Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis.

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that tran...

journal_title：Oncogene

authors： Matsuoka M,Jeang KT

更新日期：2011-03-24 00:00:00

abstract：:Liver metastasis remains a serious problem in the management of gastric cancer (GC). Our aims were to identify through transcriptome analysis a molecule that mediates hepatic metastasis in GC, and to evaluate its potential as a diagnostic marker and a therapeutic target. The effects of knocking out a relevant molecule...

journal_title：Oncogene

authors： Kanda M,Tanaka H,Shimizu D,Miwa T,Umeda S,Tanaka C,Kobayashi D,Hattori N,Suenaga M,Hayashi M,Iwata N,Yamada S,Fujiwara M,Kodera Y

更新日期：2018-09-01 00:00:00

abstract：:We previously showed that the proto-oncogene RON encodes the tyrosine kinase receptor for Macrophage Stimulating Protein (MSP), originally isolated as a chemotactic factor for peritoneal macrophages. To elucidate the biological role of MSP we studied the expression of the Ron receptor in vivo, and the response to the ...

journal_title：Oncogene

authors： Gaudino G,Avantaggiato V,Follenzi A,Acampora D,Simeone A,Comoglio PM

更新日期：1995-12-21 00:00:00

abstract：:The extracellular matrix glycoprotein, fibronectin, influences a variety of cellular functions including adhesion, migration, survival, differentiation, and growth. Fibronectin has also been shown to increase the migration and proliferation of human lung carcinoma cells. However, the role of fibronectin in controlling...

journal_title：Oncogene

authors： Han SW,Roman J

更新日期：2006-07-20 00:00:00

abstract：:Several lines of evidence suggest that gastrin and the CCK-2 receptor (CCK2R) could contribute to pancreatic carcinogenesis by modulating processes such as proliferation, cell adhesion or migration. In the current study, we used a 'cancer gene array' and identified beta1-integrin subunit as a new gastrin-regulated gen...

journal_title：Oncogene

authors： Cayrol C,Clerc P,Bertrand C,Gigoux V,Portolan G,Fourmy D,Dufresne M,Seva C

更新日期：2006-07-27 00:00:00

abstract：:Acetylation is thought to be a key event for p53 activation. We demonstrate that p14ARF-induced senescence of human mammary epithelial cells (MEC) is associated with p53 acetylation and requires hAda3, a component of histone acetyltransferase complexes and a p53 transcriptional coactivator. Expression of the N-termina...

journal_title：Oncogene

authors： Sekaric P,Shamanin VA,Luo J,Androphy EJ

更新日期：2007-09-20 00:00:00

abstract：:After publication of this Article, the Authors noticed errors in some of the Figures. In Figures 2e, 2f-g, 4a, 4j, 5a and 6b, unmatched β-actin was inadvertently used as loading control for the immunoblots. These have been corrected using repeat data from a similar set of samples and the revised Figures containing mat...

journal_title：Oncogene

authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

更新日期：2020-10-01 00:00:00

abstract：:We have isolated rat cDNAs that encode two related receptor-like tyrosine kinases. One of these receptors, TIE-1, is the rat homolog of a recently described human receptor-like kinase termed TIE (Partanen et al., 1992). The related TIE-2 receptor has the same organization of amino acid sequence motifs characteristic o...

journal_title：Oncogene

authors： Maisonpierre PC,Goldfarb M,Yancopoulos GD,Gao G

更新日期：1993-06-01 00:00:00

abstract：:The cancer chemopreventive synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR) can inhibit the growth and induce apoptosis of tumor cells. In this study we analysed the growth suppressive effect of HPR on human breast cancer cell lines in vitro and the role of the retinoblastoma protein (pRb) in this response. Trea...

journal_title：Oncogene

authors： Panigone S,Debernardi S,Taya Y,Fontanella E,Airoldi R,Delia D

更新日期：2000-08-17 00:00:00

abstract：:Understanding how disruption of differentiation contributes to the cancer cell phenotype is required to identify alterations essential for malignant transformation and provide experimental basis for their correction. We investigated whether primary quail neuroretina cells, transformed by a conditional v-Src mutant (QN...

journal_title：Oncogene

authors： Mateos S,Amarir S,Laugier D,Marx M,Calothy G

更新日期：2007-05-17 00:00:00

abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...

journal_title：Oncogene

authors： Green AL,DeSisto J,Flannery P,Lemma R,Knox A,Lemieux M,Sanford B,O'Rourke R,Ramkissoon S,Jones K,Perry J,Hui X,Moroze E,Balakrishnan I,O'Neill AF,Dunn K,DeRyckere D,Danis E,Safadi A,Gilani A,Hubbell-Engler B,Nus

更新日期：2020-03-01 00:00:00

abstract：:Inactivation of the transforming growth factor-beta (TGF-beta) pathway occurs often in malignancies of the gastrointestinal (GI) system. However, only a fraction of sporadic GI tumors exhibit inactivating mutations in early stages of cancer formation, suggesting that other mechanisms play a critical role in the inacti...

journal_title：Oncogene

authors： Katuri V,Tang Y,Li C,Jogunoori W,Deng CX,Rashid A,Sidawy AN,Evans S,Reddy EP,Mishra B,Mishra L

更新日期：2006-03-23 00:00:00

abstract：:Tumor suppressor Pdcd4 has recently been shown to inhibit invasion by activating activator protein-1 (AP-1); however, little is known of the functionally significant Pdcd4-target genes. The urokinase receptor (u-PAR) promotes invasion/metastasis, and is associated with poor cancer-patient survival. The present study w...

journal_title：Oncogene

authors： Leupold JH,Yang HS,Colburn NH,Asangani I,Post S,Allgayer H

更新日期：2007-07-05 00:00:00

abstract：:Granulocyte macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5 belong to a family of cytokines that regulate proliferation, differentiation and function of haematopoietic cells. Their receptor consists of a ligand specific alpha-chain and a signal transducing beta-chain (betac)...

journal_title：Oncogene

authors： Geijsen N,Spaargaren M,Raaijmakers JA,Lammers JW,Koenderman L,Coffer PJ

更新日期：1999-09-09 00:00:00

abstract：:The regulation of cell adhesion and motility in human prostate is not well understood. We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion. Endoglin is a transmembrane transforming growth factor beta binding protein typically expressed by endothelial cells....

journal_title：Oncogene

authors： Liu Y,Jovanovic B,Pins M,Lee C,Bergan RC

更新日期：2002-11-28 00:00:00

abstract：:Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o...

journal_title：Oncogene

authors： Mysliwiec T,Perego R,Kruh GD

更新日期：1996-02-01 00:00:00

abstract：:FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues for the constitutive act...

journal_title：Oncogene

authors： Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y

更新日期：2005-12-08 00:00:00

abstract：:The nuclear transport receptor importin-β/karyopherin-β1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. In addition to its role in nucleo-cytoplasmic transport, importin-β regulates mitosis, but the programmes and pathways i...

journal_title：Oncogene

authors： Verrico A,Rovella P,Di Francesco L,Damizia M,Staid DS,Le Pera L,Schininà ME,Lavia P

更新日期：2020-01-01 00:00:00

abstract：:Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that is mutated in the Simpson-Golabi-Behmel syndrome. This is an X-linked condition characterized by overgrowth, and various visceral and skeletal dysmorphisms. The phenotype of the Simpson-Golabi-Behmel syndrome patients and GPC3-deficient mice, as w...

journal_title：Oncogene

authors： Xiang YY,Ladeda V,Filmus J

更新日期：2001-11-01 00:00:00

abstract：:Mutations in VHL underlie von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome with several subtypes depending on the risk of developing certain combination of classic features, such as clear cell renal cell carcinoma (ccRCC), hemangioblastoma and pheochromocytoma. Although numerous potential substrates and f...

journal_title：Oncogene

authors： Tarade D,Ohh M

更新日期：2018-01-11 00:00:00

abstract：:The t(8;21) is associated with 12-15% of acute myelogenous leukemias of the M2 subtype. The translocation results in the fusion of two genes, AML1 (CBFA2) on chromosome 21 and ETO (MTG8) on chromosome 8. AML1 encodes a DNA binding factor; the ETO protein product is less well characterized, but is thought to be a trans...

journal_title：Oncogene

authors： Davis JN,Williams BJ,Herron JT,Galiano FJ,Meyers S

更新日期：1999-02-11 00:00:00

abstract：:The Ewing sarcoma is the second most common bone tumor in children and young adults. Despite the advances in therapy, the 5-year survival rate for patients with metastatic disease is poor, indicating the need for alternative treatments. Here, we report that 2-methoxy-estradiol (2-Me), a natural estrogen metabolite, in...

journal_title：Oncogene

authors： Djavaheri-Mergny M,Wietzerbin J,Besançon F

更新日期：2003-05-01 00:00:00

abstract：:Wnt/β-catenin signaling is one of the key cascades regulating embryogenesis and tissue homeostasis; it has also been intimately associated with carcinogenesis. This pathway is deregulated in several tumors, including colorectal cancer, breast cancer, and desmoid tumors. It has been shown that CTNNB1 exon 3 mutations a...

journal_title：Oncogene

authors： Braggio D,Zewdu A,Londhe P,Yu P,Lopez G,Batte K,Koller D,Costas Casal de Faria F,Casadei L,Strohecker AM,Lev D,Pollock RE

更新日期：2020-08-01 00:00:00

abstract：:We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...

journal_title：Oncogene

authors： Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

更新日期：2003-10-30 00:00:00

abstract：:P21waf1/cip1 is a potent inhibitor of cell cycle progression and can inhibit the growth of both normal cells and cells transformed by a number of oncogenes. However, the ability of p21waf1/cip1 to inhibit the growth of cells that overexpress the transcriptional transactivator E2F1 is controversial: it has been reporte...

journal_title：Oncogene

authors： Givol I,Givol D,Hughes SH

更新日期：1998-06-18 00:00:00

abstract：:In this age of targeted therapy, identification of molecular pathways that are deregulated in cancer will not only elucidate underlying tumorigenic mechanisms, but may also help to determine the classes of drugs that are used for treatment. In kidney cancer, a spectrum of histological subtypes exists that are characte...

journal_title：Oncogene

authors： Furge KA,Tan MH,Dykema K,Kort E,Stadler W,Yao X,Zhou M,Teh BT

更新日期：2007-02-26 00:00:00

abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...

journal_title：Oncogene

authors： Olmeda D,Jordá M,Peinado H,Fabra A,Cano A

更新日期：2007-03-22 00:00:00

abstract：:Reduced co-expression of the c-fos and c-jun protooncogenes has been correlated with the down regulation of H-2K class I major histocompatibility antigens in high-metastatic cell lines from the Lewis lung carcinoma, B16 melanoma and the K1735 melanoma. Transfection of c-jun and c-fos genes into the high metastatic clo...

journal_title：Oncogene

authors： Yamit-Hezi A,Plaksin D,Eisenbach L

更新日期：1994-04-01 00:00:00

abstract：:Although cell invasion is a necessary early step in cancer metastasis, its regulation is not well understood. We have previously shown, in human prostate cancer, that transforming growth factor beta (TGFbeta)-mediated increases in cell invasion are dependent upon activation of the serine/threonine kinase, p38 MAP kina...

journal_title：Oncogene

authors： Xu L,Chen S,Bergan RC

更新日期：2006-05-18 00:00:00

abstract：:The SCL/TAL1 gene was originally identified by virtue of its rearrangement and transcriptional activation in patients with T cell acute lymphoblastic leukaemia. It encodes a helix-loop-helix transcription factor, is not normally expressed in T cells, but is expressed in erythroid, mast, megakaryocytic and progenitor c...

journal_title：Oncogene

authors： Murrell AM,Bockamp EO,Göttgens B,Chan YS,Cross MA,Heyworth CM,Green AR

更新日期：1995-07-06 00:00:00