IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes.

abstract：:Radicicol, an inhibitor of Src-family protein-tyrosine kinases, causes morphological reversion of v-src- and v-Ha-ras-transformed fibroblasts and arrest of the cell cycle at both the G1 and the G2 phases. Radicicol was found to inhibit the growth of several other oncogene-transformed cell lines and human carcinoma cel...

journal_title：Oncogene

authors： Kwon HJ,Yoshida M,Nagaoka R,Obinata T,Beppu T,Horinouchi S

更新日期：1997-11-20 00:00:00

abstract：:Gastric carcinogenesis is a multistep process involving genetic and epigenetic alteration of protein-coding proto-oncogenes and tumor-suppressor genes. Recent discoveries have shed new light on the involvement of a class of noncoding RNA known as microRNA (miRNA) in gastric cancer. A substantial number of miRNAs show ...

journal_title：Oncogene

authors： Wu WK,Lee CW,Cho CH,Fan D,Wu K,Yu J,Sung JJ

更新日期：2010-10-28 00:00:00

abstract：:Cell to cell communication is vital throughout the development of multicellular organisms and during adult homeostasis. One way in which communication is achieved is through the secretion of signaling molecules that are received by neighboring responding cells. Wnt ligands comprise a large family of secreted, hydropho...

journal_title：Oncogene

authors： Mikels AJ,Nusse R

更新日期：2006-12-04 00:00:00

abstract：:It is presently unclear if ovarian cancers arise through malignant transformation of pre-existing benign tumours. The apparent rarity of loss of heterozygosity (LOH) reported for benign tumours has led to speculation that they lack malignant potential and represent a biological entity distinct from ovarian carcinoma. ...

journal_title：Oncogene

authors： Roy WJ Jr,Watson RH,Hitchcock A,Campbell IG

更新日期：1997-10-23 00:00:00

abstract：:Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...

journal_title：Oncogene

authors： Liu W,Li H,Hong SH,Piszczek GP,Chen W,Rodgers GP

更新日期：2016-10-06 00:00:00

abstract：:The tumor suppressor p53 transcriptionally regulates a large number of target genes that may affect cell growth and cell death pathways. To better understand the role of p53 loss in tumorigenesis, we have developed a mouse mammary cancer model, the Wnt-1 TG/p53 model. Wnt-1 transgenic females that are p53-/- develop m...

journal_title：Oncogene

authors： Cui XS,Donehower LA

更新日期：2000-12-07 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This toroidal-shaped protein encircles DNA and can slide bidirectionally along the duplex. One of the well-established functions for PCNA is its role as the processivity ...

journal_title：Oncogene

authors： Kelman Z

更新日期：1997-02-13 00:00:00

abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

journal_title：Oncogene

authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

更新日期：2005-08-04 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells, overactivation of mTOR has been reported. In addition, mTOR inhibitors, such as rapamycin and its derivatives, are being evaluated ...

journal_title：Oncogene

authors： Sato T,Nakashima A,Guo L,Coffman K,Tamanoi F

更新日期：2010-05-06 00:00:00

abstract：:We have cloned a cDNA from the Drosophila elg gene, a new member of the ets family of genes. The D-elg gene is located at 97D on chromosome 3R and is expressed as a 2.0kb RNA in the embryos, pupae and adults, with no detectable expression in third instar larvae. D-elg expression is observed in all cells of early stage...

journal_title：Oncogene

authors： Pribyl LJ,Watson DK,Schulz RA,Papas TS

更新日期：1991-07-01 00:00:00

abstract：:Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly in the mammary epithelium, and to determine recurrent genomic changes associated with...

journal_title：Oncogene

authors： Cheng L,Zhou Z,Flesken-Nikitin A,Toshkov IA,Wang W,Camps J,Ried T,Nikitin AY

更新日期：2010-10-21 00:00:00

abstract：:Fli-1 is a proto-oncogene which is rearranged in tumors induced by three different retroviruses, Cas-Br-E, F-MuLV, and 10A1. This gene is a member of the Ets gene family, a class of transcription factors that recognize and bind to a DNA motif known as the Ets binding site (EBS). Our laboratory has previously cloned an...

journal_title：Oncogene

authors： Barbeau B,Barat C,Bergeron D,Rassart E

更新日期：1999-09-30 00:00:00

abstract：:The products of ras and src proto-oncogenes are frequently activated in a constitutive state in human colorectal cancer. In this study we attempted to establish whether the tumorigenic progression induced by oncogenic activation of p21ras or pp60c-src in human colonic cells is associated with alterations of the activi...

journal_title：Oncogene

authors： Cadoret A,Bertrand F,Baron-Delage S,Lévy P,Courtois G,Gespach C,Capeau J,Cherqui G

更新日期：1997-04-03 00:00:00

abstract：:The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and, rarely, late-onset Parkinson's disease, as the third large gene to be localized within a large CFS. Initial analyses of Parkin indicated th...

journal_title：Oncogene

authors： Denison SR,Wang F,Becker NA,Schüle B,Kock N,Phillips LA,Klein C,Smith DI

更新日期：2003-11-13 00:00:00

abstract：:Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated th...

journal_title：Oncogene

authors： Busch S,Acar A,Magnusson Y,Gregersson P,Rydén L,Landberg G

更新日期：2015-01-02 00:00:00

abstract：:RNA polymerase (pol) III synthesizes a range of essential products, including tRNA, 5S rRNA and 7SL RNA, which are required for protein synthesis and trafficking. High rates of pol III transcription are necessary for cells to sustain growth. A wide range of transformed and tumour cell types have been shown to express ...

journal_title：Oncogene

authors： White RJ

更新日期：2004-04-19 00:00:00

abstract：:Although Kruppel-like factor 5 (KLF5) is a transcription factor that has been implicated in pathways critical to carcinogenesis, controversy persists as to whether it functions as a tumor suppressor or as an oncogene. Here, we describe a novel role for KLF5 in a p53-independent apoptotic pathway. Using RNA-interferenc...

journal_title：Oncogene

authors： Zhao Y,Hamza MS,Leong HS,Lim CB,Pan YF,Cheung E,Soo KC,Iyer NG

更新日期：2008-01-03 00:00:00

abstract：:Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...

journal_title：Oncogene

authors： Chen Y,Xu L,Lin RY,Müschen M,Koeffler HP

更新日期：2020-10-01 00:00:00

abstract：:Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell a...

journal_title：Oncogene

authors： Godin-Heymann N,Brabetz S,Murillo MM,Saponaro M,Santos CR,Lobley A,East P,Chakravarty P,Matthews N,Kelly G,Jordan S,Castellano E,Downward J

更新日期：2016-06-23 00:00:00

abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...

journal_title：Oncogene

authors： Olmeda D,Jordá M,Peinado H,Fabra A,Cano A

更新日期：2007-03-22 00:00:00

abstract：:CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA) in its extracellular domain and to contain at least one ankyrin-binding site in its cytoplasmic domain. In this study we have examined CD44 expression in a mouse fibroblast cell line transfected with the pl85(neu) oncogene cDNA. The results of RT-...

journal_title：Oncogene

authors： Zhu D,Bourguignon L

更新日期：1996-06-06 00:00:00

abstract：:Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppre...

journal_title：Oncogene

authors： Umeda Y,Hasegawa Y,Otsuka M,Ariki S,Takamiya R,Saito A,Uehara Y,Saijo H,Kuronuma K,Chiba H,Ohnishi H,Sakuma Y,Takahashi H,Kuroki Y,Takahashi M

更新日期：2017-11-16 00:00:00

abstract：:The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...

journal_title：Oncogene

authors： O'Neil J,Look AT

更新日期：2007-10-15 00:00:00

abstract：:Bcl-2 and Bcl-XL serve as critical inhibitors of apoptosis triggered by a broad range of stimuli, mainly acting on the mitochondria. We identified two members of the reticulon (RTN) family as Bcl-XL binding proteins, i.e., NSP-C (RTN1-C) and a new family member, RTN-XS, both of which did not belong to the Bcl-2 family...

journal_title：Oncogene

authors： Tagami S,Eguchi Y,Kinoshita M,Takeda M,Tsujimoto Y

更新日期：2000-11-23 00:00:00

abstract：:Loss of heterozygosity on chromosome 10p was observed frequently in human prostate cancers. Studies have demonstrated that the introduction of the short arm of human chromosome 10 into a human prostate cancer cell line, PPC-1, by microcell-mediated chromosome transfer (MMCT), suppressed the malignant phenotype, sugges...

journal_title：Oncogene

authors： Fukuhara H,Maruyama T,Nomura S,Oshimura M,Kitamura T,Sekiya T,Murakami Y

更新日期：2001-01-18 00:00:00

abstract：:Tumor cells typically contain a genome that is highly divergent from the genome of normal, non-transformed cells. This genetic divergence is caused by a number of distinct changes that the tumor cell acquires during its transformation from a normal cell into a tumorigenic counterpart. Changes to the genome include mut...

journal_title：Oncogene

authors： Janssen A,Medema RH

更新日期：2013-09-19 00:00:00

abstract：:Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, ...

journal_title：Oncogene

authors： Beyne-Rauzy O,Recher C,Dastugue N,Demur C,Pottier G,Laurent G,Sabatier L,Mansat-De Mas V

更新日期：2004-09-30 00:00:00

abstract：:The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma. In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-...

journal_title：Oncogene

authors： Clark J,Benjamin H,Gill S,Sidhar S,Goodwin G,Crew J,Gusterson BA,Shipley J,Cooper CS

更新日期：1996-01-18 00:00:00

abstract：:Estrogen receptor-alpha (ERalpha) and its ligand estradiol (E2) has critical roles in breast cancer growth and are key therapeutic targets. In this study, we report a novel dual role of the adenosine A1 receptor (Adora1) as an E2/ERalpha target and a regulator of ERalpha transcriptional activity. In ERalpha-positive b...

journal_title：Oncogene

authors： Lin Z,Yin P,Reierstad S,O'Halloran M,Coon VJ,Pearson EK,Mutlu GM,Bulun SE

更新日期：2010-02-25 00:00:00

abstract：:The death mediator caspase acts as the dominant regulator during cell death induction. The CPP32 subfamily, including caspase 3 (CPP32/Yama/Apopain), is essential for the cell death signaling. We recently reported that activation of caspase 3 is regulated by complex formation with p21 or ILP. In the present study, we ...

journal_title：Oncogene

authors： Suzuki A,Tsutomi Y,Miura M,Akahane K

更新日期：1999-02-04 00:00:00