A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17)(p11.2;q23).

abstract：:As tumors grow and invade beyond their homeostatic limits, the tumor cells are subjected to insufficient nutrient and oxygen supplies because of excessive demand for nutrition and oxygen, and insufficient vascularization. We therefore hypothesized that tolerance to nutrient deprivation as well as angiogenesis may be c...

journal_title：Oncogene

authors： Kato K,Ogura T,Kishimoto A,Minegishi Y,Nakajima N,Miyazaki M,Esumi H

更新日期：2002-09-05 00:00:00

abstract：:Autophagy, hallmarked by the formation of double-membrane bound organelles known as autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of autophagy in carcinogenesis is context dependent. As a tumor-suppressing mechanism in early-stage carcinogenesis, autophagy inhibits inflammation and ...

journal_title：Oncogene

authors： Wu WK,Coffelt SB,Cho CH,Wang XJ,Lee CW,Chan FK,Yu J,Sung JJ

更新日期：2012-02-23 00:00:00

abstract：:Activating the protein-tyrosine kinase activity of v-Src rapidly induced expression of the two 'primary response' genes, TIS10 and Egr-1, in Balb/c 3T3 cells. Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10 expression, but had n...

journal_title：Oncogene

authors： Qureshi SA,Joseph CK,Rim M,Maroney A,Foster DA

更新日期：1991-06-01 00:00:00

abstract：:Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific effects in urothelial cells or the basis for the observed mutation spectrum. We investigated the phenotypic and signaling consequences of three FGFR3 mutations ...

journal_title：Oncogene

authors： di Martino E,L'Hôte CG,Kennedy W,Tomlinson DC,Knowles MA

更新日期：2009-12-03 00:00:00

abstract：:Ets1, the founder member of the Ets transcription factor family, is involved in a variety of developmental and cellular processes. Previous studies have shown that serine phosphorylation of Ets1 inhibits its DNA binding activity, suggesting that phosphorylation is important in the regulation of Ets1 function. To furth...

journal_title：Oncogene

authors： Rabault B,Roussel MF,Quang CT,Ghysdael J

更新日期：1996-08-15 00:00:00

abstract：:Philadelphia chromosome (Ph)-positive leukaemia cells express the chimeric bcr/abl oncoprotein, whose deregulated protein tyrosine kinase (PTK) activity antagonizes the induction of apoptosis by DNA damaging agents. Treatment of Ph-positive K562, TOM 1 and KCL-22 cells with etoposide for 2d induced cytosolic vacuolati...

journal_title：Oncogene

authors： Riordan FA,Bravery CA,Mengubas K,Ray N,Borthwick NJ,Akbar AN,Hart SM,Hoffbrand AV,Mehta AB,Wickremasinghe RG

更新日期：1998-03-26 00:00:00

abstract：:Previous studies have shown that the cell cycle-regulated B-myb promoter contains a conserved E2F binding site that is critical for repressing transcription in quiescent cells. To investigate its significance for permanent promoter silencing, we have inactivated this binding site in the mouse genome. Mice homozygous f...

journal_title：Oncogene

authors： Tavner F,Frampton J,Watson RJ

更新日期：2007-04-26 00:00:00

abstract：:To identify potential microRNA (miRNA) links between Smad3, a mediator of TGF-β (transforming growth factor-β) signaling, and E-cadherin, we characterized the miRNA profiles of two gastric cancer cell lines: SNU484-LPCX, which does not express Smad3, and SNU484-Smad3, in which Smad3 is overexpressed. We found that amo...

journal_title：Oncogene

authors： Ahn SM,Cha JY,Kim J,Kim D,Trang HT,Kim YM,Cho YH,Park D,Hong S

更新日期：2012-06-21 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosin...

journal_title：Oncogene

authors： Kiyoi H,Ohno R,Ueda R,Saito H,Naoe T

更新日期：2002-04-11 00:00:00

abstract：:Oligodendroglioma is an important type of lower-grade glioma (LGG), which is a slowly progressing brain tumor. Many LGGs eventually transform into a more aggressive or malignant type. Enhanced angiogenesis is a characteristic of malignantly transformed oligodendroglioma (m-oligodendroglioma). However, the pathogenesis...

journal_title：Oncogene

authors： Qi L,Wang ZY,Shao XR,Li M,Chen SN,Liu XQ,Yan S,Zhang B,Zhang XD,Li X,Zhao W,Pan JA,Zhao B,Zhang XD

更新日期：2020-09-01 00:00:00

abstract：:Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal expression of mRNAs encoding many factors involved in cancer hallmarks. While conventional anticancer therapies usually target one pathway at a time, targeting key RBP would affect multiple genes and thus overcome drug resistance....

journal_title：Oncogene

authors： Rataj F,Planel S,Denis J,Roelants C,Filhol O,Guyon L,Feige JJ,Cherradi N

更新日期：2019-06-01 00:00:00

abstract：:High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient outcomes in various cancer types, the relationship between autophagy and...

journal_title：Oncogene

authors： Whelan KA,Chandramouleeswaran PM,Tanaka K,Natsuizaka M,Guha M,Srinivasan S,Darling DS,Kita Y,Natsugoe S,Winkler JD,Klein-Szanto AJ,Amaravadi RK,Avadhani NG,Rustgi AK,Nakagawa H

更新日期：2017-08-24 00:00:00

abstract：:In search of human homologues of the anti-apoptotic protein Nr-13, we have characterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among the Bcl-2 family members, to date known, in humans. Phylogenetic analyses suggest Human nrh, Mouse diva/boo and Quail nr-13 to be ...

journal_title：Oncogene

authors： Aouacheria A,Arnaud E,Venet S,Lalle P,Gouy M,Rigal D,Gillet G

更新日期：2001-09-13 00:00:00

abstract：:In CCL39 cells thrombin is a potent growth factor which requires sustained activation of mitogen activated protein kinases (MAPKs) to promote DNA synthesis. Some of the effects of thrombin can be mimicked by peptides based on the new amino terminus of the cleaved receptor; however, these thrombin receptor peptides (TR...

journal_title：Oncogene

authors： Balmanno K,Cook SJ

更新日期：1999-05-20 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/AKT and RAS oncogenic signalling modules are frequently mutated in sporadic human cancer. Although each of these pathways has been shown to play critical roles in driving tumour growth and proliferation, their activation in normal human cells can also promote cell senescence. A...

journal_title：Oncogene

authors： Astle MV,Hannan KM,Ng PY,Lee RS,George AJ,Hsu AK,Haupt Y,Hannan RD,Pearson RB

更新日期：2012-04-12 00:00:00

abstract：:Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an in...

journal_title：Oncogene

authors： Modugno M,Tagliabue E,Ardini E,Berno V,Galmozzi E,De Bortoli M,Castronovo V,Ménard S

更新日期：2002-10-24 00:00:00

abstract：:The breast cancer susceptibility gene 1 (Brca1) has a key role in both hereditary and sporadic mammary tumorigenesis. However, the reasons why Brca1-deficiency leads to the development of cancer are not clearly understood. Activation of Akt kinase is one of the most common molecular alterations associated with human m...

journal_title：Oncogene

authors： Xiang T,Jia Y,Sherris D,Li S,Wang H,Lu D,Yang Q

更新日期：2011-05-26 00:00:00

abstract：:Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment. ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1α by upregulating FIH1. In ...

journal_title：Oncogene

authors： Feng J,Zhang Y,She X,Sun Y,Fan L,Ren X,Fu H,Liu C,Li P,Zhao C,Liu Q,Liu Q,Li G,Wu M

更新日期：2019-01-01 00:00:00

abstract：:One of the hallmarks of malignancy is the polarization of tumor-associated macrophages (TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) phenotype. However, the molecular basis of the process is still unclear. MicroRNA (miRNA) comprises a group of small, non-coding RNAs that are broadly e...

journal_title：Oncogene

authors： Yang J,Zhang Z,Chen C,Liu Y,Si Q,Chuang TH,Li N,Gomez-Cabrero A,Reisfeld RA,Xiang R,Luo Y

更新日期：2014-06-05 00:00:00

abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...

journal_title：Oncogene

authors： Olmeda D,Jordá M,Peinado H,Fabra A,Cano A

更新日期：2007-03-22 00:00:00

abstract：:Chromosomal translocation t(X;14)(q28;q11) has been observed in patients with pro-lymphocytic T-cell leukaemia (T-PLL). In two cases of T-PLL, one of which was associated with Ataxia telangiectasia (AT), the chromosomal break occurred in two different introns of a gene c6.1A, located at the Xq28 locus. Fusion transcri...

journal_title：Oncogene

authors： Fisch P,Forster A,Sherrington PD,Dyer MJ,Rabbitts TH

更新日期：1993-12-01 00:00:00

abstract：:Acute myeloid leukemia 1 (AML1) gene on chromosome 21 is involved in several chromosomal translocations, including t(8;21) and t(16;21), that produce chimeric fusion proteins AML1-eight twenty-one (ETO) and AML-myeloid transforming gene chromosome 16 (MTG16), which contribute to leukemogenesis. The molecular basis for...

journal_title：Oncogene

authors： Qiu J,Wong J,Tweardy DJ,Dong S

更新日期：2006-06-29 00:00:00

abstract：:We previously reported the presence of mitotic check-point impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mut...

journal_title：Oncogene

authors： Nomoto S,Haruki N,Takahashi T,Masuda A,Koshikawa T,Takahashi T,Fujii Y,Osada H,Takahashi T

更新日期：1999-11-25 00:00:00

abstract：:To better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure. NMuMG cells became proliferation-arrested and apoptotic after exposure to TGFbeta for 2-5 days, w...

journal_title：Oncogene

authors： Gal A,Sjöblom T,Fedorova L,Imreh S,Beug H,Moustakas A

更新日期：2008-02-21 00:00:00

abstract：:The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino a...

journal_title：Oncogene

authors： Tamagnone L,Partanen J,Armstrong E,Lasota J,Ohgami K,Tazunoki T,LaForgia S,Huebner K,Alitalo K

更新日期：1993-07-01 00:00:00

abstract：:The human trk oncogene (originally identified in a colon carcinoma) was activated by a genetic rearrangement which resulted in replacement of the extracellular ligand-binding domain of the proto-trk transmembrane receptor by non-muscle tropomyosin sequences. The product of the trk oncogene, a protein of 70 kDa (p70trk...

journal_title：Oncogene

authors： Mitra G

更新日期：1991-12-01 00:00:00

abstract：:The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human breast cancer and correlated with a poor prognosis. Genetic deficiency or pharmacological inhibition of CTSB attenuates tumor growth, invasion and metastasis in mouse models of human cancers. CTSB is expressed in both cancer cells and cells ...

journal_title：Oncogene

authors： Bengsch F,Buck A,Günther SC,Seiz JR,Tacke M,Pfeifer D,von Elverfeldt D,Sevenich L,Hillebrand LE,Kern U,Sameni M,Peters C,Sloane BF,Reinheckel T

更新日期：2014-09-04 00:00:00

abstract：:Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+,HCO3--cotransporter NBCn1 (Slc4a7) to intracellular a...

journal_title：Oncogene

authors： Lee S,Axelsen TV,Jessen N,Pedersen SF,Vahl P,Boedtkjer E

更新日期：2018-10-01 00:00:00

abstract：:Maf b-Zip transcription factors are involved in both terminal differentiation and oncogenesis. To investigate this apparent contradiction, we used two different primary cell types and performed an extensive analysis of transformation parameters induced by Maf proteins. We show that MafA and c-Maf are potent oncogenes ...

journal_title：Oncogene

authors： Pouponnot C,Sii-Felice K,Hmitou I,Rocques N,Lecoin L,Druillennec S,Felder-Schmittbuhl MP,Eychène A

更新日期：2006-03-02 00:00:00

abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

journal_title：Oncogene

authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

更新日期：2004-04-15 00:00:00