Abstract:
:Deletions involving chromosome 9 occur in more than 50% of human bladder cancers of all grades and stages. Most involve loss of the whole chromosome or of an entire chromosome arm but some small deletions are found which can be used to define critical regions which may contain tumour suppressor genes. We have localized such a critical region of deletion at 9q34 between the markers D9S149 and D9S66, an interval which contains the Tuberous Sclerosis gene TSC1. Single strand conformation polymorphism (SSCP) and sequence analysis of TSC1 in bladder tumours and cell lines with 9q34 loss of heterozygosity (LOH) has identified five mutations in retained TSC1 alleles. Our results support the hypothesis that TSC1 can act as a bladder tumour suppressor gene.
journal_name
Oncogenejournal_title
Oncogeneauthors
Hornigold N,Devlin J,Davies AM,Aveyard JS,Habuchi T,Knowles MAdoi
10.1038/sj.onc.1202854subject
Has Abstractpub_date
1999-04-22 00:00:00pages
2657-61issue
16eissn
0950-9232issn
1476-5594journal_volume
18pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::The p53 tumor suppressor protein is frequently mutated in human tumors. It is thought that the p53 pathway is indirectly impaired in the remaining tumors, for example by overexpression of its important regulators Mdm2 and Mdm4, making them attractive targets for the development of anti-cancer agents. Recent studies ha...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.522
更新日期:2010-04-22 00:00:00
abstract::E mu-bcl-2 transgenic mice bearing the bcl-2 proto-oncogene linked to the immunoglobulin enhancer (E mu) sporadically develop B or T cell lymphomas after a long latent period. To identify genes that play important roles in development of lymphoid malignancies, proviral insertional mutagenesis with Moloney murine leuke...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-11-02 00:00:00
abstract::Hypoxia induces transcription of a range of physiologically important genes including erythropoietin and vascular endothelial growth factor. The transcriptional activation is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric member of the basic helix-loop-helix PAS family, composed of alpha and beta ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203938
更新日期:2000-11-16 00:00:00
abstract::Advanced Bladder Cancer (BLCA) remains a clinical challenge that lacks effective therapeutic measures. Here, we show that distinct, stage-wise metabolic alterations in BLCA are associated with the loss of function of aldehyde oxidase (AOX1). AOX1 associated metabolites have a high predictive value for advanced BLCA an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0902-7
更新日期:2020-10-01 00:00:00
abstract::Oncogene-induced senescence (OIS) is an intrinsic tumor suppression mechanism that requires the p53 and RB pathways and post-translational activation of C/EBPβ through the RAS-ERK cascade. We previously reported that in transformed/proliferating cells, C/EBPβ activation is inhibited by G/U-rich elements (GREs) in its ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0190-7
更新日期:2018-06-01 00:00:00
abstract::Biomarkers that predict disease progression might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the role of collagen type XI alpha 1 (COL11A1) in cell invasiveness and tumor formation and the prognostic impact of COL11A1 expression in ovar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.307
更新日期:2014-06-26 00:00:00
abstract::Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202608
更新日期:1999-04-29 00:00:00
abstract::The Interleukin-1beta converting enzyme (ICE) family of proteins, homologs of the C elegans cell death gene product CED-3, play important roles in controlling vertebrate programmed cell death. Because inhibition of apoptosis may be an essential step in tumorigenesis, we investigated the interaction of the simian virus...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200943
更新日期:1997-03-13 00:00:00
abstract::Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202667
更新日期:1999-05-06 00:00:00
abstract::The adenovirus E1A protein has been shown to be involved in the potentiation of apoptosis induced by chemotherapeutic agents, yet the molecular events of E1A-mediated apoptosis are not very clear. A recent report has suggested that deamidation of the Bcl-X(L) protein inhibits its antiapoptotic ability and leads to apo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209294
更新日期:2006-04-27 00:00:00
abstract::Human WWOX gene encodes a proapoptotic WW domain-containing oxidoreductase WOX1 (also named WWOX, FOR2 or WWOXv1). Apoptotic and stress stimuli activate WOX1 via Tyr33 phosphorylation and nuclear translocation. WOX1 possesses a tetrad NSYK motif in the C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domai...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208124
更新日期:2005-01-20 00:00:00
abstract::The programmed cell death 4 (PDCD4) gene was originally identified as a tumor-related gene in humans and acts as a tumor-suppressor in mouse epidermal carcinoma cells. However, its function and regulatory mechanisms of expression in human cancer remain to be elucidated. We therefore investigated the expression of PDCD...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209634
更新日期:2006-10-05 00:00:00
abstract::Overexpression of the receptor tyrosine kinase ERBB2 (also known as HER2) occurs in around 15% of breast cancers and is driven by amplification of the ERBB2 gene. ERBB2 amplification is a marker of poor prognosis, and although anti-ERBB2-targeted therapies have shown significant clinical benefit, de novo and acquired ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.625
更新日期:2014-01-30 00:00:00
abstract::Hepatitis B virus (HBV)-induced liver necrosis takes great part in liver cirrhosis progression. However, less is known about whether hepatitis B virus X protein (HBx) has effect on liver fibrosis. Here, we report that HBV leads to liver fibrosis and hepatocarcinogenesis through miR-30e targeting P4HA2. HBV transgenic ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.291
更新日期:2017-12-14 00:00:00
abstract::Cell cycle checkpoints and tumor suppressor gene functions appear to be required for the maintenance of a stable genome in proliferating cells. In this study chromosomal destabilization was monitored in relation to telomere structure, lifespan control and G2 checkpoint function. Replicative senescence was inactivated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201711
更新日期:1998-04-09 00:00:00
abstract::BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA). Here we report that transcription inhibition can be alleviated by interferon treatment and the degradati...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209245
更新日期:2006-04-06 00:00:00
abstract::Ras genes, frequently mutated in human tumors, promote malignant transformation. Ras transformation requires membrane anchorage, which is promoted by Ras farnesylcysteine carboxymethylester and by a second signal. Previously we showed that the farnesylcysteine mimetic, farnesylthiosalicylic acid (FTS) disrupts Ras mem...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204950
更新日期:2001-11-08 00:00:00
abstract::Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.599
更新日期:2015-02-05 00:00:00
abstract::Protein kinases are known to undergo phosphorylation to regulate their activity. To determine whether the protein kinase activity of p37v-mos was similarly regulated, we investigated the influence of two well known protein kinases, namely protein kinase C and protein kinase A, on the activity of p37v-mos in vivo. NIH3...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms underlying HCC development and identifying new prevention and therapeutic targets. Here, we demonstrate a unique protumorigenic niche in the livers of Ncoa5...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1256-x
更新日期:2020-05-01 00:00:00
abstract::Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210296
更新日期:2007-04-02 00:00:00
abstract::The rodent S100-related calcium-binding protein, S100A4 induces metastasis in non-metastatic rat and mouse benign mammary cells and co-operates with benign-tumour-inducing changes in two transgenic mouse models, to yield metastatic mammary tumours. Co-transfection of the human gene for S100A4 with pSV2neo into the ben...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201948
更新日期:1998-07-30 00:00:00
abstract::The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Hepatocyte growth factor (HGF) is an important multifunctional cytokine whose gene expression is regulated mainly at the transcriptional level. Previous studies using transgenic mice as well as in vitro analyses showed that a potential regulatory element(s) exists between -260 to -230 bp in the upstream region of the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203581
更新日期:2000-05-25 00:00:00
abstract::The activities of E2F transcription factors are inhibited by interactions with members of the retinoblastoma (RB) tumor suppressor family, p105RB, p107 and p130. In cycling cells p107 and p130 also interact with heterodimers comprised of Cdk2 and either A or E cyclins. We characterized E2F complexes present in C2C12 a...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-09-07 00:00:00
abstract::CCAAT/enhancer-binding protein-δ (C/EBP-δ), a transcription factor, is elevated in carcinoma compared with that in normal tissue. This study reports a novel function of C/EBP-δ in lymphangiogenesis and tumor metastasis. Genetic deletion of C/EBP-δ in mice resulted in a significant reduction of lymphangiogenesis and pu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.187
更新日期:2011-12-08 00:00:00
abstract::DNA double-stranded breaks (DSBs) elicit a checkpoint response that causes a delay in cell cycle progression. Early in the checkpoint response, histone H2AX is phosphorylated in the chromatin region flanking the DSB by ATM/ATR and DNA-PK kinases. The resulting foci of phosphorylated H2AX (gamma-H2AX) serve as a platfo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.501
更新日期:2010-04-15 00:00:00
abstract::The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.213
更新日期:2017-01-19 00:00:00
abstract::We have previously reported the isolation of several temperature-sensitive (ts) mutants of F9 cells. Further investigations showed that some mutants were induced to differentiate at non-permissive temperature of cell growth, accompanied by changes in the expression of various genes, whereas others were not. During the...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::There is strong evidence at the individual level and the population level that an efficient cytotoxic T lymphocyte (CTL) response to HTLV-1 limits the proviral load and the risk of associated inflammatory diseases such as HAM/TSP. This evidence comes from host population genetics, viral genetics, DNA expression microa...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208970
更新日期:2005-09-05 00:00:00