Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer.

abstract：:Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast and ovarian cancer cells. To define the nature of the interaction between rhuMAb HER2 and other classes of cytotoxic drugs, we applied multiple drug effect/combination index (CI) isobologra...

journal_title：Oncogene

authors： Pegram M,Hsu S,Lewis G,Pietras R,Beryt M,Sliwkowski M,Coombs D,Baly D,Kabbinavar F,Slamon D

更新日期：1999-04-01 00:00:00

abstract：:Syndecan-1 is a heparan sulfate proteoglycan (HSPG) commonly upregulated in AIDS-related B lymphoid malignancies. Tat is the main HIV-1 transactivating factor that has a major role in the pathogenesis of AIDS-related lymphomas (ARL) by engaging heparan sulfate proteoglycans (HSPGs), chemokine receptors and integrins a...

journal_title：Oncogene

authors： Urbinati C,Grillo E,Chiodelli P,Tobia C,Caccuri F,Fiorentini S,David G,Rusnati M

更新日期：2017-05-04 00:00:00

abstract：:D-type cyclins are important cell cycle regulators that promote cellular proliferation in response to growth factors by inactivation of the retinoblastoma protein (Rb). Cyclin D1 has been shown to be overexpressed in several cancer types and to act as an oncogene in breast cancers. As D-type cyclins are rate limiting ...

journal_title：Oncogene

authors： Russell A,Thompson MA,Hendley J,Trute L,Armes J,Germain D

更新日期：1999-03-18 00:00:00

abstract：:Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotype changes related to malignant progression including increased motility and invasion. Concurrent with these phenotypic effects are changes in the expression of multiple gene targets. We previously demonstrated that e...

journal_title：Oncogene

authors： Briggs J,Chamboredon S,Castellazzi M,Kerry JA,Bos TJ

更新日期：2002-10-10 00:00:00

abstract：:MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression is not well defined. We aimed to determine whether specific miRNAs and their target mRNAs contribute to head and neck cancer pathogenesis and progression. To ide...

journal_title：Oncogene

authors： Nakanishi H,Taccioli C,Palatini J,Fernandez-Cymering C,Cui R,Kim T,Volinia S,Croce CM

更新日期：2014-02-06 00:00:00

abstract：:N-cadherin is a cell-cell adhesion molecule that plays a role in breast cancer metastasis. Here, we show that in vivo expression of N-cadherin in the PyMT mouse model, which enhances mammary tumor metastasis, results in selective inhibition of Akt3 expression and phosphorylation. Similarly, exogenous expression of N-c...

journal_title：Oncogene

authors： Chung S,Yao J,Suyama K,Bajaj S,Qian X,Loudig OD,Eugenin EA,Phillips GR,Hazan RB

更新日期：2013-01-24 00:00:00

abstract：:Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined. Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells were...

journal_title：Oncogene

authors： Kim SG,Kim SN,Jong HS,Kim NK,Hong SH,Kim SJ,Bang YJ

更新日期：2001-03-08 00:00:00

abstract：:Cellular senescence functions as a tumor suppressor that protects against cancer progression. α-Catulin, an α-catenin-related protein, is reported to have tumorigenic potential because it regulates the nuclear factor-κB (NF-κB) pathway, but little is known about its clinical relevance and the mechanism through which i...

journal_title：Oncogene

authors： Fan LC,Chiang WF,Liang CH,Tsai YT,Wong TY,Chen KC,Hong TM,Chen YL

更新日期：2011-06-09 00:00:00

abstract：:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...

journal_title：Oncogene

authors： Azzam EI,de Toledo SM,Little JB

更新日期：2003-10-13 00:00:00

abstract：:Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular ada...

journal_title：Oncogene

authors： Tsygankov AY,Teckchandani AM,Feshchenko EA,Swaminathan G

更新日期：2001-10-01 00:00:00

abstract：:The reciprocal chromosomal translocation t(4;11) is correlated with infant, childhood, adult and therapy-related high-risk acute leukemia. Here, we investigated the biological effects of MLL.AF4, AF4.MLL or the combination of both reciprocal fusion proteins in a conditional in vitro cell culture model system. Several ...

journal_title：Oncogene

authors： Gaussmann A,Wenger T,Eberle I,Bursen A,Bracharz S,Herr I,Dingermann T,Marschalek R

更新日期：2007-05-17 00:00:00

abstract：:We have studied the relationship between ras-GAP and G protein coupled receptors in a proliferative setting comprised of NIH3T3 expressing transfected muscarinic receptors (mAChRs). GAP expression plasmids were engineered to encode wild-type GAP, its carboxyl-terminal catalytic domain, a mutant lacking a portion of th...

journal_title：Oncogene

authors： Xu N,McCormick F,Gutkind JS

更新日期：1994-02-01 00:00:00

abstract：:Overexpression of members of the myc family of oncogenes contributes to the development of many vertebrate malignancies. Although several functions for myc gene products have been proposed, the targets for Myc activity during oncogenesis or normal development remain to be identified. Oocytes of Xenopus laevis, which a...

journal_title：Oncogene

authors： Gibson AW,Ye R,Johnston RN,Browder LW

更新日期：1992-11-01 00:00:00

abstract：:A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess...

journal_title：Oncogene

authors： Sumigama S,Ito T,Kajiyama H,Shibata K,Tamakoshi K,Kikkawa F,Williams T,Tainsky MA,Nomura S,Mizutani S

更新日期：2004-07-15 00:00:00

abstract：:Activating mutations of the N-ras gene occur at relatively high frequency in acute myeloid leukemia and myelodysplastic syndrome. Somewhat paradoxically, ectopic expression of activated N-ras in primary hematopoietic cells and myeloid cell lines (in some cases) can lead to inhibition of proliferation. Expression of mu...

journal_title：Oncogene

authors： Passioura T,Shen S,Symonds G,Dolnikov A

更新日期：2005-11-10 00:00:00

abstract：:Lung adenocarcinomas, like other cancers, develop through the accumulation of epigenetic and genetic alterations. Numerous studies have shown that K-RAS mutation is among the most important early events in carcinogenesis of the lung. However, it is also well established that growth-stimulating signals feed back into g...

journal_title：Oncogene

authors： Lee YS,Bae SC

更新日期：2016-02-18 00:00:00

abstract：:Signet-ring cell carcinoma is classified in poorly differentiated adenocarcinoma with an aggressive nature and a poor prognosis. We have shown that the activation of PI 3-kinase in highly differentiated adenocarcinomas induces loss of cell-cell contact and formation of vacuoles, giving phenotypes similar to those of s...

journal_title：Oncogene

authors： Xu Q,Karouji Y,Kobayashi M,Ihara S,Konishi H,Fukui Y

更新日期：2003-08-28 00:00:00

abstract：:Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...

journal_title：Oncogene

authors： Healy E,Belgaid C,Takata M,Harrison D,Zhu NW,Burd DA,Rigby HS,Matthews JN,Rees JL

更新日期：1998-04-30 00:00:00

abstract：:Increased glucose consumption is a hallmark of cancer cells. The increased consumption and subsequent metabolism of glucose during proliferation creates the need for a constant supply of NAD, a co-factor in glycolysis. Regeneration of the NAD required to support enhanced glycolysis has been attributed to the terminal ...

journal_title：Oncogene

authors： Hanse EA,Ruan C,Kachman M,Wang D,Lowman XH,Kelekar A

更新日期：2017-07-06 00:00:00

abstract：:Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...

journal_title：Oncogene

authors： Beristain AG,Molyneux SD,Joshi PA,Pomroy NC,Di Grappa MA,Chang MC,Kirschner LS,Privé GG,Pujana MA,Khokha R

更新日期：2015-02-26 00:00:00

abstract：:A vector, derived from the human K1 keratin gene, has been employed to target v-fos expression exclusively in the epidermis of transgenic mice. Adult transgenic mice expressors (3-4 months) displayed hyperplasia and hyperkeratosis, initially in wounded (tagged) ears, which later became bilateral. This phenotype appear...

journal_title：Oncogene

authors： Greenhalgh DA,Rothnagel JA,Wang XJ,Quintanilla MI,Orengo CC,Gagne TA,Bundman DS,Longley MA,Fisher C,Roop DR

更新日期：1993-08-01 00:00:00

abstract：:The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite in...

journal_title：Oncogene

authors： Yuan Z,Sotsky Kent T,Weber TK

更新日期：2003-09-18 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:The oligomerization chain reaction (OCR) strategy is a recently described technique for inactivation of target proteins that function as homoassociate complexes. This novel strategy is based on the fusion of self-associating coiled-coil (CC) domain of the nuclear factor promyelocytic leukemia (PML) to target proteins....

journal_title：Oncogene

authors： Napolitano G,Mazzocco A,Fraldi A,Majello B,Lania L

更新日期：2003-07-31 00:00:00

abstract：:Progesterone receptor (PR) is usually co-localized with estrogen receptor (ER) in normal mammary cells. It is not known whether ER/PR-negative human breast cancer arises from an ER/PR-negative cell or from an ER/PR-positive cell that later lost ER/PR. Using intraductal injection of a lentivirus to deliver both an onco...

journal_title：Oncogene

authors： Dong J,Zhao W,Shi A,Toneff M,Lydon J,So D,Li Y

更新日期：2016-08-04 00:00:00

abstract：:Integrin-linked kinase (ILK) is a highly evolutionarily conserved intracellular protein that was originally identified as an integrin-interacting protein, and extensive genetic and biochemical studies have shown that ILK expression is vital during both embryonic development and tissue homeostasis. At the cellular and ...

journal_title：Oncogene

authors： Hannigan GE,McDonald PC,Walsh MP,Dedhar S

更新日期：2011-10-27 00:00:00

abstract：:The p21WAF1/CIP1/SDI1 gene is an important regulator of crucial cellular processes, including cell cycle control, cellular differentiation, and the response to genotoxic stress. Induction of p21 gene expression upon DNA damage is widely believed to be p53-dependent. In the present study we analysed the expression of p...

journal_title：Oncogene

authors： Butz K,Geisen C,Ullmann A,Zentgraf H,Hoppe-Seyler F

更新日期：1998-08-13 00:00:00

abstract：:We tested the cytotoxic action of 8-hydroxyguanine (8ohG) by observing the viability of several leukemic cell lines (KG-1, U937, Jurkat and K 562) in the presence of 8-hydroxydeoxyguanosine (8ohdG), a nucleoside of 8ohG. It was found that 8ohdG showed cytotoxic action only to KG-1 and that only KG-1 showed a homozygou...

journal_title：Oncogene

authors： Hyun JW,Choi JY,Zeng HH,Lee YS,Kim HS,Yoon SH,Chung MH

更新日期：2000-09-14 00:00:00

abstract：:In less than 10 years, the number and importance of non-surgical treatment modalities in patients with colorectal cancer (CRC) have increased dramatically, both in the adjuvant and the advanced settings. However, despite the improvement of cytotoxic therapy in CRC, many patients still develop progressive disease and u...

journal_title：Oncogene

authors： Pfeiffer P,Qvortrup C,Eriksen JG

更新日期：2007-05-28 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimens...

journal_title：Oncogene

authors： Handler J,Cullis J,Avanzi A,Vucic EA,Bar-Sagi D

更新日期：2018-08-01 00:00:00