Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer.

abstract：:Anemia in cancer patients is associated with reduced quality of life and local failure after radiation treatment. However, the use of erythropoietin to correct cancer anemia and to improve radiation efficacy was disappointing. Erythropoietin-receptor signaling mainly acts via activation of STAT 5, but also crossactiva...

journal_title：Oncogene

authors： Pajonk F,Weil A,Sommer A,Suwinski R,Henke M

更新日期：2004-11-25 00:00:00

abstract：:We previously reported cloning the rLot1 gene, and its human homolog (hLOT1), through analysis of differential gene expression in normal and malignant rat ovarian surface epithelial cells. Both human and rat ovarian carcinoma cell lines exhibited lost or decreased expression of this gene. Interestingly, the LOT1 gene ...

journal_title：Oncogene

authors： Abdollahi A,Bao R,Hamilton TC

更新日期：1999-11-11 00:00:00

abstract：:Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel disease and arise as a consequence of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironment. An intrinsic defect in the...

journal_title：Oncogene

authors： Kosa P,Szabo R,Molinolo AA,Bugge TH

更新日期：2012-08-09 00:00:00

abstract：:Undifferentiated cells and embryos express high levels of endogenous non-telomerase reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT inhibitors modulate cell growth and differentiation in several cell lines. We have now sought to establish whether high levels of RT activity are d...

journal_title：Oncogene

authors： Sciamanna I,Landriscina M,Pittoggi C,Quirino M,Mearelli C,Beraldi R,Mattei E,Serafino A,Cassano A,Sinibaldi-Vallebona P,Garaci E,Barone C,Spadafora C

更新日期：2005-06-02 00:00:00

abstract：:We have cloned and sequenced a Xenopus p53 homologue which differs by one amino acid deletion from a previously published Xenopus sequence (Soussi et al., 1987). Transcription analysis revealed that this gene is activated during early oogenesis and that zygotic transcription initiates after midblastula transition. Tra...

journal_title：Oncogene

authors： Hoever M,Clement JH,Wedlich D,Montenarh M,Knöchel W

更新日期：1994-01-01 00:00:00

abstract：:The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the cell cycle and inactivation of the gene has been found in a variety of human cancers. In order to investigate the role of p16 gene in the tumorigenesis of hepatocellular carcinoma (HCC), 48 cases of HCC were analysed for p16 alterations...

journal_title：Oncogene

authors： Liew CT,Li HM,Lo KW,Leow CK,Chan JY,Hin LY,Lau WY,Lai PB,Lim BK,Huang J,Leung WT,Wu S,Lee JC

更新日期：1999-01-21 00:00:00

abstract：:The receptor tyrosine kinase FLT3 is expressed in myeloid and lymphoid progenitor cells. Activating mutations in FLT3 occur in 25-30% of acute myeloid leukaemia (AML) patients. Most common are internal tandem duplications of sequence (ITD) leading to constitutive FLT3-ITD kinase activity with an altered signalling qua...

journal_title：Oncogene

authors： Kresinsky A,Schnöder TM,Jacobsen ID,Rauner M,Hofbauer LC,Ast V,König R,Hoffmann B,Svensson CM,Figge MT,Hilger I,Heidel FH,Böhmer FD,Müller JP

更新日期：2019-06-01 00:00:00

abstract：:The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma. In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-...

journal_title：Oncogene

authors： Clark J,Benjamin H,Gill S,Sidhar S,Goodwin G,Crew J,Gusterson BA,Shipley J,Cooper CS

更新日期：1996-01-18 00:00:00

abstract：:The Abelson (Abl) family of non-receptor tyrosine kinases has an important role in cell morphogenesis, motility, and proliferation. Although the function of Abl has been extensively studied in leukemia, its role in epithelial cell invasion remains obscure. Using the Drosophila wing epithelium as an in vivo model syste...

journal_title：Oncogene

authors： Singh J,Aaronson SA,Mlodzik M

更新日期：2010-07-15 00:00:00

abstract：:Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion between TEL and genes encoding proteins of various types. The most frequent 12p13 translocation is the t(12;21)(p13;q22), which recombines TEL with the AML1 gene on chromosome 21 and is frequently...

journal_title：Oncogene

authors： Poirel H,Lacronique V,Mauchauffé M,Le Coniat M,Raffoux E,Daniel MT,Erickson P,Drabkin H,MacLeod RA,Drexler HG,Ghysdael J,Berger R,Bernard OA

更新日期：1998-06-04 00:00:00

abstract：:Oxygen is the ultimate source of oxidizing power for disulfide bond formation, suggesting that under limiting oxygen proper protein folding might be compromised. We show that secretion of vascular endothelial growth factor (VEGF), a protein with multiple disulfide bonds, was indeed impeded under hypoxia and was partia...

journal_title：Oncogene

authors： May D,Itin A,Gal O,Kalinski H,Feinstein E,Keshet E

更新日期：2005-02-03 00:00:00

abstract：:Checkpoint protein Chk1 has been identified as an Hsp90 client. Treatment with 100 nM geldanamycin (GM) for 24 h markedly reduced the Chk1 amount in Jurkat and ML-1 leukemia cell lines. Because Chk1 plays a central role in G2 checkpoint, we added GM to G2-arrested Jurkat and HL-60 cells pretreated with 50 nM doxorubic...

journal_title：Oncogene

authors： Sugimoto K,Sasaki M,Isobe Y,Tsutsui M,Suto H,Ando J,Tamayose K,Ando M,Oshimi K

更新日期：2008-05-15 00:00:00

abstract：:To understand the mechanism of interferon (IFN)-mediated suppression of cell cycle progression, we have earlier shown that IFN-alpha enhances the expression of underphosphorylated retinoblastoma protein by inhibiting the cyclin-dependent kinase-2 (CDK-2) activity (Kumar and Atlas, Proc. Natl. Acad. Sci. 89, 6599-6603,...

journal_title：Oncogene

authors： Mandal M,Bandyopadhyay D,Goepfert TM,Kumar R

更新日期：1998-01-15 00:00:00

abstract：:We have isolated a human cDNA clone encoding a novel protein of 22 kDa that is a human counterpart of the rat oncoprotein PTTG. We show that the corresponding gene (hpttg) is overexpressed in Jurkat cells (a human T lymphoma cell line) and in samples from patients with different kinds of hematopoietic malignancies. An...

journal_title：Oncogene

authors： Domínguez A,Ramos-Morales F,Romero F,Rios RM,Dreyfus F,Tortolero M,Pintor-Toro JA

更新日期：1998-10-29 00:00:00

abstract：:Lymphoblastoid cell lines derived from cancer prone Bloom's Syndrome patients differ from cell lines representative of several other disorders by exhibiting a constitutive elevation in the level of the c-myc protein. This may be a contributing factor in the strong predisposition to malignancy observed in Bloom's syndr...

journal_title：Oncogene

authors： Sullivan NF,Willis AE,Moore JP,Lindahl T

更新日期：1989-12-01 00:00:00

abstract：:By NIH3T3 transfection assay in conjunction with in vitro transient neomycin selection, activated c-H-ras-1 oncogenes were detected in two squamous cell carcinoma cell lines, ZA and HOC-313, newly established from human oral cancer patients. ZA had a point mutational activation at the 13th codon, this activation of c-...

journal_title：Oncogene

authors： Tadokoro K,Ueda M,Ohshima T,Fujita K,Rikimaru K,Takahashi N,Enomoto S,Tsuchida N

更新日期：1989-04-01 00:00:00

abstract：:Fibronectin extracellular matrix plays a critical role in the microenvironment of cells. Loss of this matrix frequently accompanies oncogenic transformation, allowing changes in cell growth, morphology, and tissue organization. The HT1080 human fibrosarcoma cell line is deficient in formation of fibronectin matrix fib...

journal_title：Oncogene

authors： Brenner KA,Corbett SA,Schwarzbauer JE

更新日期：2000-06-29 00:00:00

abstract：:Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen. Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is most often increased in tumour cells. HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-...

journal_title：Oncogene

authors： Lincet H,Icard P

更新日期：2015-07-01 00:00:00

abstract：:An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon, and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting functional analysis. He...

journal_title：Oncogene

authors： Lauring J,Cosgrove DP,Fontana S,Gustin JP,Konishi H,Abukhdeir AM,Garay JP,Mohseni M,Wang GM,Higgins MJ,Gorkin D,Reis M,Vogelstein B,Polyak K,Cowherd M,Buckhaults PJ,Park BH

更新日期：2010-04-22 00:00:00

abstract：:The importance of apoptosis as a natural means to eliminate unwanted or damaged cells has been realized over the past decade. Many components required to exercise programmed cell death have been identified and shown to pre-exist in most, if not all, cells. Such ubiquity requires that apoptosis be tightly controlled an...

journal_title：Oncogene

authors： Stambolic V,Mak TW,Woodgett JR

更新日期：1999-11-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that tran...

journal_title：Oncogene

authors： Matsuoka M,Jeang KT

更新日期：2011-03-24 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT), marked by the dissolution of cell-cell junctions, loss of cell polarity and increased cell motility, is one of the essential steps for prostate cancer metastasis. However, the underlying mechanism has not been fully explored. We report in this study that Shp2 is upregulated ...

journal_title：Oncogene

authors： Zhang K,Zhao H,Ji Z,Zhang C,Zhou P,Wang L,Chen Q,Wang J,Zhang P,Chen Z,Zhu HH,Gao WQ

更新日期：2016-03-10 00:00:00

abstract：:Damage induced in the DNA after exposure of cells to ionizing radiation activates checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and induce a transient delay in the progression through S phase. Checkpoints together with repair and apoptosis are integrated in a circuitry that determi...

journal_title：Oncogene

authors： Iliakis G,Wang Y,Guan J,Wang H

更新日期：2003-09-01 00:00:00

abstract：:Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

journal_title：Oncogene

authors： Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

更新日期：2017-03-30 00:00:00

abstract：:The eph gene encodes a putative receptor tyrosine kinase for an as yet unknown ligand. Some human cancer cells have been found to overexpress eph mRNAs without gene amplification. We show here that NIH3T3 cells acquire tumorigenic ability in nude mice and make colonies in soft agar with a viral LTR (Long Terminal Repe...

journal_title：Oncogene

authors： Maru Y,Hirai H,Takaku F

更新日期：1990-03-01 00:00:00

abstract：:p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2). Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism. In this st...

journal_title：Oncogene

authors： Zhang Y,Feng X,Zhang J,Chen M,Huang E,Chen X

更新日期：2019-08-01 00:00:00

abstract：:The Dbl oncogene is the putative exchange factor for two small GTP-binding proteins, RhoA and CDC42 which are involved in the polymerization of actin to produce stress fibers and filopodia, respectively. We report here that Dbl oncogene-transformed NIH3T3 cells show actin stress fibers only when cells are plated on fi...

journal_title：Oncogene

authors： Defilippi P,Olivo C,Tarone G,Mancini P,Torrisi MR,Eva A

更新日期：1997-04-24 00:00:00

abstract：:Tumor necrosis factor (TNF) induces both cell death and survival signals. NF-kappaB, a transcription factor activated by TNF, is critical for controlling survival signals through trans-activation of downstream target genes. However, few NF-kappaB target survival genes have been identified with direct roles in oncogene...

journal_title：Oncogene

authors： Au PY,Martin N,Chau H,Moemeni B,Chia M,Liu FF,Minden M,Yeh WC

更新日期：2005-04-28 00:00:00

abstract：:B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...

journal_title：Oncogene

authors： Charrasse S,Carena I,Brondani V,Klempnauer KH,Ferrari S

更新日期：2000-06-15 00:00:00

abstract：:Previously, we have mimicked human neurofibromatosis type 2 (NF2) in conditional Nf2 mutant (P0Cre;Nf2flox2/flox2) mice. Schwannomas, characteristic for NF2, were found at low frequency in older mice. Here, we report that these mice, upon additional hemizygosity for p53, rapidly develop multiple tumours showing featur...

journal_title：Oncogene

authors： Robanus-Maandag E,Giovannini M,van der Valk M,Niwa-Kawakita M,Abramowski V,Antonescu C,Thomas G,Berns A

更新日期：2004-08-26 00:00:00