The adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300.

abstract：:Spindle cell sarcomas consist of tumors with different biological features, of which distant metastasis is the most ominous sign for a poor prognosis. However, metastasis is difficult to predict on the basis of current histopathological analyses. We have identified actin filament-associated protein 1-like 1 (AFAP1L1) ...

journal_title：Oncogene

authors： Furu M,Kajita Y,Nagayama S,Ishibe T,Shima Y,Nishijo K,Uejima D,Takahashi R,Aoyama T,Nakayama T,Nakamura T,Nakashima Y,Ikegawa M,Imoto S,Katagiri T,Nakamura Y,Toguchida J

更新日期：2011-09-22 00:00:00

abstract：:DNA methylation alterations are now widely recognized as a contributing factor in human tumorigenesis. A significant number of tumor suppressor genes are transcriptionally silenced by promoter hypermethylation, and recent research implicates alterations in chromatin structure as the mechanistic basis for this repressi...

journal_title：Oncogene

authors： Karpf AR,Jones DA

更新日期：2002-08-12 00:00:00

abstract：:The oncogene EWS-FLI1 encodes a chimeric transcription factor expressed in Ewing's sarcoma family tumors (ESFTs). EWS-FLI1 target gene expression is thought to drive ESFT pathogenesis and, therefore, inhibition of EWS-FLI1 activity holds high therapeutic promise. As the activity of many transcription factors is regula...

journal_title：Oncogene

authors： Bachmaier R,Aryee DN,Jug G,Kauer M,Kreppel M,Lee KA,Kovar H

更新日期：2009-03-05 00:00:00

abstract：:The tumor suppressor p53 transcriptionally regulates a large number of target genes that may affect cell growth and cell death pathways. To better understand the role of p53 loss in tumorigenesis, we have developed a mouse mammary cancer model, the Wnt-1 TG/p53 model. Wnt-1 transgenic females that are p53-/- develop m...

journal_title：Oncogene

authors： Cui XS,Donehower LA

更新日期：2000-12-07 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of t...

journal_title：Oncogene

authors： Kretschmer C,Murphy C,Biesinger B,Beckers J,Fickenscher H,Kirchner T,Fleckenstein B,Rüther U

更新日期：1996-04-18 00:00:00

abstract：:We have isolated rat cDNAs that encode two related receptor-like tyrosine kinases. One of these receptors, TIE-1, is the rat homolog of a recently described human receptor-like kinase termed TIE (Partanen et al., 1992). The related TIE-2 receptor has the same organization of amino acid sequence motifs characteristic o...

journal_title：Oncogene

authors： Maisonpierre PC,Goldfarb M,Yancopoulos GD,Gao G

更新日期：1993-06-01 00:00:00

abstract：:Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma cells. The activation of the erk cascade has been implicated in transducing the multitude of signals induced by NGF. In order to explore the role of this signaling cascade in NGF mediated survival, differentiation and proliferation, ...

journal_title：Oncogene

authors： Klesse LJ,Meyers KA,Marshall CJ,Parada LF

更新日期：1999-03-25 00:00:00

abstract：:Bracken fern is the environmental co-carcinogen of BPV-4 in the induction of neoplasias of the upper alimentary canal of cattle. The flavonoid quercetin is one of the most potent and best characterised mutagens present in the fern. We have shown that transfection with BPV-4 DNA and exposure to a single dose of quercet...

journal_title：Oncogene

authors： Connolly JA,Morgan IM,Jackson ME,Campo MS

更新日期：1998-05-28 00:00:00

abstract：:The steady-state levels of p53 mRNA were dramatically lower in immortal chicken embryo fibroblast (CEF) cell lines compared to primary CEF cells. In the presence of cycloheximide (CHX), the steady-state levels of p53 mRNA markedly increased in immortal CEF cell lines, similar to levels found in primary cells. The de n...

journal_title：Oncogene

authors： Kim H,You S,Foster LK,Farris J,Foster DN

更新日期：2001-08-23 00:00:00

abstract：:Ubiquilin1 (UBQLN1) is a ubiquitin-like domain and a ubiquitin-associated domain containing protein that has been reported to be involved in shuttling proteins to the proteasome, especially during endoplasmic reticulum-associated protein degradation. Thus, UBQLN1 function has been shown to be critical for combating a ...

journal_title：Oncogene

authors： Shah PP,Lockwood WW,Saurabh K,Kurlawala Z,Shannon SP,Waigel S,Zacharias W,Beverly LJ

更新日期：2015-03-26 00:00:00

abstract：:Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small inter...

journal_title：Oncogene

authors： Rzymski T,Milani M,Pike L,Buffa F,Mellor HR,Winchester L,Pires I,Hammond E,Ragoussis I,Harris AL

更新日期：2010-08-05 00:00:00

abstract：:Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth, differentiation and cell migration. In this study, we show that mammalian target of rapamycin complex 2 (mTORC2) regulates invasive cancer cell migration through selective activation of Akt1. Insuli...

journal_title：Oncogene

authors： Kim EK,Yun SJ,Ha JM,Kim YW,Jin IH,Yun J,Shin HK,Song SH,Kim JH,Lee JS,Kim CD,Bae SS

更新日期：2011-06-30 00:00:00

abstract：:Mutations in mismatch repair (MMR) genes result in microsatellite instability (MSI) and early onset of colorectal cancer. To get mechanistic insights into the time scale, sequence and frequency of intestinal stem cell (ISC) transformation, we quantified MSI and growth characteristics of organoids of Msh2-deficient and...

journal_title：Oncogene

authors： Keysselt K,Kreutzmann T,Rother K,Kerner C,Krohn K,Przybilla J,Buske P,Löffler-Wirth H,Loeffler M,Galle J,Aust G

更新日期：2017-05-11 00:00:00

abstract：:Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine...

journal_title：Oncogene

authors： Boggon TJ,Eck MJ

更新日期：2004-10-18 00:00:00

abstract：:We have established conditions for the immortalization of human fibroblasts by the large T antigen of the rodent virus polyoma. This allows the mechanism of immortalization to be studied, without interference by transformation events, in cells with relatively stable chromosomes. Large T antigen could immortalize human...

journal_title：Oncogene

authors： Strauss M,Hering S,Lubbe L,Griffin BE

更新日期：1990-08-01 00:00:00

abstract：:Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and displ...

journal_title：Oncogene

authors： Deblois G,St-Pierre J,Giguère V

更新日期：2013-07-25 00:00:00

abstract：:As leukemic transformation of myeloproliferative neoplasms (MPNs) worsens the clinical outcome, reducing the inherent risk of the critical event in MPN cases could be beneficial. Among genetic alterations concerning the transformation, the frequent one is TP53 mutation. Here we show that retroviral overexpression of J...

journal_title：Oncogene

authors： Tsuruta-Kishino T,Koya J,Kataoka K,Narukawa K,Sumitomo Y,Kobayashi H,Sato T,Kurokawa M

更新日期：2017-06-08 00:00:00

abstract：:The human DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed by most carcinomas of the breast and other epithelia. The contribution of MUC1 overexpression to the malignant phenotype is, however, not known. In the present studies, we have stably expressed MUC1 in rat 3Y1 fibroblasts. MUC1-positive cells were ...

journal_title：Oncogene

authors： Li Y,Liu D,Chen D,Kharbanda S,Kufe D

更新日期：2003-09-04 00:00:00

abstract：:Branching morphogenesis within the peripubertal mouse mammary gland is directed by progesterone (P). A role for the homeobox-containing transcription factor, Msx2, during branching morphogenesis is suggested from its ontogenic expression profile and hormonal regulation. Herein, we define the spatio-temporal control of...

journal_title：Oncogene

authors： Satoh K,Hovey RC,Malewski T,Warri A,Goldhar AS,Ginsburg E,Saito K,Lydon JP,Vonderhaar BK

更新日期：2007-11-29 00:00:00

abstract：:Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen. Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is most often increased in tumour cells. HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-...

journal_title：Oncogene

authors： Lincet H,Icard P

更新日期：2015-07-01 00:00:00

abstract：:Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, characterized by childhood sarcoma, leukemia and early onset breast cancer and has occasionally been found also in familial breast-ovarian cancer. Most mutations found are of missense type and located in the central regio...

journal_title：Oncogene

authors： Sun XF,Johannsson O,Håkansson S,Sellberg G,Nordenskjöld B,Olsson H,Borg A

更新日期：1996-07-18 00:00:00

abstract：:The phosphatidylinositol 3'-kinase (PI3K) pathway is dysregulated in multiple myeloma (MM); we therefore tested a highly selective class I PI3K inhibitor, GDC-0941, for anti-myeloma activity. Functional and mechanistic studies were first performed in MM cell lines, then extended to primary MM patient samples cultured ...

journal_title：Oncogene

authors： Munugalavadla V,Mariathasan S,Slaga D,Du C,Berry L,Del Rosario G,Yan Y,Boe M,Sun L,Friedman LS,Chesi M,Leif Bergsagel P,Ebens A

更新日期：2014-01-16 00:00:00

abstract：:p21(Waf1/Cip1) is a p53 transcription target implicated in both major functions of the tumor suppressor--cell cycle arrest and apoptosis. It is a potent inhibitor of the key cyclin-dependent kinases (CDK1-4), and has been thought to be the main mediator of p53-dependent G1 and G2 arrest. However, an increasing body of...

journal_title：Oncogene

authors： Xia M,Knezevic D,Vassilev LT

更新日期：2011-01-20 00:00:00

abstract：:The transcript encoding endonuclein, the human homolog of yeast PWP1, was previously found up-regulated in pancreatic cancer tissue. By immunohistochemistry we detected a ubiquitous presence in several tissues examined: skin, liver, thyroid gland, heart muscle, neurons, kidney, bladder, pancreas, adrenal gland, ovary,...

journal_title：Oncogene

authors： Honoré B,Baandrup U,Nielsen S,Vorum H

更新日期：2002-02-07 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...

journal_title：Oncogene

authors： Hsu PC,Gopinath RK,Hsueh YA,Shieh SY

更新日期：2019-02-01 00:00:00

abstract：:The genetic instability driving tumorigenesis is fueled by DNA damage and by errors made by the DNA replication. Upon DNA damage the cell organizes an integrated response not only by the classical DNA repair mechanisms but also involving mechanisms of replication, transcription, chromatin structure dynamics, cell cycl...

journal_title：Oncogene

authors： Ceruti JM,Scassa ME,Fló JM,Varone CL,Cánepa ET

更新日期：2005-06-09 00:00:00

abstract：:Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can...

journal_title：Oncogene

authors： Caracciolo V,Reiss K,Khalili K,De Falco G,Giordano A

更新日期：2006-08-28 00:00:00

abstract：:The most common mutations in the familial breast and ovarian cancer susceptibility gene BRCA1 are frameshift and nonsense mutations, which lead to the synthesis of truncated proteins. On this ground, we have analysed BRCA1 exon 11, which includes about 61% of coding region, in germline DNA from 70 Italian breast and/o...

journal_title：Oncogene

authors： De Benedetti VM,Radice P,Mondini P,Spatti G,Conti A,Illeni MT,Caligo MA,Cipollini G,Bevilaqua G,Pilotti S,Pierotti MA

更新日期：1996-09-19 00:00:00

abstract：:SHPTP2 is a ubiquitously-expressed SH2-containing tyrosine phosphatase that is tyrosine phosphorylated in response to activation of various receptor and nonreceptor tyrosine kinases. SHPTP2 associates with the platelet-derived growth factor (PDGF) receptor after ligand stimulation, and binding of SHPTP2 to this recept...

journal_title：Oncogene

authors： Keegan K,Cooper JA

更新日期：1996-04-04 00:00:00