Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.

abstract：:Expression of oncogenic H-Ras in 23A2 myoblasts (A2:H-Ras cells) is sufficient to induce both a transformed phenotype and a differentiation-defective phenotype. Because oncogenic Ras is known to induce the secretion of several different growth factors involved in maintaining the transformed phenotype of both fibroblas...

journal_title：Oncogene

authors： Weyman CM,Wolfman A

更新日期：1997-11-20 00:00:00

abstract：:Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...

journal_title：Oncogene

authors： Beristain AG,Molyneux SD,Joshi PA,Pomroy NC,Di Grappa MA,Chang MC,Kirschner LS,Privé GG,Pujana MA,Khokha R

更新日期：2015-02-26 00:00:00

abstract：:p73, a p53 family member, is highly similar to p53 in both structure and function. Like p53, the p73 protein contains an N-terminal activation domain, a DNA-binding domain, a tetramerization domain, and several PXXP motifs. Previously, we and others have shown that some functional domains in p53, such as the DNA-bindi...

journal_title：Oncogene

authors： Nozell S,Wu Y,McNaughton K,Liu G,Willis A,Paik JC,Chen X

更新日期：2003-07-10 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently needed. Inhibitors against programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have shown significant efficacy in various solid cancers, but their activity against T...

journal_title：Oncogene

authors： Castagnoli L,Cancila V,Cordoba-Romero SL,Faraci S,Talarico G,Belmonte B,Iorio MV,Milani M,Volpari T,Chiodoni C,Hidalgo-Miranda A,Tagliabue E,Tripodo C,Sangaletti S,Di Nicola M,Pupa SM

更新日期：2019-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...

journal_title：Oncogene

authors： Joseph J,Radulovich N,Wang T,Raghavan V,Zhu CQ,Tsao MS

更新日期：2020-01-01 00:00:00

abstract：:Deregulated expression of c-Myc has been shown to induce or enhance apoptosis in various different cell types. c-Myc requires p53 for apoptosis in some but not all the cell types, indicating heterogeneous mechanisms for c-Myc-induced apoptosis. In B lymphoma line WEHI-231, stable expression of c-Myc has been demonstra...

journal_title：Oncogene

authors： Hagiyama H,Adachi T,Yoshida T,Nomura T,Miyasaka N,Honjo T,Tsubata T

更新日期：1999-07-15 00:00:00

abstract：:Most normal cells require both mitogens and integrin-mediated attachment for growth. It is generally accepted that the p42/p44 MAP kinase module, which can be activated by both growth factors and adhesion, plays a critical role in G0 to S phase progression of quiescent cells. Studies on various cultured fibroblasts ha...

journal_title：Oncogene

authors： Le Gall M,Grall D,Chambard JC,Pouysségur J,Van Obberghen-Schilling E

更新日期：1998-09-10 00:00:00

abstract：:E2F is a complex family of transcription factors which appears to regulate the transcription of genes required for the S phase of the mammalian cell cycle. In the present work, we have examined the mechanisms regulating E2F-3 accumulation in mouse fibroblasts. We have determined that E2F-3 DNA binding activity is rest...

journal_title：Oncogene

authors： Flores AM,Kassatly RF,Cress WD

更新日期：1998-03-12 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) has pivotal roles during embryonic development and carcinoma progression. Members of the Snai1 family of zinc finger transcription factors are central mediators of EMT and induce EMT in part by directly repressing epithelial markers such as E-cadherin, a gatekeeper of the epithe...

journal_title：Oncogene

authors： Lin T,Ponn A,Hu X,Law BK,Lu J

更新日期：2010-09-02 00:00:00

abstract：:The extracellular matrix glycoprotein, fibronectin, influences a variety of cellular functions including adhesion, migration, survival, differentiation, and growth. Fibronectin has also been shown to increase the migration and proliferation of human lung carcinoma cells. However, the role of fibronectin in controlling...

journal_title：Oncogene

authors： Han SW,Roman J

更新日期：2006-07-20 00:00:00

abstract：:Hepatitis B virus (HBV)-induced liver necrosis takes great part in liver cirrhosis progression. However, less is known about whether hepatitis B virus X protein (HBx) has effect on liver fibrosis. Here, we report that HBV leads to liver fibrosis and hepatocarcinogenesis through miR-30e targeting P4HA2. HBV transgenic ...

journal_title：Oncogene

authors： Feng GX,Li J,Yang Z,Zhang SQ,Liu YX,Zhang WY,Ye LH,Zhang XD

更新日期：2017-12-14 00:00:00

abstract：:Recent genetic investigations have established that RhoB gain-of-function is sufficient to mediate the antitransforming effects of farnesyltransferase inhibitors (FTIs) in H-Ras-transformed fibroblast systems. In this study, we addressed the breadth and mechanism of RhoB action in epithelial cells transformed by oncop...

journal_title：Oncogene

authors： Zeng PY,Rane N,Du W,Chintapalli J,Prendergast GC

更新日期：2003-02-27 00:00:00

abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

journal_title：Oncogene

authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

更新日期：2004-10-14 00:00:00

abstract：:Antimicrobial peptides, such as the cathelicidin LL-37/hCAP-18 and its mouse homolog cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune system with direct anti-bacterial activity. Cathelicidin is possibly involved in the regulation of tumor cell growth. The aim of this stu...

journal_title：Oncogene

authors： Li D,Beisswenger C,Herr C,Schmid RM,Gallo RL,Han G,Zakharkina T,Bals R

更新日期：2014-05-22 00:00:00

abstract：:We have sought to identify and isolate target genes for the zinc finger protein, EVI-1, which has been implicated in the genesis of myelogenous leukemia both in mouse and human. We have approached this with a two-step selection: we first selected for genomic fragments of mouse DNA that bind to the protein with high af...

journal_title：Oncogene

authors： Kim JH,Hui P,Yue D,Aycock J,Leclerc C,Bjoring AR,Perkins AS

更新日期：1998-09-24 00:00:00

abstract：:Targeting Bruton tyrosine kinase (BTK) by ibrutinib is an effective treatment for patients with relapsed/refractory mantle cell lymphoma (MCL). However, both primary and acquired resistance to ibrutinib have developed in a significant number of these patients. A combinatory strategy targeting multiple oncogenic pathwa...

journal_title：Oncogene

authors： Li Y,Bouchlaka MN,Wolff J,Grindle KM,Lu L,Qian S,Zhong X,Pflum N,Jobin P,Kahl BS,Eickhoff JC,Wuerzberger-Davis SM,Miyamoto S,Thomas CJ,Yang DT,Capitini CM,Rui L

更新日期：2016-12-01 00:00:00

abstract：:The programmed cell death 4 (PDCD4) gene was originally identified as a tumor-related gene in humans and acts as a tumor-suppressor in mouse epidermal carcinoma cells. However, its function and regulatory mechanisms of expression in human cancer remain to be elucidated. We therefore investigated the expression of PDCD...

journal_title：Oncogene

authors： Zhang H,Ozaki I,Mizuta T,Hamajima H,Yasutake T,Eguchi Y,Ideguchi H,Yamamoto K,Matsuhashi S

更新日期：2006-10-05 00:00:00

abstract：:Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma subgroup by affecting expression levels of corresponding genes. This study analysed the relationship of 11q los...

journal_title：Oncogene

authors： Fischer M,Bauer T,Oberthür A,Hero B,Theissen J,Ehrich M,Spitz R,Eils R,Westermann F,Brors B,König R,Berthold F

更新日期：2010-02-11 00:00:00

abstract：:Observations that genome-wide DNA hypomethylation induces genome instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that allows the quantifi...

journal_title：Oncogene

authors： Maslov AY,Lee M,Gundry M,Gravina S,Strogonova N,Tazearslan C,Bendebury A,Suh Y,Vijg J

更新日期：2012-12-13 00:00:00

abstract：:The p53 gene has been implicated as a tumor suppressor gene with mutations found in common human cancers. We examined 51 early stage, primary, resected non-small cell lung cancer specimens using an RNAase protection assay and cDNA sequencing. Mutations changing the p53 coding sequence were found in 23/51 (45%) tumor s...

journal_title：Oncogene

authors： Chiba I,Takahashi T,Nau MM,D'Amico D,Curiel DT,Mitsudomi T,Buchhagen DL,Carbone D,Piantadosi S,Koga H

更新日期：1990-10-01 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...

journal_title：Oncogene

authors： Leung N,Turbide C,Olson M,Marcus V,Jothy S,Beauchemin N

更新日期：2006-09-07 00:00:00

abstract：:Neuroendocrine prostate cancer (NEPC) has increasingly become a clinical challenge. The mechanisms by which neuroendocrine (NE) cells arises from prostate adenocarcinoma cells are poorly understood. FOXA1 is a transcription factor of the forkhead family that is required for prostate epithelial differentiation. In this...

journal_title：Oncogene

authors： Kim J,Jin H,Zhao JC,Yang YA,Li Y,Yang X,Dong X,Yu J

更新日期：2017-07-13 00:00:00

abstract：:Transgenic mice expressing the c-Myc oncogene driven by woodchuck hepatitis virus (WHV) regulatory sequences develop hepatocellular carcinoma with a high frequency. To investigate genetic lesions that cooperate with Myc in liver carcinogenesis, we conducted a genome-wide scan for loss of heterozygosity (LOH) and mutat...

journal_title：Oncogene

authors： Wu Y,Renard CA,Apiou F,Huerre M,Tiollais P,Dutrillaux B,Buendia MA

更新日期：2002-02-28 00:00:00

abstract：:Due to its high proclivity to metastasize, and despite the recent development of targeted and immune therapy strategies, melanoma is still the deadliest form of skin cancer. Therefore, understanding the molecular mechanisms underlying melanoma invasion remains crucial. We previously characterized Tspan8 for its abilit...

journal_title：Oncogene

authors： El Kharbili M,Agaësse G,Barbollat-Boutrand L,Pommier RM,de la Fouchardière A,Larue L,Caramel J,Puisieux A,Berthier-Vergnes O,Masse I

更新日期：2019-05-01 00:00:00

abstract：:Ultraviolet light (UV) induced DNA lesions efficiently block transcript elongation and induce the p53 response. Although p53 contributes to transcriptional activation of the p21waf1 and bax genes, accumulation of these proteins requires that these genes are free of UV induced pyrimidine dimers. We assessed the level o...

journal_title：Oncogene

authors： McKay BC,Ljungman M,Rainbow AJ

更新日期：1998-08-06 00:00:00

abstract：:P16 was originally discovered by its ability to interact with CDK4 and to specifically inhibit the catalytic activity of the CDK4/D1 kinase. Increased attention has focused on the p16 gene because of its location on chromosome 9p21, a region involved in chromosomal rearrangements in a large number of tumor types. The ...

journal_title：Oncogene

authors： Wick ST,Dubay MM,Imanil I,Brizuela L

更新日期：1995-11-16 00:00:00

abstract：:The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...

journal_title：Oncogene

authors： Miyata Y,Yahara I

更新日期：2000-03-09 00:00:00

abstract：:The human papovaviruses BK virus (BKV) and JC virus (JCV) both encode a large-tumor (T) antigen which are highly homologous to each other as well as to simian virus 40 (SV40) large-T antigen. This high conservation of amino acid sequence has resulted in overlapping antigenicity such that immunological differentiation ...

journal_title：Oncogene

authors： Marshall J,Smith AE,Cheng SH

更新日期：1991-09-01 00:00:00

abstract：:The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...

journal_title：Oncogene

authors： O'Neil J,Look AT

更新日期：2007-10-15 00:00:00

abstract：:Pax3 is an evolutionarily conserved transcription factor that plays a major role in a variety of developmental processes. Mutations in Pax3 lead to severe malformations as seen in human Waardenburg syndrome and in the Splotch mutant mice. The transcriptional activity of Pax3 was recently shown to be repressed by Daxx ...

journal_title：Oncogene

authors： Lehembre F,Müller S,Pandolfi PP,Dejean A

更新日期：2001-01-04 00:00:00