当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.

Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.

Abstract：

:Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemotherapeutic regimens. CD95L, the cognate ligand of CD95, can be cleaved by metalloproteases and released as a soluble molecule (cl-CD95L). Unlike transmembrane CD95L, cl-CD95L does not induce apoptosis but triggers cell motility. Electron paramagnetic resonance was used to show that EMT and cl-CD95L treatment both led to augmentation of plasma membrane fluidity that was instrumental in inducing cell migration. Compaction of the plasma membrane is modulated, among other factors, by the ratio of certain lipids such as sphingolipids in the membrane. An integrative analysis of gene expression in NCI tumor cell lines revealed that expression of ceramide synthase-6 (CerS6) decreased during EMT. Furthermore, pharmacological and genetic approaches established that modulation of CerS6 expression/activity in cancer cells altered the level of C16-ceramide, which in turn influenced plasma membrane fluidity and cell motility. Therefore, this study identifies CerS6 as a novel EMT-regulated gene that has a pivotal role in the regulation of cell migration.

journal_name

Oncogene

journal_title

Oncogene

authors

Edmond V,Dufour F,Poiroux G,Shoji K,Malleter M,Fouqué A,Tauzin S,Rimokh R,Sergent O,Penna A,Dupuy A,Levade T,Theret N,Micheau O,Ségui B,Legembre P

doi

10.1038/onc.2014.55

subject

Has Abstract

pub_date

2015-02-19 00:00:00

pages

996-1005

issue

8

eissn

0950-9232

issn

1476-5594

pii

onc201455

journal_volume

34

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.

    abstract：:Previous studies have shown that the adenovirus E1A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300. In this study, wild-type E1A12S or two deletion mutants (delN, which binds pRb but not CBP/p300; delCR2, which binds to CBP/p300 bu...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205050

    authors： Chen Q,Ash JD,Branton P,Fromm L,Overbeek PA

    更新日期：2002-02-07 00:00:00

  • Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2.

    abstract：:The RBTN1 and RBTN2 genes are activated by distinct translocations involving chromosome 11 in some T cell acute leukaemias. The RBTN proteins belong to the LIM family which comprises proteins with one, two or three cysteine-rich LIM domains, sometimes together with homeodomains or protein kinase domains. The RBTN1 and...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Sánchez-García I,Axelson H,Rabbitts TH

    更新日期：1995-04-06 00:00:00

  • ATR mediates cisplatin resistance in a p53 genotype-specific manner.

    abstract：:The protein kinase encoded by the ataxia telangiectasia and Rad3-related (ATR) gene is activated by DNA-damaging agents that are frequently used as anticancer therapeutics. Inhibition of ATR expression in cultured cancer cells has been demonstrated to increase sensitivity to chemotherapeutic drugs, including the DNA-c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.624

    authors： Sangster-Guity N,Conrad BH,Papadopoulos N,Bunz F

    更新日期：2011-06-02 00:00:00

  • TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.

    abstract：:TEA domain (TEAD) transcription factors are key components of the Hippo-YAP1 signaling pathway, but their functional role and regulatory mechanisms remain unclear. This study aims to comprehensively explore the expression pattern and functional role of TEAD family in gastric carcinogenesis and investigate its regulati...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2017.257

    authors： Zhou Y,Huang T,Zhang J,Wong CC,Zhang B,Dong Y,Wu F,Tong JHM,Wu WKK,Cheng ASL,Yu J,Kang W,To KF

    更新日期：2017-11-23 00:00:00

  • PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2.

    abstract：:The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.213

    authors： Dong H,Ma L,Gan J,Lin W,Chen C,Yao Z,Du L,Zheng L,Ke C,Huang X,Song H,Kumar R,Yeung SC,Zhang H

    更新日期：2017-01-19 00:00:00

  • From smoking to lung cancer: the CHRNA5/A3/B4 connection.

    abstract：:Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiological processes ranging from neurotransmission to cancer signaling. These receptors are activated by the neurotransmitter, acetylcholine, and the tobacco alkaloid, nicotine. Recently, the gene cluster encoding the alpha3...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2010.256

    authors： Improgo MR,Scofield MD,Tapper AR,Gardner PD

    更新日期：2010-09-02 00:00:00

  • Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction.

    abstract：:Smad4 is a critical component in transforming growth factor beta (TGF-beta) signaling and frequently mutated in pancreatic and colorectal cancers. Smad4 has two important functional domains, MH1 and MH2, that are involved in different biological processes. The MH1 domain comprises a DNA binding domain and the MH2 doma...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207219

    authors： Kuang C,Chen Y

    更新日期：2004-02-05 00:00:00

  • Hereditary suppression of lethal (2) giant larvae malignant tumor development in Drosophila by gene transfer.

    abstract：:Homozygous mutations of the recessive oncogene lethal-(2) giant larvae (l(2)gl) of Drosophila melanogaster cause lethal neoplasms of the imaginal discs and the brain hemisphere. A 13-kb DNA segment spanning the l(2)gl+ locus has been inserted into P element vectors and used for P-mediated transformation. The P-l(2)gl+...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Opper M,Schuler G,Mechler BM

    更新日期：1987-05-01 00:00:00

  • Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1.

    abstract：:We tested the cytotoxic action of 8-hydroxyguanine (8ohG) by observing the viability of several leukemic cell lines (KG-1, U937, Jurkat and K 562) in the presence of 8-hydroxydeoxyguanosine (8ohdG), a nucleoside of 8ohG. It was found that 8ohdG showed cytotoxic action only to KG-1 and that only KG-1 showed a homozygou...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203787

    authors： Hyun JW,Choi JY,Zeng HH,Lee YS,Kim HS,Yoon SH,Chung MH

    更新日期：2000-09-14 00:00:00

  • p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer.

    abstract：:The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous cell carcinoma cell lines following irradiation. Isogenic p53-null radioresistant cancer cells established through cumulative irradi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0697-6

    authors： Chang HW,Kim MR,Lee HJ,Lee HM,Kim GC,Lee YS,Nam HY,Lee M,Jang HJ,Lee KE,Lee JC,Byun Y,Kim SW,Kim SY

    更新日期：2019-05-01 00:00:00

  • Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins.

    abstract：:An early event of cell migration is characterized as the rapid reorganization of the actin cytoskeleton. Recently, we have demonstrated that rapamycin inhibits tumor cell motility. To understand the underlying mechanism, this study was set to determine whether rapamycin inhibition of cell motility is related to its pr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.137

    authors： Liu L,Chen L,Chung J,Huang S

    更新日期：2008-08-28 00:00:00

  • CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation.

    abstract：:The matricellular protein CCN5/WISP-2 represents a promising target in triple-negative breast cancer (TNBC) because treatment or induced activation of CCN5 in TNBC cells promotes cell growth arrest at the G0/G1 phase, reduces cell proliferation and delays tumor growth in the xenograft model. Our studies found that the...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.250

    authors： Haque I,Banerjee S,De A,Maity G,Sarkar S,Majumdar M,Jha SS,McGragor D,Banerjee SK

    更新日期：2015-06-11 00:00:00

  • CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.

    abstract：:Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and is a promising drug target for osteo...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.340

    authors： Nie J,Liu L,Xing G,Zhang M,Wei R,Guo M,Li X,Xie P,Li L,He F,Han W,Zhang L

    更新日期：2014-07-10 00:00:00

  • An FGFR inhibitor converts the tumor promoting effect of TGF-β by the induction of fibroblast-associated genes of hepatoma cells.

    abstract：:Tumors consistently mimic wound-generating chronic inflammation; however, why they do not heal like wounds with fibrotic scars remains unknown. The components of the tumor microenvironment, such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGFs), may account for this phenomenon. Tumor formati...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.512

    authors： Zhang HR,Wang XD,Yang X,Chen D,Hao J,Cao R,Wu XZ

    更新日期：2017-07-06 00:00:00

  • Mutations in the thymidine kinase gene that allow expression of the enzyme in quiescent (G0) cells.

    abstract：:Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Kauffman MG,Rose PA,Kelly TJ

    更新日期：1991-08-01 00:00:00

  • MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.

    abstract：:The identification of target mRNAs is a key step for assessing the role of aberrantly expressed microRNAs in human cancer. MiR-221 is upregulated in human hepatocellular carcinoma (HCC) as well as in other malignancies. One proven target of miR-221 is CDKN1B/p27, whose downregulation affects HCC prognosis. Here, we pr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.178

    authors： Fornari F,Gramantieri L,Ferracin M,Veronese A,Sabbioni S,Calin GA,Grazi GL,Giovannini C,Croce CM,Bolondi L,Negrini M

    更新日期：2008-09-25 00:00:00

  • Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways.

    abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204629

    authors： David M,Ford D,Bertoglio J,Maizel AL,Pierre J

    更新日期：2001-10-11 00:00:00

  • Requirement of an ETS-binding element for transcription of the human lck type I promoter.

    abstract：:The requirement for cis-acting DNA sequences for transcriptional activity of the human lck type I promoter was investigated in two human cell lines that express type I transcripts, the leukemic T-cell line, Jurkat, and the colon carcinoma line, SW620. Transient transfection assays in Jurkat and SW620 cells revealed ne...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Leung S,McCracken S,Ghysdael J,Miyamoto NG

    更新日期：1993-04-01 00:00:00

  • Mechanistic insight into taxol-induced cell death.

    abstract：:We analysed the involvement of proteases during taxol-mediated cell death of human A549 non-small-cell lung carcinoma cells using a proteomics approach that specifically targets protein N termini and further detects newly formed N termini that are the result of protein processing. Our analysis revealed 27 protease-med...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.96

    authors： Impens F,Van Damme P,Demol H,Van Damme J,Vandekerckhove J,Gevaert K

    更新日期：2008-07-31 00:00:00

  • Alternative splicing in cancer: implications for biology and therapy.

    abstract：:Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest th...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2013.570

    authors： Chen J,Weiss WA

    更新日期：2015-01-02 00:00:00

  • Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects.

    abstract：:The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replication in mammalian cells. We show that RAD1 is an essential gene f...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207753

    authors： Bao S,Lu T,Wang X,Zheng H,Wang LE,Wei Q,Hittelman WN,Li L

    更新日期：2004-07-22 00:00:00

  • Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition.

    abstract：:The molecular interactions implicated in the mammalian G1/S cell cycle phase transition comprise a highly nonlinear network which can produce seemingly paradoxical results and make intuitive interpretations unreliable. A new approach to this problem is presented, consisting of (1) a convention of unambiguous reaction ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201608

    authors： Kohn KW

    更新日期：1998-02-26 00:00:00

  • Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3.

    abstract：:Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins. Though evidence supports a role for Gli action in prostate cancer (PCa) cell growth and prog...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-017-0098-7

    authors： Li N,Truong S,Nouri M,Moore J,Al Nakouzi N,Lubik AA,Buttyan R

    更新日期：2018-04-01 00:00:00

  • Proteomics analysis of H-RAS-mediated oncogenic transformation in a genetically defined human ovarian cancer model.

    abstract：:RAS is a small GTP binding protein mutated in approximately 30% human cancer. Despite its important role in the initiation and progression of human cancer, the underlying mechanism of RAS-induced human epithelial transformation remains elusive. In this study, we probe the cellular and molecular mechanisms of RAS-media...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208753

    authors： Young T,Mei F,Liu J,Bast RC Jr,Kurosky A,Cheng X

    更新日期：2005-09-08 00:00:00

  • Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.

    abstract：:Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon ti...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Mossie K,Jallal B,Alves F,Sures I,Plowman GD,Ullrich A

    更新日期：1995-11-16 00:00:00

  • Metabolic reprogramming of the tumor.

    abstract：:Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...

    journal_title：Oncogene

    pub_type： 历史文章,杂志文章,评审

    doi：10.1038/onc.2011.576

    authors： Ferreira LM,Hebrant A,Dumont JE

    更新日期：2012-09-06 00:00:00

  • Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.

    abstract：:The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor. Loss of pVHL function results in c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.160

    authors： Rankin EB,Rha J,Unger TL,Wu CH,Shutt HP,Johnson RS,Simon MC,Keith B,Haase VH

    更新日期：2008-09-11 00:00:00

  • The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

    abstract：:Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is crucially important, especially for those cases in which aberrant levels of regulatory proteins (e.g., beta-catenin, p27) result from a der...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202653

    authors： Latres E,Chiaur DS,Pagano M

    更新日期：1999-01-28 00:00:00

  • MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma.

    abstract：:In the childhood cancer neuroblastoma (NB), the level of expression of the multidrug resistance-associated protein (MRP1) gene is strongly correlated with expression of the MYCN oncogene in primary NB tumors, suggesting that MRP1 may be a target for MYCN-mediated gene regulation. In this study, we show that MYCN induc...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207151

    authors： Manohar CF,Bray JA,Salwen HR,Madafiglio J,Cheng A,Flemming C,Marshall GM,Norris MD,Haber M,Cohn SL

    更新日期：2004-01-22 00:00:00

  • Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes.

    abstract：:Genetic analysis of beta-catenin-induced oncogenic transformation in chicken embryo fibroblasts (CEF) revealed the following prerequisites for oncogenicity: (1) removal of the N terminal phosphorylation sites targeted by glycogen synthase kinase 3beta (GSK3beta), (2) retention of the N terminal transactivation domain,...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205796

    authors： Aoki M,Sobek V,Maslyar DJ,Hecht A,Vogt PK

    更新日期：2002-10-10 00:00:00