Abstract:
:Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen. Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is most often increased in tumour cells. HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-3-phosphate dehydrogenase activate survival pathways (Akt and so on); phosphofructokinase 1 and triose phosphate isomerase participate in cell cycle activation; aldolase promotes epithelial mesenchymal transition; PKM2 enhances various nuclear effects such as transcription, stabilisation and so on. This review outlines the multiple non-glycolytic roles of glycolytic enzymes, which are essential for promoting cancer cells' survival, proliferation, chemoresistance and dissemination.
journal_name
Oncogenejournal_title
Oncogeneauthors
Lincet H,Icard Pdoi
10.1038/onc.2014.320subject
Has Abstractpub_date
2015-07-01 00:00:00pages
3751-9issue
29eissn
0950-9232issn
1476-5594pii
onc2014320journal_volume
34pub_type
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