A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma.

abstract：:With the development of a specific anti-rab2 antiserum, p23rab2, a ras-like GTPase with a -GGGCC C-terminus, has been localized mainly to the particulate (P100) fraction in NIH3T3 cells, although a small amount of this protein also appears in the soluble fraction. The endogenous p23rab2 is isoprenylated in intact cell...

journal_title：Oncogene

authors： Wei C,Lutz R,Sinensky M,Macara IG

更新日期：1992-03-01 00:00:00

abstract：:14-3-3sigma proteins regulate numerous cellular processes that are important to cancer development. One of its biological roles involves G2 cell-cycle arrest following DNA damage. It has also been reported that the loss of 14-3-3sigma expression via CpG methylation may contribute to malignant transformation by impairi...

journal_title：Oncogene

authors： Pulukuri SM,Rao JS

更新日期：2006-08-03 00:00:00

abstract：:The 120 kD product of the c-cbl oncogene is rapidly tyrosine phosphorylated and recruited to the EGF receptor following ligand binding. Cbl's oncogenic potential is activated by a large carboxy-terminal truncation that generated v-cbl and removes the Ring finger and proline-rich SH3-binding domains. Here we show that ...

journal_title：Oncogene

authors： Thien CB,Langdon WY

更新日期：1997-05-08 00:00:00

abstract：:Syndecan-1 is a heparan sulfate proteoglycan (HSPG) commonly upregulated in AIDS-related B lymphoid malignancies. Tat is the main HIV-1 transactivating factor that has a major role in the pathogenesis of AIDS-related lymphomas (ARL) by engaging heparan sulfate proteoglycans (HSPGs), chemokine receptors and integrins a...

journal_title：Oncogene

authors： Urbinati C,Grillo E,Chiodelli P,Tobia C,Caccuri F,Fiorentini S,David G,Rusnati M

更新日期：2017-05-04 00:00:00

abstract：:Stimulator of interferon genes (STING) is a cellular sensor that controls cytosolic DNA-activated innate immune signaling. We have previously demonstrated that STING-deficient mice are resistant to carcinogen-induced skin cancer, similar to myeloid differentiation primary response gene 88 (MyD88) deficient mice, since...

journal_title：Oncogene

authors： Ahn J,Konno H,Barber GN

更新日期：2015-10-08 00:00:00

abstract：:WEE1 kinase has been described as a major gate keeper at the G2 cell cycle checkpoint and to be involved in tumour progression in different malignant tumours. Here we analysed the expression levels of WEE1 in a series of melanoma patient samples and melanoma cell lines using immunoblotting, quantitative real-time PCR ...

journal_title：Oncogene

authors： Bhattacharya A,Schmitz U,Wolkenhauer O,Schönherr M,Raatz Y,Kunz M

更新日期：2013-06-27 00:00:00

abstract：:The Wilms' tumor suppressor gene, WT1, functions as a transcriptional regulator that represses or activates the expression of a variety of putative target genes. However, it is not clear which genes are the biological targets of WT1, nor which cellular pathway(s) is critically altered in tumors as a result of WT1 muta...

journal_title：Oncogene

authors： Udtha M,Lee SJ,Alam R,Coombes K,Huff V

更新日期：2003-06-12 00:00:00

abstract：:Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in liver TIC self-renewal. However, the molecular mechanism of Wnt/β-catenin initiation in liver tumori...

journal_title：Oncogene

authors： Chen Z,Gao Y,Yao L,Liu Y,Huang L,Yan Z,Zhao W,Zhu P,Weng H

更新日期：2018-06-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemotherapeutic regimens. CD95L, the cognate ligand of CD95, can be cleaved by metalloproteases and released as a solu...

journal_title：Oncogene

authors： Edmond V,Dufour F,Poiroux G,Shoji K,Malleter M,Fouqué A,Tauzin S,Rimokh R,Sergent O,Penna A,Dupuy A,Levade T,Theret N,Micheau O,Ségui B,Legembre P

更新日期：2015-02-19 00:00:00

abstract：:Phosphorylation of linker histone H1(S)-3 (previously named H1b) and core histone H3 is elevated in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase (MAPK) kinase (MEK). H1(S)-3 phosphorylation is the only histone modification known to be dependent upon transcripti...

journal_title：Oncogene

authors： Chadee DN,Peltier CP,Davie JR

更新日期：2002-12-05 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected by stromal microenvironment. Based on previous observations that CLL cells exhibit mitochondrial dysfunction and altered lipid...

journal_title：Oncogene

authors： Liu PP,Liu J,Jiang WQ,Carew JS,Ogasawara MA,Pelicano H,Croce CM,Estrov Z,Xu RH,Keating MJ,Huang P

更新日期：2016-10-27 00:00:00

abstract：:Undifferentiated cells and embryos express high levels of endogenous non-telomerase reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT inhibitors modulate cell growth and differentiation in several cell lines. We have now sought to establish whether high levels of RT activity are d...

journal_title：Oncogene

authors： Sciamanna I,Landriscina M,Pittoggi C,Quirino M,Mearelli C,Beraldi R,Mattei E,Serafino A,Cassano A,Sinibaldi-Vallebona P,Garaci E,Barone C,Spadafora C

更新日期：2005-06-02 00:00:00

abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...

journal_title：Oncogene

authors： Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

更新日期：1998-03-26 00:00:00

abstract：:We show that SV40 infection of human mesothelial cells directly causes overexpression of Notch-1, a key cell regulatory gene. Notch-1 induction is achieved at the transcriptional level and requires both the SV40 large T-antigen and the small t-antigen. Notch-1 upregulation is maintained in SV40-transformed human mesot...

journal_title：Oncogene

authors： Bocchetta M,Miele L,Pass HI,Carbone M

更新日期：2003-01-09 00:00:00

abstract：:In this study, we examined the role of the E-cadherin-repressed gene human Nanos1 (hNanos1) in tumor invasion process. First, our in vivo study revealed that hNanos1 mRNAs were overexpressed in invasive lung carcinomas. Moreover, hNanos1 was co-localized with MT1-MMP (membrane type 1-matrix metalloproteinase) in E-cad...

journal_title：Oncogene

authors： Bonnomet A,Polette M,Strumane K,Gilles C,Dalstein V,Kileztky C,Berx G,van Roy F,Birembaut P,Nawrocki-Raby B

更新日期：2008-06-12 00:00:00

abstract：:Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular metabolism. One example of this is an antioxidant function th...

journal_title：Oncogene

authors： Itahana Y,Han R,Barbier S,Lei Z,Rozen S,Itahana K

更新日期：2015-04-02 00:00:00

abstract：:Overexpression of HER-2/neu (also known as c-erbB-2) proto-oncogene frequently occurs in many different types of human cancers, including ovarian carcinoma, and is known to enhance tumor metastasis and chemoresistance. Previous studies showed that inhibition of HER-2/neu expression by various agents, such as adenoviru...

journal_title：Oncogene

authors： Lin YC,Peng JM,Wang WB

更新日期：2000-05-18 00:00:00

abstract：:Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-re...

journal_title：Oncogene

authors： Peng F,Wang JH,Fan WJ,Meng YT,Li MM,Li TT,Cui B,Wang HF,Zhao Y,An F,Guo T,Liu XF,Zhang L,Lv L,Lv DK,Xu LZ,Xie JJ,Lin WX,Lam EW,Xu J,Liu Q

更新日期：2018-02-22 00:00:00

abstract：:Maspin has been demonstrated to be a suppressor of invasion and cell motility in vitro, whereas in vivo analyses have reported that increased expression of maspin is associated with malignant behavior. The present study examined maspin expression in normal lung and non-small-cell lung cancers. Only proximal airway cel...

journal_title：Oncogene

authors： Yatabe Y,Mitsudomi T,Takahashi T

更新日期：2004-05-20 00:00:00

abstract：:Ets1, the founder member of the Ets transcription factor family, is involved in a variety of developmental and cellular processes. Previous studies have shown that serine phosphorylation of Ets1 inhibits its DNA binding activity, suggesting that phosphorylation is important in the regulation of Ets1 function. To furth...

journal_title：Oncogene

authors： Rabault B,Roussel MF,Quang CT,Ghysdael J

更新日期：1996-08-15 00:00:00

abstract：:Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven dist...

journal_title：Oncogene

authors： Dhanasekaran N,Premkumar Reddy E

更新日期：1998-09-17 00:00:00

abstract：:Signal transducers and activators of transcription (Stats) are known to transduce signals from the cell surface to the nucleus in cytokine receptor signaling. We examined the capacity of platelet-derived growth factor (PDGF) receptor to interact with and activate Stat molecules. Activation of the PDGF beta-receptor le...

journal_title：Oncogene

authors： Valgeirsdóttir S,Paukku K,Silvennoinen O,Heldin CH,Claesson-Welsh L

更新日期：1998-01-29 00:00:00

abstract：:The E2F1 transcription factor, which is deregulated in most human cancers by mutations in the p16-cyclin D-Rb pathway, has both oncogenic and tumor-suppressive properties. This is dramatically illustrated by the phenotype of an E2F1 transgenic mouse model that spontaneously develops tumors in the skin and other epithe...

journal_title：Oncogene

authors： Russell JL,Weaks RL,Berton TR,Johnson DG

更新日期：2006-02-09 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) family members play pivotal roles in cell proliferation, differentiation and survival. Overexpression and mutations of EGFRs, or aberrant EGFR signaling are commonly associated with the development of various cancers, where constitutive NF-κB activation is often found to promote...

journal_title：Oncogene

authors： Jiang C,Zhu Y,Zhou Z,Gumin J,Bengtsson L,Wu W,Songyang Z,Lang FF,Lin X

更新日期：2017-05-18 00:00:00

abstract：:P53 wild-type and p53-null or mutant cells undergo a G(2)-phase cell-cycle arrest in response to ionizing radiation (IR). In this study we examined the effect of heat-shock protein 90 (HSP90) inhibitor, geldanamycin (GA), on IR-induced G(2) arrest in human colon adenocarcinoma cells with different p53 status. We show ...

journal_title：Oncogene

authors： Moran DM,Gawlak G,Jayaprakash MS,Mayar S,Maki CG

更新日期：2008-09-18 00:00:00

abstract：:Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation. The protein is predicted to have a tripartite domain structure, where the N- and C-terminal domains are linked through a coiled-coil mid-domain. Experimental analysis ...

journal_title：Oncogene

authors： Patzke S,Hauge H,Sioud M,Finne EF,Sivertsen EA,Delabie J,Stokke T,Aasheim HC

更新日期：2005-02-10 00:00:00

abstract：:Promoter hypermethylation is an important means for the transcriptional repression of a number of cancer-associated genes. However, the underlying mechanism of this aberration in cancer remains unclear. Here, we examined 5' CpG island methylation status and expression of the p14(ARF), p16(INK4a) and RASSF1A tumor supp...

journal_title：Oncogene

authors： Sato M,Horio Y,Sekido Y,Minna JD,Shimokata K,Hasegawa Y

更新日期：2002-07-18 00:00:00

abstract：:We have examined the mitogenic potential of platelet-derived growth factor (PDGF) on AIDS (acquired immune deficiency syndrome)-related and sporadic Kaposi's sarcoma cells in comparison to fibroblasts at physiological and subphysiological calcium concentrations of the culture medium. At low calcium concentrations in t...

journal_title：Oncogene

authors： Roth WK,Werner S,Schirren CG,Hofschneider PH

更新日期：1989-04-01 00:00:00

abstract：:Genetic and biochemical evidence suggest that conserved region 3 (CR3) of the adenovirus Ela polypeptide can provide two distinct and separable functions: an N-terminal transcriptional activation region and a C-terminal promoter targeting region. It is thought that the promoter targeting region of Ela CR3 interacts wi...

journal_title：Oncogene

authors： Agoff SN,Wu B

更新日期：1994-12-01 00:00:00