Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice.

abstract：:Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...

journal_title：Oncogene

authors： Gooding AJ,Zhang B,Gunawardane L,Beard A,Valadkhan S,Schiemann WP

更新日期：2019-03-01 00:00:00

abstract：:We have previously demonstrated that the expression of FGFR3 is frequently downregulated in colorectal carcinoma cells. Here we have shown that FGFR1 is overexpressed in colorectal carcinoma cells and the gene expressions between FGFR1 and FGFR3 are mutually exclusive. Moreover, we have also shown that the disruption ...

journal_title：Oncogene

authors： Jang JH

更新日期：2005-01-27 00:00:00

abstract：:p73 is a member of the p53 family. Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p...

journal_title：Oncogene

authors： Chen X,Zheng Y,Zhu J,Jiang J,Wang J

更新日期：2001-02-08 00:00:00

abstract：:Hepatitis C virus (HCV) core has a pleiotropic effect on various promoters. In this study, we found that the expression of nucleolar phosphoprotein B23 was enhanced in HCV core-expressing cells and, moreover, HCV core interacts directly with the C-terminal end of B23. Using sucrose gradient centrifugation analysis and...

journal_title：Oncogene

authors： Mai RT,Yeh TS,Kao CF,Sun SK,Huang HH,Wu Lee YH

更新日期：2006-01-19 00:00:00

abstract：:Clinical and epidemiological data support a role for human papilloma virus (HPV) type 16 in the pathogenesis of cervical carcinoma. The W12 cell line contains HPV16 sequences, predominantly as a high copy number episome, and is immortalised in vitro, but non-tumourigenic. A morphologically distinct sub-line of the par...

journal_title：Oncogene

authors： Crook T,Greenfield I,Howard J,Stanley M

更新日期：1990-04-01 00:00:00

abstract：:High-risk papillomavirus type 18 (HPV18) is one of the less represented HPV types in low-grade lesions of the anogenital tract, whereas it occupies the second place in cervical cancer, where it can be found in 16% of the cases worldwide, after HPV16 present in 54% of them. These epidemiological data indicate that HPV1...

journal_title：Oncogene

authors： Teissier S,Pang CL,Thierry F

更新日期：2010-09-09 00:00:00

abstract：:During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...

journal_title：Oncogene

authors： Langer EM,Kendsersky ND,Daniel CJ,Kuziel GM,Pelz C,Murphy KM,Capecchi MR,Sears RC

更新日期：2018-02-22 00:00:00

abstract：:The product of the RB susceptibility gene has been shown to be differentially phosphorylated during the cell cycle, suggesting a role in the regulation of cell cycle progression. We examined the expression and phosphorylation status of the RB protein in senescent Syrian hamster embryo cells. Both phosphorylated and un...

journal_title：Oncogene

authors： Futreal PA,Barrett JC

更新日期：1991-07-01 00:00:00

abstract：:We screened cdc2 kinase inhibitors from cultured mediums of micro organisms using purified mouse cyclin B-cdc2 kinase and a specific substrate peptide for cdc2 kinase. A selective inhibitor of cdc2 kinase was isolated from the cultured medium of Aspergillus species F-25799, and identified as butyrolactone I. Butyrolac...

journal_title：Oncogene

authors： Kitagawa M,Okabe T,Ogino H,Matsumoto H,Suzuki-Takahashi I,Kokubo T,Higashi H,Saitoh S,Taya Y,Yasuda H

更新日期：1993-09-01 00:00:00

abstract：:The cdk2 gene has been identified as a human cdc2/CDC28-related gene that encodes a protein kinase essential for the G1/S transition in mammalian cells, but not for the G2/M transition, which requires Cdk1, another p34cdc2/CDC28 homolog. Novel potential functions of Cdk2 have been uncovered by using two potent and spe...

journal_title：Oncogene

authors： David-Pfeuty T

更新日期：1999-12-09 00:00:00

abstract：:The development of hepatocellular carcinomas (HCC) depends on their local microenvironment and the induction of neovascularization is a decisive step in tumor progression, since the growth of solid tumors is limited by nutrient and oxygen supply. Hypoxia is the critical factor that induces transcription of the hypoxia...

journal_title：Oncogene

authors： Wen Y,Zhou X,Lu M,He M,Tian Y,Liu L,Wang M,Tan W,Deng Y,Yang X,Mayer MP,Zou F,Chen X

更新日期：2019-03-01 00:00:00

abstract：:Shb is a recently described Src homology 2 (SH2) domain-containing adaptor protein. Here we show that Shb is expressed in lymphoid tissues, and is recruited into signaling complexes upon activation of Jurkat T cells. Grb2 binds proline-rich motifs in Shb via its SH3 domains. As a result, a number of proteins detected ...

journal_title：Oncogene

authors： Welsh M,Songyang Z,Frantz JD,Trüb T,Reedquist KA,Karlsson T,Miyazaki M,Cantley LC,Band H,Shoelson SE

更新日期：1998-02-19 00:00:00

abstract：:Ets1, the founder member of the Ets transcription factor family, is involved in a variety of developmental and cellular processes. Previous studies have shown that serine phosphorylation of Ets1 inhibits its DNA binding activity, suggesting that phosphorylation is important in the regulation of Ets1 function. To furth...

journal_title：Oncogene

authors： Rabault B,Roussel MF,Quang CT,Ghysdael J

更新日期：1996-08-15 00:00:00

abstract：:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...

journal_title：Oncogene

authors： Azzam EI,de Toledo SM,Little JB

更新日期：2003-10-13 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) are the predominant excitatory neurotransmitter receptors in the mammalian brain. We found that among the three NMDARs examined (NMDAR1, NMDAR2A, NMDAR2B), only NMDAR2A was silenced in colorectal carcinoma (CRC) cell lines at basal line and reactivated by the demethylating agent...

journal_title：Oncogene

authors： Kim MS,Chang X,Nagpal JK,Yamashita K,Baek JH,Dasgupta S,Wu G,Osada M,Woo JH,Westra WH,Trink B,Ratovitski EA,Moon C,Sidransky D

更新日期：2008-03-27 00:00:00

abstract：:Mitochondrial membrane permeabilization is a critical event in the process leading to physiological or chemotherapy-induced apoptosis. This permeabilization event is at least in part under the control of the permeability transition pore complex (PTPC), which interacts with oncoproteins from the Bcl-2 family as well as...

journal_title：Oncogene

authors： Costantini P,Belzacq AS,Vieira HL,Larochette N,de Pablo MA,Zamzami N,Susin SA,Brenner C,Kroemer G

更新日期：2000-01-13 00:00:00

abstract：:We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces an increase of intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide, leading us to propose that defec...

journal_title：Oncogene

authors： White-Gilbertson S,Mullen T,Senkal C,Lu P,Ogretmen B,Obeid L,Voelkel-Johnson C

更新日期：2009-02-26 00:00:00

abstract：:Glioblastoma is the most common and lethal primary malignant brain tumor in adults. The tumor suppressor gene PTEN is deleted, mutated or hypermethylated in more than 60% of glioblastoma cases resulting in hyperactivation of the phosphoinositide 3-kinase pathway, which leads to sustained PI(3,4,5)P3 signaling, and the...

journal_title：Oncogene

authors： Davies EM,Kong AM,Tan A,Gurung R,Sriratana A,Bukczynska PE,Ooms LM,McLean CA,Tiganis T,Mitchell CA

更新日期：2015-07-01 00:00:00

abstract：:A two-stage (initiation and promotion) model of chemical transformation of mouse embryonic fibroblasts was used to elucidate the molecular mechanisms of tumor promotion in vitro. C3H10T1/2 cells which had been initiated with a subcarcinogenic dose (0.5 micrograms ml-1) of benzo[a]pyrene (B[a]P) were isolated after 12-...

journal_title：Oncogene

authors： Wu WS,Lin JK,Wu FY

更新日期：1992-11-01 00:00:00

abstract：:Activator protein one (AP1) (jun/fos) factors comprise a family of transcriptional regulators (c-jun, junB, junD, c-fos, FosB, Fra-1 and Fra-2) that are key controllers of epidermal keratinocyte survival and differentiation, and are important drivers of cancer development. Understanding the role of these factors in ep...

journal_title：Oncogene

authors： Rorke EA,Adhikary G,Jans R,Crish JF,Eckert RL

更新日期：2010-11-04 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine that regulates the proliferation of some tumor cells including multiple myeloma (MM). Ectopic expression of fibroblast growth factor receptor 3 (FGFR 3) associated with the chromosomal translocation, t(4;14)(p16.3;q32), is frequently found in MM, and therefore, has been implicated in...

journal_title：Oncogene

authors： Ishikawa H,Tsuyama N,Liu S,Abroun S,Li FJ,Otsuyama K,Zheng X,Ma Z,Maki Y,Iqbal MS,Obata M,Kawano MM

更新日期：2005-09-15 00:00:00

abstract：:p8 is a stress-induced DNA-binding protein, biochemically related to the architectural chromatin binding HMG protein family and whose function is presently unknown. We obtained fibroblast from mice lacking p8 and found that p8 is involved in cell growth regulation and in apoptosis. p8(-/-) mouse embryonic fibroblasts ...

journal_title：Oncogene

authors： Vasseur S,Hoffmeister A,Garcia-Montero A,Mallo GV,Feil R,Kühbandner S,Dagorn JC,Iovanna JL

更新日期：2002-03-07 00:00:00

abstract：:While studying Bim, a BH3-only proapoptotic protein, we identified an approximately 36 kDa protein, which was abundantly expressed in all five strains of primary normal human prostate (NHP) epithelial cells but significantly reduced or lost in seven prostate cancer cell lines. The approximately 36 kDa protein was subs...

journal_title：Oncogene

authors： Liu JW,Shen JJ,Tanzillo-Swarts A,Bhatia B,Maldonado CM,Person MD,Lau SS,Tang DG

更新日期：2003-03-13 00:00:00

abstract：:We have previously shown that each of four activated oncogenes (c-myc, neu, ras, and int-2) can serve as transgenic initiators of morphologically distinct adenocarcinomas of the murine mammary gland. Since abnormalities of these oncogenes are found frequently in human breast cancers, such differences are of particular...

journal_title：Oncogene

authors： Morrison BW,Leder P

更新日期：1994-12-01 00:00:00

abstract：:Transcripts of the c-mos proto-oncogene were recently found to accumulate to high levels in mouse oocytes. We report here that the oocyte c-mos RNA is polyadenylated in concert with oocyte maturation, retained in mature ovulated eggs and zygotes but degraded by the late two cell embryo stage. These results suggest tha...

journal_title：Oncogene

authors： Goldman DS,Kiessling AA,Cooper GM

更新日期：1988-08-01 00:00:00

abstract：:Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is crucially important, especially for those cases in which aberrant levels of regulatory proteins (e.g., beta-catenin, p27) result from a der...

journal_title：Oncogene

authors： Latres E,Chiaur DS,Pagano M

更新日期：1999-01-28 00:00:00

abstract：:Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target gene...

journal_title：Oncogene

authors： Niida A,Hiroko T,Kasai M,Furukawa Y,Nakamura Y,Suzuki Y,Sugano S,Akiyama T

更新日期：2004-11-04 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is an inducible enzyme that contributes to the generation of chronic inflammation in response to chemical carcinogens and environmental stresses, including ultraviolet B (UVB) irradiation. Although post-translational histone modifications are believed to have an important role in modulating tr...

journal_title：Oncogene

authors： Keum YS,Kim HG,Bode AM,Surh YJ,Dong Z

更新日期：2013-01-24 00:00:00

abstract：:SIAH-1 and SIAH-2 are the human members of an evolutionary highly conserved E3 ligase family. SIAH-1 is a p53 and p21(Waf-1/Cip-1) induced gene during apoptosis and tumor suppression. In stable-transfected clones of MCF-7 cells, SIAH-1 overexpression was associated with apoptosis, mitotic alterations and p21(Waf-1/Cip...

journal_title：Oncogene

authors： Germani A,Prabel A,Mourah S,Podgorniak MP,Di Carlo A,Ehrlich R,Gisselbrecht S,Varin-Blank N,Calvo F,Bruzzoni-Giovanelli H

更新日期：2003-12-04 00:00:00

abstract：:Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosph...

journal_title：Oncogene

authors： Wang W,Liao P,Shen M,Chen T,Chen Y,Li Y,Lin X,Ge X,Wang P

更新日期：2016-01-28 00:00:00