The human papillomavirus E6 protein and its contribution to malignant progression.

Abstract:

:The human papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to the development of human malignancy many laboratories have focused their attention on identifying the cellular proteins with which E6 interacts. In this review we discuss these interactions in the light of their respective contributions to the malignant progression of HPV transformed cells.

journal_name

Oncogene

journal_title

Oncogene

authors

Mantovani F,Banks L

doi

10.1038/sj.onc.1204869

subject

Has Abstract

pub_date

2001-11-26 00:00:00

pages

7874-87

issue

54

eissn

0950-9232

issn

1476-5594

journal_volume

20

pub_type

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