The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.

abstract：:Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+,HCO3--cotransporter NBCn1 (Slc4a7) to intracellular a...

journal_title：Oncogene

authors： Lee S,Axelsen TV,Jessen N,Pedersen SF,Vahl P,Boedtkjer E

更新日期：2018-10-01 00:00:00

abstract：:The tumor suppressor gene phosphatase and tensin homologue (PTEN) regulates the phosphatidylinositol-3'-kinase (PI3K) signaling pathway and has been shown to correlate with poor prognosis in high-grade astrocytomas when mutational inactivation or loss of the PTEN gene occurs. PTEN mutation leads to constitutive activa...

journal_title：Oncogene

authors： Edwards LA,Thiessen B,Dragowska WH,Daynard T,Bally MB,Dedhar S

更新日期：2005-05-19 00:00:00

abstract：:The SCL/TAL1 gene was originally identified by virtue of its rearrangement and transcriptional activation in patients with T cell acute lymphoblastic leukaemia. It encodes a helix-loop-helix transcription factor, is not normally expressed in T cells, but is expressed in erythroid, mast, megakaryocytic and progenitor c...

journal_title：Oncogene

authors： Murrell AM,Bockamp EO,Göttgens B,Chan YS,Cross MA,Heyworth CM,Green AR

更新日期：1995-07-06 00:00:00

abstract：:AP-1 transcription factors play a critical role in signal transduction pathways in many cells. We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and have previously shown that AP-1 complexes are activated by peptide and steroid growth factors in both normal and malignant breas...

journal_title：Oncogene

authors： Liu Y,Ludes-Meyers J,Zhang Y,Munoz-Medellin D,Kim HT,Lu C,Ge G,Schiff R,Hilsenbeck SG,Osborne CK,Brown PH

更新日期：2002-10-31 00:00:00

abstract：:There is a large body of evidence suggesting the connexin gap junction proteins appear to act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main function of cell coupling through gap junctions. However, some cancer cells (e.g. the rat bladder carcinoma BC31 cell line) are cell-...

journal_title：Oncogene

authors： Krutovskikh VA,Troyanovsky SM,Piccoli C,Tsuda H,Asamoto M,Yamasaki H

更新日期：2000-01-27 00:00:00

abstract：:Apoptin, a small protein from the chicken anemia virus, has attracted attention because of its specificity in killing tumor cells. Localization of apoptin in the nucleus of tumor cells has been shown to be vital for proapoptotic activity, however, targeted expression of apoptin in the nucleus of normal cells does not ...

journal_title：Oncogene

authors： Maddika S,Wiechec E,Ande SR,Poon IK,Fischer U,Wesselborg S,Jans DA,Schulze-Osthoff K,Los M

更新日期：2008-05-08 00:00:00

abstract：:Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal expression of mRNAs encoding many factors involved in cancer hallmarks. While conventional anticancer therapies usually target one pathway at a time, targeting key RBP would affect multiple genes and thus overcome drug resistance....

journal_title：Oncogene

authors： Rataj F,Planel S,Denis J,Roelants C,Filhol O,Guyon L,Feige JJ,Cherradi N

更新日期：2019-06-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell...

journal_title：Oncogene

authors： Nakamura N,Fujii M,Tsukahara T,Arai M,Ohashi T,Wakao H,Kannagi M,Yamamoto N

更新日期：1999-04-29 00:00:00

abstract：:Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...

journal_title：Oncogene

authors： Varga AE,Stourman NV,Zheng Q,Safina AF,Quan L,Li X,Sossey-Alaoui K,Bakin AV

更新日期：2005-07-28 00:00:00

abstract：:While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...

journal_title：Oncogene

authors： Morris SM,Mhyre AJ,Carmack SS,Myers CH,Burns C,Ye W,Ferrer M,Olson JM,Klinghoffer RA

更新日期：2018-08-01 00:00:00

abstract：:Deletions involving chromosome 9 occur in more than 50% of human bladder cancers of all grades and stages. Most involve loss of the whole chromosome or of an entire chromosome arm but some small deletions are found which can be used to define critical regions which may contain tumour suppressor genes. We have localize...

journal_title：Oncogene

authors： Hornigold N,Devlin J,Davies AM,Aveyard JS,Habuchi T,Knowles MA

更新日期：1999-04-22 00:00:00

abstract：:Constitutively active HER2/neu activates nuclear factor kappa-B (NF-kappaB) in cells and induces their resistance to apoptotic stimuli such as tumor necrosis factor-alpha (TNF-alpha). Here, we show that integrin-linked kinase (ILK), the crucial signal transducer in the integrin pathway, is involved in HER2/neu-mediate...

journal_title：Oncogene

authors： Makino K,Day CP,Wang SC,Li YM,Hung MC

更新日期：2004-05-06 00:00:00

abstract：:Oligodendroglioma is an important type of lower-grade glioma (LGG), which is a slowly progressing brain tumor. Many LGGs eventually transform into a more aggressive or malignant type. Enhanced angiogenesis is a characteristic of malignantly transformed oligodendroglioma (m-oligodendroglioma). However, the pathogenesis...

journal_title：Oncogene

authors： Qi L,Wang ZY,Shao XR,Li M,Chen SN,Liu XQ,Yan S,Zhang B,Zhang XD,Li X,Zhao W,Pan JA,Zhao B,Zhang XD

更新日期：2020-09-01 00:00:00

abstract：:To investigate the role of protein kinase C (PKC) in apoptotic signaling induced by cytokine withdrawal, we expressed PKC-alpha, -delta and -epsilon individually in the 32D myeloid progenitor cells. The parental and PKC-delta- and PKC-epsilon-transfected 32D cells underwent apoptosis within 24 h in the absence of inte...

journal_title：Oncogene

authors： Li W,Zhang J,Flechner L,Hyun T,Yam A,Franke TF,Pierce JH

更新日期：1999-11-11 00:00:00

abstract：:Several cytokines, growth factors and the HIV transactivator Tat were shown to be involved in the pathogenesis of Kaposi's sarcoma. BKV/tat transgenic mice develop Kaposi's sarcoma-like lesions, and spindle-shaped cells (TTB) have been derived from these lesions. Here we show that TTB cells co-express hepatocyte growt...

journal_title：Oncogene

authors： Maier J,Mariotti M,Comoglio PM,Soria MR

更新日期：1996-09-05 00:00:00

abstract：:A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding muri...

journal_title：Oncogene

authors： Reynolds AB,Herbert L,Cleveland JL,Berg ST,Gaut JR

更新日期：1992-12-01 00:00:00

abstract：:Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome characterized by the development of tumors in a variety of tissues. We have previously shown that tuberin is a widely expressed 180 kDa protein which exhibits specific GTP...

journal_title：Oncogene

authors： Wienecke R,Maize JC Jr,Shoarinejad F,Vass WC,Reed J,Bonifacino JS,Resau JH,de Gunzburg J,Yeung RS,DeClue JE

更新日期：1996-09-05 00:00:00

abstract：:FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover nove...

journal_title：Oncogene

authors： Nadratowska-Wesolowska B,Haugsten EM,Zakrzewska M,Jakimowicz P,Zhen Y,Pajdzik D,Wesche J,Wiedlocha A

更新日期：2014-10-02 00:00:00

abstract：:Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined. Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells were...

journal_title：Oncogene

authors： Kim SG,Kim SN,Jong HS,Kim NK,Hong SH,Kim SJ,Bang YJ

更新日期：2001-03-08 00:00:00

abstract：:DNA adducts associated with tobacco smoking could provide a marker of biologically effective dose of tobacco carcinogens and improve individual cancer risk prediction. A significant number of clinical and epidemiologic studies have reported associations of increased DNA adduct levels with the occurrence of the prevale...

journal_title：Oncogene

authors： Wiencke JK

更新日期：2002-10-21 00:00:00

abstract：:Prostate cancer (PCa) cell proliferation is dependent on activation of the androgen receptor (AR), a ligand-dependent transcription factor. AR activation controls G1-S phase progression through fostering enhanced translation of the D-type cyclins, which promote cell cycle progression through activation of CDK4/6. Howe...

journal_title：Oncogene

authors： Olshavsky NA,Groh EM,Comstock CE,Morey LM,Wang Y,Revelo MP,Burd C,Meller J,Knudsen KE

更新日期：2008-05-15 00:00:00

abstract：:As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional co-activator, whereas the SSX proteins are thought to act as transcriptional co...

journal_title：Oncogene

authors： de Bruijn DR,van Dijk AH,Willemse MP,van Kessel AG

更新日期：2008-01-24 00:00:00

abstract：:TGF-beta/Smads regulate a wide variety of biological responses through transcriptional regulation of target genes. ELF, a beta-spectrin, plays a key role in the transmission of TGF-beta-mediated transcriptional response through Smads. ELF was originally identified as a key protein involved in endodermal stem/progenito...

journal_title：Oncogene

authors： Katuri V,Tang Y,Marshall B,Rashid A,Jogunoori W,Volpe EA,Sidawy AN,Evans S,Blay J,Gallicano GI,Premkumar Reddy E,Mishra L,Mishra B

更新日期：2005-12-01 00:00:00

abstract：:The oncoprotein Qin is a member of the winged helix family of transcriptional regulators. The region C-terminal to its winged helix DNA-binding domain is required for transformation of chicken embryo fibroblasts. We isolated the corepressor TLE1 as a binding partner for Qin in a yeast two-hybrid screen and localized t...

journal_title：Oncogene

authors： Sonderegger CK,Vogt PK

更新日期：2003-03-27 00:00:00

abstract：:Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic regulation of gene expression, organization of chromatin structure, chromosome segregation, DNA replication and DNA repair. Males absent on the first (MOF) is responsible...

journal_title：Oncogene

authors： Rea S,Xouri G,Akhtar A

更新日期：2007-08-13 00:00:00

abstract：:During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...

journal_title：Oncogene

authors： Langer EM,Kendsersky ND,Daniel CJ,Kuziel GM,Pelz C,Murphy KM,Capecchi MR,Sears RC

更新日期：2018-02-22 00:00:00

abstract：:The occurrence of peritoneal carcinomatosis is a major cause of treatment failure in colorectal cancer and is considered incurable. However, new therapeutic approaches have been proposed, including cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Although HIPEC has been effective ...

journal_title：Oncogene

authors： Zunino B,Rubio-Patiño C,Villa E,Meynet O,Proics E,Cornille A,Pommier S,Mondragón L,Chiche J,Bereder JM,Carles M,Ricci JE

更新日期：2016-01-14 00:00:00

abstract：:Induction of apoptosis by adenovirus E1A in rodent cells is stimulated by wild type (wt) p53 but completely suppressed by mutated p53. The suppression is overcome by coexpression with Id proteins (Ids). The cells expressing E1A and Ids undergo apoptosis after accumulation in S phase, suggesting that S phase events are...

journal_title：Oncogene

authors： Yageta M,Tsunoda H,Yamanaka T,Nakajima T,Tomooka Y,Tsuchida N,Oda K

更新日期：1999-08-26 00:00:00

abstract：:To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...

journal_title：Oncogene

authors： Furukawa Y,DeCaprio JA,Belvin M,Griffin JD

更新日期：1991-08-01 00:00:00

abstract：:Tbx3 is a member of the T-box family of transcription factors. Mutations in Tbx3 cause ulnar-mammary syndrome, an autosomal dominant disorder characterized by upper limb defects, apocrine-gland defects including mammary hypoplasia, and tooth, hair and genital defects. In cell culture, Tbx3 and its close relative Tbx2 ...

journal_title：Oncogene

authors： Carlson H,Ota S,Song Y,Chen Y,Hurlin PJ

更新日期：2002-05-30 00:00:00