Abstract:
:Esophageal cancer is one of the most lethal cancers worldwide with poor survival and limited therapeutic options. The discovery of microRNAs created a new milestone in cancer research. miR-377 is located in chromosome region 14q32, which is frequently deleted in esophageal squamous cell carcinoma (ESCC), but the biological functions, clinical significance and therapeutic implication of miR-377 in ESCC are largely unknown. In this study, we found that miR-377 expression was significantly downregulated in tumor tissue and serum of patients with ESCC. Both tumor tissue and serum miR-377 expression levels were positively correlated with patient survival. Higher serum miR-377 expression was inversely associated with pathologic tumor stage, distant metastasis, residual tumor status and chemoradiotherapy resistance. The roles of miR-377 in suppressing tumor initiation and progression, and the underlying molecular mechanisms were investigated. Results of in vitro and in vivo experiments showed that miR-377 overexpression inhibited the initiation, growth and angiogenesis of ESCC tumors as well as metastatic colonization of ESCC cells, whereas silencing of miR-377 had opposite effects. Mechanistically, miR-377 regulated CD133 and VEGF by directly binding to their 3' untranslated region. Moreover, systemic delivery of formulated miR-377 mimic not only suppressed tumor growth in nude mice but also blocked tumor angiogenesis and metastasis of ESCC cells to the lungs without overt toxicity to mice. Collectively, our study established that miR-377 plays a functional and significant role in suppressing tumor initiation and progression, and may represent a promising non-invasive diagnostic and prognostic biomarker and therapeutic strategy for patients with ESCC.
journal_name
Oncogenejournal_title
Oncogeneauthors
Li B,Xu WW,Han L,Chan KT,Tsao SW,Lee NPY,Law S,Xu LY,Li EM,Chan KW,Qin YR,Guan XY,He QY,Cheung ALMdoi
10.1038/onc.2017.29subject
Has Abstractpub_date
2017-07-13 00:00:00pages
3986-4000issue
28eissn
0950-9232issn
1476-5594pii
onc201729journal_volume
36pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::O-linked glycans of secreted and membrane-bound proteins have an important role in the pathogenesis of pancreatic cancer by modulating immune responses, inflammation and tumorigenesis. A critical aspect of O-glycosylation, the position at which proteins are glycosylated with N-acetyl-galactosamine on serine and threon...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.194
更新日期:2011-12-08 00:00:00
abstract::Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experiments, we determined invadopodia contain receptors involved in chemota...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0667-4
更新日期:2019-05-01 00:00:00
abstract::Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1362-9
更新日期:2020-07-01 00:00:00
abstract::Acquired therapeutic resistance is the major drawback to effective systemic therapies for cancers. Aggressive triple-negative breast cancers (TNBC) develop resistance to chemotherapies rapidly, whereas the underlying mechanisms are not completely understood. Here we show that genotoxic treatments significantly increas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.189
更新日期:2016-03-10 00:00:00
abstract::Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205957
更新日期:2002-10-24 00:00:00
abstract::Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of cyclin D1 correlates with MCL development, expression of wild-type (WT) cyclin D1 transgene in murine lymphocytes is unable to drive B-cell lymphoma. As cyclin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209147
更新日期:2006-02-16 00:00:00
abstract::We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs. Furthermore, we show functional interchangeability with hTERT in in vitro telomeras...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201933
更新日期:1998-04-02 00:00:00
abstract::Expression of the p75 neurotrophin receptor (p75(NTR)) in primary melanomas is associated with deeply invasive lesions. In turn, there is expression of high levels of neurotrophins at the invasion front of normal tissue adjacent to brain metastases, thus implicating this growth factor-receptor system in melanoma tumor...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206561
更新日期:2003-06-05 00:00:00
abstract::MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2009.353
更新日期:2008-12-01 00:00:00
abstract::Post-translational acetylation of lysines is most extensively studied in histones, but this modification is also found in many other proteins and is implicated in a wide range of biological processes in both the cell nucleus and the cytoplasm. Like phosphorylation, acetylation patterns and levels are often altered in ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2014.453
更新日期:2015-09-17 00:00:00
abstract::SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING protein required for the activity of Cullin-RING ligase (CRL). Our recent study showed that Sag total knockout caused embryonic lethality at E11.5-12.5 days with associated defects in vasculogenesis. Whether Sag is required for de novo vasculogen...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.473
更新日期:2014-10-30 00:00:00
abstract::Interleukin-8 (IL-8), a chemokine implicated in the metastasis and angiogenesis of a variety of cancers, has been reported to be overexpressed in prostate cancer. In this study, we ascribe a new role for IL-8 in prostate cancer progression using LNCaP cells. We demonstrate that IL-8 activates the androgen receptor and...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207344
更新日期:2004-03-18 00:00:00
abstract::We evaluated the effect of nitric oxide (NO) on vascular endothelial growth factor (VEGF) gene expression in human A-172 glioblastoma cells and human HepG2 hepatocellular carcinoma cells. The mRNA level of VEGF increased in response to S-Nitroso-N-acetyl-D,L-penicillamine (SNAP) in both cell lines, and increased in mR...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201201
更新日期:1997-07-24 00:00:00
abstract::The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205374
更新日期:2002-04-25 00:00:00
abstract::To investigate the tumorigenic potential of mutant p53 when selectively expressed in lung tissue, a transgenic mouse model was developed in which a mutant form of p53 (p53-273H) was placed under the transcriptional control of the lung-specific human surfactant protein C (SP-C) promoter. Two founder mice were identifie...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205909
更新日期:2002-11-07 00:00:00
abstract::Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0728-3
更新日期:2019-05-01 00:00:00
abstract::Acute myeloid leukemia 1 (AML1) gene on chromosome 21 is involved in several chromosomal translocations, including t(8;21) and t(16;21), that produce chimeric fusion proteins AML1-eight twenty-one (ETO) and AML-myeloid transforming gene chromosome 16 (MTG16), which contribute to leukemogenesis. The molecular basis for...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209431
更新日期:2006-06-29 00:00:00
abstract::The cellular and molecular mechanisms of tumor progression following chemotherapy are largely unknown. Here, we demonstrate that cisplatin (CDDP) treatment upregulates VEGF and Flt1 expression leading to the survival and expansion of a highly tumorigenic fraction of side-population (SP) cells in osteosarcoma (HOS), ne...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.38
更新日期:2008-06-26 00:00:00
abstract::Oxygen is the ultimate source of oxidizing power for disulfide bond formation, suggesting that under limiting oxygen proper protein folding might be compromised. We show that secretion of vascular endothelial growth factor (VEGF), a protein with multiple disulfide bonds, was indeed impeded under hypoxia and was partia...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208325
更新日期:2005-02-03 00:00:00
abstract::PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by influencing the expression, protein stability and subcellular location of cyclin D1. Here, we provide evidence that PTEN modulates the tran...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210033
更新日期:2007-04-12 00:00:00
abstract::The E2F1 transcription factor binds to sites within the promoters of a number of cell cycle regulated genes through a basic-helix-loop-helix motif (bHLH). It is shown here that the basic region of E2F1 is distinct from that of all other bHLH proteins. The center of the basic region contains a helix breaking proline-gl...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Neuroblastoma (Nb) is a malignancy of the sympathetic nervous system which affects children in their first decade. It is the most common extra-cranial solid tumor in children with an incidence of approximately 1 in 8-10 000 live births annually and accounts for approximately 10% of all children's cancers. Ganglioneuro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205734
更新日期:2002-08-29 00:00:00
abstract::A 56 kDa protein kinase was molecularly cloned from human fetal brain. This protein kinase (p56 KKIAMRE) shares homology with p42 KKIALRE (Meyerson et al., 1992) and is related to the proline-directed protein kinase group of signal transducing enzymes. The p56 KKIAMRE and p42 KKIALRE protein kinases exhibit mutually e...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-12-19 00:00:00
abstract::Telomerase expression is the hallmark of tumor cells in which this ribonucleoprotein complex preserves chromosome integrity by maintaining telomere length and thereby prevents cell death. However, recent data support a role of the combination of p53 and telomerase inactivation in initiating genetic instability that pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206468
更新日期:2003-06-12 00:00:00
abstract::Poly(ADP-ribose) polymerase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress early-onset T-lineage lymphomas in the mouse, but the underlying mechanisms have remained unknown. To address this question, we analyzed a series of lymphomas arising in PARP1(-/-)...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.199
更新日期:2013-04-04 00:00:00
abstract::Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta signaling in human tumor cell lines. Some of these GTPases are post-translationally modified by farnesylation, a lipid modification catalyzed by farnesyltransferase and required for the proteins to attach to membranes and to function. I...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203920
更新日期:2000-11-16 00:00:00
abstract::Hepatocyte growth factor (HGF) is an important multifunctional cytokine whose gene expression is regulated mainly at the transcriptional level. Previous studies using transgenic mice as well as in vitro analyses showed that a potential regulatory element(s) exists between -260 to -230 bp in the upstream region of the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203581
更新日期:2000-05-25 00:00:00
abstract::Somatostatin receptors (sst1-5) are present in different types of tumors, where they inhibit key cellular processes such as proliferation and invasion. Although ssts are densely expressed in breast cancer, especially sst2, their role and therapeutic potential remain uncertain. Recently, we identified a new truncated s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.389
更新日期:2012-04-19 00:00:00
abstract::Many cells die with apoptotic morphology and with documented activation of an effector caspase, but there are also many exceptions. Cells frequently display activation of other proteases, including granzymes, lysosomal cathepsins, matrix metalloproteinases, and proteasomal proteases, and others display morphologies th...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207514
更新日期:2004-04-12 00:00:00