Abstract:
:The oncoprotein Qin is a member of the winged helix family of transcriptional regulators. The region C-terminal to its winged helix DNA-binding domain is required for transformation of chicken embryo fibroblasts. We isolated the corepressor TLE1 as a binding partner for Qin in a yeast two-hybrid screen and localized the TLE1-binding region to a 60 amino-acid stretch directly C-terminal of the winged helix domain of Qin. We show in vivo interaction of full-length Qin and TLE1 in a mammalian two-hybrid system. Coexpression of TLE1-binding Qin and TLE1 induces phosphorylation of TLE1. The DNA-binding activity of Qin is not required for this function. Binding of Qin to TLE1 correlates with Qin-induced transformation. Addition of the TLE1-binding motif WRPW to the C-terminus of a transformation-defective Qin deletion mutant restores binding to TLE1 and significantly enhances transformation. Expression of TLE1 in CEF by the retroviral vector RCAS enhances cell growth and induces formation of agar colonies.
journal_name
Oncogenejournal_title
Oncogeneauthors
Sonderegger CK,Vogt PKdoi
10.1038/sj.onc.1206308subject
Has Abstractpub_date
2003-03-27 00:00:00pages
1749-57issue
12eissn
0950-9232issn
1476-5594pii
1206308journal_volume
22pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::We report here the nucleic acid sequence and deduced amino acid sequence of a cDNA for TIS7, a gene induced by mitogens in 3T3 cells and by nerve growth factor in PC12 pheochromocytoma cells. A fragment of the TIS7 gene has previously been cloned from murine fibroblast cells infected with Newcastle Disease Virus. The ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::The transcriptional activity of the androgen receptor (AR) is regulated by both ligand binding and post-translational modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation. Histone deacetylases (HDACs) are known to catalyze the removal of acetyl groups from both histones and non-histone ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.600
更新日期:2011-05-12 00:00:00
abstract::Heat shock protein 90 (Hsp90) is a survival signaling chaperone and a cancer chemotherapeutic target. However, we have found that inhibitors of Hsp90 diminished the apoptotic response induced in leukemic cells by the antitumor alkyl-lysophospholipid analog edelfosine, which acts through lipid raft reorganization. Edel...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210816
更新日期:2008-03-13 00:00:00
abstract::Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.527
更新日期:2012-08-02 00:00:00
abstract::Hepatocyte Growth Factor (HGF) exerts its biological effects via binding and activating a transmembrane protein tyrosine kinase receptor known as c-Met. Previous studies from our laboratory demonstrated that c-met gene expression is inducible by its own ligand (HGF). However, the molecular mechanism(s) involved in thi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203404
更新日期:2000-02-24 00:00:00
abstract::Tumor suppressor p53 functions are downregulated in most cervical cancers, because the product of human papilloma virus (HPV) oncogene E6 binds to and inactivates p53 by promoting its degradation. p73, a p53 homologue, is similar to p53 in structure and function but yet not degraded by HPV E6 gene product. In this stu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206908
更新日期:2003-11-20 00:00:00
abstract::Mammalian heparanase (endo-beta-glucuronidase) degrades heparan sulfate proteoglycans and is an important modulator of the extracellular matrix and associated factors. The enzyme is preferentially expressed in neoplastic tissues and contributes to tumour metastasis and angiogenesis. To investigate the epigenetic regul...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207056
更新日期:2003-10-30 00:00:00
abstract::Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice, show an increased susceptibility to spontaneous tumor development. Human and mouse Ptc1 heterozygotes (Ptc1(+/-)) are also hypersensitive to ionizing radiation...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205973
更新日期:2002-10-24 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) has pivotal roles during embryonic development and carcinoma progression. Members of the Snai1 family of zinc finger transcription factors are central mediators of EMT and induce EMT in part by directly repressing epithelial markers such as E-cadherin, a gatekeeper of the epithe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.234
更新日期:2010-09-02 00:00:00
abstract::PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204765
更新日期:2001-10-29 00:00:00
abstract::The REL gene is amplified in many human B-cell lymphomas and we have previously shown that expression of REL from a retroviral vector can malignantly transform chicken spleen cells in vitro. To identify REL protein functions necessary for malignant transformation, we have performed deletion analysis on REL sequences e...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206801
更新日期:2003-10-09 00:00:00
abstract::Wnt genes encode a set of structurally related cell surface glycoproteins that appear to have roles in cell-cell signalling. The ectopic expression of several murine Wnt genes has been implicated in the transformation of mammary epithelial and the onset of mammary tumours. Wnt11 is expressed in the developing embryo i...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-06-20 00:00:00
abstract::The WARTS gene encodes a kinase that localizes to the mitotic apparatus of a dividing cell. Named WARTS after the growths that develop in the eyes of Drosophila in which the gene is deleted. WARTS is also implicated as a tumor suppressor in mice and humans. In this issue of Oncogene, Iida et al. describe experiments s...
journal_title:Oncogene
pub_type: 评论,杂志文章
doi:10.1038/sj.onc.1207686
更新日期:2004-07-08 00:00:00
abstract::Aurora kinases are known to play a key role in maintaining mitotic fidelity, and overexpression of aurora kinases has been noted in various tumors. Overexpression of aurora kinase activity is thought to promote cancer development through a loss of centrosome or chromosome number integrity. Here we observed augmentatio...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208293
更新日期:2005-02-03 00:00:00
abstract::BRAF mutations occur in ~10% of colorectal cancer (CRC) and are associated with poor prognosis. Inhibitors selective for the BRAFV600E oncoprotein, the most common BRAF mutant, elicit only poor response rates in BRAF-mutant CRC as single agents. This unresponsiveness was mechanistically attributed to the loss of negat...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0063-5
更新日期:2018-03-01 00:00:00
abstract::Ataxia Telangiectasia Mutated (ATM) kinase, a central regulator of the DNA damage response, regulates the activity of several E3-ubiquitin ligases, and the ubiquitination-proteasome system is a consistent target of ATM. ITCH is an E3-ubiquitin ligase that modulates the ubiquitination of several targets, therefore part...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.52
更新日期:2014-02-27 00:00:00
abstract::A distinctive property of Hepatocyte Growth Factor (HGF) is its ability to induce differentiation of tubular structures from epithelial and endothelial cells (branching tubulogenesis). The HGF receptor directly activates PI3 kinase, Ras and STAT signalling pathways and phosphorylates the adaptator GRB2 Associated Bind...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203514
更新日期:2000-03-16 00:00:00
abstract::Human papillomaviruses (HPVs) are involved in the pathogenesis of cancer of the cervix (CaCx). MicroRNA (miRNA) expression analysis using Ambion (Austin, TX, USA) arrays showed that three miRNAs were overexpressed and 24 underexpressed in cervical cell lines containing integrated HPV-16 DNA compared to the normal cerv...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210919
更新日期:2008-04-17 00:00:00
abstract::Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.485
更新日期:2013-09-26 00:00:00
abstract::Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotype changes related to malignant progression including increased motility and invasion. Concurrent with these phenotypic effects are changes in the expression of multiple gene targets. We previously demonstrated that e...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205857
更新日期:2002-10-10 00:00:00
abstract::To explore the molecular mechanisms by which retinoic acid inhibits oncogenic transformation, we have examined the effects of retinoic acid on the polyomavirus-induced transformation of rat fibroblasts. Treatment of rat F111 fibroblasts with high concentrations of retinoic acid (10(-6) M) partially inhibited the abili...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::The 2;13 chromosomal translocation occurs in most cases of the cancer alveolar rhabdomyosarcoma (ARMS), and juxtaposes the genes encoding the PAX3 and FKHR transcription factors. The resulting chimeric protein PAX3-FKHR is a potent transcriptional activator, and is hypothesized to function as a dominant acting oncogen...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207850
更新日期:2004-09-09 00:00:00
abstract::Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer. Bioinformatics analysis revealed that PLOD1 is associated with the progression of GBM, particularly the most malignant mesenchymal subtype (MES). Moreover, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01635-y
更新日期:2021-01-08 00:00:00
abstract::Bloom's syndrome (BS) arises through mutations in both copies of the BLM gene that encodes a RecQ 3'-5' DNA helicase. BS patients are predisposed to developing all the cancers that affect the general population, and BS cells exhibit marked genetic instability. We showed recently that BLM protein contributes to the cel...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205246
更新日期:2002-03-27 00:00:00
abstract::To identify genes that are differentially over-expressed in Small Cell Lung Carcinoma (SCLC) we have used a combination of suppression subtractive hybridization and cDNA microarray to analyse the expression profiles of 2400 cDNAs clones. Genes that are over-expressed in SCLC were identified using 32 pairs of fluoresce...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205480
更新日期:2002-05-23 00:00:00
abstract::Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined. Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells were...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204203
更新日期:2001-03-08 00:00:00
abstract::von Hippel-Lindau (VHL) disease is a dominantly inherited family cancer syndrome characterized by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma (RCC) and phaeochromocytoma. Specific germline VHL mutations may predispose to haemangioblastomas, RCC and phaeochromocytoma t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209932
更新日期:2007-03-08 00:00:00
abstract::Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01495-6
更新日期:2020-12-01 00:00:00
abstract::Fatty acid binding protein 4 (FABP4) is a fatty acid chaperone, which is induced during adipocyte differentiation. Previously we have shown that FABP4 in endothelial cells is induced by the NOTCH1 signalling pathway, the latter of which is involved in mechanisms of resistance to antiangiogenic tumour therapy. Here, we...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.256
更新日期:2017-02-16 00:00:00
abstract::Fanconi anemia is a hereditary cancer susceptibility disorder characterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to DNA cross-linking agents such as mitomycin C. This phenotype suggests a possible role for the Fanconi anemia proteins in the repair of DNA lesions in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205656
更新日期:2002-07-25 00:00:00