Mutation of the 9q34 gene TSC1 in sporadic bladder cancer.

Abstract:

:Deletions involving chromosome 9 occur in more than 50% of human bladder cancers of all grades and stages. Most involve loss of the whole chromosome or of an entire chromosome arm but some small deletions are found which can be used to define critical regions which may contain tumour suppressor genes. We have localized such a critical region of deletion at 9q34 between the markers D9S149 and D9S66, an interval which contains the Tuberous Sclerosis gene TSC1. Single strand conformation polymorphism (SSCP) and sequence analysis of TSC1 in bladder tumours and cell lines with 9q34 loss of heterozygosity (LOH) has identified five mutations in retained TSC1 alleles. Our results support the hypothesis that TSC1 can act as a bladder tumour suppressor gene.

journal_name

Oncogene

journal_title

Oncogene

authors

Hornigold N,Devlin J,Davies AM,Aveyard JS,Habuchi T,Knowles MA

doi

10.1038/sj.onc.1202854

subject

Has Abstract

pub_date

1999-04-22 00:00:00

pages

2657-61

issue

16

eissn

0950-9232

issn

1476-5594

journal_volume

18

pub_type

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