The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death.

abstract：:Chromatin remodeling proteins regulate multiple aspects of cell homeostasis, making them ideal candidates for misregulation in transformed cells. Here, we explore Sin3A, a member of the Sin3 family of proteins linked to tumorigenesis that are thought to regulate gene expression through their role as histone deacetylas...

journal_title：Oncogene

authors： Das TK,Sangodkar J,Negre N,Narla G,Cagan RL

更新日期：2013-06-27 00:00:00

abstract：:The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial tran...

journal_title：Oncogene

authors： Ahmad R,Kumar B,Chen Z,Chen X,Müller D,Lele SM,Washington MK,Batra SK,Dhawan P,Singh AB

更新日期：2017-11-23 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) has pivotal role in the degradation of extracellular matrix, and thereby enhances the invasive, proliferative and metastatic potential in cancer. Knockdown of MMP-2 using MMP-2 small interfering RNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation ...

journal_title：Oncogene

authors： Kesanakurti D,Chetty C,Dinh DH,Gujrati M,Rao JS

更新日期：2013-01-17 00:00:00

abstract：:Mutant p53 frequently accumulates in cancer cells and promotes tumor cell invasion, as part of its gain of function. Its accumulation is partially due to enhanced stability, but little is known about how the mRNA levels of mutant p53 can be regulated. Likewise, the impact of cancer therapy on the levels of mutant p53 ...

journal_title：Oncogene

authors： Bug M,Dobbelstein M

更新日期：2011-08-18 00:00:00

abstract：:Transgenic mice expressing the c-Myc oncogene driven by woodchuck hepatitis virus (WHV) regulatory sequences develop hepatocellular carcinoma with a high frequency. To investigate genetic lesions that cooperate with Myc in liver carcinogenesis, we conducted a genome-wide scan for loss of heterozygosity (LOH) and mutat...

journal_title：Oncogene

authors： Wu Y,Renard CA,Apiou F,Huerre M,Tiollais P,Dutrillaux B,Buendia MA

更新日期：2002-02-28 00:00:00

abstract：:Deletion or loss-of-function mutation of LKB1, frequently occurring in non-small cell lung cancers (NSCLCs), is a predominant caution of NSCLC initiation and progression. However, the upstream signaling pathways governing LKB1 activation are largely unknown. Here, we report that LKB1 undergoes Aurora kinase A (AURKA)-...

journal_title：Oncogene

authors： Zheng X,Chi J,Zhi J,Zhang H,Yue D,Zhao J,Li D,Li Y,Gao M,Guo J

更新日期：2018-01-25 00:00:00

abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

journal_title：Oncogene

authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

更新日期：2004-10-14 00:00:00

abstract：:Primary cilia are microtubule-based, dynamic organelles characterized by continuous assembly and disassembly. The intraflagellar transport (IFT) machinery, including IFT88 in cilia, is involved in the maintenance of bidirectional motility along the axonemes, which is required for ciliogenesis and functional competence...

journal_title：Oncogene

authors： Lee J,Yi S,Won M,Song YS,Yi HS,Park YJ,Park KC,Kim JT,Chang JY,Lee MJ,Sul HJ,Choi JE,Kim KS,Kero J,Kim J,Shong M

更新日期：2018-08-01 00:00:00

abstract：:A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...

journal_title：Oncogene

authors： Jacob AN,Kandpal G,Kandpal RP

更新日期：1996-07-04 00:00:00

abstract：:The c-myb gene is the normal cellular homolog of v-myb, the oncogenic component of Avian Myeloblastosis Virus (AMV). The c-myb gene has previously been shown to code for a single protein species of about 75 kd. However, accumulating evidence indicates that this gene could code for multiple mRNAs as a result of differe...

journal_title：Oncogene

authors： Dudek H,Reddy EP

更新日期：1989-09-01 00:00:00

abstract：:Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL)-independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficient (FL(-/-)...

journal_title：Oncogene

authors： Zheng R,Bailey E,Nguyen B,Yang X,Piloto O,Levis M,Small D

更新日期：2011-09-22 00:00:00

abstract：:We identified the chromosome 11q23 region as containing a putative tumour suppressor gene(s) frequently deleted in nonfamilial breast and other cancers. To define this region(s) further, we performed a systematic genetic analysis at chromosome 11q14-qterm in sporadic breast and colorectal cancer. Tumour and constituti...

journal_title：Oncogene

authors： Koreth J,Bakkenist CJ,McGee JO

更新日期：1997-01-30 00:00:00

abstract：:Transforming Growth Factor-beta1 (TGF-beta1) inhibits the proliferation of most cells, but stimulates some mesenchymal cell types, including murine NIH3T3 fibroblasts. We show here that TGF-beta1 growth stimulation of NIH3T3 fibroblasts is reversed when these cells are transformed by SV40 or are transfected with a pla...

journal_title：Oncogene

authors： Dkhissi F,Raynal S,Jullien P,Lawrence DA

更新日期：1999-01-21 00:00:00

abstract：:The mixed lineage leukemia (MLL) gene at chromosome band 11q23 is commonly involved in reciprocal translocations that are detected in acute leukemias. Evidence suggests that the resulting MLL fusion genes contribute to leukemogenesis. AF9 is a common MLL fusion partner in acute myeloid leukemia. The AF9 protein functi...

journal_title：Oncogene

authors： Srinivasan RS,de Erkenez AC,Hemenway CS

更新日期：2003-05-29 00:00:00

abstract：:Expression of oncogenic H-Ras in 23A2 myoblasts (A2:H-Ras cells) is sufficient to induce both a transformed phenotype and a differentiation-defective phenotype. Because oncogenic Ras is known to induce the secretion of several different growth factors involved in maintaining the transformed phenotype of both fibroblas...

journal_title：Oncogene

authors： Weyman CM,Wolfman A

更新日期：1997-11-20 00:00:00

abstract：:Ras proteins activate Raf and PI-3 kinases, as well as exchange factors for RalA and RalB GTPases. Many previous studies have reported that the Ral-signaling cascade contributes positively to Ras-mediated oncogenesis. Here, using a bioengineered tissue model of early steps in Ras-induced human squamous cell carcinoma ...

journal_title：Oncogene

authors： Sowalsky AG,Alt-Holland A,Shamis Y,Garlick JA,Feig LA

更新日期：2010-01-07 00:00:00

abstract：:BRCA2 is a breast cancer susceptibility gene. Germline mutations of BRCA2 account for about 10-30% of familial breast cancer cases. Consistent with its tumor-suppressor activity, BRCA2 plays an important role in DNA repair. To assess the susceptibility of carriers of mutant BRCA2 to tumorigenesis induced by DNA-damagi...

journal_title：Oncogene

authors： Yan DH,Wen Y,Su LK,Xia W,Wang SC,Zhang S,Gan L,Lee DF,Spohn B,Frey JA,Hortobagyi GN,Hung MC

更新日期：2004-03-11 00:00:00

abstract：:B-RAF is a serine/threonine-specific protein kinase that is mutated in approximately 70% of human melanomas. However, the role of this signalling molecule in cancer is unclear. Here, we show that ERK is constitutively activated in melanoma cells expressing oncogenic B-RAF and that this activity is required for prolife...

journal_title：Oncogene

authors： Karasarides M,Chiloeches A,Hayward R,Niculescu-Duvaz D,Scanlon I,Friedlos F,Ogilvie L,Hedley D,Martin J,Marshall CJ,Springer CJ,Marais R

更新日期：2004-08-19 00:00:00

abstract：:In the present study, we have analysed the effects of transforming growth factor-beta (TGF-beta) signaling on the growth behavior of pancreatic carcinoma cells in vitro and on their tumorigenicity in vivo. Ectopic expression of dominant-negative mutants of the TGF-beta type II receptor or type I receptor/activin recep...

journal_title：Oncogene

authors： Schniewind B,Groth S,Sebens Müerköster S,Sipos B,Schäfer H,Kalthoff H,Fändrich F,Ungefroren H

更新日期：2007-07-19 00:00:00

abstract：:Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that is mutated in the Simpson-Golabi-Behmel syndrome. This is an X-linked condition characterized by overgrowth, and various visceral and skeletal dysmorphisms. The phenotype of the Simpson-Golabi-Behmel syndrome patients and GPC3-deficient mice, as w...

journal_title：Oncogene

authors： Xiang YY,Ladeda V,Filmus J

更新日期：2001-11-01 00:00:00

abstract：:Menin, the product of the MEN1 tumor suppressor gene, binds to the AP1 transcription factor JunD and represses JunD transcriptional activity. The effects of human or mouse JunD missense mutations upon menin interaction were studied by random and alanine scanning mutagenesis of the menin binding region of JunD (amino a...

journal_title：Oncogene

authors： Knapp JI,Heppner C,Hickman AB,Burns AL,Chandrasekharappa SC,Collins FS,Marx SJ,Spiegel AM,Agarwal SK

更新日期：2000-09-28 00:00:00

abstract：:Wild-type human p53 protein is able to self-associate and consists predominantly of homotetramers in solution. In earlier work we identified the protein sequence motifs involved in p53 quaternary structure and showed that while monomeric p53 protein retains tumour suppressor function, monomeric tumour mutant p53 lacks...

journal_title：Oncogene

authors： Tarunina M,Jenkins JR

更新日期：1993-11-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein whose activity has been detected in germline cells and in neoplastic and immortal cells. Telomerase compensates the telomere loss arising by the end replication problem by synthesizing telomeric repeats at the 3' end of the eukaryotic chromosomes. Telomerase is reactivated during canc...

journal_title：Oncogene

authors： Hande MP,Balajee AS,Natarajan AT

更新日期：1997-10-02 00:00:00

abstract：:A new region of the adenovirus E1a protein essential for immortalization and transformation of primary rat kidney cells has been identified. This region is located between amino acid residues 18 to 20 in an N-terminal domain that is not conserved among the various adenovirus serotypes. The transformation defective mut...

journal_title：Oncogene

authors： Subramanian T,Kuppuswamy M,Nasr RJ,Chinnadurai G

更新日期：1988-02-01 00:00:00

abstract：:Antimicrobial peptides, such as the cathelicidin LL-37/hCAP-18 and its mouse homolog cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune system with direct anti-bacterial activity. Cathelicidin is possibly involved in the regulation of tumor cell growth. The aim of this stu...

journal_title：Oncogene

authors： Li D,Beisswenger C,Herr C,Schmid RM,Gallo RL,Han G,Zakharkina T,Bals R

更新日期：2014-05-22 00:00:00

abstract：:FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues for the constitutive act...

journal_title：Oncogene

authors： Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y

更新日期：2005-12-08 00:00:00

abstract：:Loss of heterozygosity on chromosome 10p was observed frequently in human prostate cancers. Studies have demonstrated that the introduction of the short arm of human chromosome 10 into a human prostate cancer cell line, PPC-1, by microcell-mediated chromosome transfer (MMCT), suppressed the malignant phenotype, sugges...

journal_title：Oncogene

authors： Fukuhara H,Maruyama T,Nomura S,Oshimura M,Kitamura T,Sekiya T,Murakami Y

更新日期：2001-01-18 00:00:00

abstract：:Polymorphisms and somatic mutations in Flap Endonuclease 1 (FEN1), an essential enzyme involved in DNA replication and repair, can lead to functional deficiencies of the FEN1 protein and a predisposition to cancer. We identified a FEN1 germline mutation that changed residue E359 to K in a patient whose family had a hi...

journal_title：Oncogene

authors： Chung L,Onyango D,Guo Z,Jia P,Dai H,Liu S,Zhou M,Lin W,Pang I,Li H,Yuan YC,Huang Q,Zheng L,Lopes J,Nicolas A,Chai W,Raz D,Reckamp KL,Shen B

更新日期：2015-02-12 00:00:00

abstract：:Brn-3a is a transcription factor belonging to the class IV of POU domain transcription factors. It is expressed throughout the peripheral nervous system but especially in postmitotic sensory neurons of dorsal root ganglia. Brn-3a is known to regulate different genes involved in neuronal differentiation and survival. I...

journal_title：Oncogene

authors： Calissano M,Latchman DS

更新日期：2003-08-21 00:00:00

abstract：:A wealth of cytogenetic data has demonstrated that numerous somatic genetic changes are involved in the pathogenesis of human lung cancer. Despite the complexity of the genomic changes observed in these neoplasms, recurrent chromosomal patterns have emerged. In this review, we summarize chromosomal alterations identif...

journal_title：Oncogene

authors： Balsara BR,Testa JR

更新日期：2002-10-07 00:00:00