当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.

Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.

Abstract：

:Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting various oncogenic pathways. It has been demonstrated that miR-489 directly targets HER2 and inhibits the HER2 signaling pathway; however, its role in mammary gland development and HER2-induced tumor initiation hasn't been studied. To dissect the role of miR-489, we sorted different populations of mammary epithelial cells and determined that miR-489 was highly expressed in mammary stem cells. MMTV-miR-489 mice that overexpressed miR-489 in mammary epithelial cells were developed and these mice exhibited an inhibition of mammary gland development in early ages with a specific impact on highly proliferative cells. Double transgenic MMTV-Her2-miR489 mice were then generated to observe how miR-489 overexpression affects HER2-induced tumorigenesis. miR-489 overexpression delayed HER2-induced tumor initiation significantly. Moreover, miR-489 overexpression inhibited tumor growth and lung metastasis. miR-489 overexpression reduced mammary progenitor cell population significantly in preneoplastic mammary glands of MMTV-Her2 mice which showed a putative transformed population in HER2-induced tumorigenesis. The miR-489 overexpression reduced CD49fhiCD61hi populations in tumors that have stem-like properties, and miR-489 overexpression altered the HER2 signaling pathway in mammary tumors. Altogether, these data indicate that the inhibition of HER2-induced tumorigenesis by miR-489 overexpression was due to altering progenitor cell populations while decreasing tumor growth and metastasis via influencing tumor promoting genes DEK and SHP2.

journal_name

Oncogene

journal_title

Oncogene

authors

Patel Y,Soni M,Awgulewitsch A,Kern MJ,Liu S,Shah N,Singh UP,Chen H

doi

10.1038/s41388-018-0439-1

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

445-453

issue

3

eissn

0950-9232

issn

1476-5594

pii

10.1038/s41388-018-0439-1

journal_volume

38

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Identification of p53 genetic suppressor elements which confer resistance to cisplatin.

    abstract：:Loss of p53 function is associated with the acquisition of cisplatin resistance in the human ovarian adenocarcinoma A2780 cell line. Selection for cisplatin resistance of A2780 cells was used to isolate genetic suppressor elements (GSEs) from a retroviral library expressing random fragments of human or murine TP53 cDN...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1200813

    authors： Gallagher WM,Cairney M,Schott B,Roninson IB,Brown R

    更新日期：1997-01-16 00:00:00

  • Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells.

    abstract：:The cysteinyl leukotriene1 (CysLT1) receptor (CysLT1R) enhances survival and proliferation of intestinal cells via distinct pathways. Here, we have demonstrated that there is significant endogenous production of CysLTs from both non-tumour- and tumour-derived intestinal epithelial cells. Treatment of two non-tumour ce...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209666

    authors： Paruchuri S,Mezhybovska M,Juhas M,Sjölander A

    更新日期：2006-10-26 00:00:00

  • V-erbA generates ribosomes devoid of RPL11 and regulates translational activity in avian erythroid progenitors.

    abstract：:The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.93

    authors： Nguyen-Lefebvre AT,Leprun G,Morin V,Viñuelas J,Couté Y,Madjar JJ,Gandrillon O,Gonin-Giraud S

    更新日期：2014-03-20 00:00:00

  • Concurrent activation of c-myc and inactivation of bcl-2 by chromosomal translocation in a lymphoblastic lymphoma cell line.

    abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Kiem HP,Nourse J,Saltman DL,Blume KG,Cleary ML

    更新日期：1990-12-01 00:00:00

  • Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.

    abstract：:The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201980

    authors： Hallberg B,Ashcroft M,Loeb DM,Kaplan DR,Downward J

    更新日期：1998-08-13 00:00:00

  • Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.

    abstract：:The HER-2/neu proto-oncogene is homologous with, but distinct from, the epidermal growth factor receptor. Current evidence indicates that this gene is frequently amplified and/or overexpressed in some human breast and ovarian cancers and that these alterations may be clinically important; however, little is known abou...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Press MF,Cordon-Cardo C,Slamon DJ

    更新日期：1990-07-01 00:00:00

  • Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer.

    abstract：:Testicular germ cell tumours are classified into two major histological subgroups, seminomas and nonseminomas. All tumours display several recurrent chromosomal aberrations, but few target genes have been identified. Previous studies have shown that genome-wide hypermethylation of CpG islands is significantly more pre...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205978

    authors： Smith-Sørensen B,Lind GE,Skotheim RI,Fosså SD,Fodstad Ø,Stenwig AE,Jakobsen KS,Lothe RA

    更新日期：2002-12-12 00:00:00

  • Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma.

    abstract：:Microsatellite-stable, near-diploid (MSI-CIN-) colorectal carcinomas have been reported, but it is not clear as to whether these tumours form a discrete group or represent one end of the distribution of MSI-CIN+ cancers. In order to address this question, we screened 23 MSI-CIN- colorectal cancers for gains and losses...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208194

    authors： Jones AM,Douglas EJ,Halford SE,Fiegler H,Gorman PA,Roylance RR,Carter NP,Tomlinson IP

    更新日期：2005-01-06 00:00:00

  • Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.

    abstract：:To clarify the incidence, timing and pathogenetic significance of p53 gene alterations in the progression of small-cell lung carcinoma (SCLC), 17 primary tumors, 13 metastases and nine cell lines from 27 patients were analysed by a polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Sameshima Y,Matsuno Y,Hirohashi S,Shimosato Y,Mizoguchi H,Sugimura T,Terada M,Yokota J

    更新日期：1992-03-01 00:00:00

  • Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol.

    abstract：:A dominant negative mutant of Ras, M17 Ras, was used to study the role of Ras in receptor coupling of Raf-1 and B-Raf protein serine/threonine kinases (PSKs). We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf P...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Troppmair J,Bruder JT,App H,Cai H,Liptak L,Szeberényi J,Cooper GM,Rapp UR

    更新日期：1992-09-01 00:00:00

  • Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.

    abstract：:Lysyl oxidase (LOX) is a multifunctional protein required for normal collagen and elastin biosynthesis and maturation. In addition, LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro-LOX has tumor-suppressor activity, while the active enzyme promotes metastasis. In pr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.147

    authors： Bais MV,Ozdener GB,Sonenshein GE,Trackman PC

    更新日期：2015-04-09 00:00:00

  • Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.

    abstract：:Juvenile myelomonocytic leukemia (JMML) is a malignant hematopoietic disorder whose proliferative component is a result of RAS pathway deregulation caused by somatic mutation in the RAS or PTPN11 oncogenes or in patients with underlying neurofibromatosis type 1 (NF-1), by loss of NF1 gene function. To search for poten...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210361

    authors： Flotho C,Steinemann D,Mullighan CG,Neale G,Mayer K,Kratz CP,Schlegelberger B,Downing JR,Niemeyer CM

    更新日期：2007-08-23 00:00:00

  • Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.

    abstract：:Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR) remains a critical driver in CRPC, understanding the determinants of its transcriptional acti...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.508

    authors： Robinson JL,Hickey TE,Warren AY,Vowler SL,Carroll T,Lamb AD,Papoutsoglou N,Neal DE,Tilley WD,Carroll JS

    更新日期：2014-12-11 00:00:00

  • Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.

    abstract：:Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth, differentiation and cell migration. In this study, we show that mammalian target of rapamycin complex 2 (mTORC2) regulates invasive cancer cell migration through selective activation of Akt1. Insuli...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.22

    authors： Kim EK,Yun SJ,Ha JM,Kim YW,Jin IH,Yun J,Shin HK,Song SH,Kim JH,Lee JS,Kim CD,Bae SS

    更新日期：2011-06-30 00:00:00

  • Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells.

    abstract：:The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expres...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210626

    authors： Goto T,Takano M,Albergaria A,Briese J,Pomeranz KM,Cloke B,Fusi L,Feroze-Zaidi F,Maywald N,Sajin M,Dina RE,Ishihara O,Takeda S,Lam EW,Bamberger AM,Ghaem-Maghami S,Brosens JJ

    更新日期：2008-01-03 00:00:00

  • Direct integrin alphavbeta6-ERK binding: implications for tumour growth.

    abstract：:Blockade of the mitogen-activated protein (MAP) kinase pathway suppresses growth of colon cancer in vivo. Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells. Down-regulation of beta6 integ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205286

    authors： Ahmed N,Niu J,Dorahy DJ,Gu X,Andrews S,Meldrum CJ,Scott RJ,Baker MS,Macreadie IG,Agrez MV

    更新日期：2002-02-21 00:00:00

  • Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.

    abstract：:Cbl proteins are ubiquitin protein ligases, which ubiquitinate activated tyrosine kinases and target them for degradation. Both c-Cbl and Cbl-b have an ubiquitin associated (UBA) domain at their C-terminal end. We observed that high molecular weight ubiquitinated proteins constitutively coimmunoprecipitated with trans...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207952

    authors： Davies GC,Ettenberg SA,Coats AO,Mussante M,Ravichandran S,Collins J,Nau MM,Lipkowitz S

    更新日期：2004-09-16 00:00:00

  • The role of BRCA1 in transcriptional regulation and cell cycle control.

    abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1209872

    authors： Mullan PB,Quinn JE,Harkin DP

    更新日期：2006-09-25 00:00:00

  • The proto-oncoprotein KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding.

    abstract：:The BTB/POZ family of proteins has been implicated in multiple biological processes, including tumourigenesis, DNA damage responses and cell cycle progression and development. MIZ-1 (Myc-interacting zinc-finger protein 1) is known to activate transcription of CDKN1A. We recently found that a kidney cancer-related POK ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.331

    authors： Lee KM,Choi WI,Koh DI,Kim YJ,Jeon BN,Yoon JH,Lee CE,Kim SH,Oh J,Hur MW

    更新日期：2012-03-15 00:00:00

  • Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis.

    abstract：:c-Myc overexpression has been associated with several types of human cancers. To study the role of c-myc in epidermal differentiation and carcinogenesis, a transgenic mouse model was created to overexpress c-Myc in the epidermis. Human c-myc 2 cDNA was subcloned into a 6.5 kb mouse loricrin expression vector, ML.myc2....

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203040

    authors： Waikel RL,Wang XJ,Roop DR

    更新日期：1999-08-26 00:00:00

  • Transcript map and complete genomic sequence for the 310 kb region of minimal allele loss on chromosome segment 11p15.5 in non-small-cell lung cancer.

    abstract：:Molecular, functional, and clinical analyses strongly suggest that chromosome segment 11p15.5 contains a gene involved in lung cancer pathogenesis. The critical region of allele loss is 310 kb in size. We used our contig of P1-phage artificial chromosome (PAC) clones together with newly identified bacterial artificial...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205027

    authors： Zhao B,Bepler G

    更新日期：2001-12-06 00:00:00

  • Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.

    abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207440

    authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

    更新日期：2004-04-15 00:00:00

  • Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation.

    abstract：:The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that ultimately leads to cellular transformation. Although a large number of protein-encoding genes as well as non-coding RNAs were identified as Myc targets, only a few have been validated to be function...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.602

    authors： Feng M,Li Z,Aau M,Wong CH,Yang X,Yu Q

    更新日期：2011-05-12 00:00:00

  • Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.

    abstract：:Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle. Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary. In this study, ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202544

    authors： Ohtani K,Iwanaga R,Nakamura M,Ikeda M,Yabuta N,Tsuruga H,Nojima H

    更新日期：1999-04-08 00:00:00

  • Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion.

    abstract：:Minichromosome maintenance (MCM) proteins 2-7 are important in DNA replication licensing. Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear. In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinica...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.287

    authors： Lau KM,Chan QK,Pang JC,Li KK,Yeung WW,Chung NY,Lui PC,Tam YS,Li HM,Zhou L,Wang Y,Mao Y,Ng HK

    更新日期：2010-10-07 00:00:00

  • RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma.

    abstract：:Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.497

    authors： Liu-Chittenden Y,Jain M,Gaskins K,Wang S,Merino MJ,Kotian S,Kumar Gara S,Davis S,Zhang L,Kebebew E

    更新日期：2017-06-22 00:00:00

  • In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions.

    abstract：:Cell lines derived from cervical neoplasias, as well as cells from normal cervix and neonatal foreskin were examined in an in vitro culture system (raft system) that allows for stratification and differentiation of epithelial cells at an air-liquid interface. Epithelial cells from human foreskin and ectocervix were ob...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Rader JS,Golub TR,Hudson JB,Patel D,Bedell MA,Laimins LA

    更新日期：1990-04-01 00:00:00

  • Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.

    abstract：:Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis. It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1. In ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.153

    authors： Rodríguez MI,González-Flores A,Dantzer F,Collard J,de Herreros AG,Oliver FJ

    更新日期：2011-10-20 00:00:00

  • Vital functions for lethal caspases.

    abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1208524

    authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

    更新日期：2005-08-04 00:00:00

  • Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.

    abstract：:Small cell lung cancer (SCLC) is an aggressive cancer characterized by several autocrine growth mechanisms including stem cell factor and its receptor c-Kit. In order to arrive at potentially new and novel therapy for SCLC, we have investigated the effects of the tyrosine kinase inhibitor, STI 571, on SCLC cell lines....

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203698

    authors： Wang WL,Healy ME,Sattler M,Verma S,Lin J,Maulik G,Stiles CD,Griffin JD,Johnson BE,Salgia R

    更新日期：2000-07-20 00:00:00