Abstract：
:Stimulator of interferon genes (STING) is a cellular sensor that controls cytosolic DNA-activated innate immune signaling. We have previously demonstrated that STING-deficient mice are resistant to carcinogen-induced skin cancer, similar to myeloid differentiation primary response gene 88 (MyD88) deficient mice, since the production of STING-dependent DNA-damage-induced proinflammatory cytokines, that likely require MyD88 signaling to exert their growth-promoting activity, are prevented. In contrast, MyD88-deficient mice are sensitive to colitis-associated cancer (CAC), since selected cytokines generated following DNA-damage also activate repair pathways, which can help prevent tumor development. Here, we demonstrate that STING signaling facilitates wound repair processes and that analogous to MyD88-deficient mice, STING-deficient mice (SKO) are prone to CAC induced by DNA-damaging agents. SKO mice harboring tumors exhibited low levels of tumor-suppressive interleukin-22 binding protein (IL-22BP) compared to normal mice, a cytokine considered critical for preventing colon-related cancer. Our data indicate that STING constitutes a critical component of the host early response to intestinal damage and is essential for invigorating tissue repair pathways that may help prevent tumorigenesis.
journal_name
Oncogenejournal_title
Oncogeneauthors
Ahn J,Konno H,Barber GNdoi
10.1038/onc.2014.457subject
Has Abstractpub_date
2015-10-08 00:00:00pages
5302-8issue
41eissn
0950-9232issn
1476-5594pii
onc2014457journal_volume
34pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:The products of two cellular proto-oncogenes c-fos and c-jun form a heterodimeric complex that contribute to the DNA-binding activity referred to as AP-1 (activator protein-1). Two domains have been proposed to be required for heterodimer formation and protein-DNA complex formation. The leucine zipper domain mediated ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Abnormalities of the p53 tumour suppressor gene occur in many types of cancer including approximately 60% of colorectal carcinomas. This study investigates in 47 colorectal carcinomas the relationship between stabilised p53 protein detected by immunocytochemistry (ICC), and p53 mutation. 27 cases stained positively wi...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:The transcription factor NF-kappa-B is normally sequestered in the cytoplasm by its inhibitory subunit IkappaB. Most extracellular signals activate NF-kappa-B through a mechanism involving the phosphorylation and proteasome-dependent degradation of IkappaB. EGF activates NF-kappaB in A-431 carcinoma cells, which overe...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201731
更新日期：1998-04-23 00:00:00
abstract：:Many anticancer drugs exert their cytotoxicity through DNA damage and induction of apoptosis. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) have different sensitivity to treatment with radiation and chemotherapeutic agents with SCLC being more sensitive than NSCLC both in vitro and in vivo...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204402
更新日期：2001-05-24 00:00:00
abstract：:Mcl-1 is an antiapoptotic member of the Bcl-2 family that can promote cell viability. We report here that Mcl-1 is a new substrate for caspases during induction of apoptosis. Mcl-1 cleavage occurs after Asp127 and Asp157 and generates four fragments of 24, 19, 17 and 12 kDa in both intact cells and in vitro, an effect...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208069
更新日期：2004-10-14 00:00:00
abstract：:The skin represents a physical and chemical barrier against invading pathogens, which is additionally supported by restriction factors that provide intrinsic cellular immunity. These factors detect viruses to block their replication cycle. Here, we uncover the Myb-related transcription factor, partner of profilin (MYP...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0398-6
更新日期：2018-11-01 00:00:00
abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-020-1343-z
更新日期：2020-07-01 00:00:00
abstract：:Transmembrane tyrosine kinases are involved in the control of cell growth and differentiation by extracellular signals. To enable identification of new receptor tyrosine kinases we developed a method that selectively amplifies segments of receptor genes. The method is based on a combination of polymerase chain reactio...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:DDB2, a gene mutated in XPE patients, is involved in global genomic repair especially the repair of cyclobutane pyrimidine dimers (CPDs), and is regulated by p53 in human cells. We show that DDB2 is expressed in mouse tissues and demonstrate, using primary mouse epithelial cells, that mouse DDB2 is regulated by E2F tr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210151
更新日期：2007-05-24 00:00:00
abstract：:Immunoreceptor tyrosine-based activation motifs (ITAMs) are involved in the transduction of signals necessary for activation, differentiation, and survival in hematopoietic cells. Several viruses have been shown to encode ITAM-containing transmembrane proteins. Although expression of these viral proteins has in some c...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209296
更新日期：2006-05-04 00:00:00
abstract：:MEK kinases (MEKKs) are serine-threonine kinases that regulate sequential protein phosphorylation pathways involving mitogen-activated protein kinases (MAPKs), including members of the Jun kinase (JNK) family. MEKK1 is a 196 kDa protein that when cleaved by caspase-3-like proteases generates an active COOH-terminal ki...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201421
更新日期：1997-11-13 00:00:00
abstract：:Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2015.503
更新日期：2016-08-18 00:00:00
abstract：:The Neuregulins and their receptors, the ErbB/HER subfamily of receptor tyrosine kinases, have critical roles in animal physiology, and their deregulation is frequent in cancer. Here we report the identification of the guanine nucleotide exchange factor, phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.489
更新日期：2011-03-03 00:00:00
abstract：:Retinoic acid receptor-beta (RAR beta) and signal transducer and activator of transcription 1 (STAT1) are important mediators of the antiproliferative and apoptotic actions of retinoids and cytokines/growth factors, respectively. Expression of both RAR beta and STAT1 is lost in most breast cancer cell lines but it can...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203084
更新日期：1999-11-18 00:00:00
abstract：:Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase which belongs to the insulin receptor superfamily and is mainly expressed in pre-B lymphocytes and neuronal tissues. Recently, we demonstrated that LTK utilizes Shc and IRS-1 as two major substrates and while both equally activate the Ras pathway, only IRS-...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201153
更新日期：1997-06-26 00:00:00
abstract：:ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208088
更新日期：2004-12-02 00:00:00
abstract：:MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer cell lines showed that miR-330 is a potential tumor-suppressor gene. However, the function and molec...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.192
更新日期：2009-09-24 00:00:00
abstract：:To investigate Mad1 function in vivo, transgenic mice were generated that express a Mad1 transgene in T lineage cells under the control of the proximal lck promoter. Thymus size in lck-Mad1 transgenic mice is drastically reduced although representation of the various thymocyte sub populations appears normal. To invest...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204196
更新日期：2001-03-08 00:00:00
abstract：:Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly associated with nuclear structures, it undergoes extensive autophosphorylation and phosphorylates myosin light chain and core histones H3, H2A and H4 in vitro. M...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203170
更新日期：1999-12-02 00:00:00
abstract：:Prostate stem cell antigen (PSCA) is a recently defined homologue of the Thy-1/Ly-6 family of glycosylphosphatidylinositol (GPI)-anchored cell surface antigens. PSCA mRNA is expressed in the basal cells of normal prostate and in more than 80% of prostate cancers. The purpose of the present study was to examine PSCA pr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203426
更新日期：2000-03-02 00:00:00
abstract：:Each step in the synthesis of functional transcript by RNA polymerase II provides a level at which gene expression can be regulated. Control over the elongation phase of transcription is a recognized regulatory mechanism in prokaryotes; however, only recently have examples of conditional transcription elongation block...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：
更新日期：1990-06-01 00:00:00
abstract：:BRCA1 and BRCA2 are breast cancer susceptibility genes. Mutations within BRCA1 and BRCA1 are responsible for most familial breast cancer cases. Targeted deletion of Brca1 or Brca2 in mice has revealed an essential function for their encoded products, BRCA1 and BRCA2, in cell proliferation during embryogenesis. Mouse m...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1203968
更新日期：2000-12-11 00:00:00
abstract：:Inherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investiga...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202847
更新日期：1999-08-12 00:00:00
abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.369
更新日期：2013-08-01 00:00:00
abstract：:Hepatocyte growth factor (HGF) is an important multifunctional cytokine whose gene expression is regulated mainly at the transcriptional level. Previous studies using transgenic mice as well as in vitro analyses showed that a potential regulatory element(s) exists between -260 to -230 bp in the upstream region of the ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203581
更新日期：2000-05-25 00:00:00
abstract：:A 56 kDa protein kinase was molecularly cloned from human fetal brain. This protein kinase (p56 KKIAMRE) shares homology with p42 KKIALRE (Meyerson et al., 1992) and is related to the proline-directed protein kinase group of signal transducing enzymes. The p56 KKIAMRE and p42 KKIALRE protein kinases exhibit mutually e...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-12-19 00:00:00
abstract：:Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-020-01495-6
更新日期：2020-12-01 00:00:00
abstract：:Expression of the avian E26-derived Gag-Myb-Ets fusion oncogene in interleukin-3(IL3)-dependent murine hematopoietic cell lines results in a pattern of cell line dependent changes in growth factor-induced proliferation and apoptosis. A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-01-18 00:00:00
abstract：:Prostate carcinoma (PCA) is the most frequently diagnosed malignancy in American men. PCA at advanced stages can both proliferate abnormally and resist apoptosis. Among the many known signal transduction pathways, phosphatidylinositide-3'OH kinase (PI3-kinase) has been shown to play an important role in cell survival ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202687
更新日期：1999-06-03 00:00:00
abstract：:The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and, rarely, late-onset Parkinson's disease, as the third large gene to be localized within a large CFS. Initial analyses of Parkin indicated th...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207072
更新日期：2003-11-13 00:00:00
