Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA.

abstract：:Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...

journal_title：Oncogene

authors： Lopez-Delisle L,Pierre-Eugène C,Louis-Brennetot C,Surdez D,Raynal V,Baulande S,Boeva V,Grossetête-Lalami S,Combaret V,Peuchmaur M,Delattre O,Janoueix-Lerosey I

更新日期：2018-03-01 00:00:00

abstract：:We analysed 30 primary invasive oral and laryngeal squamous carcinomas (SC), with concurrent dysplastic lesions, for genetic alterations at 15 microsatellite loci on the short arm of chromosome 8. Overall, loss of heterozygosity (LOH) was observed, in at least one informative locus, in 27% of the dysplastic lesions an...

journal_title：Oncogene

authors： El-Naggar AK,Coombes MM,Batsakis JG,Hong WK,Goepfert H,Kagan J

更新日期：1998-06-11 00:00:00

abstract：:There is a large body of evidence suggesting the connexin gap junction proteins appear to act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main function of cell coupling through gap junctions. However, some cancer cells (e.g. the rat bladder carcinoma BC31 cell line) are cell-...

journal_title：Oncogene

authors： Krutovskikh VA,Troyanovsky SM,Piccoli C,Tsuda H,Asamoto M,Yamasaki H

更新日期：2000-01-27 00:00:00

abstract：:The putative tumor suppressor CDKN1C is an imprinted gene at 11p15.5, a well-known imprinted region often deleted in tumors. The absence of somatic mutations and the frequent diminished expression in tumors would suggest that CDKN1C expression is regulated epigenetically. It has been, however, controversial whether th...

journal_title：Oncogene

authors： Soejima H,Nakagawachi T,Zhao W,Higashimoto K,Urano T,Matsukura S,Kitajima Y,Takeuchi M,Nakayama M,Oshimura M,Miyazaki K,Joh K,Mukai T

更新日期：2004-05-27 00:00:00

abstract：:The initiation, magnitude and duration of an immune response against antigens are a tightly regulated process involving a dynamic, orchestrated balance of pro- and anti-inflammatory pathways in immune cells. Such a delicate balance is critical for allowing efficient immune response against foreign antigens while preve...

journal_title：Oncogene

authors： Villagra A,Sotomayor EM,Seto E

更新日期：2010-01-14 00:00:00

abstract：:The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), espe...

journal_title：Oncogene

authors： Teshima K,Nara M,Watanabe A,Ito M,Ikeda S,Hatano Y,Oshima K,Seto M,Sawada K,Tagawa H

更新日期：2014-04-24 00:00:00

abstract：:High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) and a number of other tumors suggest the existence of a tumor suppressor gene(s) within the deleted regions. Two small cell lung cancer lines, NCI H740 and GLC20, have been described which have homozygous deletions in th...

journal_title：Oncogene

authors： Todd MC,Xiang RH,Garcia DK,Kerbacher KE,Moore SL,Hensel CH,Liu P,Siciliano MJ,Kok K,van den Berg A,Veldhuis P,Buys CH,Killary AM,Naylor SL

更新日期：1996-12-05 00:00:00

abstract：:Replication origins are 'licensed' for a single initiation event by loading Mcm2-7 complexes during late mitosis and G1. Licensing is blocked at other cell cycle stages by the activity of cyclin-dependent kinases and a small protein called geminin. Here, we describe the effects of over-expressing a non-degradable form...

journal_title：Oncogene

authors： Shreeram S,Sparks A,Lane DP,Blow JJ

更新日期：2002-09-26 00:00:00

abstract：:Lung adenocarcinomas, like other cancers, develop through the accumulation of epigenetic and genetic alterations. Numerous studies have shown that K-RAS mutation is among the most important early events in carcinogenesis of the lung. However, it is also well established that growth-stimulating signals feed back into g...

journal_title：Oncogene

authors： Lee YS,Bae SC

更新日期：2016-02-18 00:00:00

abstract：:TFAP2C/AP-2γ influences development of the mammary gland and regulates patterns of gene expression in luminal and HER2-amplified breast cancer. The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to cancer progression remain poorly understood. To gain greater insight into oncogenic mechanisms r...

journal_title：Oncogene

authors： Park JM,Wu T,Cyr AR,Woodfield GW,De Andrade JP,Spanheimer PM,Li T,Sugg SL,Lal G,Domann FE,Zhang W,Weigel RJ

更新日期：2015-12-10 00:00:00

abstract：:Unique hybrids (HINS and CANS lines) between macrophages and a myeloma cell line, NS1 initially expressed myeloma functions but later expressed active macrophage functions together with constitutive expression of c-fos gene. Enhancement of c-fos transcription was also observed in activated mouse peritoneal macrophages...

journal_title：Oncogene

authors： Higuchi Y,Setoguchi M,Yoshida S,Akizuki S,Yamamoto S

更新日期：1988-05-01 00:00:00

abstract：:dMax, a naturally occurring splice variant of the Myc binding protein Max, lacks the DNA binding basic region and helix 1 of the Helix-Loop-Helix domain; dMax interacts with c-Myc in vitro and in vivo, and inhibits E-box Myc site driven transcription in transient transfection assays. Here we have investigated the expr...

journal_title：Oncogene

authors： FitzGerald MJ,Arsura M,Bellas RE,Yang W,Wu M,Chin L,Mann KK,DePinho RA,Sonenshein GE

更新日期：1999-04-15 00:00:00

abstract：:In the present study, we have analysed the effects of transforming growth factor-beta (TGF-beta) signaling on the growth behavior of pancreatic carcinoma cells in vitro and on their tumorigenicity in vivo. Ectopic expression of dominant-negative mutants of the TGF-beta type II receptor or type I receptor/activin recep...

journal_title：Oncogene

authors： Schniewind B,Groth S,Sebens Müerköster S,Sipos B,Schäfer H,Kalthoff H,Fändrich F,Ungefroren H

更新日期：2007-07-19 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for lung cancer and an aberrant microbiota of the lung. Microbial colonization contributes to chronic neutrophilic inflammation in COPD. Nontypeable Haemophilus influenzae (NTHi) is frequently found in lungs of stable COPD patients and i...

journal_title：Oncogene

authors： Jungnickel C,Schmidt LH,Bittigkoffer L,Wolf L,Wolf A,Ritzmann F,Kamyschnikow A,Herr C,Menger MD,Spieker T,Wiewrodt R,Bals R,Beisswenger C

更新日期：2017-07-20 00:00:00

abstract：:Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes that cooperate with the E2A-PBX1 transgene in lymphomagenesis. Neonatal retroviral infection substantially r...

journal_title：Oncogene

authors： Feldman BJ,Reid TR,Cleary ML

更新日期：1997-11-27 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemotherapeutic regimens. CD95L, the cognate ligand of CD95, can be cleaved by metalloproteases and released as a solu...

journal_title：Oncogene

authors： Edmond V,Dufour F,Poiroux G,Shoji K,Malleter M,Fouqué A,Tauzin S,Rimokh R,Sergent O,Penna A,Dupuy A,Levade T,Theret N,Micheau O,Ségui B,Legembre P

更新日期：2015-02-19 00:00:00

abstract：:Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth, differentiation and cell migration. In this study, we show that mammalian target of rapamycin complex 2 (mTORC2) regulates invasive cancer cell migration through selective activation of Akt1. Insuli...

journal_title：Oncogene

authors： Kim EK,Yun SJ,Ha JM,Kim YW,Jin IH,Yun J,Shin HK,Song SH,Kim JH,Lee JS,Kim CD,Bae SS

更新日期：2011-06-30 00:00:00

abstract：:The most common mutations in the familial breast and ovarian cancer susceptibility gene BRCA1 are frameshift and nonsense mutations, which lead to the synthesis of truncated proteins. On this ground, we have analysed BRCA1 exon 11, which includes about 61% of coding region, in germline DNA from 70 Italian breast and/o...

journal_title：Oncogene

authors： De Benedetti VM,Radice P,Mondini P,Spatti G,Conti A,Illeni MT,Caligo MA,Cipollini G,Bevilaqua G,Pilotti S,Pierotti MA

更新日期：1996-09-19 00:00:00

abstract：:Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional respon...

journal_title：Oncogene

authors： Choudhry H,Albukhari A,Morotti M,Haider S,Moralli D,Smythies J,Schödel J,Green CM,Camps C,Buffa F,Ratcliffe P,Ragoussis J,Harris AL,Mole DR

更新日期：2015-08-20 00:00:00

abstract：:Pilocytic astrocytomas (PAs, WHO grade I) are the most common brain tumors in the pediatric and adolescent population, accounting for approximately one-fifth of central nervous system tumors. Because few consistent molecular alterations have been identified in PAs compared to higher grade gliomas, we performed array c...

journal_title：Oncogene

authors： Deshmukh H,Yeh TH,Yu J,Sharma MK,Perry A,Leonard JR,Watson MA,Gutmann DH,Nagarajan R

更新日期：2008-08-07 00:00:00

abstract：:Tripartite motif 24 protein (TRIM24) is a plant homeodomain/bromodomain histone reader, recently associated with poor overall survival of breast-cancer patients. At a molecular level, TRIM24 is a negative regulator of p53 levels and a co-activator of estrogen receptor. However, the role of TRIM24 in breast tumorigenes...

journal_title：Oncogene

authors： Pathiraja TN,Thakkar KN,Jiang S,Stratton S,Liu Z,Gagea M,Shi X,Shah PK,Phan L,Lee MH,Andersen J,Stampfer M,Barton MC

更新日期：2015-05-28 00:00:00

abstract：:Downregulation of E-cadherin by the transcriptional repressor Snail is associated with acquisition of metastatic potential. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, it is unclear whether Snail is involved in HCV core-induced dysregulation of E-cadherin. Herein, we inve...

journal_title：Oncogene

authors： Nie D,Shan X,Nie L,Duan Y,Chen Z,Yang Y,Li Z,Tian L,Gao Q,Shan Y,Tang N

更新日期：2016-07-14 00:00:00

abstract：:Met tyrosine kinase has been implicated in tumorigenesis and metastasis; its overexpression and deregulation is often observed in cancer. Although Met's functions in cell motility has been studied extensively, its involvement in bleb-based, amoeboid motility is yet to be determined. The aim of this work is to study th...

journal_title：Oncogene

authors： Laser-Azogui A,Diamant-Levi T,Israeli S,Roytman Y,Tsarfaty I

更新日期：2014-04-03 00:00:00

abstract：:The ability of glioma cells to migrate great distances from a primary tumor mass is the primary cause of tumor recurrence. The urokinase-type plasminogen activator (uPA) is a serine protease that can initiate proteolytic cascades, which result in remodeling of extracellular matrix and basement membrane, allowing cells...

journal_title：Oncogene

authors： Chandrasekar N,Mohanam S,Gujrati M,Olivero WC,Dinh DH,Rao JS

更新日期：2003-01-23 00:00:00

abstract：:VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth factor family. VEGFRs are indispensable for embryonic vascular development, and are involved in the regulation of many aspects of physiological and pathological ...

journal_title：Oncogene

authors： Karkkainen MJ,Petrova TV

更新日期：2000-11-20 00:00:00

abstract：:The p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is post-translationally activated by a variety of stresses, enacting different protective biological functions. Since one critical issue in cancer gene therapy is tumor specificity, we asked whether the tight p53 regula...

journal_title：Oncogene

authors： Bossi G,Mazzaro G,Porrello A,Crescenzi M,Soddu S,Sacchi A

更新日期：2004-01-15 00:00:00

abstract：:Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stability by repressing t...

journal_title：Oncogene

authors： Gu P,Wang Y,Bisht KK,Wu L,Kukova L,Smith EM,Xiao Y,Bailey SM,Lei M,Nandakumar J,Chang S

更新日期：2017-04-06 00:00:00

abstract：:Class I HLA expression is low in neuroblastoma tumours and cell lines. We have recently mapped a modifier of methylation for HLA-C (MEMO-1) to chromosomal bands 1p35-36.1, a region deleted in many neuroblastomas. Hypomethylation of HLA-C is strongly correlated with allelic loss of the MEMO-1 locus. Here, we show that ...

journal_title：Oncogene

authors： Cheng NC,Beitsma M,Chan A,Op den Camp I,Westerveld A,Pronk J,Versteeg R

更新日期：1996-10-17 00:00:00

abstract：:Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor Sp1 in active expression from the promoter, particularly from the -5...

journal_title：Oncogene

authors： Chen X,Wright KL,Berkowitz EA,Azizkhan JC,Ting JP,Lee DC

更新日期：1994-11-01 00:00:00

abstract：:Exposure of CV-1P cells to hypoxic conditions results in reversible cell cycle arrest concomitant with accumulation of pRB in the hypophosphorylated, growth suppressive form. Similar to cell cycle arrest induced by serum starvation, we show here that hypoxia-induced arrest is accompanied by a decrease in pRB-directed ...

journal_title：Oncogene

authors： Krtolica A,Krucher NA,Ludlow JW

更新日期：1998-11-05 00:00:00