Interferon-gamma suppresses transforming growth factor-beta-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model.

abstract：:The HER-2/neu proto-oncogene is homologous with, but distinct from, the epidermal growth factor receptor. Current evidence indicates that this gene is frequently amplified and/or overexpressed in some human breast and ovarian cancers and that these alterations may be clinically important; however, little is known abou...

journal_title：Oncogene

authors： Press MF,Cordon-Cardo C,Slamon DJ

更新日期：1990-07-01 00:00:00

abstract：:TFAP2C/AP-2γ influences development of the mammary gland and regulates patterns of gene expression in luminal and HER2-amplified breast cancer. The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to cancer progression remain poorly understood. To gain greater insight into oncogenic mechanisms r...

journal_title：Oncogene

authors： Park JM,Wu T,Cyr AR,Woodfield GW,De Andrade JP,Spanheimer PM,Li T,Sugg SL,Lal G,Domann FE,Zhang W,Weigel RJ

更新日期：2015-12-10 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...

journal_title：Oncogene

authors： Altieri DC

更新日期：2003-11-24 00:00:00

abstract：:Dysregulated microRNA (miRNA) mediate malignant phenotypes, including metabolic reprogramming. By performing an integrative analysis of miRNA and metabolome data for the NCI-60 cell line panel, we identified an miRNA cluster strongly associated with both c-Myc expression and global metabolic variation. Within this clu...

journal_title：Oncogene

authors： Koufaris C,Valbuena GN,Pomyen Y,Tredwell GD,Nevedomskaya E,Lau CH,Yang T,Benito A,Ellis JK,Keun HC

更新日期：2016-05-01 00:00:00

abstract：:Unique hybrids (HINS and CANS lines) between macrophages and a myeloma cell line, NS1 initially expressed myeloma functions but later expressed active macrophage functions together with constitutive expression of c-fos gene. Enhancement of c-fos transcription was also observed in activated mouse peritoneal macrophages...

journal_title：Oncogene

authors： Higuchi Y,Setoguchi M,Yoshida S,Akizuki S,Yamamoto S

更新日期：1988-05-01 00:00:00

abstract：:Topoisomerase IIalpha (topoIIalpha) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry because of insuffici...

journal_title：Oncogene

authors： Bower JJ,Karaca GF,Zhou Y,Simpson DA,Cordeiro-Stone M,Kaufmann WK

更新日期：2010-08-26 00:00:00

abstract：:Imatinib-acquired resistance related to the presence of secondary point mutations has become a frequent event in gastrointestinal stromal tumors. Here, transient transfection experiments with plasmids carrying two different KIT-acquired point mutations were performed along with immunoprecipitation of total protein ext...

journal_title：Oncogene

authors： Tamborini E,Pricl S,Negri T,Lagonigro MS,Miselli F,Greco A,Gronchi A,Casali PG,Ferrone M,Fermeglia M,Carbone A,Pierotti MA,Pilotti S

更新日期：2006-10-05 00:00:00

abstract：:Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can...

journal_title：Oncogene

authors： Caracciolo V,Reiss K,Khalili K,De Falco G,Giordano A

更新日期：2006-08-28 00:00:00

abstract：:The oncogene EWS-FLI1 encodes a chimeric transcription factor expressed in Ewing's sarcoma family tumors (ESFTs). EWS-FLI1 target gene expression is thought to drive ESFT pathogenesis and, therefore, inhibition of EWS-FLI1 activity holds high therapeutic promise. As the activity of many transcription factors is regula...

journal_title：Oncogene

authors： Bachmaier R,Aryee DN,Jug G,Kauer M,Kreppel M,Lee KA,Kovar H

更新日期：2009-03-05 00:00:00

abstract：:A wealth of cytogenetic data has demonstrated that numerous somatic genetic changes are involved in the pathogenesis of human lung cancer. Despite the complexity of the genomic changes observed in these neoplasms, recurrent chromosomal patterns have emerged. In this review, we summarize chromosomal alterations identif...

journal_title：Oncogene

authors： Balsara BR,Testa JR

更新日期：2002-10-07 00:00:00

abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

journal_title：Oncogene

authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

更新日期：2004-04-15 00:00:00

abstract：:The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different c...

journal_title：Oncogene

authors： Ling LS,Voskas D,Woodgett JR

更新日期：2013-11-21 00:00:00

abstract：:Exposure of normal adult human skin to doses of UV irradiation that induced mild sunburn resulted in the rapid appearance of p53 protein in the epidermis and superficial dermal fibroblasts. Immunohistological analysis with a panel of antibodies established that while p53 staining was not seen in normal skin it appeare...

journal_title：Oncogene

authors： Hall PA,McKee PH,Menage HD,Dover R,Lane DP

更新日期：1993-01-01 00:00:00

abstract：:The gene for von Recklinghausen neurofibromatosis type 1 (NF1) was recently identified by positional cloning and found to encode a protein with sequence similarity to a family of eucaryotic GTPase-activating proteins (GAPs). Expression of the NF1-GAP-related domain (NF1GRD) has been shown to complement yeast strains d...

journal_title：Oncogene

authors： Gutmann DH,Boguski M,Marchuk D,Wigler M,Collins FS,Ballester R

更新日期：1993-03-01 00:00:00

abstract：:Tek/Tie2 is an endothelial cell-specific receptor tyrosine kinase that has been shown to play a role in vascular development of the mouse. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathway(s) mediated by this rec...

journal_title：Oncogene

authors： Jones N,Dumont DJ

更新日期：1998-09-03 00:00:00

abstract：:Cellular senescence functions as a tumor suppressor that protects against cancer progression. α-Catulin, an α-catenin-related protein, is reported to have tumorigenic potential because it regulates the nuclear factor-κB (NF-κB) pathway, but little is known about its clinical relevance and the mechanism through which i...

journal_title：Oncogene

authors： Fan LC,Chiang WF,Liang CH,Tsai YT,Wong TY,Chen KC,Hong TM,Chen YL

更新日期：2011-06-09 00:00:00

abstract：:The transcription factor NF-kappa-B is normally sequestered in the cytoplasm by its inhibitory subunit IkappaB. Most extracellular signals activate NF-kappa-B through a mechanism involving the phosphorylation and proteasome-dependent degradation of IkappaB. EGF activates NF-kappaB in A-431 carcinoma cells, which overe...

journal_title：Oncogene

authors： Sun L,Carpenter G

更新日期：1998-04-23 00:00:00

abstract：:The carboxyl terminus of c-Myb contains a negative regulatory domain that is absent in the v-Myb oncoprotein, but conserved among all the known Myb proteins of animals. This domain inhibits transcriptional activation by c-Myb in animal cells, but not in budding yeast, suggesting that additional protein(s) present in a...

journal_title：Oncogene

authors： Ladendorff NE,Wu S,Lipsick JS

更新日期：2001-01-04 00:00:00

abstract：:Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that is mutated in the Simpson-Golabi-Behmel syndrome. This is an X-linked condition characterized by overgrowth, and various visceral and skeletal dysmorphisms. The phenotype of the Simpson-Golabi-Behmel syndrome patients and GPC3-deficient mice, as w...

journal_title：Oncogene

authors： Xiang YY,Ladeda V,Filmus J

更新日期：2001-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer cell lines showed that miR-330 is a potential tumor-suppressor gene. However, the function and molec...

journal_title：Oncogene

authors： Lee KH,Chen YL,Yeh SD,Hsiao M,Lin JT,Goan YG,Lu PJ

更新日期：2009-09-24 00:00:00

abstract：:The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino a...

journal_title：Oncogene

authors： Tamagnone L,Partanen J,Armstrong E,Lasota J,Ohgami K,Tazunoki T,LaForgia S,Huebner K,Alitalo K

更新日期：1993-07-01 00:00:00

abstract：:The human papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to ...

journal_title：Oncogene

authors： Mantovani F,Banks L

更新日期：2001-11-26 00:00:00

abstract：:A hallmark of cancer is the deregulation of cell-cycle machinery, ultimately facilitating aberrant proliferation that fuels tumorigenesis and disease progression. Particularly, in breast cancers, cyclin D1 has a crucial role in the development of disease. Recently, a highly specific inhibitor of CDK4/6 activity (PD-03...

journal_title：Oncogene

authors： Dean JL,Thangavel C,McClendon AK,Reed CA,Knudsen ES

更新日期：2010-07-15 00:00:00

abstract：:Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...

journal_title：Oncogene

authors： Ying M,Zhang L,Zhou Q,Shao X,Cao J,Zhang N,Li W,Zhu H,Yang B,He Q

更新日期：2016-08-18 00:00:00

abstract：:Solid tumors frequently contain hypoxic subregions due to insufficient blood supply. In these domains, cells can undergo p53-dependent apoptosis. Therefore, hypoxia has been implicated as a physiological stimulus for p53 accumulation and activation. In such an environment, p53 mutant cells exhibit a selective growth a...

journal_title：Oncogene

authors： Pan Y,Oprysko PR,Asham AM,Koch CJ,Simon MC

更新日期：2004-06-24 00:00:00

abstract：:Prolonged activation of protein kinase Cs (PKCs) by long-term treatment of cells with phorbol ester tumor promoters down-regulates the expression of many PKCs. To investigate the molecular mechanisms involved in the down-regulation of PKC eta, we expressed the novel PKCs eta and θ and various mutant forms in bab...

journal_title：Oncogene

authors： Kang BS,French OG,Sando JJ,Hahn CS

更新日期：2000-08-31 00:00:00

abstract：:Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive. Alpha-isozyme of protein kinase C (PKCalpha), which is involved in cancer development and progression, has been suggested to be activated by ErbB2 without direct evidence. In addition, the roles of PK...

journal_title：Oncogene

authors： Tan M,Li P,Sun M,Yin G,Yu D

更新日期：2006-06-01 00:00:00

abstract：:Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta signaling in human tumor cell lines. Some of these GTPases are post-translationally modified by farnesylation, a lipid modification catalyzed by farnesyltransferase and required for the proteins to attach to membranes and to function. I...

journal_title：Oncogene

authors： Adnane J,Bizouarn FA,Chen Z,Ohkanda J,Hamilton AD,Munoz-Antonia T,Sebti SM

更新日期：2000-11-16 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by an accumulation of immature T cells. Although patient outcomes have improved, novel targeted therapies are needed to reduce the intensity of chemotherapy and improve the prognosis of high-risk patients. Interleukin-7...

journal_title：Oncogene

authors： Buffière A,Uzan B,Aucagne R,Hermetet F,Mas M,Nassurdine S,Aznague A,Carmignac V,Tournier B,Bouchot O,Ballerini P,Barata JT,Bastie JN,Delva L,Pflumio F,Quéré R

更新日期：2019-11-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior and lack of effective therapy. Owing to its tendency for early dissemination, only a third of patients have limited-stage disease at the time of diagnosis. SCLC is thought to derive from pulmonary neuroendocrine cells. Although se...

journal_title：Oncogene

authors： Kalari S,Jung M,Kernstine KH,Takahashi T,Pfeifer GP

更新日期：2013-07-25 00:00:00