Abstract：
:Although increasing evidence indicated that the deregulation of microRNAs (miRNAs) contributes to tumorigenesis and invasion, little is known about the role of miR-637 in human gliomas. In the present study, we found that the expression level of miR-637 was significantly reduced in clinical glioma tissues compared with normal brain tissues. Moreover, we revealed that the introduction of miR-637 dramatically suppressed glioma cell growth, migration and invasion in vitro and in vivo. Further studies revealed that Akt1 is a direct target gene of miR-637. Silencing of Akt1 inhibited the growth and invasion of glioma cells by decreasing phosphorylated Akt, β-catenin, phosphorylated Foxo1 and Cyclin D1 and inducing the expression of Foxo1, which was consistent with the effect of miR-637 overexpression. Suppressed expression of miR-637 and increased Akt1 protein levels were correlated with unfavorable progression and poor prognosis, respectively, and a negative relationship between the miR-637 expression and Akt1 protein levels was observed in gliomas. Our findings provide new insights into the role of miR-637 in the development of gliomas, and implicate the potential application of miR-637 in cancer therapy.
journal_name
Oncogenejournal_title
Oncogeneauthors
Que T,Song Y,Liu Z,Zheng S,Long H,Li Z,Liu Y,Wang G,Liu Y,Zhou J,Zhang X,Fang W,Qi Sdoi
10.1038/onc.2014.419subject
Has Abstractpub_date
2015-09-17 00:00:00pages
4952-63issue
38eissn
0950-9232issn
1476-5594pii
onc2014419journal_volume
34pub_type
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