Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation.

abstract：:AMID, also called PRG3, is an AIF-homologous and mitochondria-associated protein that has been implicated in caspase-independent apoptosis. In this report, we demonstrated that human AMID gene promoter was activated by p53 in reporter gene assays. Chromatin immunoprecipitation experiments indicated that p53 could bind...

journal_title：Oncogene

authors： Wu M,Xu LG,Su T,Tian Y,Zhai Z,Shu HB

更新日期：2004-09-02 00:00:00

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:We have cloned a cDNA from the Drosophila elg gene, a new member of the ets family of genes. The D-elg gene is located at 97D on chromosome 3R and is expressed as a 2.0kb RNA in the embryos, pupae and adults, with no detectable expression in third instar larvae. D-elg expression is observed in all cells of early stage...

journal_title：Oncogene

authors： Pribyl LJ,Watson DK,Schulz RA,Papas TS

更新日期：1991-07-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progressi...

journal_title：Oncogene

authors： Stieglitz D,Lamm S,Braig S,Feuerer L,Kuphal S,Dietrich P,Arndt S,Echtenacher B,Hellerbrand C,Karrer S,Bosserhoff AK

更新日期：2019-01-01 00:00:00

abstract：:Mammalian Vav signal transducer proteins couple receptor tyrosine kinase signals to the activation of the Rho/Rac GTPases, leading to cell differentiation and/or proliferation. The unique and complex structure of mammalian Vav proteins is preserved in the Drosophila melanogaster homologue, DroVav. We demonstrate that ...

journal_title：Oncogene

authors： Hornstein I,Mortin MA,Katzav S

更新日期：2003-10-02 00:00:00

abstract：:The retinoblastoma suppressor gene product Rb has been assigned a critical role in cell cycle regulation, the induction of differentiation, and inhibition of oncogenic transformation. Inheritance of a mutant RB allele in humans is responsible for bilateral retinoblastoma, a malignant tumor of the retina. Trilateral re...

journal_title：Oncogene

authors： Vooijs M,te Riele H,van der Valk M,Berns A

更新日期：2002-07-11 00:00:00

abstract：:Melanoma dedifferentiation, characterized by the loss of MITF and MITF regulated genes and by upregulation of stemness markers as CD271, is implicated in resistance to chemotherapy, target therapy and immunotherapy. The identification of intrinsic mechanisms fostering melanoma dedifferentiation may provide actionable ...

journal_title：Oncogene

authors： Perotti V,Baldassari P,Molla A,Vegetti C,Bersani I,Maurichi A,Santinami M,Anichini A,Mortarini R

更新日期：2016-06-02 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach. Thus, there is a strong need for novel therapies, targeting more directly the molecular aberrations of...

journal_title：Oncogene

authors： Calabretta S,Bielli P,Passacantilli I,Pilozzi E,Fendrich V,Capurso G,Fave GD,Sette C

更新日期：2016-04-21 00:00:00

abstract：:The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss als...

journal_title：Oncogene

authors： Hunter JE,Butterworth JA,Zhao B,Sellier H,Campbell KJ,Thomas HD,Bacon CM,Cockell SJ,Gewurz BE,Perkins ND

更新日期：2016-06-30 00:00:00

abstract：:Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most abundantly expressed variant that drives p...

journal_title：Oncogene

authors： Liu LL,Xie N,Sun S,Plymate S,Mostaghel E,Dong X

更新日期：2014-06-12 00:00:00

abstract：:Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progression springs from the combined forces of both genetic and epigenetic events, which produce variant clonal populations, together with the selective pressures of the microenvironment, which promote growth and, perhaps, d...

journal_title：Oncogene

authors： Macaluso M,Paggi MG,Giordano A

更新日期：2003-09-29 00:00:00

abstract：:ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix-loop-helix transcription factors. Certain human primary breast cancers reportedly have low or no expression of ID4 protein, but its role in carcinogenesis and cancer progression is unknown. To determine its poss...

journal_title：Oncogene

authors： Umetani N,Mori T,Koyanagi K,Shinozaki M,Kim J,Giuliano AE,Hoon DS

更新日期：2005-07-07 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common and malignant carcinoma worldwide, and the incidence and mortality are increasing rapidly. Immunotherapy targeting programmed death 1/programmed death ligand 1 (PD-L1) signaling has shown prominent clinical effects in treating NSCLC; however, a poor understa...

journal_title：Oncogene

authors： Wang J,Jia Y,Zhao S,Zhang X,Wang X,Han X,Wang Y,Ma M,Shi J,Liu L

更新日期：2017-11-09 00:00:00

abstract：:Blockade of the mitogen-activated protein (MAP) kinase pathway suppresses growth of colon cancer in vivo. Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells. Down-regulation of beta6 integ...

journal_title：Oncogene

authors： Ahmed N,Niu J,Dorahy DJ,Gu X,Andrews S,Meldrum CJ,Scott RJ,Baker MS,Macreadie IG,Agrez MV

更新日期：2002-02-21 00:00:00

abstract：:Differentiation inducible leukemic as well as normal myeloid precursors treated with physiological myeloid differentiation inducer have been used to explore the immediate early genetic response of cells to terminal differentiation and growth arrest stimuli. cDNA clones of 12 distinct genes, referred to as MyD genes, w...

journal_title：Oncogene

authors： Lord KA,Hoffman-Liebermann B,Liebermann DA

更新日期：1990-03-01 00:00:00

abstract：:An integrative functional genomics study of multiple forms of data are vital for discovering molecular drivers of cancer development and progression. Here, we present an integrated genomic strategy utilizing DNA methylation and transcriptome profile data to discover epigenetically regulated genes implicated in cancer ...

journal_title：Oncogene

authors： Mondal B,Patil V,Shwetha SD,Sravani K,Hegde AS,Arivazhagan A,Santosh V,Kanduri M,Somasundaram K

更新日期：2017-01-05 00:00:00

abstract：:Undifferentiated cells and embryos express high levels of endogenous non-telomerase reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT inhibitors modulate cell growth and differentiation in several cell lines. We have now sought to establish whether high levels of RT activity are d...

journal_title：Oncogene

authors： Sciamanna I,Landriscina M,Pittoggi C,Quirino M,Mearelli C,Beraldi R,Mattei E,Serafino A,Cassano A,Sinibaldi-Vallebona P,Garaci E,Barone C,Spadafora C

更新日期：2005-06-02 00:00:00

abstract：:Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...

journal_title：Oncogene

authors： Gupta A,Jha S,Engel DA,Ornelles DA,Dutta A

更新日期：2013-10-17 00:00:00

abstract：:An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...

journal_title：Oncogene

authors： Arlt A,Bauer I,Schafmayer C,Tepel J,Müerköster SS,Brosch M,Röder C,Kalthoff H,Hampe J,Moyer MP,Fölsch UR,Schäfer H

更新日期：2009-11-12 00:00:00

abstract：:To evaluate the role of the NF-kappaB signaling pathway in oncogenic transformation, we expressed IkappaBbeta, a specific inhibitor of NF-kappaB, in two human lung adenocarcinoma cell lines, A549 and H441. Expression of IkappaBbeta significantly reduced NF-kappaB activation induced by cotransfection with p65/RelA or T...

journal_title：Oncogene

authors： Jiang Y,Cui L,Yie TA,Rom WN,Cheng H,Tchou-Wong KM

更新日期：2001-04-26 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...

journal_title：Oncogene

authors： Sastry KJ,Marin MC,Nehete PN,McConnell K,el-Naggar AK,McDonnell TJ

更新日期：1996-08-01 00:00:00

abstract：:Primary cilia are microtubule-based, dynamic organelles characterized by continuous assembly and disassembly. The intraflagellar transport (IFT) machinery, including IFT88 in cilia, is involved in the maintenance of bidirectional motility along the axonemes, which is required for ciliogenesis and functional competence...

journal_title：Oncogene

authors： Lee J,Yi S,Won M,Song YS,Yi HS,Park YJ,Park KC,Kim JT,Chang JY,Lee MJ,Sul HJ,Choi JE,Kim KS,Kero J,Kim J,Shong M

更新日期：2018-08-01 00:00:00

abstract：:Cancer reflects the progressive accumulation of genetic alterations and subsequent genetic instability of cells. Cytogenetic studies have demonstrated the importance of aneuploidy in differentiated thyroid cancer development. The pituitary tumour transforming gene (PTTG), also known as securin, is a mitotic checkpoint...

journal_title：Oncogene

authors： Kim D,Pemberton H,Stratford AL,Buelaert K,Watkinson JC,Lopes V,Franklyn JA,McCabe CJ

更新日期：2005-07-14 00:00:00

abstract：:cDNA clones of the ski-related gene, sno, were isolated from a chicken cDNA library and sequenced. In contrast to the human system, from which two forms of sno cDNAs have been isolated, we obtained only one type of chicken sno cDNA, that encoding snoN. The coding region for chicken snoN was inserted into the retrovira...

journal_title：Oncogene

authors： Boyer PL,Colmenares C,Stavnezer E,Hughes SH

更新日期：1993-02-01 00:00:00

abstract：:We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response...

journal_title：Oncogene

authors： Haapasalo A,Saarelainen T,Moshnyakov M,Arumäe U,Kiema TR,Saarma M,Wong G,Castrén E

更新日期：1999-02-11 00:00:00

abstract：:Hypoxia induces transcription of a range of physiologically important genes including erythropoietin and vascular endothelial growth factor. The transcriptional activation is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric member of the basic helix-loop-helix PAS family, composed of alpha and beta ...

journal_title：Oncogene

authors： Krieg M,Haas R,Brauch H,Acker T,Flamme I,Plate KH

更新日期：2000-11-16 00:00:00

abstract：:Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion between TEL and genes encoding proteins of various types. The most frequent 12p13 translocation is the t(12;21)(p13;q22), which recombines TEL with the AML1 gene on chromosome 21 and is frequently...

journal_title：Oncogene

authors： Poirel H,Lacronique V,Mauchauffé M,Le Coniat M,Raffoux E,Daniel MT,Erickson P,Drabkin H,MacLeod RA,Drexler HG,Ghysdael J,Berger R,Bernard OA

更新日期：1998-06-04 00:00:00

abstract：:The short isoform of single-minded 2 (SIM2s), a basic helix-loop-helix/PAS (bHLH/PAS) transcription factor, is upregulated in pancreatic and prostate tumours; however, a mechanistic role for SIM2s in these cancers is unknown. Microarray studies in prostate DU145 cells identified the pro-cell death gene, BNIP3 (Bcl-2/a...

journal_title：Oncogene

authors： Farrall AL,Whitelaw ML

更新日期：2009-10-15 00:00:00

abstract：:Breast cancer cells that overexpress HER-2/neu are more resistant to chemotherapeutic agents such as paclitaxel (Taxol) and docetaxel (Taxotere) than those that do not overexpress HER-2/neu. In previous work, we showed that the adenovirus type 5 E1A can repress HER-2/neu expression at the transcriptional level. Here w...

journal_title：Oncogene

authors： Ueno NT,Yu D,Hung MC

更新日期：1997-08-18 00:00:00

abstract：:The myb family of genes encodes highly homologous nuclear transcription factors that play distinct roles in the development of breast, germ cells and hematoid organs. While the mechanisms associated with the regulation of these genes remain unknown, the transactivation of c-Myb was previously shown to be upregulated b...

journal_title：Oncogene

authors： Kang AD,Park G,Kim YH,Oh IH

更新日期：2004-05-20 00:00:00