Use of the two hybrid system to detect the association of the protein-tyrosine-phosphatase, SHPTP2, with another SH2-containing protein, Grb7.

abstract：:Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...

journal_title：Oncogene

authors： Lee GH,Yoo KC,An Y,Lee HJ,Lee M,Uddin N,Kim MJ,Kim IG,Suh Y,Lee SJ

更新日期：2018-04-01 00:00:00

abstract：:Ewing sarcoma is a pediatric bone tumor characterized in 85% of cases by the fusion between EWS and FLI1 genes that results in the expression of the EWS-FLI1 aberrant transcription factor. Histologically, the Ewing tumor expresses high levels of the CD99 membrane glycoprotein. It has been recently described that CD99 ...

journal_title：Oncogene

authors： Franzetti GA,Laud-Duval K,Bellanger D,Stern MH,Sastre-Garau X,Delattre O

更新日期：2013-08-15 00:00:00

abstract：:Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment. ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1α by upregulating FIH1. In ...

journal_title：Oncogene

authors： Feng J,Zhang Y,She X,Sun Y,Fan L,Ren X,Fu H,Liu C,Li P,Zhao C,Liu Q,Liu Q,Li G,Wu M

更新日期：2019-01-01 00:00:00

abstract：:The cellular and molecular mechanisms of tumor progression following chemotherapy are largely unknown. Here, we demonstrate that cisplatin (CDDP) treatment upregulates VEGF and Flt1 expression leading to the survival and expansion of a highly tumorigenic fraction of side-population (SP) cells in osteosarcoma (HOS), ne...

journal_title：Oncogene

authors： Tsuchida R,Das B,Yeger H,Koren G,Shibuya M,Thorner PS,Baruchel S,Malkin D

更新日期：2008-06-26 00:00:00

abstract：:Microsatellite-stable, near-diploid (MSI-CIN-) colorectal carcinomas have been reported, but it is not clear as to whether these tumours form a discrete group or represent one end of the distribution of MSI-CIN+ cancers. In order to address this question, we screened 23 MSI-CIN- colorectal cancers for gains and losses...

journal_title：Oncogene

authors： Jones AM,Douglas EJ,Halford SE,Fiegler H,Gorman PA,Roylance RR,Carter NP,Tomlinson IP

更新日期：2005-01-06 00:00:00

abstract：:Amplification of HER-2 oncogene was analysed in DNAs obtained from 291 primary human mammary carcinomas. 52/291 (18%) were found to contain amplified HER-2 oncogene. Moderate amplification (2- to 5-fold) was noted in 36/291 (12%). Thirteen tumors (4.5%) had a copy number of 5 to 10. A 10- to 20-fold and greater than 2...

journal_title：Oncogene

authors： Zeillinger R,Kury F,Czerwenka K,Kubista E,Sliutz G,Knogler W,Huber J,Zielinski C,Reiner G,Jakesz R

更新日期：1989-01-01 00:00:00

abstract：:Malignant mesotheliomas (MMs) are very aggressive tumors that respond poorly to standard chemotherapeutic approaches. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been implicated in tumor aggressiveness, in part by mediating cell survival and reducing sensitivity to chemotherapy. Using antibodies recognizi...

journal_title：Oncogene

authors： Altomare DA,You H,Xiao GH,Ramos-Nino ME,Skele KL,De Rienzo A,Jhanwar SC,Mossman BT,Kane AB,Testa JR

更新日期：2005-09-08 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimens...

journal_title：Oncogene

authors： Handler J,Cullis J,Avanzi A,Vucic EA,Bar-Sagi D

更新日期：2018-08-01 00:00:00

abstract：:Persistent infection with hepatitis B virus (HBV) is one of the primary risk factors for human hepatocellular carcinoma (HCC). In a human ecological study, we have shown that, in addition to HBV, animal food consumption also significantly contributes to the variance of HCC. To test the interacting effect of HBV and an...

journal_title：Oncogene

authors： Hu JF,Cheng Z,Chisari FV,Vu TH,Hoffman AR,Campbell TC

更新日期：1997-12-04 00:00:00

abstract：:Currently, trastuzumab resistance is a major clinical problem in the treatment of Her2-overexpressing breast cancer. The underlying molecular mechanisms are not fully understood. Our previous study demonstrates that β2-adrenergic receptor (β2-AR) and Her2 comprise a positive feedback loop in human breast cancer cells ...

journal_title：Oncogene

authors： Liu D,Yang Z,Wang T,Yang Z,Chen H,Hu Y,Hu C,Guo L,Deng Q,Liu Y,Yu M,Shi M,Du N,Guo N

更新日期：2016-01-07 00:00:00

abstract：:The DCC (deleted in colorectal cancer) gene was originally identified as a candidate tumour suppressor gene in colon carcinogenesis on the basis of allelic losses in chromosome 18q.21 in 70% of colon cancers. Reverse transcriptase polymerase chain reaction (RT-PCR) of DCC mRNA suggests that DCC expression may also be ...

journal_title：Oncogene

authors： Gotley DC,Reeder JA,Fawcett J,Walsh MD,Bates P,Simmons DL,Antalis TM

更新日期：1996-08-15 00:00:00

abstract：:The Ste20-like kinase, SLK, is involved in the control of cell motility through its effects on actin reorganization and focal adhesion turnover. Here we investigated the role of SLK in chemotaxis downstream of the tyrosine kinase receptor, HER2/ErbB2/Neu, which is frequently overexpressed in human breast cancers. Our ...

journal_title：Oncogene

authors： Roovers K,Wagner S,Storbeck CJ,O'Reilly P,Lo V,Northey JJ,Chmielecki J,Muller WJ,Siegel PM,Sabourin LA

更新日期：2009-08-06 00:00:00

abstract：:MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the go...

journal_title：Oncogene

authors： Galland F,Pirisi V,de Lapeyriere O,Birnbaum D

更新日期：1991-05-01 00:00:00

abstract：:Mouse malignant T-lymphoma CS-21 cells grow in vitro in the presence of CA-12 lymph node stromal cells, but they undergo apoptotic cell death when separated from CA-12 stromal cells. In the course of examining the nursing effects of CA-12 stromal cells, we found that these cells provided some soluble factors that supp...

journal_title：Oncogene

authors： Lee SH,Fujita N,Mashima T,Tsuruo T

更新日期：1996-11-21 00:00:00

abstract：:Hec1 (highly expressed in cancer 1) or Nek2 (NIMA-related kinase 2) is often overexpressed in cancers with poor prognosis. Both are critical mitotic regulators, and phosphorylation of Hec1 S165 by Nek2 is required for proper chromosome segregation. Therefore, inactivation of Hec1 and Nek2 by targeting their interactio...

journal_title：Oncogene

authors： Hu CM,Zhu J,Guo XE,Chen W,Qiu XL,Ngo B,Chien R,Wang YV,Tsai CY,Wu G,Kim Y,Lopez R,Chamberlin AR,Lee EY,Lee WH

更新日期：2015-03-05 00:00:00

abstract：:Non-small cell lung carcinomas (NSCLCs) are typically resistant against apoptosis induced by standard chemotherapy. We evaluated the effects of the two potential antitumor agents of the lamellarin class on a highly apoptosis-resistant NSCLC cell line. Both the marine alkaloid lamellarin-D and its synthetic amino deriv...

journal_title：Oncogene

authors： Gallego MA,Ballot C,Kluza J,Hajji N,Martoriati A,Castéra L,Cuevas C,Formstecher P,Joseph B,Kroemer G,Bailly C,Marchetti P

更新日期：2008-03-27 00:00:00

abstract：:The tumor suppressor transcription factor IRF-1 inhibits cell growth. In this report we show that IRF-1 also induces apoptosis of highly transformed and tumorigenic cell lines. This activity of IRF-1 is demonstrated with cell lines expressing HER oncogenes and an activatable IRF-1 fusion protein. Growth of cell lines ...

journal_title：Oncogene

authors： Kirchhoff S,Hauser H

更新日期：1999-06-24 00:00:00

abstract：:PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor regulates a variety of cellular processes including cell proliferation, growth, migration and death. This master regulator itself is also under deliberative regulation. Although the evidence for PTEN regulation and its significance in norm...

journal_title：Oncogene

authors： Wang X,Jiang X

更新日期：2008-09-18 00:00:00

abstract：:Embryonic stem (ES) cells have provided a valid model to understand early events of mammalian lineage specification and differentiation, leading to important insights into the mechanisms that control embryogenesis at the molecular and cellular levels. Furthermore, ES cells have recently evoked great scientific interes...

journal_title：Oncogene

authors： Minchiotti G

更新日期：2005-08-29 00:00:00

abstract：:Previous studies have demonstrated that activation of Kit by stem cell factor (SCF), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant protection against apoptosis induced by growth factor deprivation or radiation. However, the effects of Kit activation on the c...

journal_title：Oncogene

authors： Plo I,Lautier D,Casteran N,Dubreuil P,Arock M,Laurent G

更新日期：2001-10-11 00:00:00

abstract：:Hedgehog pathway activity has been demonstrated in malignant glioma. However, its role in tumor growth has not been determined. Here we demonstrate that pharmacological inhibition of the Hedgehog pathway in established orthotopic malignant glioma xenografts confers a survival advantage. Pathway inhibition is measured ...

journal_title：Oncogene

authors： Sarangi A,Valadez JG,Rush S,Abel TW,Thompson RC,Cooper MK

更新日期：2009-10-01 00:00:00

abstract：:TEA domain (TEAD) transcription factors are key components of the Hippo-YAP1 signaling pathway, but their functional role and regulatory mechanisms remain unclear. This study aims to comprehensively explore the expression pattern and functional role of TEAD family in gastric carcinogenesis and investigate its regulati...

journal_title：Oncogene

authors： Zhou Y,Huang T,Zhang J,Wong CC,Zhang B,Dong Y,Wu F,Tong JHM,Wu WKK,Cheng ASL,Yu J,Kang W,To KF

更新日期：2017-11-23 00:00:00

abstract：:We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...

journal_title：Oncogene

authors： Avila MA,Velasco JA,Cho C,Lupu R,Wen D,Notario V

更新日期：1995-03-02 00:00:00

abstract：:A hallmark of human cancer is heterogeneity, reflecting the complex series of changes resulting in the activation of oncogenes coupled with inactivation of tumor suppressor genes. Breast cancer is no exception and indeed, many studies have revealed considerable complexity and heterogeneity in the population of primary...

journal_title：Oncogene

authors： Leung JY,Andrechek ER,Cardiff RD,Nevins JR

更新日期：2012-05-17 00:00:00

abstract：:Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LN...

journal_title：Oncogene

authors： Urbanucci A,Sahu B,Seppälä J,Larjo A,Latonen LM,Waltering KK,Tammela TL,Vessella RL,Lähdesmäki H,Jänne OA,Visakorpi T

更新日期：2012-04-26 00:00:00

abstract：:Transformed cells express high levels of non-telomeric reverse-transcriptase (RT) activity of retrotransposon and endogenous retrovirus origin. We previously reported that RT inhibition, either pharmacological or through transient silencing of RT-encoding LINE-1 (L1) elements by RNA interference (RNAi), reduced prolif...

journal_title：Oncogene

authors： Oricchio E,Sciamanna I,Beraldi R,Tolstonog GV,Schumann GG,Spadafora C

更新日期：2007-06-21 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) represents the most frequent and therapy-refractive sub-class of lung cancer. Improving apoptosis induction in NSCLC represents a logical way forward in treating this tumor. Cisplatin, a commonly used therapeutic agent in NSCLC, induces activation of N-terminal-c-Jun kinase (JNK) tha...

journal_title：Oncogene

authors： Chattopadhyay S,Machado-Pinilla R,Manguan-García C,Belda-Iniesta C,Moratilla C,Cejas P,Fresno-Vara JA,de Castro-Carpeño J,Casado E,Nistal M,Gonzalez-Barón M,Perona R

更新日期：2006-06-01 00:00:00

abstract：:Alterations in expression of c-myb can have profound effects on the growth and differentiation of hematopoietic cells. Thus, it is important to understand the mechanisms by which c-myb is regulated during hematopoietic cell differentiation. Previous studies pertaining to the regulation of c-myb have been carried out w...

journal_title：Oncogene

authors： Boise LH,Gorse KM,Westin EH

更新日期：1992-09-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is characterized by 11q13 chromosomal translocation and CCND1 overexpression, but additional genomic changes are also important for lymphomagenesis. To identify the genomic aberrations of MCL at higher resolutions, we analysed 29 patient samples and seven cell lines using array-based compara...

journal_title：Oncogene

authors： Tagawa H,Karnan S,Suzuki R,Matsuo K,Zhang X,Ota A,Morishima Y,Nakamura S,Seto M

更新日期：2005-02-17 00:00:00

abstract：:From the sequences of Rel/NF-kappa B and I kappa B proteins, we constructed an alignment of their Rel Homology Domain (RHD) and ankyrin repeat domain. Using this alignment, we performed tree reconstruction with both distance matrix and parsimony analysis and estimated the branching robustness using bootstrap resamplin...

journal_title：Oncogene

authors： Huguet C,Crepieux P,Laudet V

更新日期：1997-12-11 00:00:00