Abstract:
:The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.
journal_name
Oncogenejournal_title
Oncogeneauthors
Matsuoka M,Jeang KTdoi
10.1038/onc.2010.537subject
Has Abstractpub_date
2011-03-24 00:00:00pages
1379-89issue
12eissn
0950-9232issn
1476-5594pii
onc2010537journal_volume
30pub_type
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