Abstract:
:The transcription factor hypoxia inducible factor 1 (HIF1), an HIF1alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) dimeric factor, is essential to the cellular response to hypoxia. We described a t(1;12)(q21;p13) chromosomal translocation in human acute myeloblastic leukemia that involves the translocated Ets leukemia (TEL/ETV6) and the ARNT genes and results in the expression of a TEL-ARNT fusion protein. Functional studies show that TEL-ARNT interacts with HIF1alpha and the complex binds to consensus hypoxia response element. In low oxygen tension conditions, the HIF1alpha/TEL-ARNT complex does not activate transcription but exerts a dominant-negative effect on normal HIF1 activity. Differentiation of normal human CD34+ progenitors cells along all the erythrocytic, megakaryocytic and granulocytic pathways was accelerated in low versus high oxygen tension conditions. Murine 32Dcl3 myeloid cells also show accelerated granulocytic differentiation in low oxygen tension in response to granulocyte colony-stimulating factor. Interestingly, stable expression of the TEL-ARNT in 32Dcl3 subclones resulted in impaired HIF1-mediated transcriptional response and inhibition of differentiation enhancement in hypoxic conditions. Taken together, our results underscore the role of oxygen tension in the modulation of normal hematopoietic differentiation, whose targeting can participate in human malignancies.
journal_name
Oncogenejournal_title
Oncogeneauthors
Nguyen-Khac F,Della Valle V,Lopez RG,Ravet E,Mauchauffé M,Friedman AD,Huang LE,Fichelson S,Ghysdael J,Bernard OAdoi
10.1038/sj.onc.1209503subject
Has Abstractpub_date
2006-08-10 00:00:00pages
4840-7issue
35eissn
0950-9232issn
1476-5594pii
1209503journal_volume
25pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Matrilysin (MMP-7) is thought to contribute to invasive growth and metastasis of colon carcinoma and many other human cancers. The present study demonstrates that treatment of human colon carcinoma cells with active matrilysin induces cell aggregation in vitro and promotes liver metastasis in nude mice. When two kinds...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207181
更新日期:2003-11-27 00:00:00
abstract::Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposid...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202868
更新日期:1999-08-05 00:00:00
abstract::A flow cytometric assay was developed to examine the expression of the cellular myc oncogene in relation to cell cycle in individual cells. C-myc-oncoprotein was detected by indirect immunofluorescence using a purified sheep polyclonal antibody, anti-human-myc. Specific binding of anti-human-myc was measured by flow c...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remains unclear. A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigenesis ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0995-z
更新日期:2020-01-01 00:00:00
abstract::Cell cycle checkpoints and tumor suppressor gene functions appear to be required for the maintenance of a stable genome in proliferating cells. In this study chromosomal destabilization was monitored in relation to telomere structure, lifespan control and G2 checkpoint function. Replicative senescence was inactivated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201711
更新日期:1998-04-09 00:00:00
abstract::Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myelogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloprolifera...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207673
更新日期:2004-05-24 00:00:00
abstract::SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-02-16 00:00:00
abstract::Tumor suppressor p53 functions are downregulated in most cervical cancers, because the product of human papilloma virus (HPV) oncogene E6 binds to and inactivates p53 by promoting its degradation. p73, a p53 homologue, is similar to p53 in structure and function but yet not degraded by HPV E6 gene product. In this stu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206908
更新日期:2003-11-20 00:00:00
abstract::Casitas B-lineage lymphoma (CBL) protein family functions as multifunctional adaptor proteins and E3 ubiquitin ligases that are implicated as regulators of signaling in various cell types. Recent discovery revealed mutations of proto-oncogenic CBL in the linker region and RING finger domain in human acute myeloid neop...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.18
更新日期:2012-12-13 00:00:00
abstract::The effect of p53-dependent cell-cycle arrest and senescence on Emu-myc-induced B-cell lymphoma development remains controversial. To address this question, we crossed Emu-myc mice with the p53(515C) mutant mouse, encoding the mutant p53R172P protein that retains the ability to activate the cell-cycle inhibitor and se...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.423
更新日期:2010-03-04 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is as...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.481
更新日期:2016-08-04 00:00:00
abstract::A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding muri...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202608
更新日期:1999-04-29 00:00:00
abstract::The MAP kinase pathway impinging on ERK2 has been shown to be integrally associated with mitogenic signalling in many cell types. Previously, we and others have demonstrated that oncogenic forms of Raf-1 kinase, when expressed in fibroblasts, lead to the constitutive activation of ERK2, the de-regulation of c-fos expr...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-11-16 00:00:00
abstract::In chronic myelogenous leukemia (CML), the oncogene bcr-abl encodes a dysregulated tyrosine kinase that inhibits apoptosis. We showed previously that human erythroleukemia K562 cells are resistant to antineoplastic drug (taxol)-induced apoptosis through the atypical protein kinase C iota isozyme (PKC iota), a kinase d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204607
更新日期:2001-08-09 00:00:00
abstract::Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction through TSC1/TSC2 is often compromised in cancer, leading to aberra...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0381-2
更新日期:2018-11-01 00:00:00
abstract::The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show that FOXM1 SUMOylation...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.546
更新日期:2014-08-21 00:00:00
abstract::Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting v...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0439-1
更新日期:2019-01-01 00:00:00
abstract::High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) and a number of other tumors suggest the existence of a tumor suppressor gene(s) within the deleted regions. Two small cell lung cancer lines, NCI H740 and GLC20, have been described which have homozygous deletions in th...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-12-05 00:00:00
abstract::Wnt genes encode a set of structurally related cell surface glycoproteins that appear to have roles in cell-cell signalling. The ectopic expression of several murine Wnt genes has been implicated in the transformation of mammary epithelial and the onset of mammary tumours. Wnt11 is expressed in the developing embryo i...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-06-20 00:00:00
abstract::Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-1045-6
更新日期:2020-01-01 00:00:00
abstract::Environmental signals in the cellular milieu such as hypoxia, growth factors, extracellular matrix (ECM), or cell-surface molecules on adjacent cells can activate signaling pathways that communicate the state of the environment to the nucleus. Several groups have evaluated gene expression or signaling pathways in resp...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204972
更新日期:2001-11-15 00:00:00
abstract::Anemia in cancer patients is associated with reduced quality of life and local failure after radiation treatment. However, the use of erythropoietin to correct cancer anemia and to improve radiation efficacy was disappointing. Erythropoietin-receptor signaling mainly acts via activation of STAT 5, but also crossactiva...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208140
更新日期:2004-11-25 00:00:00
abstract::Animal models of BCR-ABL+ leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206091
更新日期:2002-12-09 00:00:00
abstract::Transgenic mice expressing the c-Myc oncogene driven by woodchuck hepatitis virus (WHV) regulatory sequences develop hepatocellular carcinoma with a high frequency. To investigate genetic lesions that cooperate with Myc in liver carcinogenesis, we conducted a genome-wide scan for loss of heterozygosity (LOH) and mutat...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205208
更新日期:2002-02-28 00:00:00
abstract::Radicicol, a macrocyclic anti-fungal antibiotic, has the ability to suppress transformation by diverse oncogenes such as Src, Ras and Mos. Despite this useful property, the mechanism by which radicicol exerts its anti-transformation effects is currently unknown. To understand the transformation-suppressing effects of ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201790
更新日期:1998-05-01 00:00:00
abstract::Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0586-4
更新日期:2019-03-01 00:00:00
abstract::Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205957
更新日期:2002-10-24 00:00:00
abstract::p8 is a stress-induced DNA-binding protein, biochemically related to the architectural chromatin binding HMG protein family and whose function is presently unknown. We obtained fibroblast from mice lacking p8 and found that p8 is involved in cell growth regulation and in apoptosis. p8(-/-) mouse embryonic fibroblasts ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205222
更新日期:2002-03-07 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis in patients with resistant or relapsed disease. Although NOTCH is a known driver in T-ALL, its clinical inhibition has significant limitations. Our previous studies suggested that NRARP, a negative regulator o...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-1042-9
更新日期:2020-01-01 00:00:00