Control of myeloid differentiation and survival by Stats.

abstract：:Previously, we cloned two gene fragments encoding novel protein tyrosine phosphatases, termed PTP-U1 and PTP-U2. Here, we report the full-length sequence, expression, and chromosomal localization of the PTP-U2 gene. The cDNA for PTP-U2, which was obtained from a human normal kidney library, predicts a protein of 1216 ...

journal_title：Oncogene

authors： Seimiya H,Sawabe T,Inazawa J,Tsuruo T

更新日期：1995-05-04 00:00:00

abstract：:Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...

journal_title：Oncogene

authors： Chen Y,Xu L,Lin RY,Müschen M,Koeffler HP

更新日期：2020-10-01 00:00:00

abstract：:PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...

journal_title：Oncogene

authors： Jensen K,Shiels C,Freemont PS

更新日期：2001-10-29 00:00:00

abstract：:wnt genes encode secretory glycoproteins that have been implicated in growth control and development in mice, frogs and insects. In this report we examine properties of two wnt genes recently identified in the nematode Caenorhabditis elegans. The first gene, Ce-wnt-1, was previously identified by a polymerase chain re...

journal_title：Oncogene

authors： Shackleford GM,Shivakumar S,Shiue L,Mason J,Kenyon C,Varmus HE

更新日期：1993-07-01 00:00:00

abstract：:T-cell lymphoproliferative diseases are often associated with recurrent chromosomal translocations involving T cell receptor genes (TCR) and genes that are thought to play a role in the pathogenesis of these diseases. Whereas numerous such genes have already been identified in acute T cell leukemias, no candidate gene...

journal_title：Oncogene

authors： Stern MH,Soulier J,Rosenzwajg M,Nakahara K,Canki-Klain N,Aurias A,Sigaux F,Kirsch IR

更新日期：1993-09-01 00:00:00

abstract：:H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types of cancer. However, its functional roles in tumor progression remain largely unknown, especially in hepatocellular carcinoma (HCC). We found tha...

journal_title：Oncogene

authors： Zhao J,Hou Y,Yin C,Hu J,Gao T,Huang X,Zhang X,Xing J,An J,Wan S,Li J

更新日期：2020-02-01 00:00:00

abstract：:Retinoic Acid (RA) treatment induces disease remission of Acute Promyelocytic Leukaemia (APL) patients by triggering terminal differentiation of neoplastic cells. RA-sensitivity in APL is mediated by its oncogenic protein, which results from the recombination of the PML and the RA receptor alpha (RAR alpha) genes (PML...

journal_title：Oncogene

authors： Grignani F,Gelmetti V,Fanelli M,Rogaia D,De Matteis S,Ferrara FF,Bonci D,Grignani F,Nervi C,Pelicci PG

更新日期：1999-11-04 00:00:00

abstract：:Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel disease and arise as a consequence of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironment. An intrinsic defect in the...

journal_title：Oncogene

authors： Kosa P,Szabo R,Molinolo AA,Bugge TH

更新日期：2012-08-09 00:00:00

abstract：:p66(Shc), an isoform of Shc adaptor proteins, is shown to mediate various signals, including cellular stress. However, little is known about its involvement in carcinogenesis. We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (...

journal_title：Oncogene

authors： Veeramani S,Igawa T,Yuan TC,Lin FF,Lee MS,Lin JS,Johansson SL,Lin MF

更新日期：2005-11-03 00:00:00

abstract：:The adenomatous polyposis coli (APC) tumor suppressor is a nucleocytoplasmic protein. The nuclear accumulation of APC was recently found to vary depending on cell density, suggesting that putative APC function(s) in the nucleus is controlled by the establishment of cell contacts. We report here that the density-depend...

journal_title：Oncogene

authors： Fagman H,Larsson F,Arvidsson Y,Meuller J,Nordling M,Martinsson T,Helmbrecht K,Brabant G,Nilsson M

更新日期：2003-09-04 00:00:00

abstract：:In this issue of Oncogene, Mollinedo and co-workers present promising evidence that cholesterol-sensitive signaling pathways involving lipid rafts can be therapeutically targeted in multiple myeloma. Because the pathways considered in their study are used by other types of tumor cells, one implication of this report i...

journal_title：Oncogene

authors： Freeman MR,Di Vizio D,Solomon KR

更新日期：2010-07-01 00:00:00

abstract：:SHPTP2 is a ubiquitously-expressed SH2-containing tyrosine phosphatase that is tyrosine phosphorylated in response to activation of various receptor and nonreceptor tyrosine kinases. SHPTP2 associates with the platelet-derived growth factor (PDGF) receptor after ligand stimulation, and binding of SHPTP2 to this recept...

journal_title：Oncogene

authors： Keegan K,Cooper JA

更新日期：1996-04-04 00:00:00

abstract：:The neu oncogene encodes a 185,000 dalton transmembrane glycoprotein, p185. The current study examined the effects of p185-specific monoclonal antibody administration on the tumorigenic growth of neu-transformed NIH3T3 cells implanted into nude mice. Treatment with anti-p185 monoclonal antibodies of the IgG1, IgG2a, I...

journal_title：Oncogene

authors： Drebin JA,Link VC,Greene MI

更新日期：1988-03-01 00:00:00

abstract：:The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...

journal_title：Oncogene

authors： Hallberg B,Ashcroft M,Loeb DM,Kaplan DR,Downward J

更新日期：1998-08-13 00:00:00

abstract：:Many of the signaling responses induced by transforming growth factor-beta (TGF-beta) are mediated by Smad proteins, but there is evidence that it can also signal independently of Smads. Here, we provide evidence that multiple signal pathways induced by TGF-beta1-including Src family tyrosine kinases (SFKs), generatio...

journal_title：Oncogene

authors： Joo CK,Kim HS,Park JY,Seomun Y,Son MJ,Kim JT

更新日期：2008-01-24 00:00:00

abstract：:TP53 mutation in acute myeloid leukemia (AML) is associated with poor prognosis. Since no targeted therapy is available to restore p53 function, it is of great interest to test whether other pathways activated by TP53 mutations can be therapeutically targeted. Here, we showed HIF-1α target genes are enriched in TP53-m...

journal_title：Oncogene

authors： Wang Y,Liu Y,Bailey C,Zhang H,He M,Sun D,Zhang P,Parkin B,Baer MR,Zheng P,Malek SN,Liu Y

更新日期：2020-04-01 00:00:00

abstract：:Gene expression patterns in normal and v-myc-transformed quail embryo fibroblasts were compared by mRNA differential display. Displaying approximately 2500 mRNA species by reverse transcription/PCR, reamplification of 73 differential cDNA fragments and rescreening by Northern analysis led to the isolation of a clone, ...

journal_title：Oncogene

authors： Oberst C,Weiskirchen R,Hartl M,Bister K

更新日期：1997-03-06 00:00:00

abstract：:The BNLF-1 protein is the only non-nuclear Epstein-Barr virus (EBV) encoded protein that has been detected in B-lymphocytes immortalized by EBV. We demonstrate that the BNLF-1 gene induces anchorage-independent growth and tumorigenic transformation of the murine cell-line, Balb/3T3. This demonstration extends the earl...

journal_title：Oncogene

authors： Baichwal VR,Sugden B

更新日期：1988-05-01 00:00:00

abstract：:During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in...

journal_title：Oncogene

authors： Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC,Wang BJ,Huang SH,Yang P,Yang JC,Chu CY,Hsieh CL,Sung SY,Li CF,Tepper CG,Ann DK,Gao AC,Evans CP,Izumiya Y,Chuu CP,Wang WC,Chen HW,Kung HJ

更新日期：2019-01-01 00:00:00

abstract：:The mechanism by which the p53 family of proteins coordinately regulates select target genes after various types of cell stress is not well understood. To further define factors that dictate regulation of target genes, we examined the binding of p53, DeltaNp63alpha and RNA polymerase II (pol II) to the regulatory regi...

journal_title：Oncogene

authors： Schavolt KL,Pietenpol JA

更新日期：2007-09-13 00:00:00

abstract：:Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe here an experimental approach to this problem based on the analysis o...

journal_title：Oncogene

authors： Burns PA,Kemp CJ,Gannon JV,Lane DP,Bremner R,Balmain A

更新日期：1991-12-01 00:00:00

abstract：:Recent genetic investigations have established that RhoB gain-of-function is sufficient to mediate the antitransforming effects of farnesyltransferase inhibitors (FTIs) in H-Ras-transformed fibroblast systems. In this study, we addressed the breadth and mechanism of RhoB action in epithelial cells transformed by oncop...

journal_title：Oncogene

authors： Zeng PY,Rane N,Du W,Chintapalli J,Prendergast GC

更新日期：2003-02-27 00:00:00

abstract：:Gastric carcinogenesis is a multistep process involving genetic and epigenetic alteration of protein-coding proto-oncogenes and tumor-suppressor genes. Recent discoveries have shed new light on the involvement of a class of noncoding RNA known as microRNA (miRNA) in gastric cancer. A substantial number of miRNAs show ...

journal_title：Oncogene

authors： Wu WK,Lee CW,Cho CH,Fan D,Wu K,Yu J,Sung JJ

更新日期：2010-10-28 00:00:00

abstract：:In the search for retinoids active against Burkitt's lymphoma (BL), we found that the arotinoid mofarotene (Ro 40-8757) induced strong antiproliferative and apoptotic responses in most established BL cell lines as well as in primary BL cells. Ro 40-8757-induced apoptosis is associated with mitochondrial membrane depol...

journal_title：Oncogene

authors： Cariati R,Zancai P,Righetti E,Rizzo S,De Rossi A,Boiocchi M,Dolcetti R

更新日期：2003-02-13 00:00:00

abstract：:The NF-kappa B precursor p100 (lyt-10, p97, p98) generates after proteolytic processing a 52 kDa subunit, which can bind to kappa B-motifs. A deregulated form of the p100 gene, which is structurally altered by a t(10;14) translocation, has a potential oncogenic role in certain human B cell lymphomas. In this study p10...

journal_title：Oncogene

authors： Naumann M,Nieters A,Hatada EN,Scheidereit C

更新日期：1993-08-01 00:00:00

abstract：:The long-term cellular response to DNA damage is controlled by the tumor suppressor p53. It results in cell-cycle arrest followed by DNA repair and, depending on the degree of damage inflicted, premature senescence or apoptotic cell death. Here we show that in normal diploid fibroblasts the ubiquitin ligase anaphase-p...

journal_title：Oncogene

authors： Wiebusch L,Hagemeier C

更新日期：2010-06-17 00:00:00

abstract：:TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-β signaling are process-and stage-dependent, and it is not uncommon that TGF-β exerts distinct and sometimes opposing effects on a di...

journal_title：Oncogene

authors： Muppala S,Xiao R,Krukovets I,Verbovetsky D,Yendamuri R,Habib N,Raman P,Plow E,Stenina-Adognravi O

更新日期：2017-09-07 00:00:00

abstract：:In CCL39 cells thrombin is a potent growth factor which requires sustained activation of mitogen activated protein kinases (MAPKs) to promote DNA synthesis. Some of the effects of thrombin can be mimicked by peptides based on the new amino terminus of the cleaved receptor; however, these thrombin receptor peptides (TR...

journal_title：Oncogene

authors： Balmanno K,Cook SJ

更新日期：1999-05-20 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...

journal_title：Oncogene

authors： Frieling JS,Shay G,Izumi V,Aherne ST,Saul RG,Budzevich M,Koomen J,Lynch CC

更新日期：2017-08-01 00:00:00

abstract：:SAP-1 (stomach cancer-associated protein tyrosine phosphatase-1) is a transmembrane-type protein tyrosine phosphatase that has been implicated as a negative regulator of integrin-mediated signaling. The potential role of this enzyme in hepatocarcinogenesis has now been investigated by examining its expression in 32 su...

journal_title：Oncogene

authors： Nagano H,Noguchi T,Inagaki K,Yoon S,Matozaki T,Itoh H,Kasuga M,Hayashi Y

更新日期：2003-07-24 00:00:00