Transcription elongation and eukaryotic gene regulation.

Abstract:

:Each step in the synthesis of functional transcript by RNA polymerase II provides a level at which gene expression can be regulated. Control over the elongation phase of transcription is a recognized regulatory mechanism in prokaryotes; however, only recently have examples of conditional transcription elongation blockage been reported in eukaryotic cellular genes. In several cases, control over transcription elongation clearly contributes to the regulated expression of these genes. Indeed, reports that transcription by RNA polymerase II is initiated and paused on many Drosophila promoters, prior to induction of gene expression, suggests that release of an arrested polymerase, as opposed to polymerase recruitment to a disengaged promoter, may be the key regulatory step for many genes thought to be controlled by transcription initiation (Rougvie & Lis, 1988). RNA polymerase II undergoes modifications, such as association with ancillary elongation factors and phosphorylation of its large subunit carboxy terminal domain (CTD), at stages subsequent to recruitment to a promoter and establishment of a pre-initiation complex (Reinberg & Roeder, 1987; Rappaport et al., 1987; Payne et al., 1989; Laybourn & Dahmus, 1989). It is possible that modifications such as these, or others occurring prior to, during or following transcription initiation, may alter the holoenzyme's transcription elongation properties, to allow recognition or read-through of elongation block signals within a transcription unit. In this review, we will present features of transcription elongation blockage in several eukaryotic cellular genes in the context of our understanding of attenuation and premature transcription termination in prokaryotic and viral genes. We will also present evidence supporting the model that modifications to the RNA polymerase II transcription complex are pivotal to the control of transcriptional at the level of elongation.

journal_name

Oncogene

journal_title

Oncogene

authors

Spencer CA,Groudine M

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

777-85

issue

6

eissn

0950-9232

issn

1476-5594

journal_volume

5

pub_type

杂志文章,评审

相关文献

ONCOGENE文献大全
  • Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.

    abstract::The CUB domain-containing protein-1 (CDCP1) is a transmembrane molecule that has recently been implicated in cancer progression. In this study we have established a novel mechanism for initiation of CDCP1-mediated signaling in vivo and demonstrated that specific 135→70-kDa processing of cell-surface CDCP1 by extracell...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2011.555

    authors: Casar B,He Y,Iconomou M,Hooper JD,Quigley JP,Deryugina EI

    更新日期:2012-08-30 00:00:00

  • Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

    abstract::In this study we have surveyed by immunoblotting the protein levels of Cyclin D1, D2, D3 and their catalytic partners, Cdk4 and Cdk6 in normal and transformed human cells. We found that all these proteins were differentially expressed in diploid cells derived from different tissues, in contrast to Cyclin E, Cyclin A a...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Tam SW,Theodoras AM,Shay JW,Draetta GF,Pagano M

    更新日期:1994-09-01 00:00:00

  • A novel mitochondrial amidoxime reducing component 2 is a favorable indicator of cancer and suppresses the progression of hepatocellular carcinoma by regulating the expression of p27.

    abstract::Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality in the United States. Exploring the mechanism of HCC and identifying ideal targets is critical. In the present study, we demonstrated metabolism dysfunction might be a key diver for the development of HCC. The mitochondrial amidoxime...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/s41388-020-01417-6

    authors: Wu D,Wang Y,Yang G,Zhang S,Liu Y,Zhou S,Guo H,Liang S,Cui Y,Zhang B,Ma K,Zhang C,Liu Y,Sun L,Wang J,Liu L

    更新日期:2020-09-01 00:00:00

  • Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells.

    abstract::Treatment of quiescent Balb/3T3 clone A31-1-1 cells with 0.1-0.2 mM H2O2 in the presence of 1 microM insulin induced DNA synthesis 20-24 h later at almost the same level as that in cells treated with 10% serum. Treatment with 0.1-0.2 mM H2O2 alone did not induce DNA synthesis and was not toxic to the cells. Cell cycle...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Shibanuma M,Kuroki T,Nose K

    更新日期:1990-07-01 00:00:00

  • The PR status of the originating cell of ER/PR-negative mouse mammary tumors.

    abstract::Progesterone receptor (PR) is usually co-localized with estrogen receptor (ER) in normal mammary cells. It is not known whether ER/PR-negative human breast cancer arises from an ER/PR-negative cell or from an ER/PR-positive cell that later lost ER/PR. Using intraductal injection of a lentivirus to deliver both an onco...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2015.465

    authors: Dong J,Zhao W,Shi A,Toneff M,Lydon J,So D,Li Y

    更新日期:2016-08-04 00:00:00

  • Direct association of YY-1 with c-Myc and the E-box binding protein in regulation of glycophorin gene expression.

    abstract::We previously reported that YY-1, a versatile transcription factor, regulates expression of glycophorin gene by binding to its locus control region-like region (Gp-LCR) in combination with E-box binding protein during murine erythroleukemia (MEL) cell differentiation. In the present work, we demonstrated that YY-1 and...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202026

    authors: Zhao JH,Inoue T,Shoji W,Nemoto Y,Obinata M

    更新日期:1998-08-27 00:00:00

  • Direct cancer tissue proteomics: a method to identify candidate cancer biomarkers from formalin-fixed paraffin-embedded archival tissues.

    abstract::Successful treatment of multiple cancer types requires early detection and identification of reliable biomarkers present in specific cancer tissues. To test the feasibility of identifying proteins from archival cancer tissues, we have developed a methodology, termed direct tissue proteomics (DTP), which can be used to...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1209755

    authors: Hwang SI,Thumar J,Lundgren DH,Rezaul K,Mayya V,Wu L,Eng J,Wright ME,Han DK

    更新日期:2007-01-04 00:00:00

  • Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.

    abstract::The reciprocal chromosomal translocation t(4;11) is correlated with infant, childhood, adult and therapy-related high-risk acute leukemia. Here, we investigated the biological effects of MLL.AF4, AF4.MLL or the combination of both reciprocal fusion proteins in a conditional in vitro cell culture model system. Several ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1210125

    authors: Gaussmann A,Wenger T,Eberle I,Bursen A,Bracharz S,Herr I,Dingermann T,Marschalek R

    更新日期:2007-05-17 00:00:00

  • Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.

    abstract::The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1201980

    authors: Hallberg B,Ashcroft M,Loeb DM,Kaplan DR,Downward J

    更新日期:1998-08-13 00:00:00

  • The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library.

    abstract::Tumor suppressor p53 forms a homo-tetramer through its COOH-terminal oligomerization domain and acts as a sequence-specific transcription factor. We have analysed the interrelation among the transcriptional activities, the structure and the cancer-related mutations in the oligomerization domain by using a comprehensiv...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1208839

    authors: Kawaguchi T,Kato S,Otsuka K,Watanabe G,Kumabe T,Tominaga T,Yoshimoto T,Ishioka C

    更新日期:2005-10-20 00:00:00

  • Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-kappa B.

    abstract::TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-ind...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1201088

    authors: Ivanov VN,Lee RK,Podack ER,Malek TR

    更新日期:1997-05-22 00:00:00

  • Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O2.- upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells.

    abstract::Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2016.346

    authors: Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

    更新日期:2017-03-30 00:00:00

  • p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein.

    abstract::Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent gain-of-function mutation recognized in T-cell acute lymphoblastic leukemia (T-ALL). The TAL1 proteins contain a basic helix - loop - helix (bHLH) motif characteristic of a...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202889

    authors: Huang S,Qiu Y,Stein RW,Brandt SJ

    更新日期:1999-09-02 00:00:00

  • Platelet-activating factor activates mitogen-activated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells.

    abstract::Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid modulator of allergic and inflammatory reactions, is diverse and functions as a modulator of a variety of physiological and pathological events in many cell types and tissues. Its role (if any) in modulating the prolifera...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1206348

    authors: Wang H,Chakrabarty S

    更新日期:2003-04-10 00:00:00

  • Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells.

    abstract::Cells from patients with the human genetic disorder ataxia-telangiectasia (A-T) are defective in the activation of cell cycle checkpoints in response to ionizing radiation damage. In order to understand the role of ATM in checkpoint control we investigated whether Schizosaccaromyces pombe chk1, a protein kinase implic...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202257

    authors: Chen P,Gatei M,O'Connell MJ,Khanna KK,Bugg SJ,Hogg A,Scott SP,Hobson K,Lavin MF

    更新日期:1999-01-07 00:00:00

  • The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors.

    abstract::The membrane-anchored MMP-regulator RECK is down regulated in many solid tumors; the extent of RECK down regulation correlates with poor prognosis. Forced expression of RECK in tumor cells results in suppression of angiogenesis, invasion, and metastasis. Studies on the roles and the mechanisms of regulation of the REC...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1208733

    authors: Echizenya M,Kondo S,Takahashi R,Oh J,Kawashima S,Kitayama H,Takahashi C,Noda M

    更新日期:2005-09-01 00:00:00

  • MUC1-C activates BMI1 in human cancer cells.

    abstract::B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is a component of the polycomb repressive complex 1 (PRC1) complex that is overexpressed in breast and other cancers, and promotes self-renewal of cancer stem-like cells. The oncogenic mucin 1 (MUC1) C-terminal (MUC1-C) subunit is similarly overex...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2016.439

    authors: Hiraki M,Maeda T,Bouillez A,Alam M,Tagde A,Hinohara K,Suzuki Y,Markert T,Miyo M,Komura K,Ahmad R,Rajabi H,Kufe D

    更新日期:2017-05-18 00:00:00

  • Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.

    abstract::Mammalian nuclear Dbf2-related (NDR) kinases (LATS1 and 2, NDR1 and 2) play a role in cell proliferation, apoptosis and morphological changes. These kinases are regulated by mammalian sterile 20-like kinases (MSTs) and Mps one binder (MOB) 1. Okadaic acid (OA), which activates MST2, facilitates the complex formation o...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2008.66

    authors: Hirabayashi S,Nakagawa K,Sumita K,Hidaka S,Kawai T,Ikeda M,Kawata A,Ohno K,Hata Y

    更新日期:2008-07-17 00:00:00

  • Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy.

    abstract::Loss of RASSF1A leads to several mitotic abnormalities, including cytokinesis failure and tetraploidization. Uncontrolled proliferation of tetraploid cells is known to trigger genomic instability and tumor development and is normally prevented through activation of a p53-dependent tetraploidy checkpoint. RASSF1A is th...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2010.440

    authors: Tommasi S,Besaratinia A,Wilczynski SP,Pfeifer GP

    更新日期:2011-02-10 00:00:00

  • The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors.

    abstract::We have studied the relationship between ras-GAP and G protein coupled receptors in a proliferative setting comprised of NIH3T3 expressing transfected muscarinic receptors (mAChRs). GAP expression plasmids were engineered to encode wild-type GAP, its carboxyl-terminal catalytic domain, a mutant lacking a portion of th...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Xu N,McCormick F,Gutkind JS

    更新日期:1994-02-01 00:00:00

  • Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera.

    abstract::As leukemic transformation of myeloproliferative neoplasms (MPNs) worsens the clinical outcome, reducing the inherent risk of the critical event in MPN cases could be beneficial. Among genetic alterations concerning the transformation, the frequent one is TP53 mutation. Here we show that retroviral overexpression of J...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2016.478

    authors: Tsuruta-Kishino T,Koya J,Kataoka K,Narukawa K,Sumitomo Y,Kobayashi H,Sato T,Kurokawa M

    更新日期:2017-06-08 00:00:00

  • Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma.

    abstract::Matrix metalloproteinase-2 (MMP-2) has pivotal role in the degradation of extracellular matrix, and thereby enhances the invasive, proliferative and metastatic potential in cancer. Knockdown of MMP-2 using MMP-2 small interfering RNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2012.52

    authors: Kesanakurti D,Chetty C,Dinh DH,Gujrati M,Rao JS

    更新日期:2013-01-17 00:00:00

  • neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors.

    abstract::We have previously shown that each of four activated oncogenes (c-myc, neu, ras, and int-2) can serve as transgenic initiators of morphologically distinct adenocarcinomas of the murine mammary gland. Since abnormalities of these oncogenes are found frequently in human breast cancers, such differences are of particular...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Morrison BW,Leder P

    更新日期:1994-12-01 00:00:00

  • mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.

    abstract::Cancer cells harboring oncogenic BRaf mutants, but not oncogenic KRas mutants, are sensitive to MEK inhibitors (MEKi). The mechanism underlying the intrinsic resistance to MEKi in KRas-mutant cells is under intensive investigation. Here, we pursued this mechanism by live imaging of extracellular signal-regulated kinas...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2015.16

    authors: Komatsu N,Fujita Y,Matsuda M,Aoki K

    更新日期:2015-11-05 00:00:00

  • Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.

    abstract::Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle. Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary. In this study, ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202544

    authors: Ohtani K,Iwanaga R,Nakamura M,Ikeda M,Yabuta N,Tsuruga H,Nojima H

    更新日期:1999-04-08 00:00:00

  • Cancer whole-genome sequencing: present and future.

    abstract::Recent explosive advances in next-generation sequencing technology and computational approaches to massive data enable us to analyze a number of cancer genome profiles by whole-genome sequencing (WGS). To explore cancer genomic alterations and their diversity comprehensively, global and local cancer genome-sequencing ...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/onc.2015.90

    authors: Nakagawa H,Wardell CP,Furuta M,Taniguchi H,Fujimoto A

    更新日期:2015-12-03 00:00:00

  • Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.

    abstract::Long-lived species Homo sapiens have evolved robust protection mechanisms against cancer by repressing telomerase and maintaining short telomeres, thereby delaying the onset of the majority of cancer types until post-reproductive age. Indeed, telomerase is silent in most differentiated human cells, predominantly due t...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/s41388-019-0872-9

    authors: Yuan X,Larsson C,Xu D

    更新日期:2019-08-01 00:00:00

  • RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells.

    abstract::The S-phase kinase-associated protein-2 (SKP2) plays a key role in ubiquitin-mediated proteolysis, which results in the progression of cells from a quiescence to proliferative state. SKP2 is overexpressed in a variety of tumors. In this study, we used small interfering RNAs (siRNAs) to inhibit the SKP2 expression in l...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1208459

    authors: Jiang F,Caraway NP,Li R,Katz RL

    更新日期:2005-05-12 00:00:00

  • FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease.

    abstract::Identification of prostate cancers at high risk of progression is difficult and a better understanding of how peptide growth factors influence cellular function might be useful. Fibroblast growth factors (FGFs) have been implicated in prostate cancer development. FGF8 was identified in the Shionogi mouse mammary carci...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202624

    authors: Dorkin TJ,Robinson MC,Marsh C,Bjartell A,Neal DE,Leung HY

    更新日期:1999-04-29 00:00:00

  • Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis.

    abstract::Aurora kinases are known to play a key role in maintaining mitotic fidelity, and overexpression of aurora kinases has been noted in various tumors. Overexpression of aurora kinase activity is thought to promote cancer development through a loss of centrosome or chromosome number integrity. Here we observed augmentatio...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1208293

    authors: Tatsuka M,Sato S,Kitajima S,Suto S,Kawai H,Miyauchi M,Ogawa I,Maeda M,Ota T,Takata T

    更新日期:2005-02-03 00:00:00