Abstract:
:Chromosomal deletions are a common feature of epithelial tumours and when further defined by homozygous deletions, are often the location of tumour suppressor genes. Deletions within the short arm of chromosome 3 occur very frequently in human carcinomas: a minimal region of loss at 3p21.3 (the Luca) region has been defined by overlapping homozygous deletions in lung and breast cancer cell lines. Using a rapid strategy for Cre-loxP chromosome engineering, a deletion of approximately 370 kb was created in the mouse germline corresponding to the deleted region at 3p21.3. The deletion when homozygous is embryonic lethal. Heterozygotes develop normally despite being haplo-insufficient for twelve genes including the candidate tumour suppressor gene Rassf1. Because damage to 3p21.3 often occurs very early in the sequence of genetic changes that lead to malignancy, particularly in lung and breast cancer, further genetic damage to these mice will provide the opportunity to model multi-step tumorigenesis of these tumours.
journal_name
Oncogenejournal_title
Oncogeneauthors
Smith AJ,Xian J,Richardson M,Johnstone KA,Rabbitts PHdoi
10.1038/sj.onc.1205530subject
Has Abstractpub_date
2002-07-04 00:00:00pages
4521-9issue
29eissn
0950-9232issn
1476-5594journal_volume
21pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::The DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characterized by a reversal of methylation states. CpG island associated genes, in particular tumour suppressor or rel...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1205598
更新日期:2002-08-12 00:00:00
abstract::Homozygous mutations of the recessive oncogene lethal-(2) giant larvae (l(2)gl) of Drosophila melanogaster cause lethal neoplasms of the imaginal discs and the brain hemisphere. A 13-kb DNA segment spanning the l(2)gl+ locus has been inserted into P element vectors and used for P-mediated transformation. The P-l(2)gl+...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::Deregulated expression of c-Myc has been shown to induce or enhance apoptosis in various different cell types. c-Myc requires p53 for apoptosis in some but not all the cell types, indicating heterogeneous mechanisms for c-Myc-induced apoptosis. In B lymphoma line WEHI-231, stable expression of c-Myc has been demonstra...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202772
更新日期:1999-07-15 00:00:00
abstract::In this issue of Oncogene, Mollinedo and co-workers present promising evidence that cholesterol-sensitive signaling pathways involving lipid rafts can be therapeutically targeted in multiple myeloma. Because the pathways considered in their study are used by other types of tumor cells, one implication of this report i...
journal_title:Oncogene
pub_type: 评论,杂志文章
doi:10.1038/onc.2010.132
更新日期:2010-07-01 00:00:00
abstract::Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0114-y
更新日期:2018-04-01 00:00:00
abstract::The osteogenic transcription factor, Runx2, is abnormally expressed in prostate cancer (PCa) and associated with metastatic disease. During bone development, Runx2 is activated by signals known to be hyperactive in PCa including the RAS/MAP kinase pathway, which phosphorylates Runx2 on multiple serine residues includi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.91
更新日期:2016-01-21 00:00:00
abstract::In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202165
更新日期:1998-11-19 00:00:00
abstract::Mutations in the p53 tumour suppressor gene have been recently described in hepatocellular carcinomas (HCC) from high risk areas such as China and South Africa. Our study was designed to assess the importance of p53 aberrations in HCCs from Europe, where the major risk factors in hepatocarcinogenesis, aflatoxin exposu...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The expression of the cyclin-dependent kinase inhibitor p15INK4B in normal cells after induction with TGF-beta1, or following overexpression from an adenovirus-encoded cDNA, appears on an SDS-polyacrylamide gel as a doublet. Here, the underlying mechanism behind the synthesis of the two species has been studied. By ex...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203496
更新日期:2000-03-23 00:00:00
abstract::IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204629
更新日期:2001-10-11 00:00:00
abstract::GRIM-19 (Gene associated with Retinoid-Interferon-induced Mortality 19) is a novel tumor suppressor regulated by interferon/retinoid combination. We have recently shown that GRIM-19 inhibits v-Src-induced oncogenic transformation and metastatic behavior of cells. Oncogenic v-Src induces cell motility by cytoskeletal r...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.480
更新日期:2009-03-12 00:00:00
abstract::Previous reports have demonstrated that E7 is the major transforming gene of HPV-16 and that continued expression of the gene is required to maintain the transformed phenotype of primary baby rat kidney cells transformed by HPV-16 E7 and EJ-ras. To investigate the point of action of E7 in the cell cycle we have utilis...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::Hypoxic microenvironment supports cancer stem cell survival, causes poor response to anticancer therapy and tumor recurrence. Inhibition of Notch-1 signaling in adenocarcinoma of the lung (ACL) cells causes apoptosis specifically under hypoxia. Here, we found that Akt-1 activation is a key mediator of Notch-1 pro-surv...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.7
更新日期:2010-04-29 00:00:00
abstract::Amplification of HER-2 oncogene was analysed in DNAs obtained from 291 primary human mammary carcinomas. 52/291 (18%) were found to contain amplified HER-2 oncogene. Moderate amplification (2- to 5-fold) was noted in 36/291 (12%). Thirteen tumors (4.5%) had a copy number of 5 to 10. A 10- to 20-fold and greater than 2...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Ju...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202237
更新日期:1998-12-17 00:00:00
abstract::The role of intracellular Ca2+ pools in the regulation of growth factor signal transduction pathways and mitogenesis is not well understood. We have examined the roles of basal and transiently mobilized Ca2+ in the regulation of MAP kinases by EGF. To assess the influence of Ca2+ transients we utilized Plcg1-/- and Pl...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203517
更新日期:2000-03-30 00:00:00
abstract::Mesenchymal stem cells (MSCs) are a kind of adult stem cells that can be isolated easily from bone marrow, adipose tissue, umbilical cord and many other tissues. MSCs have been shown to specifically migrate to inflammatory sites, including tumors, and hold great promise as tumor-specific vectors to deliver antitumor a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.458
更新日期:2014-10-16 00:00:00
abstract::Inhibition of apoptosis or abnormal cell survival can result in tumorigenesis by facilitating the insurgence of various mutations. Immediate-early response gene X-1 (IEX-1), protects T cells from apoptosis induced by the ligation of Fas or the T-cell receptor (TCR)/CD3 complex in Emu-IEX-1 mice that direct the gene ex...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206707
更新日期:2003-10-09 00:00:00
abstract::Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bladder cancers, possibl...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-03-21 00:00:00
abstract::Mesenchymal stromal cells (MSCs) are strongly immunosuppressive via producing nitric oxide (NO) and known to migrate into tumor sites to promote tumor growth, but the underlying mechanisms remain largely elusive. Here, we found that interferon alpha (IFNα)-secreting MSCs showed more dramatic inhibition effect on tumor...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.128
更新日期:2016-11-17 00:00:00
abstract::Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains ill-defined. The evidence for a role of energy balance, physical inactivity, and obesity has st...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207716
更新日期:2004-08-23 00:00:00
abstract::Previously, we showed that the BRCA1 protein interacts directly and functionally with estrogen receptor-alpha (ER-alpha), resulting in the inhibition of estradiol (E2)-stimulated ER-alpha transcriptional activity. The interaction sites were mapped to the N-terminus of BRCA1 (within amino acids (aa) 1-302) and the liga...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208190
更新日期:2005-03-10 00:00:00
abstract::One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular basis of how one-carbon metabolism may influence RNA methylation and tumorigenesis remains largely unknown. Here we show MTHFD2, a mitochondrial enzyme involved...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0869-4
更新日期:2019-08-01 00:00:00
abstract::We have recently identified and cloned the gene for a cytosolic polypeptide, designated oncoprotein 18 (Op18), which is expressed in acute lymphocytic leukemia and some solid tumors including neuroblastoma. Op18 is phosphorylated upon treatment of lymphoid cells with phorbol myristate acetate. We have proposed that un...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::Human papillomaviruses are the causative agents of cervical cancer. Previous studies have shown that loss of the viral E2 protein during malignant progression is an important feature of HPV-induced malignancy due to the resulting uncontrolled expression of the viral oncoproteins E6 and E7. We now show however that the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208701
更新日期:2005-08-04 00:00:00
abstract::The function of the class III histone deacetylase, Sir2, in promoting lifespan extension is well established in small model organisms. By analogy, SirT1, the mammalian orthologue of Sir2, is a candidate gene to slow down aging and forestall the onset of age-associated diseases. We have used SirT1-null mice to study th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.147
更新日期:2009-08-13 00:00:00
abstract::The promoter of the human ETS1 gene contains binding site motifs for transcription factors Sp1, Ap1, Ap2, ETS, PEA3 and Oct. It has been shown previously that Ap1, Ap2, and ETS are positive regulators for the transcription of the ETS1 gene and that the ETS1 gene is autoregulated. In addition, two regions on the ETS1 p...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Although p73alpha induces many of the same cellular events as p53, it is structurally distinct from p53 in that it possesses a unique COOH-terminal domain. To dissect the function of this domain, we performed yeast two-hybrid screening of a HeLa cDNA library using residues 552-636 of p73alpha as bait. Among the clones...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.452
更新日期:2009-02-19 00:00:00
abstract::Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.599
更新日期:2015-02-05 00:00:00
abstract::TEA domain (TEAD) transcription factors are key components of the Hippo-YAP1 signaling pathway, but their functional role and regulatory mechanisms remain unclear. This study aims to comprehensively explore the expression pattern and functional role of TEAD family in gastric carcinogenesis and investigate its regulati...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.257
更新日期:2017-11-23 00:00:00