Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.

Abstract:

:The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.

journal_name

Oncogene

journal_title

Oncogene

authors

Matsuoka M,Jeang KT

doi

10.1038/onc.2010.537

subject

Has Abstract

pub_date

2011-03-24 00:00:00

pages

1379-89

issue

12

eissn

0950-9232

issn

1476-5594

pii

onc2010537

journal_volume

30

pub_type

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