Abstract:
:A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding murine p120. The encoded protein lacks significant homology with any reported protein, but it contains four copies of an imperfect 42 amino acid repeat that occurs 12.5 times in the protein encoded by Drosophila armadillo (arm), and its direct homologs, human plakoglobin (plak) and Xenopus laevis beta-catenin (beta-cat). The presence of this motif implies that p120 may share at least one aspect of its function with the arm protein and its homologs.
journal_name
Oncogenejournal_title
Oncogeneauthors
Reynolds AB,Herbert L,Cleveland JL,Berg ST,Gaut JRsubject
Has Abstractpub_date
1992-12-01 00:00:00pages
2439-45issue
12eissn
0950-9232issn
1476-5594journal_volume
7pub_type
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