappaB, in two human lung adenocarcinoma cell lines, A549 and H441. Expression of IkappaBbeta significantly reduced NF-kappaB activation induced by cotransfection with p65/RelA or T...

journal_title：Oncogene

authors： Jiang Y,Cui L,Yie TA,Rom WN,Cheng H,Tchou-Wong KM

更新日期：2001-04-26 00:00:00

abstract：:Secreted frizzled related protein 1 (SFRP 1) is an antagonist of the transmembrane frizzled receptor, a component of the Wnt signaling pathway, and has been suggested to be a candidate tumor suppressor in several human malignancies. Since SFRP 1 is located at chromosome 8 p 11, where lung cancers also exhibit frequent...

journal_title：Oncogene

authors： Fukui T,Kondo M,Ito G,Maeda O,Sato N,Yoshioka H,Yokoi K,Ueda Y,Shimokata K,Sekido Y

更新日期：2005-09-15 00:00:00

abstract：:We previously reported that YY-1, a versatile transcription factor, regulates expression of glycophorin gene by binding to its locus control region-like region (Gp-LCR) in combination with E-box binding protein during murine erythroleukemia (MEL) cell differentiation. In the present work, we demonstrated that YY-1 and...

journal_title：Oncogene

authors： Zhao JH,Inoue T,Shoji W,Nemoto Y,Obinata M

更新日期：1998-08-27 00:00:00

abstract：:Although transforming ras oncogenes have been implicated as causative factors in liver cell transformation, the exact function and phenotypic alterations generated by the expression of such transforming genes in liver epithelial cells has yet to be defined. We have utilized a retroviral vector system to deliver an ind...

journal_title：Oncogene

authors： Huber BE,Cordingley MG

更新日期：1988-09-01 00:00:00

abstract：:TEA domain (TEAD) transcription factors are key components of the Hippo-YAP1 signaling pathway, but their functional role and regulatory mechanisms remain unclear. This study aims to comprehensively explore the expression pattern and functional role of TEAD family in gastric carcinogenesis and investigate its regulati...

journal_title：Oncogene

authors： Zhou Y,Huang T,Zhang J,Wong CC,Zhang B,Dong Y,Wu F,Tong JHM,Wu WKK,Cheng ASL,Yu J,Kang W,To KF

更新日期：2017-11-23 00:00:00

abstract：:Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we demonstrated, however, that caspase-8 can also be activated in a death receptor-independent manner via the mitochondrial apoptosis pathway, downstream of caspase-3. Here, we show that caspases-3 and -8 mediate a mitochondrial am...

journal_title：Oncogene

authors： von Haefen C,Wieder T,Essmann F,Schulze-Osthoff K,Dörken B,Daniel PT

更新日期：2003-04-17 00:00:00

abstract：:The breast cancer-associated protein, BARD1, colocalizes with BRCA1 in nuclear foci in the S phase and after DNA damage, and the two proteins form a stable heterodimer implicated in DNA repair, protein ubiquitination, and control of mRNA processing. BARD1 has a BRCA1-independent proapoptotic activity; however, little ...

journal_title：Oncogene

authors： Rodriguez JA,Schüchner S,Au WW,Fabbro M,Henderson BR

更新日期：2004-03-11 00:00:00

abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

journal_title：Oncogene

authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

更新日期：2004-04-15 00:00:00

abstract：:Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice, show an increased susceptibility to spontaneous tumor development. Human and mouse Ptc1 heterozygotes (Ptc1(+/-)) are also hypersensitive to ionizing radiation...

journal_title：Oncogene

authors： Pazzaglia S,Mancuso M,Atkinson MJ,Tanori M,Rebessi S,Majo VD,Covelli V,Hahn H,Saran A

更新日期：2002-10-24 00:00:00

abstract：:The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...

journal_title：Oncogene

authors： La Rocca SA,Crouch DH,Gillespie DA

更新日期：1994-12-01 00:00:00

abstract：:Oncogenes in DNAs from human tumor cell lines have been detected by a new transformation assay. Cellular DNAs are transfected into NIH3T3 murine fibroblasts, and transformed cells are selected by maintaining cell cultures in a defined medium lacking platelet-derived or fibroblast growth factors. DNAs from eight of 17 ...

journal_title：Oncogene

authors： Zhan X,Culpepper A,Reddy M,Loveless J,Goldfarb M

更新日期：1987-01-01 00:00:00

abstract：:Radicicol, a macrocyclic anti-fungal antibiotic, has the ability to suppress transformation by diverse oncogenes such as Src, Ras and Mos. Despite this useful property, the mechanism by which radicicol exerts its anti-transformation effects is currently unknown. To understand the transformation-suppressing effects of ...

journal_title：Oncogene

authors： Sharma SV,Agatsuma T,Nakano H

更新日期：1998-05-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is characterized by 11q13 chromosomal translocation and CCND1 overexpression, but additional genomic changes are also important for lymphomagenesis. To identify the genomic aberrations of MCL at higher resolutions, we analysed 29 patient samples and seven cell lines using array-based compara...

journal_title：Oncogene

authors： Tagawa H,Karnan S,Suzuki R,Matsuo K,Zhang X,Ota A,Morishima Y,Nakamura S,Seto M

更新日期：2005-02-17 00:00:00

abstract：:Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility. Owing to this multiplicity of potential functions relevant to cancer development, we initiated a study to decipher SYNM expression a...

journal_title：Oncogene

authors： Noetzel E,Rose M,Sevinc E,Hilgers RD,Hartmann A,Naami A,Knüchel R,Dahl E

更新日期：2010-08-26 00:00:00

abstract：:The T-box transcription factor TBX3 has been implicated in the patterning and differentiation of a number of tissues during embryonic development, and is overexpressed in a variety of cancers; however, the precise function of TBX3 in papillary thyroid carcinoma (PTC) development remains to be determined. In the curren...

journal_title：Oncogene

authors： Li X,Ruan X,Zhang P,Yu Y,Gao M,Yuan S,Zhao Z,Yang J,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-s...

journal_title：Oncogene

authors： Zhao X,Reebye V,Hitchen P,Fan J,Jiang H,Sætrom P,Rossi J,Habib NA,Huang KW

更新日期：2019-05-01 00:00:00

abstract：:Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...

journal_title：Oncogene

authors： Healy E,Belgaid C,Takata M,Harrison D,Zhu NW,Burd DA,Rigby HS,Matthews JN,Rees JL

更新日期：1998-04-30 00:00:00

abstract：:The molecular interactions implicated in the mammalian G1/S cell cycle phase transition comprise a highly nonlinear network which can produce seemingly paradoxical results and make intuitive interpretations unreliable. A new approach to this problem is presented, consisting of (1) a convention of unambiguous reaction ...

journal_title：Oncogene

authors： Kohn KW

更新日期：1998-02-26 00:00:00