Abstract:
:The human papovaviruses BK virus (BKV) and JC virus (JCV) both encode a large-tumor (T) antigen which are highly homologous to each other as well as to simian virus 40 (SV40) large-T antigen. This high conservation of amino acid sequence has resulted in overlapping antigenicity such that immunological differentiation of the large-T antigens from the three different viruses has been difficult. Here we describe the generation and characterization of a new monoclonal antibody (BK-T.1) which is specific for BKV large-T antigen and which does not cross-react with the other papovaviral T antigens. We show that when BK-T.1 is used in conjunction with preexisting monoclonal antibodies against SV40 large-T antigen, it is possible to identify the origin of papovavirus T antigens.
journal_name
Oncogenejournal_title
Oncogeneauthors
Marshall J,Smith AE,Cheng SHsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
1673-6issue
9eissn
0950-9232issn
1476-5594journal_volume
6pub_type
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