Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions.

abstract：:Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of th...

journal_title：Oncogene

authors： John B,Naczki C,Patel C,Ghoneum A,Qasem S,Salih Z,Said N

更新日期：2019-05-01 00:00:00

abstract：:ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a ...

journal_title：Oncogene

authors： Slee EA,Gillotin S,Bergamaschi D,Royer C,Llanos S,Ali S,Jin B,Trigiante G,Lu X

更新日期：2004-12-02 00:00:00

abstract：:Mammalian Vav signal transducer proteins couple receptor tyrosine kinase signals to the activation of the Rho/Rac GTPases, leading to cell differentiation and/or proliferation. The unique and complex structure of mammalian Vav proteins is preserved in the Drosophila melanogaster homologue, DroVav. We demonstrate that ...

journal_title：Oncogene

authors： Hornstein I,Mortin MA,Katzav S

更新日期：2003-10-02 00:00:00

abstract：:The p53 gene is frequently mutated in cancers and it is vital for cell cycle control, homeostasis and carcinogenesis. We describe a novel p53 mutational spectrum, different to those generally observed in human and murine tumors. Our study shows a high prevalence of nonsense mutations in the p53 N terminus of 2-acetyla...

journal_title：Oncogene

authors： Melis JP,Hoogervorst EM,van Oostrom CT,Zwart E,Breit TM,Pennings JL,de Vries A,van Steeg H

更新日期：2011-04-14 00:00:00

abstract：:By NIH3T3 transfection assay in conjunction with in vitro transient neomycin selection, activated c-H-ras-1 oncogenes were detected in two squamous cell carcinoma cell lines, ZA and HOC-313, newly established from human oral cancer patients. ZA had a point mutational activation at the 13th codon, this activation of c-...

journal_title：Oncogene

authors： Tadokoro K,Ueda M,Ohshima T,Fujita K,Rikimaru K,Takahashi N,Enomoto S,Tsuchida N

更新日期：1989-04-01 00:00:00

abstract：:The myb family of genes encodes highly homologous nuclear transcription factors that play distinct roles in the development of breast, germ cells and hematoid organs. While the mechanisms associated with the regulation of these genes remain unknown, the transactivation of c-Myb was previously shown to be upregulated b...

journal_title：Oncogene

authors： Kang AD,Park G,Kim YH,Oh IH

更新日期：2004-05-20 00:00:00

abstract：:The Interleukin-1beta converting enzyme (ICE) family of proteins, homologs of the C elegans cell death gene product CED-3, play important roles in controlling vertebrate programmed cell death. Because inhibition of apoptosis may be an essential step in tumorigenesis, we investigated the interaction of the simian virus...

journal_title：Oncogene

authors： Jung YK,Yuan J

更新日期：1997-03-13 00:00:00

abstract：:The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of v...

journal_title：Oncogene

authors： Stebbing J,Lit LC,Zhang H,Darrington RS,Melaiu O,Rudraraju B,Giamas G

更新日期：2014-02-20 00:00:00

abstract：:Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...

journal_title：Oncogene

authors： Beristain AG,Molyneux SD,Joshi PA,Pomroy NC,Di Grappa MA,Chang MC,Kirschner LS,Privé GG,Pujana MA,Khokha R

更新日期：2015-02-26 00:00:00

abstract：:The VN-11 recombinant retroviruses, originally generated by co-transfection of the avian MH2 and AKRv viral genomes, were molecularly cloned from an infected mouse cell line named N11. The analysis of the proviral genome sequence from one of these recombinants showed a possible envAKR-mycMH2 fusion. Point mutations we...

journal_title：Oncogene

authors： Sassano M,Granucci F,Seveso M,Marconi G,Foti M,Ricciardi-Castagnoli P

更新日期：1994-05-01 00:00:00

abstract：:Tripartite motif 24 protein (TRIM24) is a plant homeodomain/bromodomain histone reader, recently associated with poor overall survival of breast-cancer patients. At a molecular level, TRIM24 is a negative regulator of p53 levels and a co-activator of estrogen receptor. However, the role of TRIM24 in breast tumorigenes...

journal_title：Oncogene

authors： Pathiraja TN,Thakkar KN,Jiang S,Stratton S,Liu Z,Gagea M,Shi X,Shah PK,Phan L,Lee MH,Andersen J,Stampfer M,Barton MC

更新日期：2015-05-28 00:00:00

abstract：:The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss als...

journal_title：Oncogene

authors： Hunter JE,Butterworth JA,Zhao B,Sellier H,Campbell KJ,Thomas HD,Bacon CM,Cockell SJ,Gewurz BE,Perkins ND

更新日期：2016-06-30 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple relate...

journal_title：Oncogene

authors： Malek SN

更新日期：2013-06-06 00:00:00

abstract：:Inter-alpha-trypsin inhibitors (ITIs) are protease inhibitors stabilizing the extracellular matrix. ITIs consist of one light (bikunin) and two heavy chains (ITIHs). We have recently characterized ITIH5, a novel member of the ITIH gene family, and showed that its messenger RNA is lost in a high proportion of breast tu...

journal_title：Oncogene

authors： Veeck J,Chorovicer M,Naami A,Breuer E,Zafrakas M,Bektas N,Dürst M,Kristiansen G,Wild PJ,Hartmann A,Knuechel R,Dahl E

更新日期：2008-01-31 00:00:00

abstract：:The most ominous development in tumor progression is the transition to an invasive and metastatic phenotype. Little is known, however, about the molecular alterations that cause a tumor to become invasive. In view of this, we have used microarray expression analysis to evaluate the expression profiles of a unique pane...

journal_title：Oncogene

authors： Manos EJ,Kim ML,Kassis J,Chang PY,Wells A,Jones DA

更新日期：2001-05-17 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is as...

journal_title：Oncogene

authors： Fleskens V,Mokry M,van der Leun AM,Huppelschoten S,Pals CE,Peeters J,Coenen S,Cardoso BA,Barata JT,van Loosdregt J,Coffer PJ

更新日期：2016-08-04 00:00:00

abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...

journal_title：Oncogene

authors： Bunone G,Mariotti A,Compagni A,Morandi E,Della Valle G

更新日期：1997-03-27 00:00:00

abstract：:Mutations in epidermal growth factor receptor (EGFR) kinase domain associate with clinical responses to EGFR inhibitors and are frequently observed in non-small cell lung cancer (NSCLC) patients in East Asian populations. Clinically identified EGFR mutations cause constitutive receptor activation. The activating mecha...

journal_title：Oncogene

authors： Fu YN,Yeh CL,Cheng HH,Yang CH,Tsai SF,Huang SF,Chen YR

更新日期：2008-02-07 00:00:00

abstract：:Cells from patients with the human genetic disorder ataxia-telangiectasia (A-T) are defective in the activation of cell cycle checkpoints in response to ionizing radiation damage. In order to understand the role of ATM in checkpoint control we investigated whether Schizosaccaromyces pombe chk1, a protein kinase implic...

journal_title：Oncogene

authors： Chen P,Gatei M,O'Connell MJ,Khanna KK,Bugg SJ,Hogg A,Scott SP,Hobson K,Lavin MF

更新日期：1999-01-07 00:00:00

abstract：:Genetic suppression of the neoplastic phenotype has been demonstrated in somatic cell hybrids between tumor and normal cells. Suppression in whole-cell and microcell hybrids cannot, as yet, be attributed to specific elements defined at the molecular level. To identify a gene capable of suppressing the neoplastic pheno...

journal_title：Oncogene

authors： Schäfer R,Nirkko AC,Ambühl PM,Grzeschik KH,Schwarte-Waldhoff I

更新日期：1991-12-01 00:00:00

abstract：:Emerging evidence has shown that cancer stem cells (CSCs) are the cellular determinants to promote cancer invasion and metastasis. However, the mechanism underlying CSC invasion remains unknown. MicroRNAs are evolutionally conserved small noncoding RNAs that are critical for the regulation of gene expression, and thei...

journal_title：Oncogene

authors： Wang Z,Wang B,Shi Y,Xu C,Xiao HL,Ma LN,Xu SL,Yang L,Wang QL,Dang WQ,Cui W,Yu SC,Ping YF,Cui YH,Kung HF,Qian C,Zhang X,Bian XW

更新日期：2015-03-12 00:00:00

abstract：:Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and displ...

journal_title：Oncogene

authors： Deblois G,St-Pierre J,Giguère V

更新日期：2013-07-25 00:00:00

abstract：:Constitutive activation of signal transducer and activator of transcription (STAT) proteins has been detected in a wide variety of human primary tumor specimens and tumor cell lines including blood malignancies, head and neck cancer, and breast cancer. We have previously demonstrated a high frequency of Stat3 DNA-bind...

journal_title：Oncogene

authors： Garcia R,Bowman TL,Niu G,Yu H,Minton S,Muro-Cacho CA,Cox CE,Falcone R,Fairclough R,Parsons S,Laudano A,Gazit A,Levitzki A,Kraker A,Jove R

更新日期：2001-05-03 00:00:00

abstract：:DNA adducts associated with tobacco smoking could provide a marker of biologically effective dose of tobacco carcinogens and improve individual cancer risk prediction. A significant number of clinical and epidemiologic studies have reported associations of increased DNA adduct levels with the occurrence of the prevale...

journal_title：Oncogene

authors： Wiencke JK

更新日期：2002-10-21 00:00:00

abstract：:Replication origins are 'licensed' for a single initiation event by loading Mcm2-7 complexes during late mitosis and G1. Licensing is blocked at other cell cycle stages by the activity of cyclin-dependent kinases and a small protein called geminin. Here, we describe the effects of over-expressing a non-degradable form...

journal_title：Oncogene

authors： Shreeram S,Sparks A,Lane DP,Blow JJ

更新日期：2002-09-26 00:00:00

abstract：:Glioblastoma is the most common and lethal primary malignant brain tumor in adults. The tumor suppressor gene PTEN is deleted, mutated or hypermethylated in more than 60% of glioblastoma cases resulting in hyperactivation of the phosphoinositide 3-kinase pathway, which leads to sustained PI(3,4,5)P3 signaling, and the...

journal_title：Oncogene

authors： Davies EM,Kong AM,Tan A,Gurung R,Sriratana A,Bukczynska PE,Ooms LM,McLean CA,Tiganis T,Mitchell CA

更新日期：2015-07-01 00:00:00

abstract：:The membrane-anchored MMP-regulator RECK is down regulated in many solid tumors; the extent of RECK down regulation correlates with poor prognosis. Forced expression of RECK in tumor cells results in suppression of angiogenesis, invasion, and metastasis. Studies on the roles and the mechanisms of regulation of the REC...

journal_title：Oncogene

authors： Echizenya M,Kondo S,Takahashi R,Oh J,Kawashima S,Kitayama H,Takahashi C,Noda M

更新日期：2005-09-01 00:00:00

abstract：:The antifolates were the first class of antimetabolites to enter the clinics more than 50 years ago. Over the following decades, a full understanding of their mechanisms of action and chemotherapeutic potential evolved along with the mechanisms by which cells develop resistance to these drugs. These principals served ...

journal_title：Oncogene

authors： Zhao R,Goldman ID

更新日期：2003-10-20 00:00:00

abstract：:The cochaperone CDC37 promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions. HSP90 inhibitors induce depletion of clients, which include several oncogenic kinases. We hypothesized that the targeting of CDC37 using siRNAs would compromis...

journal_title：Oncogene

authors： Smith JR,Clarke PA,de Billy E,Workman P

更新日期：2009-01-15 00:00:00

abstract：:An early event of cell migration is characterized as the rapid reorganization of the actin cytoskeleton. Recently, we have demonstrated that rapamycin inhibits tumor cell motility. To understand the underlying mechanism, this study was set to determine whether rapamycin inhibition of cell motility is related to its pr...

journal_title：Oncogene

authors： Liu L,Chen L,Chung J,Huang S

更新日期：2008-08-28 00:00:00