Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells.

abstract：:Gene expression patterns in normal and v-myc-transformed quail embryo fibroblasts were compared by mRNA differential display. Displaying approximately 2500 mRNA species by reverse transcription/PCR, reamplification of 73 differential cDNA fragments and rescreening by Northern analysis led to the isolation of a clone, ...

journal_title：Oncogene

authors： Oberst C,Weiskirchen R,Hartl M,Bister K

更新日期：1997-03-06 00:00:00

abstract：:Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) m...

journal_title：Oncogene

authors： Braunger J,Schleithoff L,Schulz AS,Kessler H,Lammers R,Ullrich A,Bartram CR,Janssen JW

更新日期：1997-06-05 00:00:00

abstract：:The W locus of mice encodes the c-kit receptor tyrosine kinase. Recently, we characterized a novel mutant allele, Wn, and demonstrated that the c-kit protein synthesized in Wn/Wn cultured mast cells (CMC) was reduced in size and not expressed on their surface (Tsujimura et al., 1993). In this study, we further examine...

journal_title：Oncogene

authors： Koshimizu U,Tsujimura T,Isozaki K,Nomura S,Furitsu T,Kanakura Y,Kitamura Y,Nishimune Y

更新日期：1994-01-01 00:00:00

abstract：:Krüppel-like transcription factor 10 (KLF10), also named as TIEG1, plays essential roles in mediating transforming growth factor beta (TGFβ) signaling and has been shown to function as a tumor suppressor in multiple cancer types. However, its roles in mediating cancer progression in vivo have yet to be fully character...

journal_title：Oncogene

authors： Weng CC,Hawse JR,Subramaniam M,Chang VHS,Yu WCY,Hung WC,Chen LT,Cheng KH

更新日期：2017-09-28 00:00:00

abstract：:LASP-1 is a multidomain protein predominantly localized at focal contacts, where it regulates cytoskeleton dynamics and cell migration. However, in different tumor entities, a nuclear LASP-1 accumulation is observed, thought to have an important role in cancer progression. Until now, the molecular mechanisms that cont...

journal_title：Oncogene

authors： Mihlan S,Reiß C,Thalheimer P,Herterich S,Gaetzner S,Kremerskothen J,Pavenstädt HJ,Lewandrowski U,Sickmann A,Butt E

更新日期：2013-04-18 00:00:00

abstract：:ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...

journal_title：Oncogene

authors： Li Y,Zhou Z,Alimandi M,Chen C

更新日期：2009-08-20 00:00:00

abstract：:The tumour suppressor p53 is a transcription factor with high affinity for specific DNA target sequences. Wild type p53 has a very short half life in normal cells but the protein shows transient accumulation in response to DNA damage, accompanied by up-regulation of target genes such as p21 and induction of growth arr...

journal_title：Oncogene

authors： Molinari M,Milner J

更新日期：1995-05-04 00:00:00

abstract：:Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression pattern of p120 in breast cancer, we analysed 326 breast tissue biopsies by tissue microarray. Most of the lobular tumors (88%) showed exclusive cyt...

journal_title：Oncogene

authors： Sarrió D,Pérez-Mies B,Hardisson D,Moreno-Bueno G,Suárez A,Cano A,Martín-Pérez J,Gamallo C,Palacios J

更新日期：2004-04-22 00:00:00

abstract：:Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome. The most severe complication is malignant transformation into peripheral secondary chondrosarcoma. Although both benign conditions have been linked to defects ...

journal_title：Oncogene

authors： Zuntini M,Pedrini E,Parra A,Sgariglia F,Gentile FV,Pandolfi M,Alberghini M,Sangiorgi L

更新日期：2010-07-01 00:00:00

abstract：:Breast cancer cells that overexpress HER-2/neu are more resistant to chemotherapeutic agents such as paclitaxel (Taxol) and docetaxel (Taxotere) than those that do not overexpress HER-2/neu. In previous work, we showed that the adenovirus type 5 E1A can repress HER-2/neu expression at the transcriptional level. Here w...

journal_title：Oncogene

authors： Ueno NT,Yu D,Hung MC

更新日期：1997-08-18 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediati...

journal_title：Oncogene

authors： Jin HO,Seo SK,Kim YS,Woo SH,Lee KH,Yi JY,Lee SJ,Choe TB,Lee JH,An S,Hong SI,Park IC

更新日期：2011-09-01 00:00:00

abstract：:Grb2 is an adaptor protein that links receptor and cytoplasmic tyrosine kinases to the Ras signalling pathway by binding the Ras-specific guanine nucleotide exchange factor, Sos1, through its SH3 domains. The Grb2-SH3 domain binding has been localized to the carboxy-terminal two hundred amino acids of Sos1 (Sos1-c). B...

journal_title：Oncogene

authors： Sastry L,Lin W,Wong WT,Di Fiore PP,Scoppa CA,King CR

更新日期：1995-09-21 00:00:00

abstract：:The retinoblastoma suppressor gene product Rb has been assigned a critical role in cell cycle regulation, the induction of differentiation, and inhibition of oncogenic transformation. Inheritance of a mutant RB allele in humans is responsible for bilateral retinoblastoma, a malignant tumor of the retina. Trilateral re...

journal_title：Oncogene

authors： Vooijs M,te Riele H,van der Valk M,Berns A

更新日期：2002-07-11 00:00:00

abstract：:Although TGFalpha mRNA and protein are frequently elevated in neoplastic cells, neither the level at which deregulation occurs nor the mechanism(s) responsible have been well characterized. As a first step, we examined the induction of TGFalpha mRNA in two series of clonally-derived rat liver epithelial cell lines tha...

journal_title：Oncogene

authors： Berkowitz EA,Hissong MA,Lee DC

更新日期：1996-05-02 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach. Thus, there is a strong need for novel therapies, targeting more directly the molecular aberrations of...

journal_title：Oncogene

authors： Calabretta S,Bielli P,Passacantilli I,Pilozzi E,Fendrich V,Capurso G,Fave GD,Sette C

更新日期：2016-04-21 00:00:00

abstract：:Advanced Bladder Cancer (BLCA) remains a clinical challenge that lacks effective therapeutic measures. Here, we show that distinct, stage-wise metabolic alterations in BLCA are associated with the loss of function of aldehyde oxidase (AOX1). AOX1 associated metabolites have a high predictive value for advanced BLCA an...

journal_title：Oncogene

authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

更新日期：2020-10-01 00:00:00

abstract：:The t(12;21) translocation, generating the TEL/AML1 fusion protein, is the most common genetic lesion in childhood cancer. Using a bone marrow transplantation model, we demonstrate that TEL/AML1 expression impinges on normal hematopoietic differentiation, leading to the in vivo accumulation and persistence of an early...

journal_title：Oncogene

authors： Fischer M,Schwieger M,Horn S,Niebuhr B,Ford A,Roscher S,Bergholz U,Greaves M,Löhler J,Stocking C

更新日期：2005-11-17 00:00:00

abstract：:In an effort to understand the mechanisms governing the regulation of the mouse Ron receptor gene, a mouse genomic library was screened and overlapping clones coding for the Ron gene and flanking DNA were identified. Continuous DNA sequence was obtained for approximately 16.4 kilobases. The gene, from the initiator me...

journal_title：Oncogene

authors： Waltz SE,Toms CL,McDowell SA,Clay LA,Muraoka RS,Air EL,Sun WY,Thomas MB,Degen SJ

更新日期：1998-01-08 00:00:00

abstract：:The p53/p21Cip1/Waf1-dependent checkpoint control of G1/S and G2/M phases of the cell cycle in response to DNA damage is an important mechanism of genome stability maintenance in normal cells. In many tumor cells, due to frequent point mutations and deletions of p53, the stringent control of the cell cycle and apoptos...

journal_title：Oncogene

authors： Bulavin DV,Tararova ND,Aksenov ND,Pospelov VA,Pospelova TV

更新日期：1999-10-07 00:00:00

abstract：:Although increasing evidence indicated that the deregulation of microRNAs (miRNAs) contributes to tumorigenesis and invasion, little is known about the role of miR-637 in human gliomas. In the present study, we found that the expression level of miR-637 was significantly reduced in clinical glioma tissues compared wit...

journal_title：Oncogene

authors： Que T,Song Y,Liu Z,Zheng S,Long H,Li Z,Liu Y,Wang G,Liu Y,Zhou J,Zhang X,Fang W,Qi S

更新日期：2015-09-17 00:00:00

abstract：:cDNA clones of the ski-related gene, sno, were isolated from a chicken cDNA library and sequenced. In contrast to the human system, from which two forms of sno cDNAs have been isolated, we obtained only one type of chicken sno cDNA, that encoding snoN. The coding region for chicken snoN was inserted into the retrovira...

journal_title：Oncogene

authors： Boyer PL,Colmenares C,Stavnezer E,Hughes SH

更新日期：1993-02-01 00:00:00

abstract：:The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strategy for targeting tumor angiogenesis and endothelial tip cells based on DNA vaccination against DLL4. Immunization with DLL4-enco...

journal_title：Oncogene

authors： Haller BK,Bråve A,Wallgard E,Roswall P,Sunkari VG,Mattson U,Hallengärd D,Catrina SB,Hellström M,Pietras K

更新日期：2010-07-29 00:00:00

abstract：:The status of the p53 gene in lymphoblastoid cell lines (LCLs) and Burkitt lymphoma cell lines (BLs) was investigated. Southern blot analysis demonstrated that no major deletions or rearrangements had occurred in the p53 gene in any of the cell lines. The p53 protein was examined by immunoprecipitation using two monoc...

journal_title：Oncogene

authors： Wiman KG,Magnusson KP,Ramqvist T,Klein G

更新日期：1991-09-01 00:00:00

abstract：:In order to assess the functional contribution of the human c-myc promoter region in the expression of the c-myc gene, transgenic mouse lines containing a bacterial lac Z gene encoding beta-galactosidase under the control of the human c-myc protooncogene promoter were generated. Transgenic mouse embryos heterozygous f...

journal_title：Oncogene

authors： Jones DE Jr,Cui DM,Miller DM

更新日期：1995-06-15 00:00:00

abstract：:Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). To study the genetic basis for these tumors, we microdissected MTC specimens or obtaine...

journal_title：Oncogene

authors： Coxon AB,Ward JM,Geradts J,Otterson GA,Zajac-Kaye M,Kaye FJ

更新日期：1998-09-24 00:00:00

abstract：:The hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents an appealing chemotherapeutic target. Silibinin is a nontoxic flavonoid reported to exhibit anticancer properties. However, the mechanisms by which silibinin inhibits tumour growth are not f...

journal_title：Oncogene

authors： García-Maceira P,Mateo J

更新日期：2009-01-22 00:00:00

abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...

journal_title：Oncogene

authors： David M,Ford D,Bertoglio J,Maizel AL,Pierre J

更新日期：2001-10-11 00:00:00

abstract：:Skeletrophin (mindbomb homolog 2 (MIB2)) is a RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands. A previous immunohistochemical study demonstrated that skeletrophin was downregulated in many melanomas. In the present study, we have identified ...

journal_title：Oncogene

authors： Takeuchi T,Adachi Y,Sonobe H,Furihata M,Ohtsuki Y

更新日期：2006-11-09 00:00:00

abstract：:The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy. To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double tra...

journal_title：Oncogene

authors： Zörnig M,Schmidt T,Karsunky H,Grzeschiczek A,Möröy T

更新日期：1996-04-18 00:00:00

abstract：:Neuroblastomas are embryonal tumours of the sympatho-adrenal lineage with a clinical course ranging from spontaneous regression to fatal progression. The Phox2B homeobox transcription factor functions in the differentiation of the sympatho-adrenal lineage. Targets of Phox2B are, for example, genes of the (nor)adrenali...

journal_title：Oncogene

authors： van Limpt V,Schramm A,van Lakeman A,Sluis P,Chan A,van Noesel M,Baas F,Caron H,Eggert A,Versteeg R

更新日期：2004-12-09 00:00:00