Diet and cancer prevention.

abstract：:Amplification and overexpression of the E2F3 gene at 6p22 in human bladder cancer is associated with increased tumour stage, grade and proliferation index, and in prostate cancer E2F3 overexpression is linked to tumour aggressiveness. We first used small interfering RNA technology to confirm the potential importance o...

journal_title：Oncogene

authors： Olsson AY,Feber A,Edwards S,Te Poele R,Giddings I,Merson S,Cooper CS

更新日期：2007-02-15 00:00:00

abstract：:The myb family of genes encodes highly homologous nuclear transcription factors that play distinct roles in the development of breast, germ cells and hematoid organs. While the mechanisms associated with the regulation of these genes remain unknown, the transactivation of c-Myb was previously shown to be upregulated b...

journal_title：Oncogene

authors： Kang AD,Park G,Kim YH,Oh IH

更新日期：2004-05-20 00:00:00

abstract：:The v-myb oncogene of the avian myeloblastosis virus (AMV) is unique among known oncogenes in that it causes only acute leukemia in animals and transforms only hematopoietic cells in culture. AMV was discovered in the 1930s as a virus that caused a disease in chickens that is similar to acute myelogenous leukemia in h...

journal_title：Oncogene

authors： Lipsick JS,Wang DM

更新日期：1999-05-13 00:00:00

abstract：:Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell a...

journal_title：Oncogene

authors： Godin-Heymann N,Brabetz S,Murillo MM,Saponaro M,Santos CR,Lobley A,East P,Chakravarty P,Matthews N,Kelly G,Jordan S,Castellano E,Downward J

更新日期：2016-06-23 00:00:00

abstract：:A novel oncogene, rsc (rabbit squamous cell carcinoma), has been identified from a DMBA-induced rabbit squamous cell carcinoma using gene transfer and the nude mouse tumorigenesis assay. A full-length cDNA has been isolated and sequenced. rsc has potent tumorigenic activity in nude mice (latency <4 weeks), but does no...

journal_title：Oncogene

authors： D'Adamo DR,Novick S,Kahn JM,Leonardi P,Pellicer A

更新日期：1997-03-20 00:00:00

abstract：:Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has recently been shown to be upregulated in squamous cell carcinoma (SCC) and has been identified as a good tumor-specific marker for clinical staging of cervical sentinel lymph nodes in head and neck SCC. However, little is known about its biological function in c...

journal_title：Oncogene

authors： Brown L,Waseem A,Cruz IN,Szary J,Gunic E,Mannan T,Unadkat M,Yang M,Valderrama F,O'Toole EA,Wan H

更新日期：2014-05-01 00:00:00

abstract：:The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are not evident. Herein we show that Skp2 is highly expressed in NPC tumor tissues and cell lines. K...

journal_title：Oncogene

authors： Yu X,Wang R,Zhang Y,Zhou L,Wang W,Liu H,Li W

更新日期：2019-12-01 00:00:00

abstract：:The p53 family of proteins play instrumental roles in mediating the cellular response to stress. The p53-related gene product, p73, occurs as two distinct protein isoforms, referred to as alpha and beta, which differ in the length of the C-terminal region and arise through alternative splicing of the p73 RNA. Here, we...

journal_title：Oncogene

authors： Lee CW,La Thangue NB

更新日期：1999-07-22 00:00:00

abstract：:Signet-ring cell carcinoma is classified in poorly differentiated adenocarcinoma with an aggressive nature and a poor prognosis. We have shown that the activation of PI 3-kinase in highly differentiated adenocarcinomas induces loss of cell-cell contact and formation of vacuoles, giving phenotypes similar to those of s...

journal_title：Oncogene

authors： Xu Q,Karouji Y,Kobayashi M,Ihara S,Konishi H,Fukui Y

更新日期：2003-08-28 00:00:00

abstract：:Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic actin toward strong preponderance of filamentous actin and formation of actin stress fibers. A549 cells expressing FDH...

journal_title：Oncogene

authors： Oleinik NV,Krupenko NI,Krupenko SA

更新日期：2010-11-25 00:00:00

abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...

journal_title：Oncogene

authors： David M,Ford D,Bertoglio J,Maizel AL,Pierre J

更新日期：2001-10-11 00:00:00

abstract：:Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven dist...

journal_title：Oncogene

authors： Dhanasekaran N,Premkumar Reddy E

更新日期：1998-09-17 00:00:00

abstract：:Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. However, our understanding of the regulatory mechanisms of AR-V7-driven transcription ...

journal_title：Oncogene

authors： Moon SJ,Jeong BC,Kim HJ,Lim JE,Kwon GY,Kim JH

更新日期：2018-03-01 00:00:00

abstract：:Checkpoint protein Chk1 has been identified as an Hsp90 client. Treatment with 100 nM geldanamycin (GM) for 24 h markedly reduced the Chk1 amount in Jurkat and ML-1 leukemia cell lines. Because Chk1 plays a central role in G2 checkpoint, we added GM to G2-arrested Jurkat and HL-60 cells pretreated with 50 nM doxorubic...

journal_title：Oncogene

authors： Sugimoto K,Sasaki M,Isobe Y,Tsutsui M,Suto H,Ando J,Tamayose K,Ando M,Oshimi K

更新日期：2008-05-15 00:00:00

abstract：:Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...

journal_title：Oncogene

authors： Jin JK,Tien PC,Cheng CJ,Song JH,Huang C,Lin SH,Gallick GE

更新日期：2015-04-02 00:00:00

abstract：:AP-1 transcription factors play a critical role in signal transduction pathways in many cells. We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and have previously shown that AP-1 complexes are activated by peptide and steroid growth factors in both normal and malignant breas...

journal_title：Oncogene

authors： Liu Y,Ludes-Meyers J,Zhang Y,Munoz-Medellin D,Kim HT,Lu C,Ge G,Schiff R,Hilsenbeck SG,Osborne CK,Brown PH

更新日期：2002-10-31 00:00:00

abstract：:Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma subgroup by affecting expression levels of corresponding genes. This study analysed the relationship of 11q los...

journal_title：Oncogene

authors： Fischer M,Bauer T,Oberthür A,Hero B,Theissen J,Ehrich M,Spitz R,Eils R,Westermann F,Brors B,König R,Berthold F

更新日期：2010-02-11 00:00:00

abstract：:Hepatitis B virus (HBV)-induced liver necrosis takes great part in liver cirrhosis progression. However, less is known about whether hepatitis B virus X protein (HBx) has effect on liver fibrosis. Here, we report that HBV leads to liver fibrosis and hepatocarcinogenesis through miR-30e targeting P4HA2. HBV transgenic ...

journal_title：Oncogene

authors： Feng GX,Li J,Yang Z,Zhang SQ,Liu YX,Zhang WY,Ye LH,Zhang XD

更新日期：2017-12-14 00:00:00

abstract：:Class I HLA expression is low in neuroblastoma tumours and cell lines. We have recently mapped a modifier of methylation for HLA-C (MEMO-1) to chromosomal bands 1p35-36.1, a region deleted in many neuroblastomas. Hypomethylation of HLA-C is strongly correlated with allelic loss of the MEMO-1 locus. Here, we show that ...

journal_title：Oncogene

authors： Cheng NC,Beitsma M,Chan A,Op den Camp I,Westerveld A,Pronk J,Versteeg R

更新日期：1996-10-17 00:00:00

abstract：:GATA3 is an essential transcription factor that was first identified as a regulator of immune cell function. In recent microarray analyses of human breast tumors, both normal breast luminal epithelium and estrogen receptor (ESR1)-positive tumors showed high expression of GATA3. We sequenced genomic DNA from 111 breast...

journal_title：Oncogene

authors： Usary J,Llaca V,Karaca G,Presswala S,Karaca M,He X,Langerød A,Kåresen R,Oh DS,Dressler LG,Lønning PE,Strausberg RL,Chanock S,Børresen-Dale AL,Perou CM

更新日期：2004-10-07 00:00:00

abstract：:The Interleukin-1beta converting enzyme (ICE) family of proteins, homologs of the C elegans cell death gene product CED-3, play important roles in controlling vertebrate programmed cell death. Because inhibition of apoptosis may be an essential step in tumorigenesis, we investigated the interaction of the simian virus...

journal_title：Oncogene

authors： Jung YK,Yuan J

更新日期：1997-03-13 00:00:00

abstract：:The PI3K/AKT signaling pathway is aberrant in a wide variety of cancers. Downstream effectors of AKT are involved in survival, growth and metabolic-related pathways. In contrast, contradictory data relating to AKT effects on cell motility and invasion, crucial prometastatic processes, have been reported pointing to a ...

journal_title：Oncogene

authors： Zhu QS,Rosenblatt K,Huang KL,Lahat G,Brobey R,Bolshakov S,Nguyen T,Ding Z,Belousov R,Bill K,Luo X,Lazar A,Dicker A,Mills GB,Hung MC,Lev D

更新日期：2011-01-27 00:00:00

abstract：:Although activation of the STAT3 pathway has been associated with tumor progression in a wide variety of cancer types (including ovarian cancer), the precise mechanism of invasion and metastasis due to STAT3 are not fully delineated in ovarian cancer. We found that pSTAT3 Tyr705 is constitutively activated in patient ...

journal_title：Oncogene

authors： Saini U,Naidu S,ElNaggar AC,Bid HK,Wallbillich JJ,Bixel K,Bolyard C,Suarez AA,Kaur B,Kuppusamy P,Hays J,Goodfellow PJ,Cohn DE,Selvendiran K

更新日期：2017-01-12 00:00:00

abstract：:We have recently identified and cloned the gene for a cytosolic polypeptide, designated oncoprotein 18 (Op18), which is expressed in acute lymphocytic leukemia and some solid tumors including neuroblastoma. Op18 is phosphorylated upon treatment of lymphoid cells with phorbol myristate acetate. We have proposed that un...

journal_title：Oncogene

authors： Hailat N,Strahler J,Melhem R,Zhu XX,Brodeur G,Seeger RC,Reynolds CP,Hanash S

更新日期：1990-11-01 00:00:00

abstract：:L-ascorbate (L-ascorbic acid, vitamin C) clearly has an inhibitory effect on cancer cells. However, the mechanism underlying differential sensitivity of cancer cells from same tissue to L-ascorbate is yet to be clarified. Here, we demonstrate that L-ascorbate has a selective killing effect, which is influenced by sodi...

journal_title：Oncogene

authors： Hong SW,Lee SH,Moon JH,Hwang JJ,Kim DE,Ko E,Kim HS,Cho IJ,Kang JS,Kim DJ,Kim JE,Shin JS,Jung DJ,Jeong YJ,Cho BJ,Kim TW,Lee JS,Kang JS,Hwang YI,Noh DY,Jin DH,Lee WJ

更新日期：2013-03-21 00:00:00

abstract：:The Epstein-Barr virus (EBV) encoded Latent Membrane Protein-1 (LMP1) mimics a constitutively active receptor molecule, and has been shown to activate NF-kappaB and the MAPK and JNK pathways. Two regions within the cytosolic domain of LMP1 have been found to effect cell signalling. One of these, the carboxy-terminal a...

journal_title：Oncogene

authors： Floettmann JE,Eliopoulos AG,Jones M,Young LS,Rowe M

更新日期：1998-11-05 00:00:00

abstract：:During tumor initiation, oncogene-induced senescence (OIS) is proposed to limit the progression of preneoplasms to invasive carcinoma unless circumvented by the acquisition of certain tumor suppressor mutations. Using a variety of biomarkers, OIS has been previously reported in a wide range of human and murine precurs...

journal_title：Oncogene

authors： Caldwell ME,DeNicola GM,Martins CP,Jacobetz MA,Maitra A,Hruban RH,Tuveson DA

更新日期：2012-03-22 00:00:00

abstract：:DNA double-strand breaks (DSBs), the most hazardous DNA lesions, may result in genomic instability, a hallmark of cancer cells. The main DSB repair pathways are non-homologous end joining (NHEJ) and homologous recombination (HR). In mammalian cells, NHEJ, which can lead to inaccurate repair, predominates. HR repair (H...

journal_title：Oncogene

authors： Shahar OD,Raghu Ram EV,Shimshoni E,Hareli S,Meshorer E,Goldberg M

更新日期：2012-07-26 00:00:00

abstract：:The acute contractile function of the heart is controlled by the effects of released nonepinephrine (NE) on cardiac adrenergic receptors. NE can also act in a more chronic fashion to induce cardiomyocyte growth, characterized by cell enlargement (hypertrophy), increased protein synthesis, alterations in gene expressio...

journal_title：Oncogene

authors： Adams JW,Brown JH

更新日期：2001-03-26 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by the thiazolidinedione (TZD) class of antidiabetic drugs elicits growth inhibition in a variety of malignant tumors. We clarified the effects of TZDs on growth of human non-small cell lung carcinoma (NSCLC) cells that express endogenous PPAR-gamma...

journal_title：Oncogene

authors： Satoh T,Toyoda M,Hoshino H,Monden T,Yamada M,Shimizu H,Miyamoto K,Mori M

更新日期：2002-03-28 00:00:00