Modulation of c-myc oncogene expression by phorbol ester and interferon-gamma: appraisal by flow cytometry.

abstract：:Acute myeloid leukemia 1 (AML1) gene on chromosome 21 is involved in several chromosomal translocations, including t(8;21) and t(16;21), that produce chimeric fusion proteins AML1-eight twenty-one (ETO) and AML-myeloid transforming gene chromosome 16 (MTG16), which contribute to leukemogenesis. The molecular basis for...

journal_title：Oncogene

authors： Qiu J,Wong J,Tweardy DJ,Dong S

更新日期：2006-06-29 00:00:00

abstract：:Heterozygous germline mutations in PHOX2B, a transcriptional regulator of sympathetic neuronal differentiation, predispose to diseases of the sympathetic nervous system, including neuroblastoma and congenital central hypoventilation syndrome (CCHS). Although the PHOX2B variants in CCHS largely involve expansions of th...

journal_title：Oncogene

authors： Wang W,Zhong Q,Teng L,Bhatnagar N,Sharma B,Zhang X,Luther W 2nd,Haynes LP,Burgoyne RD,Vidal M,Volchenboum S,Hill DE,George RE

更新日期：2014-06-19 00:00:00

abstract：:Tumors of low malignant potential (LMP) represent 20% of epithelial ovarian cancers (EOCs) and are associated with a better prognosis than the invasive tumors (TOV). Defining the relationship between LMPs and TOVs remains an important goal towards understanding the molecular pathways that contribute to prognosis, as w...

journal_title：Oncogene

authors： Ouellet V,Provencher DM,Maugard CM,Le Page C,Ren F,Lussier C,Novak J,Ge B,Hudson TJ,Tonin PN,Mes-Masson AM

更新日期：2005-07-07 00:00:00

abstract：:Malignant glioma represents one of the most aggressive and lethal human neoplasias. A hallmark of gliomas is their rapid proliferation and destruction of vital brain tissue, a process in which excessive glutamate release by glioma cells takes center stage. Pharmacologic antagonism with glutamate signaling through iono...

journal_title：Oncogene

authors： Savaskan NE,Seufert S,Hauke J,Tränkle C,Eyüpoglu IY,Hahnen E

更新日期：2011-01-06 00:00:00

abstract：:Death receptor 5 (DR5) is a receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). TRAIL is a promising candidate for cancer therapeutics due to its ability to induce apoptosis selectively in cancer cells. Here, we report that histone deacetylase inhibitors (HDACIs) such as trichostatin A (TSA),...

journal_title：Oncogene

authors： Nakata S,Yoshida T,Horinaka M,Shiraishi T,Wakada M,Sakai T

更新日期：2004-08-19 00:00:00

abstract：:Tumor cells, stromal cell compartment and the extracellular matrix (ECM) together generate a multifaceted tumor microenvironment. Matrix metalloproteinases and their tissue inhibitors (TIMPs) provide a means for tumor-stromal interaction during tumorigenesis. Among TIMPs, TIMP-3 is uniquely localized to the ECM and is...

journal_title：Oncogene

authors： Cruz-Muñoz W,Kim I,Khokha R

更新日期：2006-01-26 00:00:00

abstract：:Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear. Here, we show that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients with tumor node metastasis stage (III or IV) or lymph node metastasis. MiR-25 inhibition si...

journal_title：Oncogene

authors： Li BS,Zuo QF,Zhao YL,Xiao B,Zhuang Y,Mao XH,Wu C,Yang SM,Zeng H,Zou QM,Guo G

更新日期：2015-05-14 00:00:00

abstract：:The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite in...

journal_title：Oncogene

authors： Yuan Z,Sotsky Kent T,Weber TK

更新日期：2003-09-18 00:00:00

abstract：:We previously described the isolation of non-tumorigenic revertants from mutagenized populations of v-fos-transformed Rat-1 cells (Zarbl et al., 1987). In the present study we examined the possibility that the revertant phenotype resulted from mutations that altered the expression or activities of the c-jun or junB pr...

journal_title：Oncogene

authors： Van Amsterdam JR,Wang Y,Sullivan RC,Zarbl H

更新日期：1994-10-01 00:00:00

abstract：:The gene for von Recklinghausen neurofibromatosis type 1 (NF1) was recently identified by positional cloning and found to encode a protein with sequence similarity to a family of eucaryotic GTPase-activating proteins (GAPs). Expression of the NF1-GAP-related domain (NF1GRD) has been shown to complement yeast strains d...

journal_title：Oncogene

authors： Gutmann DH,Boguski M,Marchuk D,Wigler M,Collins FS,Ballester R

更新日期：1993-03-01 00:00:00

abstract：:Treatment of mouse (12)1/CA cells with adriamycin or irradiation with U.V.C. induces p53-dependent transcription of a beta-galactosidase reporter and the endogenous p21/Waf1/Cip1 gene. Despite the induction of Waf1, the cells arrest only transiently in G1 or G2, then resume growth and eventually undergo apoptosis. In ...

journal_title：Oncogene

authors： Chernov MV,Stark GR

更新日期：1997-05-29 00:00:00

abstract：:Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death. MDM2 can inhibit p53 activity, in part, by promoting its rapid degradation through the ubiquitin proteolysis pathway. ...

journal_title：Oncogene

authors： Yu ZK,Geyer RK,Maki CG

更新日期：2000-11-30 00:00:00

abstract：:The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding act...

journal_title：Oncogene

authors： Gilladoga AD,Edelhoff S,Blackwood EM,Eisenman RN,Disteche CM

更新日期：1992-06-01 00:00:00

abstract：:All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that...

journal_title：Oncogene

authors： Lessard J,Faubert A,Sauvageau G

更新日期：2004-09-20 00:00:00

abstract：:The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protei...

journal_title：Oncogene

authors： Chikamori M,Fujimoto J,Tokai-Nishizumi N,Yamamoto T

更新日期：2007-05-03 00:00:00

abstract：:Keratinocytes undergo a dramatic phenotypic conversion during reepithelialization of skin wounds to become hyperproliferative, migratory, and invasive. This transient healing response phenotypically resembles malignant transformation of keratinocytes during squamous cell carcinoma progression. Here we present the firs...

journal_title：Oncogene

authors： Pedersen TX,Leethanakul C,Patel V,Mitola D,Lund LR,Danø K,Johnsen M,Gutkind JS,Bugge TH

更新日期：2003-06-19 00:00:00

abstract：:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), a gamma-2 herpesvirus, is the causative agent of KS, primary effusion lymphoma (PEL), and a plasma cell variant of multicentric Castleman's disease. Although KSHV latency is detected in KS-related tumors, oncogenic pathways activated by KSHV latent infection are not...

journal_title：Oncogene

authors： Nakayama R,Ueno Y,Ueda K,Honda T

更新日期：2019-05-01 00:00:00

abstract：:Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate that stromal-derived MMP1 may exert direct oncogenic activity by signaling through protease-activated receptor-1 (PAR1) in car...

journal_title：Oncogene

authors： Foley CJ,Fanjul-Fernández M,Bohm A,Nguyen N,Agarwal A,Austin K,Koukos G,Covic L,López-Otín C,Kuliopulos A

更新日期：2014-04-24 00:00:00

abstract：:A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...

journal_title：Oncogene

authors： Jacob AN,Kandpal G,Kandpal RP

更新日期：1996-07-04 00:00:00

abstract：:Interferon (IFN)-beta induces S-phase slowing and apoptosis in human papilloma virus (HPV)-positive cervical carcinoma cell line ME-180. Here, we show that apoptosis is a consequence of the S-phase lengthening imposed by IFN-beta, demonstrating the functional correlation between S-phase alteration and apoptosis induct...

journal_title：Oncogene

authors： Vannucchi S,Chiantore MV,Fiorucci G,Percario ZA,Leone S,Affabris E,Romeo G

更新日期：2005-04-07 00:00:00

abstract：:Wild-type (wt) p53 acts as a tumor suppressor, while certain mutant type (mt) p53 may exhibit 'oncogenic' function. We have recently demonstrated that human papillomavirus type 18 (HPV-18) E6 can partially overcome the growth-suppressive effects of wt p53, but it remains unclear what role p53 plays in cervical carcino...

journal_title：Oncogene

authors： Chen TM,Chen CA,Hsieh CY,Chang DY,Chen YH,Defendi V

更新日期：1993-06-01 00:00:00

abstract：:Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hemat...

journal_title：Oncogene

authors： Smithgall TE,Briggs SD,Schreiner S,Lerner EC,Cheng H,Wilson MB

更新日期：2000-05-15 00:00:00

abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...

journal_title：Oncogene

authors： Sansom OJ,Griffiths DF,Reed KR,Winton DJ,Clarke AR

更新日期：2005-12-08 00:00:00

abstract：:The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5. However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes...

journal_title：Oncogene

authors： Masuda K,Richter M,Song X,Berezov A,Masuda K,Murali R,Greene MI,Zhang H

更新日期：2006-12-14 00:00:00

abstract：:Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The disease carries a high prevalence of activating mutations in MyD88 (91%) and CXCR4 (28%). Because signaling through these pathways leads to Bcl-xL induction, we ex...

journal_title：Oncogene

authors： Gaudette BT,Dwivedi B,Chitta KS,Poulain S,Powell D,Vertino P,Leleu X,Lonial S,Chanan-Khan AA,Kowalski J,Boise LH

更新日期：2016-01-28 00:00:00

abstract：:Omi is a mammalian serine protease that is localized in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the X-chromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies o...

journal_title：Oncogene

authors： Junqueira D,Cilenti L,Musumeci L,Sedivy JM,Zervos AS

更新日期：2003-05-08 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted PTEN-induced kinase-1 (PINK1) and the E3 ub...

journal_title：Oncogene

authors： Bernardini JP,Lazarou M,Dewson G

更新日期：2017-03-01 00:00:00

abstract：:Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an in...

journal_title：Oncogene

authors： Modugno M,Tagliabue E,Ardini E,Berno V,Galmozzi E,De Bortoli M,Castronovo V,Ménard S

更新日期：2002-10-24 00:00:00

abstract：:In addition to breast and ovarian cancer in women, recent evidence suggests that germ-line mutations of the breast cancer susceptibility gene-1 (BRCA1) also confer an increased life-time risk for prostate cancer in male probands. However, it is not known if and how BRCA1 functions in prostate cancer. We stably express...

journal_title：Oncogene

authors： Fan S,Wang JA,Yuan RQ,Ma YX,Meng Q,Erdos MR,Brody LC,Goldberg ID,Rosen EM

更新日期：1998-06-11 00:00:00