β2-AR signaling controls trastuzumab resistance-dependent pathway.

abstract：:Diffuse intrinsic pontine glioma (or DIPG) are pediatric high-grade gliomas associated with a dismal prognosis. They harbor specific substitution in histone H3 at position K27 that induces major epigenetic dysregulations. Most clinical trials failed so far to increase survival, and radiotherapy remains the most effici...

journal_title：Oncogene

authors： Silva-Evangelista C,Barret E,Ménez V,Merlevede J,Kergrohen T,Saccasyn A,Oberlin E,Puget S,Beccaria K,Grill J,Castel D,Debily MA

更新日期：2019-09-01 00:00:00

abstract：:Cell lines derived from cervical neoplasias, as well as cells from normal cervix and neonatal foreskin were examined in an in vitro culture system (raft system) that allows for stratification and differentiation of epithelial cells at an air-liquid interface. Epithelial cells from human foreskin and ectocervix were ob...

journal_title：Oncogene

authors： Rader JS,Golub TR,Hudson JB,Patel D,Bedell MA,Laimins LA

更新日期：1990-04-01 00:00:00

abstract：:Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma cells. The activation of the erk cascade has been implicated in transducing the multitude of signals induced by NGF. In order to explore the role of this signaling cascade in NGF mediated survival, differentiation and proliferation, ...

journal_title：Oncogene

authors： Klesse LJ,Meyers KA,Marshall CJ,Parada LF

更新日期：1999-03-25 00:00:00

abstract：:PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...

journal_title：Oncogene

authors： Jensen K,Shiels C,Freemont PS

更新日期：2001-10-29 00:00:00

abstract：:Clonogenic murine B cell precursors are normally ultrasensitive to apoptosis following genotoxic exposure in vitro but can be protected by expression of an E mu-BCL-2 transgene. Such exposures are likely to be mutagenic. This in turn suggests that a level of in vivo genotoxic exposure that usually has minimal patholog...

journal_title：Oncogene

authors： Gibbons DL,MacDonald D,McCarthy KP,Cleary HJ,Plumb M,Wright EG,Greaves MF

更新日期：1999-07-01 00:00:00

abstract：:Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...

journal_title：Oncogene

authors： Wang P,Chen SH,Hung WC,Paul C,Zhu F,Guan PP,Huso DL,Kontrogianni-Konstantopoulos A,Konstantopoulos K

更新日期：2015-08-27 00:00:00

abstract：:Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic predictor of shorter survival of breast cancer pat...

journal_title：Oncogene

authors： Roy SS,Gonugunta VK,Bandyopadhyay A,Rao MK,Goodall GJ,Sun LZ,Tekmal RR,Vadlamudi RK

更新日期：2014-07-10 00:00:00

abstract：:Prostate cancer is the second highest cause of cancer-related deaths of men in the US. Signal transducers and activators of transcription (STATs) proteins are a small family of latent cytoplasmic transcription factors that act downstream of Janus kinase (JAK) activation and mediate intracellular signaling from a wide ...

journal_title：Oncogene

authors： Flowers LO,Subramaniam PS,Johnson HM

更新日期：2005-03-17 00:00:00

abstract：:Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). To study the genetic basis for these tumors, we microdissected MTC specimens or obtaine...

journal_title：Oncogene

authors： Coxon AB,Ward JM,Geradts J,Otterson GA,Zajac-Kaye M,Kaye FJ

更新日期：1998-09-24 00:00:00

abstract：:Smad4 is a critical component in transforming growth factor beta (TGF-beta) signaling and frequently mutated in pancreatic and colorectal cancers. Smad4 has two important functional domains, MH1 and MH2, that are involved in different biological processes. The MH1 domain comprises a DNA binding domain and the MH2 doma...

journal_title：Oncogene

authors： Kuang C,Chen Y

更新日期：2004-02-05 00:00:00

abstract：:The sirtuins (SIRT 1-7) comprise a family of NAD⁺-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation. These enzymes are involved in the cell's stress response systems and in regulating gene expression, DNA damage repair, metabolism and ...

journal_title：Oncogene

authors： Roth M,Chen WY

更新日期：2014-03-27 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...

journal_title：Oncogene

authors： Frieling JS,Shay G,Izumi V,Aherne ST,Saul RG,Budzevich M,Koomen J,Lynch CC

更新日期：2017-08-01 00:00:00

abstract：:Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they cause severe pain and bleeding, an...

journal_title：Oncogene

authors： Cao T,Jiang Y,Wang Z,Zhang N,Al-Hendy A,Mamillapalli R,Kallen AN,Kodaman P,Taylor HS,Li D,Huang Y

更新日期：2019-07-01 00:00:00

abstract：:Nuclear factor-kappaB (NF-kappaB) is a dynamic transcription factor that regulates important biological processes involved in cancer initiation and progression. Identifying regulators that control the half-life of NF-kappaB is important to understanding molecular processes that control the duration of transcriptional ...

journal_title：Oncogene

authors： Ramsey CS,Yeung F,Stoddard PB,Li D,Creutz CE,Mayo MW

更新日期：2008-06-05 00:00:00

abstract：:A protein of 300 kDa (p300) associates with the adenovirus E1A proteins and has been implicated in the control of cell cycle progression. In mammalian cells, p300 is actively phosphorylated in both quiescent and proliferating cells and its level of phosphorylation increases as it travels from late G1 into M phase. E1A...

journal_title：Oncogene

authors： Banerjee AC,Recupero AJ,Mal A,Piotrkowski AM,Wang DM,Harter ML

更新日期：1994-06-01 00:00:00

abstract：:The RAF-mitogen-activated protein kinase kinase 1/2-extracellular signal-regulated kinase 1/2 (RAF-MEK1/2-ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; however, most such studies have relied upon overexpression of RAF or MEK constructs that are not found in...

journal_title：Oncogene

authors： Wickenden JA,Jin H,Johnson M,Gillings AS,Newson C,Austin M,Chell SD,Balmanno K,Pritchard CA,Cook SJ

更新日期：2008-12-04 00:00:00

abstract：:Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remains unclear. A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigenesis ...

journal_title：Oncogene

authors： Wang M,Nagle RB,Knudsen BS,Cress AE,Rogers GC

更新日期：2020-01-01 00:00:00

abstract：:The v-src gene of Rous sarcoma virus (RSV) encodes pp60v-src, a tyrosine kinase that can initiate cellular transformation. High levels of v-src gene expression can either be cytotoxic or the cause of altered expression of cellular genes. Examination of cytotoxic thresholds is difficult because cells expressing high le...

journal_title：Oncogene

authors： Wu LW,Hackett PB

更新日期：1995-10-19 00:00:00

abstract：:We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response...

journal_title：Oncogene

authors： Haapasalo A,Saarelainen T,Moshnyakov M,Arumäe U,Kiema TR,Saarma M,Wong G,Castrén E

更新日期：1999-02-11 00:00:00

abstract：:O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...

journal_title：Oncogene

authors： Nakagawachi T,Soejima H,Urano T,Zhao W,Higashimoto K,Satoh Y,Matsukura S,Kudo S,Kitajima Y,Harada H,Furukawa K,Matsuzaki H,Emi M,Nakabeppu Y,Miyazaki K,Sekiguchi M,Mukai T

更新日期：2003-12-04 00:00:00

abstract：:The p53/p21Cip1/Waf1-dependent checkpoint control of G1/S and G2/M phases of the cell cycle in response to DNA damage is an important mechanism of genome stability maintenance in normal cells. In many tumor cells, due to frequent point mutations and deletions of p53, the stringent control of the cell cycle and apoptos...

journal_title：Oncogene

authors： Bulavin DV,Tararova ND,Aksenov ND,Pospelov VA,Pospelova TV

更新日期：1999-10-07 00:00:00

abstract：:Squamous cell carcinoma (SCC) of the skin represents a group of neoplasms which is associated with exposure to UV light. Recently, we obtained data suggesting that invasive skin cancer and its precursors derive from one original neoplastic clone. Here, the analysis were extended by loss of heterozygosity (LOH) analysi...

journal_title：Oncogene

authors： Ahmadian A,Ren ZP,Williams C,Pontén F,Odeberg J,Pontén J,Uhlén M,Lundeberg J

更新日期：1998-10-08 00:00:00

abstract：:We reported previously that the v-rel protein (p59v-rel) exists in a high molecular weight complex with at least four other proteins in the cytoplasm of v-rel-transformed chicken pre-B lymphoid cells (Simek, S. & Rice, N.R., J. Virol., 62, 4730-4736, 1989). One of these proteins is the chicken c-rel protein, but the i...

journal_title：Oncogene

authors： Kochel T,Mushinski JF,Rice NR

更新日期：1991-04-01 00:00:00

abstract：:Tumor suppressor p53 functions are downregulated in most cervical cancers, because the product of human papilloma virus (HPV) oncogene E6 binds to and inactivates p53 by promoting its degradation. p73, a p53 homologue, is similar to p53 in structure and function but yet not degraded by HPV E6 gene product. In this stu...

journal_title：Oncogene

authors： Das S,El-Deiry WS,Somasundaram K

更新日期：2003-11-20 00:00:00

abstract：:Cancer cells can use a variety of metabolic substrates to fulfill the bioenergetic and biosynthetic needs of their oncogenic program. Besides bioenergetics, cancer cell metabolism also directly influences genetic, epigenetic and signaling events associated with tumor progression. Many cancer cells are addicted to glut...

journal_title：Oncogene

authors： Cacace A,Sboarina M,Vazeille T,Sonveaux P

更新日期：2017-04-01 00:00:00

abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

journal_title：Oncogene

authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

更新日期：2005-08-04 00:00:00

abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

journal_title：Oncogene

authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

更新日期：1996-02-01 00:00:00

abstract：:Mutations of the RET proto-oncogene are found in the majority of patients with the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN 2). A minority of cases, however, have no detectable RET mutation and there is considerable phenotypic variation within and among MEN 2 families with the same RET mutati...

journal_title：Oncogene

authors： Vanhorne JB,Andrew SD,Harrison KJ,Taylor SA,Thomas B,McDonald TJ,Ainsworth PJ,Mulligan LM

更新日期：2005-02-03 00:00:00

abstract：:The REL gene is amplified in many human B-cell lymphomas and we have previously shown that expression of REL from a retroviral vector can malignantly transform chicken spleen cells in vitro. To identify REL protein functions necessary for malignant transformation, we have performed deletion analysis on REL sequences e...

journal_title：Oncogene

authors： Starczynowski DT,Reynolds JG,Gilmore TD

更新日期：2003-10-09 00:00:00

abstract：:Nuclear-enriched RNA-binding proteins (RBPs) are mainly involved in transcriptional regulation, which is a critical checkpoint to tune gene diversity and expression levels. We analyzed nuclear RBPs in human HCC tissues and matched normal control tissues. Based on the gene expression levels, PTBP3 was identified as top...

journal_title：Oncogene

authors： Yang X,Qu S,Wang L,Zhang H,Yang Z,Wang J,Dai B,Tao K,Shang R,Liu Z,Li X,Zhang Z,Xia C,Ma B,Liu W,Li H,Dou K

更新日期：2018-12-01 00:00:00