Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains.

abstract：:Esophageal cancer is one of the most lethal cancers worldwide with poor survival and limited therapeutic options. The discovery of microRNAs created a new milestone in cancer research. miR-377 is located in chromosome region 14q32, which is frequently deleted in esophageal squamous cell carcinoma (ESCC), but the biolo...

journal_title：Oncogene

authors： Li B,Xu WW,Han L,Chan KT,Tsao SW,Lee NPY,Law S,Xu LY,Li EM,Chan KW,Qin YR,Guan XY,He QY,Cheung ALM

更新日期：2017-07-13 00:00:00

abstract：:Gene silencing associated with aberrant methylation of promoter region CpG islands is one mechanism in which tumor suppressor genes are inactivated in human cancers. Recently, we identified a novel gene, Target of Methylation-associated Silencing-1 (TMS1) (also called ASC), which is aberrantly methylated and silenced ...

journal_title：Oncogene

authors： Levine JJ,Stimson-Crider KM,Vertino PM

更新日期：2003-05-29 00:00:00

abstract：:Although the prognosis of advanced extramammary Paget's disease (EMPD) is poor, there have been no preclinical research models for the development of novel therapeutics. This study aims to establish a preclinical research model for EMPD. We transplanted EMPD tissue into immunodeficient NOD/Scid mice. Histopathological...

journal_title：Oncogene

authors： Maeda T,Kitamura S,Nishihara H,Yanagi T

更新日期：2020-09-01 00:00:00

abstract：:Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins...

journal_title：Oncogene

authors： Li Y,Jaramillo-Lambert AN,Yang Y,Williams R,Lee NH,Zhu W

更新日期：2012-02-02 00:00:00

abstract：:PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of the CDK4 amplicon that is amplified in numerous human cancers. However, whether ...

journal_title：Oncogene

authors： Liu X,Hu Y,Hao C,Rempel SA,Ye K

更新日期：2007-07-26 00:00:00

abstract：:Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in liver TIC self-renewal. However, the molecular mechanism of Wnt/β-catenin initiation in liver tumori...

journal_title：Oncogene

authors： Chen Z,Gao Y,Yao L,Liu Y,Huang L,Yan Z,Zhao W,Zhu P,Weng H

更新日期：2018-06-01 00:00:00

abstract：:The RET proto-oncogene encodes a functional receptor tyrosine kinase (Ret) for the Glial cell line Derived Neurotrophic Factor (GDNF). RET is involved in several neoplastic and non-neoplastic human diseases. Oncogenic activation of RET is detected in human papillary thyroid tumours and in multiple endocrine neoplasia ...

journal_title：Oncogene

authors： Chiariello M,Visconti R,Carlomagno F,Melillo RM,Bucci C,de Franciscis V,Fox GM,Jing S,Coso OA,Gutkind JS,Fusco A,Santoro M

更新日期：1998-05-14 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling is dependent on the heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Activated TbetaRI then mediates TGF-beta signals by inducing the phosphorylation of Smad2 and/or Smad3, which separately hetetorodimerize ...

journal_title：Oncogene

authors： Kleeff J,Ishiwata T,Maruyama H,Friess H,Truong P,Büchler MW,Falb D,Korc M

更新日期：1999-09-23 00:00:00

abstract：:Small-cell lung cancer (SCLC) is an aggressive, rapidly metastasizing neoplasm. The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is constitutively secreted by marrow stromal cells and plays a key role for homing of hematopoietic cells to the marrow. Here, we report that tumor cells from patients with SCLC ex...

journal_title：Oncogene

authors： Burger M,Glodek A,Hartmann T,Schmitt-Gräff A,Silberstein LE,Fujii N,Kipps TJ,Burger JA

更新日期：2003-11-06 00:00:00

abstract：:A33 antigen is a membrane-bound protein that is expressed only in intestinal epithelium and in most human colon cancers. Thus, A33 antigen has been explored as a potential therapeutic target for the treatment of colon cancers. However, little is known about the mechanism responsible for the tissue-specific pattern of ...

journal_title：Oncogene

authors： Mao Z,Song S,Zhu Y,Yi X,Zhang H,Shang Y,Tong T

更新日期：2003-07-10 00:00:00

abstract：:The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30-40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen receptor-alpha (ERalpha) ...

journal_title：Oncogene

authors： Wen J,Li R,Lu Y,Shupnik MA

更新日期：2009-01-29 00:00:00

abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...

journal_title：Oncogene

authors： Green AL,DeSisto J,Flannery P,Lemma R,Knox A,Lemieux M,Sanford B,O'Rourke R,Ramkissoon S,Jones K,Perry J,Hui X,Moroze E,Balakrishnan I,O'Neill AF,Dunn K,DeRyckere D,Danis E,Safadi A,Gilani A,Hubbell-Engler B,Nus

更新日期：2020-03-01 00:00:00

abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...

journal_title：Oncogene

authors： Hsieh HY,Jou YC,Tung CL,Tsai YS,Wang YH,Chi CL,Lin RI,Hung SK,Chuang YM,Wu SF,Li C,Shen CH,Chan MWY,Hsu CD

更新日期：2018-02-01 00:00:00

abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...

journal_title：Oncogene

authors： Chatain N,Ziegler P,Fahrenkamp D,Jost E,Moriggl R,Schmitz-Van de Leur H,Müller-Newen G

更新日期：2013-08-01 00:00:00

abstract：:Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1...

journal_title：Oncogene

authors： Rondinelli RH,Haslam SZ,Fluck MM

更新日期：1995-11-02 00:00:00

abstract：:In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain (AG1521) before and after transfection with the E6 or E6/E7 genes of human papillomavirus 16 (HPV16)3. HPV E6 binds to p53, pr...

journal_title：Oncogene

authors： Tsang NM,Nagasawa H,Li C,Little JB

更新日期：1995-06-15 00:00:00

abstract：:The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. It is localized to human chromosome 10p14-15, a region that displays frequent loss of heterozygosity in glioblastoma multiforme (GBM). Indeed, mutations of the KLF6 gene have recently...

journal_title：Oncogene

authors： Kimmelman AC,Qiao RF,Narla G,Banno A,Lau N,Bos PD,Nuñez Rodriguez N,Liang BC,Guha A,Martignetti JA,Friedman SL,Chan AM

更新日期：2004-06-24 00:00:00

abstract：:Activation of the p53 tumor suppressor protein can lead to either cell cycle arrest or apoptosis. Several functional domains necessary for mediating cell cycle arrest and apoptosis in p53 have been mapped, e.g., the proline-rich domain. The proline-rich domain is located within residues 60-90, which comprise five PXXP...

journal_title：Oncogene

authors： Zhu J,Jiang J,Zhou W,Zhu K,Chen X

更新日期：1999-03-25 00:00:00

abstract：:The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite in...

journal_title：Oncogene

authors： Yuan Z,Sotsky Kent T,Weber TK

更新日期：2003-09-18 00:00:00

abstract：:Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Jun and DNA was determin...

journal_title：Oncogene

authors： Nicklin MJ,Zechner D,Kislyakova T

更新日期：1993-07-01 00:00:00

abstract：:LIM-kinase 2 (LIMK2) belongs to the LIMK family of proteins, which comprises LIMK1 and LIMK2. Both proteins regulate actin polymerization through phosphorylation and inactivation of the actin depolymerizing factor cofilin. In this study, we show that the level of LIMK2 protein is increased in neuroblastoma, BE(2)-C ce...

journal_title：Oncogene

authors： Po'uha ST,Shum MS,Goebel A,Bernard O,Kavallaris M

更新日期：2010-01-28 00:00:00

abstract：:Ras genes, frequently mutated in human tumors, promote malignant transformation. Ras transformation requires membrane anchorage, which is promoted by Ras farnesylcysteine carboxymethylester and by a second signal. Previously we showed that the farnesylcysteine mimetic, farnesylthiosalicylic acid (FTS) disrupts Ras mem...

journal_title：Oncogene

authors： Paz A,Haklai R,Elad-Sfadia G,Ballan E,Kloog Y

更新日期：2001-11-08 00:00:00

abstract：:Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-...

journal_title：Oncogene

authors： Nguyen A,Chang AC,Reddel RR

更新日期：2009-05-07 00:00:00

abstract：:The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellul...

journal_title：Oncogene

authors： Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJ

更新日期：1989-06-01 00:00:00

abstract：:Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they cause severe pain and bleeding, an...

journal_title：Oncogene

authors： Cao T,Jiang Y,Wang Z,Zhang N,Al-Hendy A,Mamillapalli R,Kallen AN,Kodaman P,Taylor HS,Li D,Huang Y

更新日期：2019-07-01 00:00:00

abstract：:Reactive oxygen species, which are prevalent in mitochondria, cause oxidative DNA damage including the mutagenic DNA lesion 7,8-dihydroxyguanine (8-oxoG). Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, and in cancer and aging. 8-oxoG is repai...

journal_title：Oncogene

authors： Stevnsner T,Nyaga S,de Souza-Pinto NC,van der Horst GT,Gorgels TG,Hogue BA,Thorslund T,Bohr VA

更新日期：2002-12-12 00:00:00

abstract：:Beta-catenin and plakoglobin are closely related armadillo family proteins with shared and distinct properties; Both are associated with cadherins in actin-containing adherens junctions. Plakoglobin is also found in desmosomes where it anchors intermediate filaments to the desmosomal plaques. Beta-catenin, on the othe...

journal_title：Oncogene

authors： Sadot E,Simcha I,Iwai K,Ciechanover A,Geiger B,Ben-Ze'ev A

更新日期：2000-04-13 00:00:00

abstract：:Hox genes encode DNA-binding proteins that are deployed in overlapping domains along various body axes during embryonic development. This sequential activation of Hox genes in temporal and spatial mode, the Hox code, is critical for the proper positioning of segmented structures along those axes, which include the ver...

journal_title：Oncogene

authors： He H,Hua X,Yan J

更新日期：2011-01-27 00:00:00

abstract：:There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well underst...

journal_title：Oncogene

authors： Kieran MW,Katz S,Vail B,Zon LI,Mayer BJ

更新日期：1999-11-18 00:00:00

abstract：:Imatinib-acquired resistance related to the presence of secondary point mutations has become a frequent event in gastrointestinal stromal tumors. Here, transient transfection experiments with plasmids carrying two different KIT-acquired point mutations were performed along with immunoprecipitation of total protein ext...

journal_title：Oncogene

authors： Tamborini E,Pricl S,Negri T,Lagonigro MS,Miselli F,Greco A,Gronchi A,Casali PG,Ferrone M,Fermeglia M,Carbone A,Pierotti MA,Pilotti S

更新日期：2006-10-05 00:00:00