The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors.

abstract：:Proteolytic cleavage of the extracellular domain of CD44 from the surface of cells has been observed recently in different cell types. In cell culture supernatants of human melanoma cell lines a 70 kDa soluble CD44 protein (solCD44) was detected at concentrations of 250-300 ng/ml. Protease inhibitor studies revealed t...

journal_title：Oncogene

authors： Ahrens T,Sleeman JP,Schempp CM,Howells N,Hofmann M,Ponta H,Herrlich P,Simon JC

更新日期：2001-06-07 00:00:00

abstract：:The BTB/POZ family of proteins has been implicated in multiple biological processes, including tumourigenesis, DNA damage responses and cell cycle progression and development. MIZ-1 (Myc-interacting zinc-finger protein 1) is known to activate transcription of CDKN1A. We recently found that a kidney cancer-related POK ...

journal_title：Oncogene

authors： Lee KM,Choi WI,Koh DI,Kim YJ,Jeon BN,Yoon JH,Lee CE,Kim SH,Oh J,Hur MW

更新日期：2012-03-15 00:00:00

abstract：:Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...

journal_title：Oncogene

authors： Takahashi M,Mutoh M,Shoji Y,Kamanaka Y,Naka M,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2003-10-23 00:00:00

abstract：:The trans-activator protein Tax of human T-cell leukemia virus type I (HTLV-I) plays an important role in the development of adult T-cell leukemia through, at least in part, its ability to stimulate cell growth. We previously reported that Tax induced cell cycle progression from G0/G1 phase to S and G2/M phases in hum...

journal_title：Oncogene

authors： Iwanaga R,Ohtani K,Hayashi T,Nakamura M

更新日期：2001-04-19 00:00:00

abstract：:The c-Met receptor is a potential therapeutic target for non-small cell lung cancer (NSCLC). Signaling interactions between c-Met and the mutant epidermal growth factor receptor (EGFR) have been studied extensively, but signaling intermediates and biological consequences of lateral signaling to c-Met in EGFR wild-type...

journal_title：Oncogene

authors： Dulak AM,Gubish CT,Stabile LP,Henry C,Siegfried JM

更新日期：2011-08-18 00:00:00

abstract：:MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, are involved in many complex cellular processes. Several miRNAs are differentially expressed in hematopoietic tissues and play important roles in normal differentiation, but, when aberrantly regulated, contribute to the abn...

journal_title：Oncogene

authors： Pelosi A,Careccia S,Lulli V,Romania P,Marziali G,Testa U,Lavorgna S,Lo-Coco F,Petti MC,Calabretta B,Levrero M,Piaggio G,Rizzo MG

更新日期：2013-08-01 00:00:00

abstract：:SMARCB1 (Snf5/Ini1/Baf47) is a potent tumor suppressor, the loss of which serves as the diagnostic feature in malignant rhabdoid tumors (MRT) and atypical teratoid/rhabdoid tumors (AT/RT), two highly aggressive forms of pediatric neoplasms. SMARCB1 is a core subunit of Swi/Snf chromatin remodeling complexes, and loss ...

journal_title：Oncogene

authors： Darr J,Klochendler A,Isaac S,Eden A

更新日期：2014-06-05 00:00:00

abstract：:Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hemat...

journal_title：Oncogene

authors： Smithgall TE,Briggs SD,Schreiner S,Lerner EC,Cheng H,Wilson MB

更新日期：2000-05-15 00:00:00

abstract：:The transcription factor hypoxia inducible factor 1 (HIF1), an HIF1alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) dimeric factor, is essential to the cellular response to hypoxia. We described a t(1;12)(q21;p13) chromosomal translocation in human acute myeloblastic leukemia that involves the translocated ...

journal_title：Oncogene

authors： Nguyen-Khac F,Della Valle V,Lopez RG,Ravet E,Mauchauffé M,Friedman AD,Huang LE,Fichelson S,Ghysdael J,Bernard OA

更新日期：2006-08-10 00:00:00

abstract：:High-throughput, human cell-based applications of RNA-mediated interference (RNAi) have emerged in recent years as perhaps the most powerful of a 'second wave' of functional genomics technologies. The available reagents and methodologies for RNAi screening studies now enable a wide range of different scopes and scales...

journal_title：Oncogene

authors： Sachse C,Echeverri CJ

更新日期：2004-11-01 00:00:00

abstract：:Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to rep...

journal_title：Oncogene

authors： Kasinski AL,Kelnar K,Stahlhut C,Orellana E,Zhao J,Shimer E,Dysart S,Chen X,Bader AG,Slack FJ

更新日期：2015-07-01 00:00:00

abstract：:Many reports have shown a link between mismatch repair (MMR) deficiency and loss of normal cell cycle control, particularly loss of G2 arrest. However almost all of these studies utilized transformed cell lines, and thus the involvement of other genes in this phenotype cannot be excluded. We have examined the effects ...

journal_title：Oncogene

authors： Strathdee G,Sansom OJ,Sim A,Clarke AR,Brown R

更新日期：2001-04-05 00:00:00

abstract：:Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can...

journal_title：Oncogene

authors： Caracciolo V,Reiss K,Khalili K,De Falco G,Giordano A

更新日期：2006-08-28 00:00:00

abstract：:Constitutive expression of the activated Rap1A protein inhibits differentiation of myogenic C2 cells whereas the inactivated Rap1A protein favours cell differentiation and induces late endocytic compartments clustering. Although the role of Rap1A in MAPK activation has been analysed in various cell types, the signalli...

journal_title：Oncogene

authors： Pizon V,Baldacci G

更新日期：2000-12-07 00:00:00

abstract：:The diverse checkpoint responses to DNA damage may reflect differential sensitivities by molecular components of the damage-signalling network to the type and amount of lesions. Here, we determined the kinetics of activation of the checkpoint kinases ATM and Chk2 (the latter substrate of ATM) in relation to the initia...

journal_title：Oncogene

authors： Buscemi G,Perego P,Carenini N,Nakanishi M,Chessa L,Chen J,Khanna K,Delia D

更新日期：2004-10-07 00:00:00

abstract：:TSC1 and TSC2 are responsible for the tumor suppressor gene syndrome tuberous sclerosis (TSC). Mammalian TSC genes have been shown to be involved in cell cycle regulation. Recently, in Drosophila, these data have been confirmed and TSC genes have further been demonstrated to affect cell size control. Here we provide s...

journal_title：Oncogene

authors： Rosner M,Hofer K,Kubista M,Hengstschläger M

更新日期：2003-07-31 00:00:00

abstract：:The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully characterized, and the mechanisms of DAB2 dysregulation in lung cancer are not defined. Here we show that low D...

journal_title：Oncogene

authors： Du L,Zhao Z,Ma X,Hsiao TH,Chen Y,Young E,Suraokar M,Wistuba I,Minna JD,Pertsemlidis A

更新日期：2014-08-21 00:00:00

abstract：:Ets1, the founder member of the Ets transcription factor family, is involved in a variety of developmental and cellular processes. Previous studies have shown that serine phosphorylation of Ets1 inhibits its DNA binding activity, suggesting that phosphorylation is important in the regulation of Ets1 function. To furth...

journal_title：Oncogene

authors： Rabault B,Roussel MF,Quang CT,Ghysdael J

更新日期：1996-08-15 00:00:00

abstract：:Inherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investiga...

journal_title：Oncogene

authors： Khoo US,Ozcelik H,Cheung AN,Chow LW,Ngan HY,Done SJ,Liang AC,Chan VW,Au GK,Ng WF,Poon CS,Leung YF,Loong F,Ip P,Chan GS,Andrulis IL,Lu J,Ho FC

更新日期：1999-08-12 00:00:00

abstract：:The p53 tumour suppressor induces cell cycle arrest and apoptosis in response to cellular stresses. p53 is inactivated by various cellular and viral factors. We set out to generate regulatable p53 derivatives that are highly inducible by synthetic ligands, escape inactivation and efficiently induce apoptosis. We have ...

journal_title：Oncogene

authors： Sengupta S,Ralhan R,Wasylyk B

更新日期：2000-01-20 00:00:00

abstract：:14-3-3sigma proteins regulate numerous cellular processes that are important to cancer development. One of its biological roles involves G2 cell-cycle arrest following DNA damage. It has also been reported that the loss of 14-3-3sigma expression via CpG methylation may contribute to malignant transformation by impairi...

journal_title：Oncogene

authors： Pulukuri SM,Rao JS

更新日期：2006-08-03 00:00:00

abstract：:BRCA1, a familial breast and ovarian cancer susceptibility gene encodes nuclear phosphoproteins that function as tumor suppressors in human breast cancer cells. Previously, we have shown that overexpression of a BRCA1 splice variant BRCA1a accelerates apoptosis in human breast cancer cells. In an attempt to determine ...

journal_title：Oncogene

authors： Wang H,Shao N,Ding QM,Cui J,Reddy ES,Rao VN

更新日期：1997-07-10 00:00:00

abstract：:E2a/Pbx1 is a fusion oncoprotein resulting from the t(1;19) translocation found in human pre-B acute lymphocytic leukemia and in a small number of acute T-lymphoid and myeloid leukemias. It was previously suggested that E2a/Pbx1 could cooperate with normal or oncogenic signaling pathways to immortalize myeloid and lym...

journal_title：Oncogene

authors： Bourette RP,Grasset MF,Mouchiroud G

更新日期：2007-01-11 00:00:00

abstract：:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...

journal_title：Oncogene

authors： Azzam EI,de Toledo SM,Little JB

更新日期：2003-10-13 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p27 is a key regulator of cell-cycle progression. Its expression and localization are altered in several types of malignancies, which has prognostic significance in cancers such as renal cell carcinoma (RCC). S-phase kinase-associated protein 2 (SKP-2) is an F-box protein that is ...

journal_title：Oncogene

authors： Shanmugasundaram K,Block K,Nayak BK,Livi CB,Venkatachalam MA,Sudarshan S

更新日期：2013-04-18 00:00:00

abstract：:Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...

journal_title：Oncogene

authors： Chu Y,Chen Y,Guo H,Li M,Wang B,Shi D,Cheng X,Guan J,Wang X,Xue C,Cheng T,Shi J,Yuan W

更新日期：2020-12-01 00:00:00

abstract：:We previously described the oral-esophageal tissue-specific expression of cyclin D1 with the Epstein-Barr virus ED-L2 promoter in transgenic mice, and resulting dysplasia. Given the evidence for an interplay between environmental and genetic factors in esophageal squamous carcinogenesis, the aim of this study was to d...

journal_title：Oncogene

authors： Jenkins TD,Mueller A,Odze R,Shahsafaei A,Zukerberg LR,Kent R,Stoner GD,Rustgi AK

更新日期：1999-01-07 00:00:00

abstract：:Apoptotic cell death is an active process which regulates the maintenance of the hematopoietic homeostasis. It has been reported that wild-type p53 (wt-p53) protein induces apoptosis in leukemia cells. To assess whether p53 is involved in the apoptotic process of normal hematopoietic cells, we introduced the temperatu...

journal_title：Oncogene

authors： Blandino G,Scardigli R,Rizzo MG,Crescenzi M,Soddu S,Sacchi A

更新日期：1995-02-16 00:00:00

abstract：:The HER-2/neu proto-oncogene is homologous with, but distinct from, the epidermal growth factor receptor. Current evidence indicates that this gene is frequently amplified and/or overexpressed in some human breast and ovarian cancers and that these alterations may be clinically important; however, little is known abou...

journal_title：Oncogene

authors： Press MF,Cordon-Cardo C,Slamon DJ

更新日期：1990-07-01 00:00:00

abstract：:Diffuse intrinsic pontine glioma (or DIPG) are pediatric high-grade gliomas associated with a dismal prognosis. They harbor specific substitution in histone H3 at position K27 that induces major epigenetic dysregulations. Most clinical trials failed so far to increase survival, and radiotherapy remains the most effici...

journal_title：Oncogene

authors： Silva-Evangelista C,Barret E,Ménez V,Merlevede J,Kergrohen T,Saccasyn A,Oberlin E,Puget S,Beccaria K,Grill J,Castel D,Debily MA

更新日期：2019-09-01 00:00:00